Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph Jr, Ellen B. Gold, Carol Derby, Howard M. Kravitz, Gail Greendale, Xiangmei Wu, Keita Ebisu, Joel Schwartz, Sung Kyun Park
Summary: This study investigated the association between air pollution and levels of estradiol (E2) and follicle-stimulating hormone (FSH) in women during menopause. The findings showed that increased levels of PM2.5 and NO2 were associated with significant decreases in E2 levels, while increased levels of NO2 were associated with decreases in FSH levels. This suggests that air pollutants have a detrimental impact on women's reproductive hormones.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Maria C. Escalante-Rojas, Carlos E. Tolussi, Aline D. Gomes, Marcela Munoz-Penuela, Gabriela Brambila-Souza, Giovana S. Branco, Renata G. Moreira
Summary: Water contaminants in polluted reservoirs can impact the reproductive physiology of Astyanax fasciatus and Hoplias malabaricus males, potentially affecting the endocrine system and physiological adjustments. The biomarkers analyzed in polluted reservoirs show changes in gonadal steroid concentrations, suggesting the presence of endocrine disrupting compounds. Despite physiological changes, both species are able to maintain testicular function for reproduction in highly polluted environments.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Genetics & Heredity
Lawrence F. Bielak, Patricia A. Peyser, Jennifer A. Smith, Wei Zhao, Edward A. Ruiz-Narvaez, Sharon L. R. Kardia, Sioban D. Harlow
Summary: By studying multiple interrelated genetic traits, we identified differences in the genetic basis of menopause between different ethnic groups.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Helen B. Chin, Jenna R. Krall, Mandy Goldberg, Frank Z. Stanczyk, Kassa Darge, Virginia A. Stallings, Walter J. Rogan, David M. Umbach, Donna D. Baird
Summary: This study aims to describe the trajectories of anti-Mullerian hormone (AMH) among healthy infant girls and investigate its relationship with other reproductive factors. The results showed that the patterns of AMH concentration varied among infant girls, with some exhibiting a decreasing trend and others peaking at around 12 weeks or 20 weeks. These findings provide insights into the potential for early identification of future reproductive conditions.
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Olayiwola O. Oduwole, Ariel Poliandri, Anthony Okolo, Phil Rawson, Milena Doroszko, Marcin Chrusciel, Nafis A. Rahman, Gilberto Serrano de Almeida, Charlotte L. Bevan, Wolfgang Koechling, Ilpo T. Huhtaniemi
Summary: The study suggests that FSH, rather than LH, may directly stimulate the growth of androgen-independent prostate cancer. Continuous suppression of FSH during GnRH antagonist treatment may offer a therapeutic advantage over agonist in inhibiting tumor growth.
Article
Endocrinology & Metabolism
Yongjie Chen, Caihong Wang, Boran Sun, Bingyi Wang, Xinlin Lu, Bei Gao, Ye Cao, Jiangtao Zhou, Xuewei Liu
Summary: This study aimed to examine the associations between follicle-stimulating hormone (FSH), luteinizing hormone (LH), LH/FSH ratio, and the risk and severity score of metabolic syndrome (MetS) in US women. The results showed that elevated levels of serum FSH and LH were associated with a lower risk of MetS, especially in postmenopausal women. However, the LH/FSH ratio had no significant connections with the risk and severity score of MetS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Gillian P. Johnson, Caitlan G. A. Onabanjo, Kate Hardy, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Summary: The glycosylation variants of follicle-stimulating hormone (FSH) have differential effects on ovarian follicle growth and survival, with partially glycosylated FSH promoting follicle function and fully glycosylated FSH causing follicle damage and apoptosis.
