Article
Medicine, General & Internal
Dong Hyun Sinn, Danbee Kang, Eliseo Guallar, Yun Soo Hong, Juhee Cho, Geum-Youn Gwak
Summary: Alcohol intake is associated with increased liver-related and all-cause mortality among individuals with elevated ALT levels.
Article
Medicine, Research & Experimental
Chunzhu Li, Chuan Xing, Jiaqi Zhang, Han Zhao, Wenjing Shi, Bing He
Summary: The research showed that time-restricted feeding can help women with anovulatory PCOS to lose weight, reduce body fat, improve menstrual irregularity, hyperandrogenemia, insulin resistance, and chronic inflammation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Haolin Zhang, Wei Wang, Jiaming Zhao, Peijie Jiao, Lin Zeng, Hua Zhang, Yue Zhao, Li Shi, Hangqi Hu, Liyan Luo, Ii Fukuzawa, Dong Li, Rong Li, Jie Qiao
Summary: This study investigated the influence of body fat on glucose metabolism and hormone profiles in women with polycystic ovary syndrome (PCOS) compared to women without PCOS. The results showed that women with PCOS, both obese and non-obese, had more severe insulin resistance and sex-hormone disorders than women without PCOS. The effect of body fat on sex-hormone disorders was only present in women with PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Jiajia Ge, Na Yang, Xiaoli Zhang, Meijuan Li, Wei Zhang, Jun He, Huaijun Zhu, Xiaoliang Cheng, Shanmei Shen, Weihong Ge
Summary: This study explores the differences in steroid metabolism between hyperandrogenic and non-hyperandrogenic women with PCOS. The findings suggest that hyperandrogenic women have increased levels of certain steroids and enzyme activities, while non-hyperandrogenic women do not. The ratio of LH to FSH is also found to be related to these differences.
REPRODUCTIVE SCIENCES
(2022)
Article
Health Care Sciences & Services
Mardia Lopez-Alarcon, Victor Saul Vital-Reyes, Eduardo Almeida-Gutierrez, Jorge Maldonado-Hernandez, Salvador Flores-Chavez, Juan Manuel Dominguez-Salgado, Jose Vite-Bautista, David Cruz-Martinez, Aly S. Barradas-Vazquez, Ricardo Z'Cruz-Lopez
Summary: Polycystic ovary syndrome (PCOS) is often accompanied by metabolic disturbances related to androgen excess and obesity. This study found that obesity is strongly associated with biomarkers related to glucose and liver metabolism, while free testosterone (FT) is only correlated with glucose and liver-related indicators. Women with obesity are at a higher risk of metabolic disorders compared to lean women, regardless of hyperandrogenemia.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Naina Kumar, Himani Agarwal
Summary: This study compared the clinical, biochemical, and radiological features of obese and non-obese women with PCOS to non-PCOS women. The results revealed significant differences in anthropometric measurements, clinical symptoms, and ultrasound features between obese PCOS cases and non-obese PCOS cases. Obesity was identified as an independent risk factor for PCOS and associated with an increased risk of complications.
HORMONE AND METABOLIC RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Hongying Shan, Renxin Luo, Xuanying Guo, Rong Li, Zhenhong Ye, Tianliu Peng, Fenting Liu, Zi Yang
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women, which is associated with infertility, menstrual irregularities, endometrial hyperplasia, and obesity. The disease and its complications are closely related to local oxidative stress imbalance in the endometrium, affecting endometrial receptivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Jiayue Liu, Ying Liu, Xiaoliang Li
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age, characterized by ovulation disorders, high androgen levels, and insulin resistance. The pathogenesis of PCOS is still unclear. Intestinal flora, known as the second genome of human beings, is closely linked to metabolic diseases, immune diseases, and infectious diseases. There is increasing evidence that intestinal flora can regulate insulin synthesis and secretion, affect androgen metabolism and follicular development, and play a role in chronic inflammation and obesity. The imbalance of intestinal flora, related to changes in microbial diversity and interactions with host cells, is associated with the occurrence and development of PCOS. Modulating intestinal flora may offer a potential direction for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medical Laboratory Technology
Huiqing Liu, Xingqi Meng, Jinyuan Wang, Yi Wei, Jinru Tang, Xiaocan Lei, Weiguo He, Suyun Li
Summary: PCOS is an endocrinemetabolic disease affecting reproductive aged women, potentially leading to various complications. Recent studies have identified a protein called SAA that may be associated with PCOS, serving as a potential inflammatory biomarker.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Svetlana Spremovic Radenovic, Miljan Pupovac, Mladen Andjic, Jovan Bila, Svetlana Sreckovic, Aleksandra Gudovic, Biljana Dragas, Nebojsa Radunovic
Summary: This review presents the current knowledge in epidemiology, pathophysiology, diagnostics, and treatment of nonalcoholic fatty liver disease (NAFLD) in polycystic ovary syndrome (PCOS) women. It highlights the associations of insulin resistance, hyperandrogenemia, obesity, adipose tissue dysfunction, and inflammation with the development of NAFLD in PCOS women. Additionally, the possible roles of the gut microbiome, mitochondrial dysfunction, and endocannabinoid system in NAFLD maintenance in PCOS women are discussed.
