Article
Cell Biology
Catalin Gabriel Herghelegiu, Alina Veduta, Miruna Florina Stefan, Stefania Lucia Magda, Iuliana Ionascu, Viorica Elena Radoi, Daniela Nuti Oprescu, Alina Mihaela Calin
Summary: Human chorionic gonadotropin (hCG) is a pregnancy-related protein produced by the placenta, with multiple variants and functions. The hyperglycosylated variant (H-hCG) plays a crucial role in trophoblast invasion, placental development, and fetal growth. Impaired H-hCG function may lead to defective perfusion of the placenta and fetal growth restriction. Understanding its role could provide new insights for managing and treating this condition.
Review
Biochemistry & Molecular Biology
Darina Bacenkova, Marianna Trebunova, Dasa Cizkova, Radovan Hudak, Erik Dosedla, Alena Findrik-Balogova, Jozef Zivcak
Summary: The article discusses the complex process of placental implantation and development, as well as current technologies used to study the behavior of placental cells. Regulation by transcription factors leads to differentiation of trophoblast cells and formation of distinct populations. The 3D in vitro model is crucial for studying placental physiology and modeling placental diseases.
Article
Cell Biology
Violeta Stojanovska, Susanne Arnold, Mario Bauer, Hermann Voss, Stefan Fest, Ana Claudia Zenclussen
Summary: This study characterized three different 3D cultures derived from trophoblast cell lines and compared them to primary fetal trophoblasts and placental tissue. The results showed that these 3D cell culture models exhibit similar functionality and gene expression profiles to primary placental tissue, making them ideal models for studying the placenta.
Article
Biochemistry & Molecular Biology
Reyna Penailillo, Stephanie Acuna-Gallardo, Felipe Garcia, Lara J. Monteiro, Gino Nardocci, Mahesh A. Choolani, Matthew W. Kemp, Roberto Romero, Sebastian E. Illanes
Summary: This study investigated the proliferation, migration, and impact on trophoblast invasion capacity of MenSCs under different physiological conditions. The findings suggest a potential role for MenSCs in the implantation process, implying a communication between maternal MenSCs and invading trophoblast cells that could be implicated in the etiology of PE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhenzhen Liu, Jiangnan Pei, Xiaoyue Zhang, Chengjie Wang, Yao Tang, Haiyan Liu, Yi Yu, Shouling Luo, Weirong Gu
Summary: This study investigated the role of apolipoprotein A1 (APOA1) in the pathophysiology of preeclampsia (PE). The expression of APOA1 was found to be elevated in both plasma and placental tissues of PE patients. Importantly, the concentration of APOA1 was positively associated with systolic blood pressure during late gestation. Additionally, APOA1 was found to promote the proliferation and invasion of trophoblast, possibly through the activation of the transcription factor PPARγ.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hitomi Matsukawa, Midori Ikezaki, Kaho Nishioka, Naoyuki Iwahashi, Masakazu Fujimoto, Kazuchika Nishitsuji, Yoshito Ihara, Kazuhiko Ino
Summary: Calnexin (CNX) plays a critical role in syncytialization-related signaling in placentation and is linked to placenta development.
Article
Endocrinology & Metabolism
Wei Peng, Ying Liu, Hongbo Qi, Qingshu Li
Summary: The study suggests that ACTN4 may play a crucial role in regulating trophoblast proliferation and differentiation in the human placenta during early pregnancy, and dysregulation of this protein may contribute to the pathogenesis of preeclampsia.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Reproductive Biology
Tae Yokouchi-Konishi, Yongjie Liu, Liping Feng
Summary: Proper extravillous trophoblast invasion is important for normal placenta development and pregnancy. This study reveals that attenuation of progesterone receptor membrane component 2 promotes cell proliferation, invasion, and angiogenesis in extravillous trophoblasts by activating hypoxia-inducible factor 1 alpha signaling. This discovery provides new insights into the mechanisms of trophoblast invasion.
BIOLOGY OF REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Martin Gauster, Gerit Moser, Stefan Wernitznig, Nadja Kupper, Berthold Huppertz
Summary: Successful pregnancy relies on the proper development of the embryo and its implantation into the uterine wall. The trophoblast cells play a crucial role in this process, differentiating and forming subpopulations that contribute to placental development and function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemical Research Methods
Yong Pu, Jeremy Gingrich, Almudena Veiga-Lopez
Summary: Placental trophoblast cell invasion into the maternal uterus is a crucial and complex event in the formation of the maternal-fetal interface. A 3D PDMS microfluidic platform has been developed to accurately evaluate trophoblast invasion, allowing for real-time monitoring, imaging, and collection of invasive cells. This platform provides insights into pathways regulating trophoblast invasion and is useful for toxicological screening.
Article
Cell Biology
Jiali You, Wei Wang, Hsun-Ming Chang, Yuyin Yi, Hongjin Zhao, Hua Zhu, Yu Sun, Minyue Tang, Chunyan Wang, Yimiao Sang, Guofang Feng, Shaobing Cheng, Peter C. K. Leung, Yi-Min Zhu
Summary: Embryo implantation and trophoblast invasion are critical for establishing pregnancy, with BMP2 playing a significant role in regulating these processes by influencing gene expression and promoting the development and invasion of embryo and trophoblast cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Lanlan Fang, Sijia Wang, Xiaoyu Han, Yibo Gao, Yuxi Li, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study investigates the role of amphiregulin (AREG) in regulating hCG production in trophoblast cells. The results show that AREG can stimulate CGB expression and hCG secretion through the EGFR-activated ERK1/2 signaling pathways. Additionally, the upregulation of inhibitor of DNA-binding protein 3 (ID3) by AREG plays a key role in this process.
