Article
Endocrinology & Metabolism
Xiao Song Liu, Xiu Juan Su, Guo Hua Li, Shi Jia Huang, Yang Liu, Han Xiang Sun, Qiao Ling Du
Summary: This study found an association between FT4 and birth weight as well as birth weight discordance in twins, while TSH was not associated with birth weight. These findings have implications for obstetricians in preventing birth weight discordance in twin pregnancies.
Article
Obstetrics & Gynecology
Fangfang Xi, Huiqi Chen, Qinqing Chen, Danqing Chen, Yuan Chen, Matthew Sagnelli, Guangdi Chen, Baihui Zhao, Qiong Luo
Summary: The study evaluated the association between lipid profiles in the second and third trimesters of pregnancy and fetal birth weight. The findings suggest that high triglyceride and low high-density lipoprotein levels during the third trimester may increase the risk of large-for-gestational-age infants and macrosomia. Strategies to lower triglyceride levels in women of reproductive age may help reduce the incidence of large-for-gestational-age infants and macrosomia in the future.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Acoustics
R. L. Deter, W. Lee, P. Dicker, E. C. Tully, F. Cody, F. D. Malone, K. M. Flood
Summary: This study found that there are seven growth restriction patterns in small fetuses with delayed growth in the third trimester. 37% of fetuses without evidence of growth restriction had vascular abnormalities. The distribution and types of normal growth and growth restriction patterns in the AGA cohort were different compared to the SGA cohort.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Nutrition & Dietetics
Emilie Bernier, Amelie Lachance, Anne-Sophie Plante, Patricia Lemieux, Karim Mourabit Amari, S. John Weisnagel, Claudia Gagnon, Andreanne Michaud, Andre Tchernof, Anne-Sophie Morisset
Summary: This study aimed to explore the variations in serum fructosamine during pregnancy and its associations with adiposity/metabolic markers. The results showed that serum fructosamine concentrations decreased during pregnancy and were inversely associated with pre-pregnancy BMI, first-trimester adiposity, and leptin. However, once corrected for albumin, most of the correlations weakened. Additionally, fructosamine concentrations were positively associated with third-trimester fasting glucose and CRP after adjusting for pre-pregnancy BMI.
Article
Multidisciplinary Sciences
Francesco D'Ambrosi, Marta Ruggiero, Nicola Cesano, Matteo Di Maso, Giulia Emily Cetera, Beatrice Tassis, Ilma Floriana Carbone, Enrico Ferrazzi
Summary: A study found that in a large population, the rate of stillbirth in singleton pregnancies at term was 0.48 per 1000, with the highest incidence at 38 weeks of gestation. The majority of stillbirths occurred before 39 weeks of gestation, and 6 out of 28 cases were small for gestational age (SGA) fetuses, with the remaining case at the 35th percentile.
Article
Medicine, General & Internal
Maria Sonsoles Galan Arevalo, Ignacio Mahillo-Fernandez, Luis Mariano Esteban, Mercedes Andeyro-Garcia, Roi Pineiro Perez, Miguel Saenz de Pipaon, Ricardo Saviron-Cornudella
Summary: Fetal growth restriction is associated with increased risk of adverse perinatal outcomes (APOs). In the study, it was found that newborns who are small-for-gestational-age (SGA) without fetal growth detention (FGD) have the highest probability of APOs. However, appropriate-for-gestational-age (AGA) newborns with FGD did not show an increased risk of APOs, except for a higher risk of cesarean section in cases where percentile cutoff fell over 40. More research is needed to identify newborns who may benefit from closer monitoring in late gestation and during delivery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Jessica L. Gleason, Edwina H. Yeung, Rajeshwari Sundaram, Diane L. Putnick, Pauline Mendola, Erin M. Bell, Kristen J. Polinski, Sonia L. Robinson, Katherine L. Grantz
Summary: This study investigates the growth patterns of twins and whether they exhibit signs of excess growth similar to singletons born small-for-gestational age (SGA), which may increase future cardiometabolic risk. The results show that although twins have lower height, weight, and BMI z-scores at birth and in early childhood, these differences diminish by 7-9 years of age, with no evidence of pathological growth or increased risk of overweight/obesity in any group of twins.