Article
Endocrinology & Metabolism
Chuan Xing, Han Zhao, Jiaqi Zhang, Bing He
Summary: The study aimed to observe the effects of MET monotherapy and MET plus LIRA combination therapy on gonadal and metabolic profiles in overweight patients with PCOS. The results showed that both MET monotherapy and MET plus LIRA combination therapy improved glucose metabolism and relieved insulin resistance in overweight patients with PCOS. Furthermore, MET plus LIRA combination therapy was more effective in improving reproductive abnormalities and hyperandrogenemia compared to MET monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chang Shan, Yu-chen Zhu, Jie Yu, Yi Zhang, Yu-ying Wang, Nan Lu, Jie Cai, Wei Liu, Tao Tao
Summary: This study found that Chinese women with PCOS have lower levels of vitamin D compared to controls, especially in those with hyperandrogenemia. Higher levels of 25(OH)D were independently associated with lower risks of hyperandrogenemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Dongxu Wang, Nan Nan, Hao Bing, Bing He
Summary: Obese patients with PCOS are more prone to develop NAFLD. Compared to the control group, the obese PCOS group showed significant increases in ALT, AST, CAP, TG, TC, LDL-C, TT, FAI, FIns, and HOMA-IR levels, along with lower HDL-C and SHBG levels. Liver CAP in PCOS patients with obesity was positively correlated with ALT, AST, TG, TT, FAI, FIns, and HOMA-IR, and negatively correlated with SHBG. Logistic regression analysis showed that TG, TT, FIns, and HOMA-IR were risk factors for NAFLD, while TT was an independent risk factor for NAFLD in PCOS patients with obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Dongxu Wang, Bing He
Summary: Polycystic ovary syndrome (PCOS) is a common reproductive, endocrine, and metabolic disorder in women, which increases the risk of nonalcoholic fatty liver disease (NAFLD). This study reviews the prevalence, risk factors, and management of NAFLD in PCOS, aiming to enhance our understanding of this field.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Article
Gastroenterology & Hepatology
Mineo Iwatate, Daizen Hirata, Carlos Paolo D. Francisco, Jonard Tan Co, Jeong-Sik Byeon, Neeraj Joshi, Rupa Banerjee, Duc Trong Quach, Than Than Aye, Han-Mo Chiu, Louis H. S. Lau, Siew C. Ng, Tiing Leong Ang, Supakij Khomvilai, Xiao-Bo Li, Shiaw-Hooi Ho, Wataru Sano, Santa Hattori, Mikio Fujita, Yoshitaka Murakami, Masaaki Shimatani, Yuzo Kodama, Yasushi Sano
Summary: This study aimed to investigate whether a web-based educational intervention with training on FIND clues could improve endoscopists' ability to detect high-risk flat and depressed lesions. The results showed that a short self-education program was effective in increasing the detection rate of high-risk lesions among Asian non-expert endoscopists.
