Article
Biochemistry & Molecular Biology
Abdul K. Siraj, Pratheesh Kumar Poyil, Sandeep Kumar Parvathareddy, Khadija Alobaisi, Saeeda O. Ahmed, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: ZNF677 is frequently downregulated in primary PTC in Middle Eastern patients, and complete loss of its expression is significantly associated with aggressive clinico-pathological markers. Loss of ZNF677 is linked to distant metastasis and lower metastasis-free survival in PTC patients, highlighting its role as a tumor suppressor in carcinogenesis and metastasis formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Daqi Zhang, Mingyu Yang, Xin Zhang, Cheng Wang, Kunlin Li, Hongbo Wang, Hao Chi, Chengqiu Sui, Gianlorenzo Dionigi, Hui Sun
Summary: This study presents a rare case series of synchronous occurrence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) in the same thyroid gland. The synchronous MTC/PTC were classified into 4 subtypes and the clinical and pathological aspects as well as the results were presented.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Yuan Qin, Wei Sun, Zhihong Wang, Wenwu Dong, Liang He, Ting Zhang, Chengzhou Lv, Hao Zhang
Summary: This study revealed the regulatory mechanism of the RBM47/SNHG5/FOXO3 axis on cell proliferation and autophagy in PTC, which may provide valuable insight for the treatment of PTC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Fabiana Pani, Yoshinori Yasuda, Sylvie T. Rousseau, Kevin C. Bermea, Solmaz Roshanmehr, Rulin Wang, Srinivasan Yegnasubramanian, Patrizio Caturegli, Luigi Adamo
Summary: The pre-conditioning of the immune system can modulate the therapeutic effect of immune checkpoint inhibitors (ICI); however, the mechanisms behind this phenomenon are still unclear. This study showed that the simultaneous induction of immune-mediated thyroiditis (IET) and papillary thyroid cancer (PTC) in mice resulted in a decreased incidence of PTC in response to ICI treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biotechnology & Applied Microbiology
Yunchao Xin, Xiaoling Shang, Xiaoran Sun, Guogang Xu, Yachao Liu, Yanbin Liu
Summary: This study found that SLC8A1-AS1 is downregulated in PTC and its overexpression can suppress the proliferation, apoptosis, invasion, and migration of PTC cells. Mechanistically, SLC8A1-AS1 maintains the stability of Numbl mRNA by interacting with FUS, and depletion of Numbl reverses the inhibitory effect of SLC8A1-AS1 on PTC.
Article
Genetics & Heredity
Brian M. Ortmann, Natalie Burrows, Ian T. Lobb, Esther Arnaiz, Niek Wit, Peter S. J. Bailey, Louise H. Jordon, Olivia Lombardi, Ana Penalver, James McCaffrey, Rachel Seear, David R. Mole, Peter J. Ratcliffe, Patrick H. Maxwell, James A. Nathan
Summary: The histone H3K4 methyltransferase SET1B plays a crucial role in the transcriptional activity of HIF target genes, and its loss results in impaired cell growth and tumor formation. Experimental findings demonstrate that SET1B accumulates on chromatin in hypoxia and is recruited to HIF target genes by the HIF complex.
Article
Oncology
Wen -Ting Peng, Xi Jin, Xiao-En Xu, Yun-Song Yang, Ding Ma, Zhi-Ming Shao, Yi-Zhou Jiang
Summary: This study identifies ACAA1 as a potential therapeutic target for TNBC, specifically in the LAR subtype. Inhibition of ACAA1 can suppress TNBC proliferation and enhance the response to abemaciclib. The combination of trimetazidine and abemaciclib shows promise in treating ACAA1-high TNBCs.
Article
Endocrinology & Metabolism
Xiaojun Zhang, Wenkuan Chen, Qigen Fang, Jie Fan, Lu Feng, Lanwei Guo, Shanting Liu, Hong Ge, Wei Du
Summary: A retrospective analysis revealed that the incidence and risk factors for lateral lymph node metastases in T1a papillary thyroid carcinoma are associated with tumor location and size. Particularly, patients with tumor located in the upper lobe of the thyroid and tumor size larger than 5 mm have a higher risk of lateral lymph node metastases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Tiantian Wang, Jinyuan Shi, Luchuan Li, Xiaoming Zhou, Hui Zhang, Xiaofang Zhang, Yong Wang, Lian Liu, Lei Sheng
Summary: This study used single-cell RNA sequencing to analyze the tumor microenvironment in PTC and found significant inter-tumor heterogeneity in bilateral PTC. They also identified biomarkers and pathways associated with prognosis and disease progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Cole Malloy, Maisie Ahern, Lin Lin, Dax A. Hoffman
Summary: The coordinated action of voltage-gated ion channels, often associated with auxiliary subunits, is crucial for controlling neuronal physiology and circuit function in the brain. Dipeptidyl aminopeptidase-like protein 6 (DPP6), an auxiliary subunit expressed in multiple brain regions, interacts with A-type K+ channels to regulate their distribution and gating properties, as well as plays an independent role in synaptic formation and maintenance. Dysfunction of DPP6 is associated with various neurological disorders. Understanding the contribution of DPP6 to these disorders is an active area of research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Hortense Didier-Mathon, Athanasia Stoupa, Dulanjalee Kariyawasam, Sonny Yde, Beatrix Cochant-Priollet, Lionel Groussin, Frederic Sebag, Nicolas Cagnard, Patrick Nitschke, Dominique Luton, Michel Polak, Aurore Carre
Summary: BOREALIN/CDCA8 mutations are associated with congenital hypothyroidism and thyroid dysgenesis. Borealin plays a critical role in mitosis and may also contribute to thyroid cancer susceptibility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Ornella Affinito, Francesca Maria Orlandella, Neila Luciano, Marco Salvatore, Giuliana Salvatore, Monica Franzese
Summary: This study reveals the dynamics of mutational processes within PTC cells and how ITH affects patient prognosis. Genetic heterogeneity increases as the disease progresses, impacting survival rates. Different mutational processes cooperate to shape a stage-specific mutational spectrum, with distinct evolutionary paths across different tumor stages.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Seok-Mo Kim, Keunwan Park, Jin Hong Lim, Hyeok Jun Yun, Sang Yong Kim, Kyung Hwa Choi, Chan Wung Kim, Jae Ha Lee, Raymond Weicker, Cheol-Ho Pan, Ki Cheong Park
Summary: In the treatment of therapy-refractory papillary thyroid carcinoma (PTC), the discovery of SERCA as an essential factor for cell survival provides a potential target for developing drugs. The novel SERCA inhibitors show promising results in reducing tumors in therapy-resistant PTC cells, providing a basis for developing a combination therapy for targeting extremely malignant cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wenwen Li, Teng Wang, Guobin Fu, Yuan Xu, Nasha Zhang, Linyu Han, Ming Yang
Summary: In this study, the researchers investigated the role of functional single-nucleotide polymorphisms (SNPs) in the adenosine-to-inosine (A-to-I) RNA editing genes in papillary thyroid cancer (PTC). They discovered that two genetic variants in the ADARB2 gene, rs904957 and rs1007147, were associated with an increased risk of PTC. Further investigations revealed that ADARB2 functions as a tumor suppressor and that the rs904957 SNP enhances miR-1180-3p-binding affinity and represses ADARB2 expression. These findings provide insights into the role of RNA editing genes in PTC development.
ENDOCRINE-RELATED CANCER
(2023)