Article
Public, Environmental & Occupational Health
Margot Guth, Tyler Pollock, Mandy Fisher, Tye E. Arbuckle, Maryse F. Bouchard
Summary: A study found a negative correlation between urinary paraben concentrations and serum hormone levels in girls, particularly estradiol, LH, and FSH. This suggests that parabens may impact the development and function of the endocrine system in females.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Obstetrics & Gynecology
Y. Wang, R. Tang, M. Luo, X. Sun, J. Li, Y. Yue, G. Liu, S. Lin, R. Chen
Summary: The study examines FSH and E2 trajectories in indigenous Chinese women through the ovarian aging process and finds that obese women may experience different levels of hormonal fluctuations during the menopause transition, while FSH levels in all women appear to remain high even at late postmenopause.
Article
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Alexander S. Busch, Emmie N. Upners, Margit Bistrup Fischer, Katharina M. Main, Anna-Maria Andersson, Trine Holm Johannsen, Casper P. Hagen, Anders Juul
Summary: This study evaluated LH/FSH ratios in serum and urine as markers of sex in healthy infants, finding that the ratios were highest in males aged 0-1.2 years with minimal overlap between sexes, serving as excellent discriminators of sex throughout the first year of life. The clinical implications and applications of these ratios require further exploration.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Teresa Zarinan, Julio Mayorga, Eduardo Jardon-Valadez, Ruben Gutierrez-Sagal, Jose Luis Maravillas-Montero, Nancy R. Mejia-Dominguez, Ivan Martinez-Luis, Omar G. Yacini-Torres, Ma del-Carmen Cravioto, Eric Reiter, Alfredo Ulloa-Aguirre
Summary: A novel missense mutation (I423T) in the FSHR second transmembrane domain was identified in a woman with primary ovarian failure, leading to impaired receptor expression and signaling. Meanwhile, the D408Y mutation severely affected membrane expression and signal transduction. Molecular dynamics simulations showed important disruptions in both mutant FSHRs, explaining the differences in expression levels, signaling, and phenotypic expression between I423T and D408Y mutant FSHRs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Victor E. Gomez-Leon, Adam D. Beard, O. J. Ginther, Milo C. Wiltbank
Summary: This study aimed to investigate the impact of low-dose hCG on multiple ovulations in lactating dairy cows. The results showed that increased hCG led to larger follicle sizes and higher FSH concentrations, resulting in an increased frequency of double ovulation.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Gabriele M. Rune, Gina Joue, Tobias Sommer
Summary: To translate findings on the effects of 178-estradiol (E2) from animal studies to humans, a placebo-controlled pharmacological enhancement of E2 levels for at least 24 hours was administered. The exogenous increase in E2 levels had an impact on the secretion of other hormones and neuroactive hormones. Overall, the E2V regimen resulted in similar E2 levels, down-regulation of FSH and LH levels, decreased P4 concentration, dropped TST and DHT levels in men, and decreased levels of IGF-1 in both sexes.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rebecca C. Thurston, Yuefang Chang, Karen A. Matthews, Sioban Harlow, Samar R. El Khoudary, Imke Janssen, Carol Derby
Summary: This study examined the relationship between interpersonal violence (including childhood abuse, adult abuse, and intimate partner violence) and the risk of cardiovascular disease (CVD) events in women. The results showed that childhood abuse, particularly sexual abuse, was associated with an increased risk of CVD in women. Intimate partner violence was also associated with CVD risk, with higher systolic blood pressure among IPV-exposed women being important in these associations.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Obstetrics & Gynecology
Meiyuzhen Qi, Xirun Chen, Ronald M. Krauss, Karen Matthews, Imke Janssen, Maria M. Brooks, Dan McConnell, Sybil L. Crawford, Samar R. El Khoudary
Summary: The study found that carotid intimal medial thickening is positively associated with small- and medium-sized LDL particles after menopause. Monitoring levels of specific lipoprotein fractions may help identify midlife women at risk for developing atherosclerotic vascular disease.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Medicine, General & Internal
Chen Liang, Hsin-Fang Chung, Annette J. Dobson, Kunihiko Hayashi, Yvonne T. van der Schouw, Diana Kuh, Rebecca Hardy, Carol A. Derby, Samar R. El Khoudary, Imke Janssen, Sven Sandin, Elisabete Weiderpass, Gita D. Mishra
Summary: Infertility, recurrent miscarriage, and stillbirth are associated with an increased risk of stroke, with different risk patterns for different stroke subtypes. These findings contribute to the monitoring and prevention of stroke in women with a history of these conditions.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Jared W. Magnani, Danielle Ferry, Gretchen Swabe, Deborah Martin, Xirun Chen, Maria M. Brooks, Everlyne Kimani, Michael K. Paasche-Orlow, Stefan Olafsson, Timothy Bickmore, Samar R. El Khoudary
Summary: This study aims to test the efficacy of a smartphone-based relational agent in improving clinical and patient-reported outcomes in rural-dwelling individuals.
