Article
Endocrinology & Metabolism
Sijie Chen, Chengcheng Niu, Qinghai Peng, Kui Tang
Summary: This study evaluated the sonographic characteristics of papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (HT) and found that factors like patient age, nodule size, shape, calcification, and vascularity were associated with central lymph node metastasis (CLNM). Preoperative ultrasound characteristics can help predict CLNM in PTCs with coexistent HT.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Liyuan Liu, Yang Yu, Lei Chen, Yang Zhang, Guizhi Lu, Ying Gao, Junqing Zhang
Summary: This study aimed to uncover the differences between IgG4 HT and PTL, and the results showed differences in age, thyroid functional status, and ultrasound images.
EUROPEAN THYROID JOURNAL
(2022)
Article
Endocrinology & Metabolism
Tina Mosaferi, Karen Tsai, Samantha Sovich, Holly Wilhalme, Nikhita Kathuria-Prakash, Stephanie S. Praw, Alexandra Drakaki, Trevor E. Angell, Melissa G. Lechner
Summary: Patients with ICI-associated hypothyroidism have different thyroid hormone dosing requirements than patients with HT. Based on our findings and prior reports, we recommend that in patients with ICI-associated thyroiditis LT4 therapy be started at an initial weight-based dose of 1.45 mcg/[kg center dot day] once serum free thyroxine levels fall below the reference range.
Article
Endocrinology & Metabolism
Andrzej Hellmann, Jacek Turyn, Agata Zwara, Justyna Korczynska, Aleksandra Taciak, Adriana Mika
Summary: The study aims to analyze amino acid metabolites in the serum of patients with papillary thyroid carcinoma (PTC) and predict their association with thyroid disease, hormone, and autoantibodies. The results showed that amino acid changes are specific for autoimmune disorders and thyroid cancer. Glutamic acid and lysine can be used as diagnostic markers to distinguish different types of PTC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Likun Cui, Chaoting Zhang, Huirong Ding, Dongdong Feng, Hongying Huang, Zheming Lu, Baoguo Liu
Summary: This study investigated the intratumor heterogeneity (ITH) of tumor infiltrating lymphocytes (TILs) in papillary thyroid carcinoma (PTC) with and without coexistent Hashimoto's thyroiditis (HT). The results revealed differences in T cell numbers and TCR repertoires between the two groups, suggesting the importance of distinct strategies based on the immune background in different situations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Shi Tang, Min Yang, Dan Zhang, Ya-fie Tong, Ying Xin
Summary: Analyzing the clinical characteristics of Hashimoto's thyroiditis in children below 3 years of age revealed that most patients presented with hypothyroidism or subclinical hypothyroidism at initial diagnosis. Children with global developmental delay require continuous screening to detect HT-induced hypothyroidism. Thyroxine replacement can partially alleviate hypothyroid clinical manifestations, emphasizing the importance of early diagnosis and treatment for improving patient prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Aniceta A. Mikulska, Marta Karazniewicz-Lada, Dorota Filipowicz, Marek Ruchala, Franciszek K. Glowka
Summary: This article provides an overview of the metabolic profile, effectiveness of micronutrient supplementation, and impact of dietary management in patients with Hashimoto's thyroiditis (HT). The review includes recent literature such as randomized controlled trials, meta-analyses, and clinical trials. Many HT patients experience excess body weight, metabolic disorders, and reduced quality of life. The role of vitamin D, selenium, and other nutrients is still debated, and there is currently no specific recommended diet for HT patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Cenlin Jia, Lin Zhang, Wenhua Liu, Xiangyan Zhang, Hongyan Wu
Summary: This study investigated the glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS) with and without Hashimoto's thyroiditis (HT). 103 women were included as controls and 213 patients diagnosed with PCOS were studied. PCOS patients had higher levels of fasting insulin, insulin resistance, low-lipoprotein cholesterol, triglyceride, apolipoprotein B, apolipoprotein B/apolipoprotein A1, and homocysteine compared to controls. Patients with PCOS and HT had higher insulin levels and insulin resistance, as well as higher total cholesterol and thyroid-stimulating hormone levels. This highlights the importance of assessing thyroid function in PCOS patients.
