Editorial Material
Immunology
Lucie Van Emmenis
Summary: This article introduces Jen Gommerman, a professor and newly appointed chair for the Department of Immunology at the University of Toronto. Her research interests include autoimmune diseases, mucosal immunology, and the role of TNF family members in immune cell biology. The article also discusses the importance of authenticity and openness in leadership, and Gommerman's goals as she begins her tenure as department chair.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Engineering, Civil
K. Wijesooriya, D. Mohotti, A. Amin, K. Chauhan
Summary: The study utilizes an innovative and time-efficient uncoupled one-way FSI simulation technique to estimate the structural response of a super-tall structure, showing good correlation with experimentally observed trends and providing similar numerical accuracy. Compared to traditional two-way FSI analysis, the uncoupled one-way FSI technique requires less computational time and is more cost-effective.
ENGINEERING STRUCTURES
(2021)
Article
Medicine, General & Internal
Alexandru Deaconu, Viviana Gondos, Radu Vatasescu
Summary: We report a case of a 41-year-old female with narrow QRS tachycardia, in which both orthodromic and antidromic atrioventricular reentry tachycardia (AVRT) as well as pre-excited atrial fibrillation were demonstrated. Unexpectedly, programmed atrial stimulation confirmed the presence of a Mahaim accessory pathway (AP). Limited 3D activation maps were used to accurately describe the atrial and ventricular insertion points, confirming the existence of a single short atrio-ventricular right free wall AP. Electroanatomical 3D mapping can help clarify the diagnosis and increase success rate in cases with complex accessory pathways.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Nuha Alamro, Afnan S. Azhri, Asma Almuqati, Firas Azzeh, Wedad Azhar, Alaa Qadhi, Najlaa H. Almohmadi, Wafaa F. Abusudah, Khloud Ghafouri
Summary: Bariatric surgery has been shown to achieve sustained weight loss and improve metabolism, reducing the risk of cardiovascular disease and diabetes. This retrospective study found that bariatric surgery resulted in significant decreases in blood pressure, glycated hemoglobin, thyroid-stimulating hormone, LDL cholesterol, triglycerides, and total cholesterol levels. The surgery also decreased the prevalence of metabolic syndrome and significantly reduced the Framingham risk score.
Article
Endocrinology & Metabolism
Fang Fang, Yu-Jia Gong, Qian Luo, Ren-Bin Ge, Mei Kang, Ming-Ming Ma, Lei Zhang, Di Mu, Da-Zhi Yin, Yu-Fan Wang
Summary: This study found that regular glycemic control in patients with type 2 diabetes led to improvements in cognition, but decreased the enhanced functional connectivity observed at baseline. Additionally, a decrease in hippocampal connectivity was associated with increased accuracy in the Stroop task, and a decrease in posterior cingulate cortex connectivity was associated with improved performance in the Montreal Cognitive Assessment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Nutrition & Dietetics
Diana L. Palacios Ovalle, Susana Rodrigo-Cano, Aranzazu Gonzalez, Carla Soler, Ana I. Catala-Gregori, J. Francisco Merino-Torres, Jose M. Soriano
Summary: This study looked at the relationship between obesity and COVID-19 during the first year of the pandemic, finding that severe COVID-19 patients had higher average BMI values. A new term, COVID obesity, was proposed to define the importance of this anthropometric parameter in relation to the pandemic.
Article
Energy & Fuels
V. Bobanac, H. Basic, H. Pandzic
Summary: This paper presents a method for obtaining individual one-way charging and discharging efficiencies dependent on the charging/discharging power. The accuracy of the proposed method is experimentally validated.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Veterinary Sciences
Lourdes Suarez, Inmaculada Bautista-Castano, Cristina Pena Romera, Jose Alberto Montoya-Alonso, Juan Alberto Corbera
Summary: This study aims to evaluate the risk factors contributing to canine obesity in a region with a high rate of human obesity. The results suggest that obese/overweight dogs in this region are mainly female, older than 6 years, and neutered, with the most important factor being overweight dog owners. There is a strong correlation between dog owners with low levels of education and obesity in their dogs.
VETERINARY SCIENCES
(2022)
Article
Engineering, Marine
Muhamad Hasfanizam Mat Yazik, Mohd Hafiz Zawawi, Ali Najah Ahmed, Lariyah Mohd Sidek, Hidayah Basri, Farzad Ismail
Summary: This paper presents a one-way three-dimensional fluid-structure interaction simulation to analyze the performance of a static Savonius hydrokinetic turbine. The results indicate that the optimal rotor position for the highest coefficient of static torque is at 15 degrees. Increasing water velocity improves the turbine's static torque, while surface roughness has a negative effect on the static torque coefficient. Different materials exhibit different stress and deformation, highlighting the importance of materials selection in the early design process.