JOURNAL OF PEDIATRICS
(2023)
Article
Acoustics
Angelo Sirico, Anke Diemert, Peter Glosemeyer, Kurt Hecher
Summary: This study found a correlation between umbilical artery pulsatility index and estimated fetal weight percentile and birthweight percentile, with low UA-PI independently associated with neonatal LGA. The results suggest that the higher the EFW and BW percentiles, the lower the UA-PI.
ULTRASCHALL IN DER MEDIZIN
(2021)
Article
Endocrinology & Metabolism
Yali Pan, Su Zou, Yingjia Xu, Ruomin Di, Huafen Gu, Zhangsheng Wang, Xiang Wei, Chenxi Yang, Gaofeng Zhang
Summary: This study aimed to investigate the association between the triglyceride-glucose index (TyG index) and the incidence of hypertensive disorder of pregnancy (HDP) and adverse pregnancy outcomes. The results showed a significant association between the TyG index and the incidence of HDP as well as the occurrence of low birth weight and fetal distress.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Guilan Xie, Ruiqi Wang, Boxing Zhang, Landi Sun, Wanwan Xiang, Mengmeng Xu, Sijing Zhu, Leqian Guo, Xu Xu, Wenfang Yang
Summary: The study revealed non-linear connections and breakpoints between maternal hemoglobin concentration and birth weight outcomes, providing guidance for preventing adverse birth weight outcomes due to abnormal maternal hemoglobin concentration.
FRONTIERS IN NUTRITION
(2022)
Article
Veterinary Sciences
Mohammad Shamim Hossein, Young-Bum Son, Yeon Ik Jeong, Mina Kang, Seejin Lee, Alex Tinson, Woo Suk Hwang
Summary: This article reports a case of monoamniotic twin abortion in a dromedary camel and discusses the rarity and significance of this condition in livestock species.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Obstetrics & Gynecology
Mehmet Mete Kirlangic, Osman Sertac Sade, Mefkure Eraslan Sahin
Summary: This study aimed to evaluate the relationship between vitamin D levels and markers of fetal development. Results showed that the marker for predicting adverse perinatal outcomes, PW/BW ratio, significantly increased in the presence of vitamin D deficiency and insufficiency.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Chengyi Zheng, Jiaqi Tian, Lan Ma, Chunjie Ding, Lin Zhang
Summary: Studies have shown that prenatal ozone exposure is associated with an increased risk of adverse pregnancy outcomes, particularly abnormal birth weight. However, the relationship between birth weight and ozone exposure remains inconclusive. This study found that prenatal ozone exposure was weakly linked to birth weight but was associated with a decreased risk of macrosomia.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Acoustics
M. van Roekel, J. Henrichs, A. Franx, C. J. Verhoeven, A. de Jonge
Summary: This study aimed to examine the implications of third-trimester small-for-gestational-age (SGA) screening accuracy on severe adverse perinatal outcome (SAPO) and obstetric intervention. The results showed that infants suspected of being SGA during pregnancy had a higher risk of SAPO and obstetric intervention. However, third-trimester sonographic growth-trajectory measurements did not provide significant additional value in predicting SAPO in low-risk populations.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Hong Cui, Ziwei Wang, Jinzhe Yu, Caixia Liu
Summary: This study investigated the birthweight and incidence of birth asphyxia in 5337 pairs of twins, revealing a higher risk of asphyxia in twins with lower birthweight. It was also found that birthweight is an independent predictor of asphyxia.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Simon Veedfald, Jens F. Rehfeld, Gerrit van Hall, Lars B. Svendsen, Jens J. Holst
Summary: The study investigated the rapid entero-pancreatic hormone secretion after nutrient ingestion and its correlation with gastric emptying and glucose absorption. Findings showed characteristic differences in timing and amplitude of early postprandial hormone responses, emphasizing the need to consider individual variations when interpreting mean responses and designing study protocols.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Orthopedics
A. E. M. Jorgensen, J. Agergaard, P. Schjerling, K. M. Heinemeier, G. van Hall, M. Kjaer