Article
Pathology
Elin Peuraharju, Jaana Hagstrom, Jussi Tarkkanen, Caj Haglund, Timo Atula
Summary: This study aimed to evaluate the presence of IgG4 and genuine IgG4-related disease in patients with chronic nonspecific sialadenitis and sialolithiasis. The results showed that patients with sialadenitis and sialolithiasis often had IgG4-positive lymphoplasmacytic infiltrates, but genuine IgG4-related disease was very rare. In sialolithiasis without sialadenitis, IgG4-positive plasma cells were often absent or present in small numbers. These findings support the hypothesis of a continuum of disease and suggest that progressive inflammation of the submandibular gland leads to the development of more specific pathological features over time.
Article
Ophthalmology
Meryem Altin Ekin, Seyda Karadeniz Ugurlu, Emine Deniz Egrilmez, Guzide Gonca Oruk
Summary: Patients with Hashimoto's thyroiditis have a higher prevalence of dry eye syndrome and ocular discomfort symptoms, even without thyroid ophthalmopathy. The occurrence of dry eye syndrome in these patients is believed to be linked to meibomian gland dysfunction and is associated with the duration of their thyroid disease.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Oncology
Yue Jie, Jingliang Ruan, Man Luo, Rongbin Liu
Summary: The objective of this study was to compare the ultrasonographic, clinical, and pathological features of children and adolescents with papillary thyroid carcinoma (PTC) with and without Hashimoto's thyroiditis (HT). The results showed that the prevalence rate of PTC in patients with HT was 27%, and papillary thyroid microcarcinomas were found more frequently in patients without HT. Patients with PTC and HT were more likely to have extrathyroidal extension, capsular invasion, and lymph node metastases.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Aagat Sharma Khatiwada, Natasha Choudhury
Summary: This article describes a case of a woman in her 50s referred for suspected thyroid malignancy, who was found to have IgG4-positive Hashimoto's thyroiditis. IgG4-related thyroid disease encompasses various types and may be associated with a systemic fibrosing condition. However, the clinical significance of IgG4-positive thyroid disease remains unclear.
Article
Medical Laboratory Technology
Mariam Ghozzi, Amani Mankai, Sarra Melayah, Fatma Mechi, Zeineb Chedly, Abdelhalim Trabelsi, Ibtissem Ghedira
Summary: A high frequency of serological markers of RA was found in patients with HT.
LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Esra Demir, Burak Onal, Hanise Ozkan, Irem Kirac Utku, Berrak Sahtiyanci, Abdulbaki Kumbasar, Guven Yenmis, Bulent Demir
Summary: This study found that plasma zonulin levels were significantly increased in patients with HT, suggesting a possible link between intestinal permeability and the etiology of autoimmune diseases.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Immunology
Xuefeng Bai, Meirong Huang, Xiaoyu Chen, Qingyan Cai, Zhengrong Jiang, Lijun Chen, Huibin Huang
Summary: This study explored the expression profile of circular RNAs (circRNAs) in the plasma of patients with Hashimoto's thyroiditis (HT) for the first time. The results showed that several upregulated and downregulated circRNAs were associated with the occurrence and development of HT, potentially through specific signaling pathways. These findings provide an important resource for further investigation into the regulatory mechanisms of circRNA in HT.