Article
Otorhinolaryngology
Shireen Samargandy, John Wadie, Haytham Msallak, Albino Chiodo, William El Masri, Bradley Hubbard, Danny Enepekides, Kevin Higgins, Angela Assal, Rebecca Fine, Raymond Fung, Everton Nicholas, Valrie Beadle, Antoine Eskander
Summary: This study aimed to develop a PTH-based protocol to predict hypocalcemia after thyroidectomy. The results showed that using postoperative PTH cut-offs can effectively predict hypocalcemia and reduce unnecessary calcium replacement and length of stay.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
News Item
Physics, Multidisciplinary
Simone Gasparinetti
Summary: The emission of light from qubits in a superconducting circuit can be controlled to determine the direction of photon propagation, allowing for information routing in quantum networks.
Article
Engineering, Civil
Desingurajan Nigitha, Deendayal Rathod, Kaloor Thottooli Krishnanunni
Summary: This study investigates the influence of embedded length on monopile behavior using finite-element analysis (Plaxis 3D) and validates the model with a centrifuge test. Numerical studies were conducted on a 6 m diameter monopile by varying the load amplitude and embedded length ratios. The results show that an increase in load amplitude leads to a higher rate of accumulated displacement, while the effect of embedded length is not as significant as that of load amplitude.
PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-MARITIME ENGINEERING
(2023)
Editorial Material
Chemistry, Physical
Mingda Li, Yao Wang
Summary: Dislocations engineered through plastic deformation are found to enhance quantum fluctuations and superconductivity in SrTiO3.
Review
Biochemistry & Molecular Biology
Ioana Balinisteanu, Monica-Cristina Panzaru, Lavinia Caba, Maria-Christina Ungureanu, Andreea Florea, Ana Maria Grigore, Eusebiu Vlad Gorduza
Summary: Cancer predisposition syndromes with thyroid cancer involve germinal pathogenic variants and have heterogeneous clinical manifestations. Understanding the genotype-phenotype correlations is crucial for managing patients and families effectively. This review provides a comprehensive synthesis of the current knowledge on genes and proteins associated with cancer predisposition syndromes and the heterogeneity observed.
Review
Medicine, General & Internal
Stefania Masone, Nunzio Velotti, Silvia Savastano, Emanuele Filice, Rossana Serao, Antonio Vitiello, Giovanna Berardi, Vincenzo Schiavone, Mario Musella
Summary: Research has shown that obesity and excess body weight are associated with an increased risk of thyroid cancer, potentially through impacting immune cells and production of pro-inflammatory factors, the action of insulin, and chronic inflammation pathways.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Laura Croce, Luca Chiovato, Massimo Tonacchera, Elena Petrosino, Maria Laura Tanda, Mariacarla Moleti, Flavia Magri, Antonella Olivieri, Elizabeth N. Pearce, Mario Rotondi
Summary: The study aimed to review the available evidence from meta-analyses on iodine supplementation during pregnancy in areas with mild-moderate deficiency. The findings suggest a U-shaped correlation between iodine status and maternal and neonatal outcomes, but the results of intervention trials are inconclusive. More high-quality studies are needed to further clarify this issue.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Environmental Sciences
Francesca Coperchini, Alessia Greco, Laura Croce, Marco Denegri, Flavia Magri, Mario Rotondi, Luca Chiovato
Summary: This study investigated the adverse effects of the pesticide Glyphosate on thyroid cells in vitro. The results showed that Glyphosate reduced cell viability and proliferation, and increased the production of reactive oxygen species. Additionally, Glyphosate increased the mRNA levels of thyroid-related genes. This study supports the detrimental effects of Glyphosate on cultured thyroid cells.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Byorn W. L. Tan, Bryce W. Q. Tan, Amelia L. M. Tan, Emily R. Schriver, Alba Gutierrez-Sacristan, Priyam Das, William Yuan, Meghan R. Hutch, Noelia Garcia Barrio, Miguel Pedrera Jimenez, Noor Abu-el-rub, Michele Morris, Bertrand Moal, Guillaume Verdy, Kelly Cho, Yuk-Lam Ho, Lav P. Patel, Arianna Dagliati, Antoine Neuraz, Jeffrey G. Klann, Andrew M. South, Shyam Visweswaran, David A. Hanauer, Sarah E. Maidlow, Mei Liu, Danielle L. Mowery, Ashley Batugo, Adeline Makoudjou, Patric Tippmann, Daniela Zoeller, Gabriel A. Brat, Yuan Luo, Paul Avillach, Riccardo Bellazzi, Luca Chiovato, Alberto Malovini, Valentina Tibollo, Malarkodi Jebathilagam Samayamuthu, Pablo Serrano Balazote, Zongqi Xia, Ne Hooi Will Loh, Lorenzo Chiudinelli, Clara-Lea Bonzel, Chuan Hong, Harrison G. Zhang, Griffin M. Weber, Isaac S. Kohane, Tianxi Cai, Gilbert S. Omenn, John H. Holmes, Kee Yuan Ngiam
Summary: This retrospective observational study analyzed data from 12,891 COVID-19 patients and found that age, severe COVID-19, severe acute kidney injury (AKI), and ischemic heart disease were associated with worse mortality outcomes. The severity of AKI was associated with poorer kidney function recovery, while the use of remdesivir was associated with better recovery. In patients without chronic kidney disease, age, male sex, severe AKI, and hypertension were associated with post-AKI kidney function impairment. COVID-19-associated AKI was also linked to higher mortality and worse long-term kidney function recovery.
