Article
Pharmacology & Pharmacy
Hong-Wei Wang, Xian-Hua Jin, Ying-Han Xu, Chun-Ping Chu, Fu-Yang Pei, Xiao-Ping Song, De-Lai Qiu
Summary: Nicotine inhibits synaptic transmission in the cerebellum by interacting with α7 nAChRs. It has no significant effect on spontaneous activity or the number of action potentials evoked by facial stimulation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Christelle Cadilhac, Isabelle Bachy, Antoine Forget, David J. Hodson, Celine Jahannault-Talignani, Andrew J. Furley, Olivier Ayrault, Patrice Mollard, Constantino Sotelo, Fabrice Ango
Summary: In the cerebellar molecular layer, GABAergic interneurons derived from the same progenitor pool utilize separate migration paths to reach their laminar position and differentiate into distinct GABAergic interneuron subtypes. Using two-photon live imaging, it was found that the final laminar position of stellate cells requires an additional step of tangential migration supported by a subpopulation of glutamatergic granule cells.
Article
Clinical Neurology
Umair Hassan, Steven Pillen, Christoph Zrenner, Til Ole Bergmann
Summary: Non-invasive brain stimulation experiments lack standardized procedures and require automated tools to increase objectivity, reliability, and reproducibility. The BEST Toolbox is a MATLAB-based software that allows users to design, run, and share multi-protocol NIBS studies, providing analysis of EMG and EEG data with real-time stimulation parameter configuration.
Article
Neurosciences
Guang-Gao Li, Chun-Jian Piao, Peng Wan, Shu-Yu Li, Yu-Xuan Wei, Guo-Jun Zhao, Wen-Yuan Wu, Lan Hong, Chun-Ping Chu, De-Lai Qiu
Summary: This study found that corticotropin-releasing factor (CRF) regulates molecular layer interneuron-Purkinje cell (MLI-PC) synaptic transmission in the cerebellum through its CRF-R1 receptor, triggering long-term potentiation (LTP) and blocking long-term depression (LTD). This modulation opposes the inhibitory effects of opioids on MLI-PC plasticity.
Article
Multidisciplinary Sciences
Tri M. Nguyen, Logan A. Thomas, Jeff L. Rhoades, Ilaria Ricchi, Xintong Cindy Yuan, Arlo Sheridan, David G. C. Hildebrand, Jan Funke, Wade G. Regehr, Wei-Chung Allen Lee
Summary: The study reveals that the neuronal network structure of the cerebellum can increase resilience to noise by employing redundant connectivity motifs without compromising overall encoding capacity. This finding has important implications for understanding the principles of biological network architecture and designing artificial neural networks.
Article
Biology
Katarzyna Kita, Catarina Albergaria, Ana S. Machado, Megan R. Carey, Martin Muller, Igor Delvendahl
Summary: GluA4 plays a crucial role in synaptic excitation and associative memory formation in the cerebellum, with its deletion causing reduced synaptic transmission and impaired granule cell coding, leading to deficits in associative learning.
Article
Multidisciplinary Sciences
Brian D. Kangas, Ann M. Iturra-Mena, Mykel A. Robble, Oanh T. Luc, David Potter, Stefanie Nickels, Jack Bergman, William A. Carlezon, Diego A. Pizzagalli
Summary: This study integrated electrophysiological recordings with rodent touchscreen-based cognitive testing, creating a rat flanker task that aligns with human cognitive control research. Purple and green photographic stimuli were found to efficiently train rats and elicit expected flanker interference effects.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Bing-Xue Li, Hua Jin, Guang-Jian Zhang, Li-Na Cui, Chun-Ping Chu, De-Lai Qiu
Summary: The study demonstrated that noradrenaline depresses mossy fiber-granule cell synaptic transmission evoked by facial stimulation through the alpha-2 adrenergic receptor in the cerebellum of mice.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Logan J. Voss, Violet Garcia
Summary: In brain slice experiments, high frequency field potential activity is used to probe the functional state of the GABAergic system. The activity is strongly associated with GABA(A) and is prominently displayed in no-magnesium seizure-like events. As time passes, the success rate of generating high frequency responses declines rapidly.
Article
Neurosciences
Bing-Xue Li, Guang-Hui Dong, Hao-Long Li, Jia-Song Zhang, Yan-Hua Bing, Chun-Ping Chu, Song-Biao Cui, De-Lai Qiu
Summary: Chronic ethanol exposure from adolescence enhances facial stimulation-evoked mossy fiber-granule cell synaptic transmission in the adult mouse cerebellar cortex through GluN2A mediation, impairing the high-fidelity transmission capability of sensory information.
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2021)
Article
Neurosciences
Wendy Xueyi Wang, Julia Qiao, Julie L. Lefebvre
Summary: Parvalbumin-expressing inhibitory neurons play a critical role in maintaining the balance and fine-tuning of complex neuronal circuits. However, the activity of PV-Cre is not restricted to inhibitory neurons in the mouse cerebellar cortex, but also occurs in excitatory granule cells. The activation process of PV-Cre in the mouse cerebellum is spatially and temporally regulated.
Article
Neurosciences
Monica Christova, Victoria Sylwester, Eugen Gallasch, Shane Fresnoza
Summary: This study explored the effects of peripherally applied vibrotactile stimuli on cerebello-cortical functional connections. The results showed that hand stimulation led to a reduction in cerebellar brain inhibition and increased vibration perception threshold, indicating functional connections between the cerebellum and primary motor cortex, and suggesting that the cerebellum influences the processing of vibrotactile stimulus through motor-sensory interactions.
Article
Biochemical Research Methods
Xu Zhang, Roeland T. Hancock, Sabato T. Santaniello
Summary: This study investigates the acute effects of transcranial direct current stimulation (tDCS) on cerebellar neurons, particularly focusing on the response of Purkinje cells to the electric field induced by tDCS. The results show that tDCS significantly modulates the synaptic encoding and postsynaptic spiking precision of Purkinje cells in the cerebellar cortex, suggesting tDCS as a potential therapeutic option for movement disorders involving cerebellar hyperactivity such as ataxia.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Clinical Neurology
Ahmet S. Asan, Qi Kang, Omer Oralkan, Mesut Sahin
Summary: The study found that the activity of cerebellar Purkinje cells can be modulated by FUS patterns, with stronger effects observed with shorter pulse durations. It is suggested that FUS may modulate single cell firing activity through the excitation and inhibition of the entire cortical network rather than specific cells.
Article
Neurosciences
Noemi Binini, Francesca Talpo, Paolo Spaiardi, Claudia Maniezzi, Matteo Pedrazzoli, Francesca Raffin, Niccolo Mattiello, Antonio N. Castagno, Sergio Masetto, Yuchio Yanagawa, Clayton T. Dickson, Stefano Ramat, Mauro Toselli, Gerardo Rosario Biella
Summary: The perirhinal cortex (PRC) acts as a gateway between cortical areas and hippocampus, with its neurons being able to amplify output signals and coordinate network activity in the brain through resonance. This resonance ability is crucial for information transmission and memory enhancement between neocortex and hippocampus.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)