Article
Obstetrics & Gynecology
Ernesto Bosch, Martin Hund, Reinhard van der Does, Laura Caracena, Silke Ahlers, Elena Labarta
Summary: The study aimed to compare the measurement of hHCG and HCG+beta for early pregnancy detection after IVF and embryo transfer. The results showed that the predictive performance of both biomarkers was similar at different time points, and the diagnostic performance improved from day 4 to day 11.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Pediatrics
Elizabeth M. Kennedy, Karen Hermetz, Amber Burt, Dong Pei, Devin C. Koestler, Ke Hao, Jia Chen, Diane Gilbert-Diamond, Usha Ramakrishnan, Margaret R. Karagas, Carmen J. Marsit
Summary: Placental microRNAs are associated with early childhood growth trajectory and play a role in regulating placental cellular dynamics, impacting infant growth beyond birth.
PEDIATRIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Meiyuan Jin, Shouying Xu, Jiayong Li, Lu Li, Chao Tang
Summary: The study showed that ARID1A regulates trophoblast cell migration and invasion in human placenta by modulating Snail and MMP-9 proteins, suggesting a critical role in supporting healthy placental function.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Pascale Gerbaud, Jean Guibourdenche, Rafika Jarray, Marc Conti, Patricia Palmic, Stephanie Leclerc-Mercier, Julie Bruneau, Olivier Hermine, Yves Lepelletier, Francoise Raynaud
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Developmental Biology
Martha Lappas, Sharon McCracken, Kelly McKelvey, Ratana Lim, Joanna James, Claire T. Roberts, Thierry Fournier, Nadia Alfaidy, Katie L. Powell, Anthony J. Borg, Jonathan M. Morris, Bryan Leaw, Harmeet Singh, Peter R. Ebeling, Euan M. Wallace, Laura J. Parry, Evdokia Dimitriadis, Padma Murthi
MOLECULAR HUMAN REPRODUCTION
(2018)
Article
Biochemistry & Molecular Biology
Julia Petit, Anais Wakx, Sophie Gil, Thierry Fournier, Nicolas Auzeil, Patrice Rat, Olivier Laprevote
Review
Pharmacology & Pharmacy
Lucie Valero, Khair Alhareth, Sophie Gil, Edouard Lecarpentier, Vassilis Tsatsaris, Nathalie Mignet, Thierry Fournier, Karine Andrieux
DRUG DISCOVERY TODAY
(2018)
Review
Medicine, Research & Experimental
Remi Gschwind, Thierry Fournier, Marie-Jose Butel, Sandra Wydau-Dematteis
M S-MEDECINE SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Lucie Valero, Khair Alhareth, Jenifer Espinoza Romero, Warren Viricel, Jeanne Leblond, Audrey Chissey, Helene Dhotel, Caroline Roques, Danielle Campiol Arruda, Virginie Escriou, Nathalie Mignet, Thierry Fournier, Karine Andrieux
Article
Developmental Biology
Severine A. Degrelle, Thierry Fournier
Article
Chemistry, Analytical
Julien Camperi, Audrey Combes, Jean Guibourdenche, Davy Guillarme, Valerie Pichon, Thierry Fournier, Nathalie Delaunay
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2018)
Article
Chemistry, Analytical
Julien Camperi, Bart De Cock, Valerie Pichon, Audrey Combes, Jean Guibourdenche, Thierry Fournier, Yvan Vander Heyden, Debby Mangelings, Nathalie Delaunay
Article
Oncology
Paul Berveiller, Olivier Mir, Severine A. Degrelle, Vassilis Tsatsaris, Lise Selleret, Jean Guibourdenche, Daniele Evain-Brion, Thierry Fournier, Sophie Gil
INVESTIGATIONAL NEW DRUGS
(2019)
Article
Peripheral Vascular Disease
Laura Trapiella-Alfonso, Lucile Alexandre, Camille Fraichard, Kelly Pons, Simon Dumas, Lucie Huart, Jean-Francois Gaucher, Marylise Hebert-Schuster, Jean Guibourdenche, Thierry Fournier, Michel Vidal, Isabelle Broutin, Laurence Lecomte-Raclet, Laurent Malaquin, Stephanie Descroix, Vassilis Tsatsaris, Nathalie Gagey-Eilstein, Edouard Lecarpentier
Article
Chemistry, Analytical
Julien Camperi, Valerie Pichon, Thierry Fournier, Nathalie Delaunay
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2019)
Meeting Abstract
Developmental Biology
Isabelle Hernandez, Sylvie Pinto, Audrey Chissey, Thierry Fournier, Jean-Louis Beaudeux, Amal Zerrad-Saadi
Meeting Abstract
Developmental Biology
Shoaito Hussein, Julia Petit, Audrey Chissey, Nicolas Auzeil, Jean Guiburdenche, Sophie Gil, Olivier Laprevote, Thierry Fournier, Severine Degrelle
Article
Biochemistry & Molecular Biology
Aleksandra R. Dukic, Pascale Gerbaud, Jean Guibourdenche, Bernd Thiede, Kjetil Tasken, Guillaume Pidoux
BIOCHEMICAL JOURNAL
(2018)