Review
Endocrinology & Metabolism
S. Pinto, L. Croce, L. Carlier, E. Cosson, M. Rotondi
Summary: This review provides an overview of the peculiar aspects of gestational diabetes mellitus (GDM) and gestational thyroid dysfunction (GTD), highlighting the potential interactions and clinical consequences of these two frequent clinical conditions.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Laura Croce, Spyridon Chytiris, Francesca Coperchini, Giovanni Ferraro, Linda Minelli, Antonella Navarra, Flavia Magri, Luca Chiovato, Pierpaolo Trimboli, Mario Rotondi
Summary: This study aimed to evaluate potential strategies for clinical and biochemical characterization of UH patients. The results showed that laboratory interferences are not more frequent in UH patients, suggesting that they should be managed in the same way as CAT patients until proven otherwise.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Rosaria Maddalena Ruggeri, Maria Cristina Barbalace, Laura Croce, Marco Malaguti, Alfredo Campenni, Mario Rotondi, Salvatore Cannavo, Silvana Hrelia
Summary: Autoimmune thyroid diseases are increasing rapidly worldwide due to environmental factors related to changed lifestyles. Unhealthy high-energy diets negatively affect autoimmunity, while the Mediterranean diet positively influences immune system function, gut microbiota composition, and redox homeostasis.
Article
Endocrinology & Metabolism
L. Croce, R. M. Ruggeri, C. Cappelli, C. Virili, F. Coperchini, M. Lagana, P. Costa, M. Dal Molin, S. Chytiris, F. Magri, L. Chiovato, M. Centanni, S. Cannavo, M. Rotondi
Summary: The aim of this study was to investigate the reason leading to the diagnosis of thyroid nodules (TN) and to compare the clinical characteristics of patients diagnosed incidentally with those of patients diagnosed for thyroid-related reasons.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Laura Croce, Cristina Pallavicini, Noemi Busca, Benedetto Cali, Giuseppe Bellastella, Francesca Coperchini, Flavia Magri, Luca Chiovato, Hellas Cena, Mario Rotondi
Summary: A prospective study was conducted to assess the efficacy of dietetic intervention in preventing post-thyroidectomy weight gain. The results showed that personalized pre-surgery diet counseling was effective in preventing weight gain after thyroidectomy.
Article
Environmental Sciences
Francesca Coperchini, Giuseppina De Marco, Laura Croce, Marco Denegri, Alessia Greco, Flavia Magri, Massimo Tonacchera, Marcello Imbriani, Mario Rotondi, Luca Chiovato
Summary: Industrial chemical PFAS are persistent pollutants. The effects of different PFAS on cell viability, proliferation, and secretion of CXCL8 in normal and cancer thyroid cells were evaluated. The specific cell type and target analyte showed strikingly different responses to individual PFAS. The results indicate that in vitro exposure to PFAS can modulate both mRNA and secreted protein levels of CXCL8.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Endocrinology & Metabolism
Rosa di Fraia, Daniela Esposito, Lucia Digitale Selvaggio, Francesca Allosso, Roberto Alfano, Mario Rotondi, Giancarlo Balercia, Giacomo Accardo, Daniela Pasquali
Summary: Compared to the control group, there is a significantly higher prevalence of nodular thyroid disease in patients with Klinefelter syndrome (KS). This increase is likely linked to low levels of FT4, inappropriate TSH secretion, and/or genetic instability.
Article
Endocrinology & Metabolism
Pierpaolo Trimboli, Nicola Ossola, Alessandro Torre, Francesco Mongelli, Massimo Quarenghi, Chiara Camponovo, Barbara Lucchini, Mario Rotondi, Lorenzo Ruinelli, Fabio Garofalo
Summary: This study evaluated the impact of bariatric surgery on the performance of LT4. The results showed that there was no significant difference in the daily dose of LT4 before and one year after surgery, but the LT4 dose per weight increased significantly, especially in RYGB patients. The study concluded that despite weight reduction, the daily dose of LT4 remains unchanged after bariatric surgery, while the dose per weight increases.
Article
Endocrinology & Metabolism
Ilenia Pirola, Mario Rotondi, Elena Di Lodovico, Letizia Chiara Pezzaioli, Barbara Agosti, Maurizio Castellano, Alberto Ferlin, Carlo Cappelli
Summary: This retrospective study evaluated the characteristics of patients who dropped out from ultrasound thyroid nodule follow-up. The results showed that one-third of patients missed their follow-ups, with the main reason being the low perceived threat from the disease. Therefore, it is crucial to reinforce patients' awareness regarding their own health state.