Summary: This study aimed to determine the regional turnover of human osteoarthritis cartilage. The results revealed that the turnover of the articular cartilage matrix across the entire joint surface is very limited, but higher turnover was observed in osteophyte cartilage.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Health Care Sciences & Services
Signe de Place Knudsen, Saud Abdulaziz Alomairah, Caroline Borup Roland, Anne Dsane Jessen, Ida-Marie Hergel, Tine D. Clausen, Jakob Eg Larsen, Gerrit van Hall, Andreas Kryger Jensen, Stig Molsted, Jane M. Bendix, Ellen Lokkegaard, Bente Stallknecht
Summary: This study aimed to evaluate the effects of structured exercise training or motivational counseling on the level of moderate-to-vigorous intensity physical activity during pregnancy. The results showed that offering exercise training was more effective in increasing physical activity among pregnant women compared to offering motivational counseling.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Endocrinology & Metabolism
Freja Barrett Mork, Jens Otto Broby Madsen, Kasper Ascanius Pilgaard, Andreas Kryger Jensen, Heidi Klakk, Jakob Tarp, Anna Bugge, Malene Heidemann, Gerrit Van Hall, Flemming Pociot, Niels Wedderkopp, Jesper Johannesen
Summary: Children and adolescents with T1D have a higher risk of developing MetS compared to healthy controls. Early prevention and health promotion strategies should be considered by clinicians and caregivers.
PEDIATRIC DIABETES
(2022)
Article
Medicine, General & Internal
Roopameera Thirumathyam, Erik Arne Richter, Jens Peter Goetze, Mogens Fenger, Gerrit Van Hall, Ulrik Dixen, Jens Juul Holst, Sten Madsbad, Niels Vejlstrup, Per Lav Madsen, Nils Bruun Jorgensen
Summary: This study aims to compare the impact of SGLT2 inhibitors and insulin treatment on myocardial function in patients with type 2 diabetes. The results will reveal the importance of different metabolic profiles for cardiovascular health.
Article
Cardiac & Cardiovascular Systems
Johanna Roche, Peter Rasmussen, Hannes Gatterer, Giulia Roveri, Rachel Turner, Gerrit van Hall, Marc Maillard, Anna Walzl, Michael Kob, Giacomo Strapazzon, Jens Peter Goetze, Simon Thomas Schaefer, Tobias Kammerer, Elie Nader, Philippe Connes, Melanie Robert, Thomas Mueller, Eric Feraille, Christoph Siebenmann
Summary: This study is the first to investigate the mechanisms underlying plasma volume (PV) contraction in response to hypoxia in women while strictly controlling for confounders. PV contraction in women has a similar time course and magnitude as in men and is driven by the same mechanism, namely, oncotically driven redistribution rather than loss of fluid. We further report that hypoxia facilitates an increase in diuresis, that is, however, short-lived and of little relevance for PV regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Allergy
Lise Gether, Heidi Storgaard, Sanja Kezic, Ivone Jakasa, Bolette Hartmann, Kirsa Skov-Jeppesen, Jens J. Holst, Anders J. Pedersen, Julie Forman, Gerrit van Hall, Ole E. Sorensen, Lone Skov, Mads A. Ropke, Filip K. Knop, Jacob Pontoppidan Thyssen
Summary: This study investigated whether whole-body treatment with topical corticosteroids for atopic dermatitis could lead to insulin resistance and increased bone resorption. The results showed that short-term use of these corticosteroids did not affect glucose metabolism but had a negative impact on bone formation.
Article
Nutrition & Dietetics
Agnethe May Ahnfeldt, Lise Aunsholt, Bo Moelholm Hansen, Bente Hoest, Valdis Johannsdottir, Susanne Soendergaard Kappel, Anja Klamer, Soren Moller, Bertha Kanijo Moeller, Per Torp Sangild, Ann Lawaetz Skovgaard, Gerrit van Hall, Louise Dyrberg Vibede, Gitte Zachariassen
Summary: Investigating the use of intact bovine colostrum as a fortifier for human milk in very preterm infants, it was found that it is feasible, safe, and showed preliminary efficacy in terms of growth and blood biochemistry. The fortification with bovine colostrum resulted in similar growth but provided more protein and elevated amino acid levels compared to conventional fortifiers.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Jakob Agergaard, Thomas Ehlig Hjermind Justesen, Simon Elmer Jespersen, Thomas Tagmose Thomsen, Lars Holm, Gerrit van Hall
Summary: This study examined the impact of evenly distributed protein intake on older adults and found that it can enhance amino acid absorption and overall protein net-balance.