DIGESTIVE ENDOSCOPY
(2022)
Article
Multidisciplinary Sciences
Tong-Yuan Tai, Chi-Ling Chen, Keh-Song Tsai, Shih-Te Tu, Jin-Shang Wu, Wei-Shiung Yang
Summary: This study investigated the relationship between serum adiponectin levels and the bone mineral density (BMD) of proximal femur and vertebrae bones. The results showed that an increase in adiponectin levels was associated with a decline in proximal femur BMD.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Yuan-Ping Chao, Wen-Hui Fang, Wei-Liang Chen, Tao-Chun Peng, Wei-Shiung Yang, Tung-Wei Kao
Summary: Age-related decline in muscle mass and function is a critical issue for the health of older adults. This study observed the natural progression of muscle health and found that age, fat-to-muscle ratio, and serum albumin level were associated with the risk of dynapenia.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Wan-Chen Wu, Kang-Yung Peng, Jin-Ying Lu, Chieh-Kai Chan, Chih-Yuan Wang, Fen-Yu Tseng, Wei-Shiung Yang, Yen-Hung Lin, Po-Chih Lin, Ting-Chu Chen, Kuo-How Huang, Jeff S. Chueh, Vin-Cent Wu
Summary: The study found that CPA-related mutations were detected in 36.7% of uPA/ACS adenomas. The presence of these mutations was associated with higher post-DST cortisol levels, larger adenoma sizes, and a high percentage of non-classical uPA. However, these mutations did not significantly affect the clinical and biochemical outcomes after adrenalectomy of uPA/ACS patients but they showed a better trend.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Tzu-Ching Kao, Yun-Chiao Hsieh, Ih-Jane Yang, Ming-Yih Wu, Mei -Jou Chen, Jehn-Hsiahn Yang, Shee-Uan Chen
Summary: This single-center retrospective study compared the incidence of premature luteinizing hormone (LH) surge and the outcome of oocyte retrieval between progestin-primed ovarian stimulation (PPOS) and gonadotropin-releasing hormone (GnRH) antagonist protocol for poor ovarian responders (PORs). The results showed that PPOS had a lower incidence of premature LH surges compared with the GnRH antagonist protocol group. There were no significant differences in the number of oocytes retrieved and oocyte retrieval rates between the two groups. The study suggests that PPOS is suitable for oocyte or embryo cryopreservation but should not replace GnRH antagonist protocol for in vitro fertilization (IVF) in PORs.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Hung-Ju Lin, Jui Wang, Po-Yuan Tseng, Li-Chen Fu, Yi-Chia Lee, Ming-Shiang Wu, Wei-Shiung Yang, Han-Mo Chiu
Summary: Lower glycemic levels than currently accepted could lead to optimal risk reduction of incident diabetes among individuals with prediabetes, highlighting the importance of stringent glycemic management for diabetes prevention.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Obstetrics & Gynecology
Chu-Chun Huang, Po-Kai Yang, Yi-Shuang Huang, Shee-Uan Chen, Yu-Shih Yang, Mei-Jou Chen
Summary: This study aimed to investigate the involvement of miRNAs in chronic anovulation and the mechanism of metformin treatment in PCOS. The baseline and chronological changes in plasma levels of 14 miRNAs were measured in 146 PCOS patients. After 6 months of metformin treatment, the levels of insulin, luteinizing hormone, and 6 circulating miRNAs decreased significantly in the ovulatory group, but remained unchanged in the anovulatory group. Logistic regression analysis was used to predict ovulation recovery after metformin treatment based on miRNA levels and clinical parameters.
FERTILITY AND STERILITY
(2023)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Francis K. L. Chan, Martin C. S. Wong, Andrew T. Chan, James E. East, Han-Mo Chiu, Govind K. Makharia, David Weller, Choon Jin Ooi, Julajak Limsrivilai, Yutaka Saito, Dao Hang, Jon D. Emery, Dadang Makmun, Kaichun Wu, Raja Affendi Raja Ali, Siew C. Ng
Summary: The Asian Pacific Association of Gastroenterology (APAGE) and the Asian Pacific Society of Digestive Endoscopy (APSDE) have jointly released a guideline on the use of non-invasive biomarkers for screening colorectal cancer (CRC). This guideline provides comprehensive information on various screening tools, including faecal immunochemical tests, faecal or blood-based tumour biomarkers, and microbial biomarkers, along with indications, patient selection, and strengths and limitations of each tool.