AMERICAN HEART JOURNAL
(2022)
Article
Hematology
Anna E. Bortnick, Petra Buzkova, James Otvos, Majken Jensen, Michael Y. Tsai, Matthew Budoff, Rachel Mackey, Samar R. El Khoudary, Elda Favari, Ryung S. Kim, Carlos J. Rodriguez, George Thanassoulis, Jorge R. Kizer
Summary: This study found that high-density lipoprotein (HDL) cholesterol, HDL particle number and size, apoC3-defined HDL subtypes were inversely associated with the long-term incidence and progression of aortic valve calcification (AVC). Further investigation of HDL composition and mechanisms could be useful in understanding pathways that slow AVC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Gerontology
Brittney S. Lange-Maia, Samar R. El Khoudary, Carolyn J. Crandall, Yanyu Zhang, Carrie A. Karvonen-Gutierrez, Kelley Pettee Gabriel, Bradley M. Appelhans, Elsa S. Strotmeyer, Kelly R. Ylitalo, Kelly Karavolos, Howard M. Kravitz, Sheila A. Dugan, Imke Janssen
Summary: The study found that physical function before menopause is associated with cardiovascular disease risk, with women who have substantial limitations having a higher risk compared to those with no limitations.
JOURNAL OF AGING AND HEALTH
(2023)
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph, Bhramar Mukherjee, Ellen B. Gold, Sung Kyun Park
Summary: Exposure to heavy metals may affect sex hormone levels in women. This study analyzed the association between urinary metal concentrations and serum levels of estradiol (E-2), follicle-stimulating hormone (FSH), testosterone, and sex hormone-binding globulin (SHBG) in a multi-ethnic group of women aged 45-56 years. The results showed that higher urinary metal concentrations were linked to lower E-2 levels for mercury and lead, higher FSH levels for lead, and higher SHBG levels for cadmium. However, no significant association was found between metals and testosterone levels.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pharmacology & Pharmacy
Samar R. El Khoudary, Xirun Chen, Meiyuzhen Qi, Carol A. Derby, Maria M. Brooks, Rebecca C. Thurston, Imke Janssen, Sybil Crawford, Jennifer S. Lee, Elizabeth A. Jackson, Claudia U. Chae, Daniel McConnell, Karen A. Matthews
Summary: The study evaluated the independent associations of AMH and E2 levels and their changes with lipids/lipoproteins levels in menopausal women. Lower premenopausal AMH levels and greater declines in AMH were associated with higher total cholesterol and high-density lipoprotein cholesterol, while lower premenopausal E2 levels and greater declines in E2 were associated with higher triglyceride and apolipoprotein B levels and lower high-density lipoprotein cholesterol. These findings are important for understanding lipid metabolism changes during the menopausal transition.
JOURNAL OF CLINICAL LIPIDOLOGY
(2023)
Article
Endocrinology & Metabolism
Ning Ding, Emily Zheutlin, Sioban D. Harlow, John F. Randolph Jr, Bhramar Mukherjee, Sung Kyun Park
Summary: This study found that ubiquitous endocrine-disrupting chemicals, phthalates, may affect ovarian folliculogenesis and steroidogenesis. In midlife women, associations were observed between urinary phthalate metabolites and hormones, as well as timing of natural menopause. The results suggest that reducing exposure to phthalates may be crucial in preventing reproductive effects.