CLINICAL NUTRITION
(2023)
Article
Physiology
Jakob Wang, Anna-Maria Godsk Mogensen, Frederik Thybo, Magnus Brandbyge, Jonas Brorson, Gerrit van Hall, Jakob Agergaard, Frank Vincenzo de Paoli, Benjamin F. Miller, Hans Erik Botker, Jean Farup, Kristian Vissing
Summary: This study found that low-load blood flow-restricted resistance exercise (BFRRE) is effective in promoting muscle hypertrophy and improving muscle function in older individuals. However, its impact on age-related skeletal muscle decay at a cellular level is still unclear. BFRRE resulted in significant increases in muscle fiber morphology, integrated muscle protein synthesis, and muscle functional capacity without changes in muscle stem cells (MuSCs) and myonuclear content.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Line O. Elingaard-Larsen, Sofie O. Villumsen, Louise Justesen, Anne Cathrine B. Thuesen, Min Kim, Mina Ali, Else R. Danielsen, Cristina Legido-Quigley, Gerrit van Hall, Torben Hansen, Tarunveer S. Ahluwalia, Allan A. Vaag, Charlotte Brons
Summary: The influence of increased liver fat content on differences in circulating metabolites and lipids between low-birth-weight (LBW) individuals and normal-birth-weight (NBW) controls remains unknown. In this study, untargeted serum metabolomics and lipidomics analyses were performed on 26 healthy LBW men, including individuals with non-alcoholic fatty liver disease (NAFLD), compared to age- and BMI-matched NBW controls. The results showed significant differences in metabolites and lipids between LBW men and NBW controls, with more pronounced differences observed in LBW men with NAFLD. The findings emphasize the importance of increased liver fat in the development of type 2 diabetes in LBW individuals.
Article
Endocrinology & Metabolism
Grit E. Legaard, Mark P. P. Lyngbaek, Thomas P. Almdal, Kristian Karstoft, Sebastian L. Bennetsen, Camilla S. Feineis, Nina S. Nielsen, Cody G. Durrer, Benedikte Liebetrau, Ulrikke Nystrup, Martin Ostergaard, Katja Thomsen, Beckey Trinh, Thomas P. J. Solomon, Gerrit Van Hall, Jan Christian Brond, Jens J. Holst, Bolette Hartmann, Robin Christensen, Bente K. Pedersen, Mathias Ried-Larsen
Summary: A randomized clinical trial showed that adding exercise to diet-induced weight loss can improve beta-cell function in people with newly diagnosed type 2 diabetes. The study found that exercise volume is important for improving beta-cell function, and there was a dose-dependent relationship between exercise and beta-cell function improvement.
Article
Nutrition & Dietetics
Nicoline Lokken, Maja Risager Nielsen, Mads Godtfeldt Stemmerik, Charlotte Ellerton, Karoline Lolk Revsbech, Margaret Macrae, Anna Slipsager, Bjorg Krett, Gry Hatting Beha, Frida Emanuelsson, Gerrit van Hall, Rosaline Quinlivan, John Vissing
Summary: McArdle disease symptoms can be improved with a modified ketogenic diet, which increases fat oxidation and improves maximal exercise capacity.
CLINICAL NUTRITION
(2023)
Article
Biochemical Research Methods
Minoo Afshar, Gerrit van Hall
Summary: This study developed a high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous analysis of ketone bodies, alpha-keto acids, lactate, pyruvate, and their tracer enrichments in human plasma. The method showed good sensitivity and accuracy, and can be used to quantify the synthesis and degradation rates of these metabolites.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)