Editorial Material
Gastroenterology & Hepatology
Rashid N. Lui, Sunny H. Wong, Nik Sheng Ding, Masau Sekiguchi, Jun Yu, Tiing-Leong Ang, Khay-Guan Yeoh, Han-Mo Chiu, Joseph J. Y. Sung
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tsun-Hsien Hsiao, Chia-Hong Chou, Yi-Lung Chen, Po-Hsiang Wang, Guo-Jie Brandon-Mong, Tzong-Huei Lee, Tien-Yu Wu, Po-Ting Li, Chen-Wei Li, Yi-Li Lai, Yu-Lin Tseng, Chao-Jen Shih, Po-Hao Chen, Mei-Jou Chen, Yin-Ru Chiang
Summary: Animal studies have suggested that gut bacteria are involved in sex steroid metabolism. This study identified a bacterium, Thauera sp. strain GDN1, which can catabolize androgen and significantly reduce serum androgen levels in mice. These findings indicate the potential use of androgen-catabolic gut bacteria as probiotics for the treatment of hyperandrogenism.
Article
Biochemistry & Molecular Biology
Pei-Fang Chiu, I-Chun Lin, Yeh-Lin Lu, Chiao-Nien Chang, Hui-Yu Chan, Tzung-Shen Lin, Keng-Chang Tsai, Yves S. Y. Hsieh, Mei-Jou Chen, Mei-Hsiang Lin, Pi-Hui Liang
Summary: Inhibition of steroid sulfatase (STS) can decrease estrogen production, thereby suppressing tumor proliferation. In this study, twenty-one tricyclic and tetraheterocyclic coumarin-based derivatives were explored and evaluated for their STS enzyme kinetic parameters, docking models, and cytotoxicity towards breast cancer and normal cells. The tricyclic derivative 9e and tetracyclic derivative 10c were found to be the most promising irreversible inhibitors, with K-I values of 0.05 and 0.4 nM, and k(inact)/K-I ratios of 28.6 and 19.1 nM(-1)min(-1) on human placenta STS, respectively.
BIOORGANIC CHEMISTRY
(2023)
Article
Gastroenterology & Hepatology
Robert S. Bresalier, Carlo Senore, Graeme P. Young, James Allison, Robert Benamouzig, Sally Benton, Patrick M. M. Bossuyt, Luis Caro, Beatriz Carvalho, Han-Mo Chiu, Veerle M. H. Coupe, Willemijn de Klaver, Clasine Maria de Klerk, Evelien Dekker, Sunil Dolwani, Callum G. Fraser, William Grady, Lydia Guittet, Samir Gupta, Stephen P. Halloran, Ulrike Haug, Geir Hoff, Steven Itzkowitz, Tim Kortlever, Anastasios Koulaouzidis, Uri Ladabaum, Beatrice Lauby-Secretan, Marcis Leja, Bernard Levin, Theodore Robert Levin, Finlay Macrae, Gerrit A. Meijer, Joshua Melson, Colm O'Morain, Susan Parry, Linda Rabeneck, David F. Ransohoff, Roque Saenz, Hiroshi Saito, Silvia Sanduleanu-Dascalescu, Robert E. Schoen, Kevin Selby, Harminder Singh, Robert J. C. Steele, Joseph J. Y. Sung, Erin Leigh Symonds, Sidney J. Winawer
Summary: New non-invasive tests for colorectal cancer (CRC) are emerging, making it challenging to conduct trials with mortality reduction as the main goal. A formal consensus approach involving experts resulted in the revision of previously established principles and the emergence of twelve new principles. The effectiveness of a new test can be evaluated by comparing it with an established non-invasive test, with the faecal immunochemical test considered as the appropriate comparator. Flexible adjustment of the new test's positivity threshold is desirable to meet different screening goals and requirements. A four-phased approach is proposed for the evaluation of new tests, including small studies, prospective estimation of accuracy, evaluation in screening populations, and monitoring for missed lesions.
Article
Endocrinology & Metabolism
William Hao-Yu Lee, Kuan-Ting Lin, Yun-Chiao Hsieh, Tzu-Ching Kao, Ting-Chi Huang, Kuang-Han Chao, Mei-Jou Chen, Jehn-Hsiahn Yang, Shee-Uan Chen
Summary: The maximum LH level during controlled ovarian stimulation can serve as a predictive factor for achieving an optimal oocyte yield using the GnRH agonist trigger alone. For hyper-responders, considering the maximum LH level to assess LH reserve can minimize the risk of obtaining a suboptimal oocyte yield and improve treatment outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)