IMMUNOLOGIC RESEARCH
(2022)
Article
Surgery
Toshitetsu Hayashi, Mitsuyoshi Hirokawa, Miyoko Higuchi, Takumi Kudo, Yasuhiro Ito, Akira Miyauchi
WORLD JOURNAL OF SURGERY
(2020)
Article
Medical Laboratory Technology
Risa Kanematsu, Mitsuyoshi Hirokawa, Miyoko Higuchi, Ayana Suzuki, Hitomi Aga, Aki Tanaka, Naoki Yamao, Toshitetsu Hayashi, Seiji Kuma, Akira Miyauchi
DIAGNOSTIC CYTOPATHOLOGY
(2020)
Review
Pathology
Toshitetsu Hayashi, Mitsuyoshi Hirokawa, Seiji Kuma, Miyoko Higuchi, Ayana Suzuki, Risa Kanematsu, Takumi Kudo, Naomi Katsuki, Reiji Haba, Akira Miyauchi
DIAGNOSTIC PATHOLOGY
(2020)
Article
Cell Biology
Miyoko Higuchi, Mitsuyoshi Hirokawa, Ayana Suzuki, Hiroo Masuoka, Akira Miyauchi
Article
Medical Laboratory Technology
Chih-Yi Liu, Andrey Bychkov, Shipra Agarwal, Yun Zhu, Jen-Fan Hang, Chiung-Ru Lai, Hee Young Na, Weiwei Li, Zhiyan Liu, Deepali Jain, Ayana Suzuki, Mitsuyoshi Hirokawa, Noel Chia, Min En Nga, Tikamporn Jitpasutham, Somboon Keelawat, So Yeon Park, Shinya Satoh, Chien-Chin Chen, Dilini Gunawardena, Priyanthi Kumarasinghe, Chan Kwon Jung, Kennichi Kakudo
Summary: This study summarizes the handling of MTC in contemporary Asian thyroid FNA practice. Although the detection rate of MTC by cytology alone is less satisfactory, integration with ancillary tests could achieve an excellent performance. Recognition of constitutive cytomorphologic features is necessary for each cytopreparatory method, which may lead to a lower threshold for further MTC workup.
DIAGNOSTIC CYTOPATHOLOGY
(2021)
Article
Medical Laboratory Technology
Ayana Suzuki, Mitsuyoshi Hirokawa, Risa Kanematsu, Aki Tanaka, Naoki Yamao, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Akihiro Miya, Akira Miyauchi
Summary: Fine-needle aspiration (FNA) is a useful tool for determining suspected parathyroid adenoma (PA) nodules, with cytological features such as wedge pattern and salt and pepper chromatin being prominent. Diagnostic cytological indicators of PA include wedge pattern, salt and pepper chromatin, with PTH measurements and GATA-3 immunocytochemistry recommended for PA-suspected nodules.
DIAGNOSTIC CYTOPATHOLOGY
(2021)
Article
Endocrinology & Metabolism
Iwao Sugitani, Yasuhiro Ito, Dai Takeuchi, Hirotaka Nakayama, Chie Masaki, Hisakazu Shindo, Masanori Teshima, Kazuhiko Horiguchi, Yusaku Yoshida, Toshiharu Kanai, Mitsuyoshi Hirokawa, Kiyomi Y. Hames, Isao Tabei, Akira Miyauchi
Summary: The management of patients with low-risk papillary thyroid microcarcinoma (PTMC; T1aN0M0) has become an important clinical issue, with the adoption of active surveillance (AS) to avoid overtreatment gradually increasing worldwide. However, not all PTMCs are suitable for AS, and the Japan Association of Endocrine Surgery has produced consensus statements regarding indications and strategies for AS in adult patients diagnosed with low-risk PTMC. These statements provide guidelines for AS and recommend immediate surgery for certain high-risk features in PTMC patients.
Article
Endocrinology & Metabolism
Tetiana I. Bogdanova, Vladimir A. Saenko, Yuko Hashimoto, Mitsuyoshi Hirokawa, Liudmyla Yu. Zurnadzhy, Toshitetsu Hayashi, Masahiro Ito, Manabu Iwadate, Norisato Mitsutake, Tatiana I. Rogounovitch, Atsuhiko Sakamoto, Hiroshi Naganuma, Akira Miyauchi, Mykola D. Tronko, Geraldine Thomas, Shunichi Yamashita, Shinichi Suzuki
Summary: Ukrainian radiogenic PTCs exhibited higher invasiveness and tumor growth patterns compared to sporadic PTCs, while no significant differences were observed in Japanese groups. These findings strongly suggest a non-radiogenic etiology of PTC in Fukushima and other Prefectures.
