期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 95, 期 9, 页码 E69-E74出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2010-0527
关键词
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资金
- National Institutes of Health [K23DK080658, 1R01HL085268, K24DK064545, UL1RR025758, P41RR14075]
- Lawson Wilkins Pediatric Endocrine Society
- Children's Hospital Boston
- NATIONAL CENTER FOR RESEARCH RESOURCES [P41RR014075, UL1RR025758] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL085268] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K24DK064545, K23DK080658, P30DK040561] Funding Source: NIH RePORTER
Context: Elderly subjects have reduced mitochondrial function. However, it remains unclear whether the decline in mitochondrial function begins earlier in the life span. Objective: The objective of the study was to determine skeletal muscle mitochondrial oxidative phosphorylation by (31)phosphorous-magnetic resonance spectroscopy (MRS) across a variety of age groups. Design: This was a cross-sectional study of 121 healthy normal-weight and overweight individuals from age 8 to 55 yr. Setting: The study was conducted at a single university medical center in Boston, MA. Participants: Participants included 68 children and 53 adults from the Boston community. Interventions and Main Outcome Measures: Phosphocreatine (PCr) recovery was evaluated by (31)phosphorous-MRS after submaximal exercise. Subjects were also evaluated with anthropometric measurements, metabolic profiles, and measures of physical activity. Results: PCr recovery determined by (31)phosphorous-MRS is positively associated with age in univariate analysis in a cohort of individuals aged 8-55 yr (r = +0.55, P < 0.0001). Stratification of subjects into four age groups (prepubertal and early pubertal children, pubertal and postpubertal children < 18 yr, young adults aged 18-39 yr, and middle aged adults aged 40-55 yr) demonstrates prolongation of PCr recovery with increasing age across the four groups (P < 0.0001 by ANOVA). The relationship between PCr recovery and age remains strong when controlling for gender; race; ethnicity; body mass index; measures of physical activity and inactivity; and anthropometric, nutritional, and metabolic parameters (P < 0.004). Conclusions: Skeletal muscle PCr recovery measured by (31)phosphorous-MRS is prolonged with age, even in children and young adults. (J Clin Endocrinol Metab 95: E69-E74, 2010)
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