JOURNAL OF THE ENDOCRINE SOCIETY
(2023)
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph Jr, Ellen B. Gold, Carol Derby, Howard M. Kravitz, Gail Greendale, Xiangmei Wu, Keita Ebisu, Joel Schwartz, Sung Kyun Park
Summary: This study investigated the association between air pollution and levels of estradiol (E2) and follicle-stimulating hormone (FSH) in women during menopause. The findings showed that increased levels of PM2.5 and NO2 were associated with significant decreases in E2 levels, while increased levels of NO2 were associated with decreases in FSH levels. This suggests that air pollutants have a detrimental impact on women's reproductive hormones.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Obstetrics & Gynecology
Samar R. El Khoudary, Meiyuzhen Qi, Xirun Chen, Karen Matthews, Amanda A. Allshouse, Sybil L. Crawford, Carol A. Derby, Rebecca C. Thurston, Rasa Kazlauskaite, Emma Barinas-Mitchell, Nanette Santoro
Summary: Menstrual cycle length affects markers of subclinical atherosclerosis, with longer cycles associated with lower risk and late-increase patterns associated with higher risk.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Obstetrics & Gynecology
Stephanie S. Faubion, Carolyn J. Crandall, Lori Davis, Samar R. El Khoudary, Howard N. Hodis, Roger A. Lobo, Pauline M. Maki, JoAnn E. Manson, JoAnn V. Pinkerton, Nanette F. Santoro, Jan L. Shifren, Chrisandra L. Shufelt, Rebecca C. Thurston, Wendy Wolfman
Summary: The 2022 Hormone Therapy Position Statement of NAMS updates the previous statement and provides recommendations for the use of hormone therapy in menopausal women. Hormone therapy is effective in treating vasomotor symptoms and preventing bone loss, but its risks vary depending on individual factors. It is important to assess the benefits and risks on an individual basis and regularly reevaluate the need for continued therapy.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Obstetrics & Gynecology
Nanette F. Santoro, Helen L. Coons, Samar R. El Khoudary, C. Neill Epperson, Julianne Holt-Lunstad, Hadine Joffe, Sarah H. Lindsey, Kara L. Marlatt, Patti Montella, Gloria Richard-Davis, Bonny Rockette-Wagner, Marcel E. Salive, Cynthia Stuenkel, Rebecca C. Thurston, Nancy Woods, Holly Wyatt
Summary: The article discusses the foundational psychosocial and behavioral approaches to healthy aging and strategies for disseminating this information. It emphasizes that wellness is an active goal to be continually pursued and accessible to all.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Health Care Sciences & Services
Terri Victoria Newman, Nico Gabriel, Qinfeng Liang, Coleman Drake, Samar R. El Khoudary, Chester B. Good, Walid F. Gellad, Inmaculada Hernandez
Summary: The study compared oral anticoagulant (OAC) use and adherence between atrial fibrillation (AF) patients enrolled in Medicare stand-alone prescription drug plans (PDPs) and those enrolled in Medicare Advantage prescription drug (MAPD) plans. The results showed that AF patients in MAPD plans had higher OAC use and adherence rates compared to those in PDP plans, possibly due to the financial incentives for MAPD plans to reduce medical costs and benefit from cost savings related to prevented strokes.
JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY
(2022)
Article
Surgery
Amanda S. Hinerman, Emma J. M. Barinas-Mitchell, Samar R. El Khoudary, Anita P. Courcoulas, Abdus S. Wahed, Wendy C. King
Summary: This study reveals a significant improvement in CRP levels after Roux-en-Y gastric bypass surgery, with the majority of participants maintaining normal levels throughout 7 years of follow-up. However, individuals with higher BMI, diabetes, and smoking habits may require additional monitoring to ensure normal inflammation levels post-surgery.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)