Article
Medicine, General & Internal
Chih-Yi Liu, Chien-Chin Chen, Andrey Bychkov, Shipra Agarwal, Yun Zhu, Jen-Fan Hang, Chiung-Ru Lai, Hee Young Na, So Yeon Park, Weiwei Li, Zhiyan Liu, Deepali Jain, Ayana Suzuki, Mitsuyoshi Hirokawa, Noel Chia, Min En Nga, Tikamporn Jitpasutham, Somboon Keelawat, Shinya Satoh, Dilini Gunawardena, Priyanthi Kumarasinghe, Chan Kwon Jung, Kennichi Kakudo
Summary: A retrospective study on MTC cases from 13 hospitals in 8 Asia-Pacific countries compared cytomorphologic features of MTC using different staining methods on FNA slides, revealing common cytologic characteristics. The study proposed a feasible scoring system based on cytomorphologic data for achieving accurate diagnosis.
Article
Endocrinology & Metabolism
Mikiko Okazaki-Hada, Eijun Nishihara, Mako Hisakado, Takumi Kudo, Mitsuru Ito, Shuji Fukata, Mitsushige Nishikawa, Takashi Akamizu, Akira Miyauchi
Summary: This study investigated the clinical characteristics and related findings of patients with mutations in the thyroid hormone receptor beta gene. The results revealed a higher prevalence of autoimmune thyroid disease in male patients compared to their unaffected relatives. Furthermore, more than 20% of patients exhibited laboratory results inconsistent with the typical features of the disease during follow-up.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Cell Biology
Mitsuyoshi Hirokawa, Miyoko Higuchi, Ayana Suzuki, Toshitetsu Hayashi, Seiji Kuma, Akira Miyauchi
Summary: This study aimed to clarify the clinical and pathological characteristics of papillary thyroid carcinoma (PTC) with unique honeycomb-like growth (HLG). Two subtypes of PTC-HLG were identified: pure type and mixed type. The pure type tended to be nonaggressive and clinically interpreted as benign, whereas the mixed type showed slightly aggressive behavior compared to conventional PTCs.
Article
Endocrinology & Metabolism
Sawako Takahashi, Mitsuru Ito, Yuzuki Masaki, Mikiko Hada, Mizuho Minakata, Kazuyoshi Kohsaka, Tomohiko Nakamura, Toshihiko Kasahara, Takumi Kudo, Eijun Nishihara, Shuji Fukata, Mitsushige Nishikawa, Takashi Akamizu, Akira Miyauchi
Summary: Research investigated the relationship between thyroid volume and thyroid hormone status in Hashimoto thyroiditis patients on levothyroxine (LT4) treatment. The study found that increasing thyroid volume led to higher serum levels of FT3 and FT3/FT4 ratio. Mild thyrotropin suppression with LT4 was needed for patients with smaller thyroid volumes to achieve normal FT3 levels.
Article
Endocrinology & Metabolism
Ken Takeshima, Yaqiong Li, Kennichi Kakudo, Mitsuyoshi Hirokawa, Eijun Nishihara, Akira Shimatsu, Yutaka Takahashi, Takashi Akamizu
Summary: Patients with IgG4-related thyroid disease (IgG4-RTD) are diagnosed based on five criteria, including thyroid enlargement, hypoechoic lesions on ultrasound, elevated serum IgG4 levels, histopathological findings, and involvement of other organs. These criteria help ensure accurate diagnosis of IgG4-RTD and can aid in differentiating it from other conditions.
Article
Biology
Tomoo Jikuzono, Tomoko Ishikawa, Mitsuyoshi Hirokawa, Iwao Sugitani, Osamu Ishibashi
BMC RESEARCH NOTES
(2020)
Review
Surgery
Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Yasuhiro Ito, Akira Miyauchi
