Article
Neurosciences
Joseph A. McQuail, Sofia Beas, Kyle B. Kelly, Caesar M. Hernandez, Jennifer L. Bizon, Charles J. Frazier
Summary: The study revealed that loss of NMDARs on interneurons in the PFC contributes to age-related impairment of cognitive flexibility, while a clear increase in AMPA/NMDA ratio in FSIs suggests a potential underlying mechanism for cognitive decline. These findings provide new insights into the neural mechanisms of cognitive decline.
Article
Biochemistry & Molecular Biology
Yang Zhou, Monica K. Chawla, Jose L. Rios-Monterrosa, Lingzhi Wang, Marc A. Zempare, Victor J. Hruby, Carol A. Barnes, Minying Cai
Summary: The study found significant correlations between the expression of MCR subtypes in the frontal cortex/hypothalamus and hippocampus regions and the performance of spatial learning and memory in aged rats, supporting the hypothesis that aging has a direct impact on MCR expression and function.
Article
Multidisciplinary Sciences
Adam M. Brickman, Lok-Kin Yeung, Daniel M. Alschuler, Javier I. Ottaviani, Gunter G. C. Kuhnle, Richard P. Sloan, Heike Luttmann-Gibson, Trisha Copeland, Hagen Schroeter, Howard D. Sesso, JoAnn E. Manson, Melanie Wall, Scott A. Small
Summary: Dietary flavanols, found in certain fruits and vegetables, have been associated with cognitive aging. In a large-scale study, habitual flavanol consumption and diet quality were positively correlated with hippocampal-dependent memory. Although the intervention did not improve memory in all participants after 1 year, it restored memory in those with lower diet quality or lower habitual flavanol consumption.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Magdalena Pereyra, Ana Belen de Landeta, Juliana Fatima Dalto, Cynthia Katche, Jorge H. Medina
Summary: The study shows that the activity of mTORC1 signaling pathway is crucial for the normal expression of aversive and non-aversive long-term memories during memory retrieval. Specifically, the de novo synthesis of GluA1 and GluA2 AMPAR subunits plays an important role in memory retrieval, with mTORC1 potentially regulating AMPAR trafficking during this process.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Cell Biology
Rui Zhou, Shufang Qian, William C. S. Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W. C. Chan, Hong Zhang
Summary: Aging affects gut microbiota compositions, microglia, and cognition abilities, and is recognized as a risk factor for neurodegenerative diseases. The communication between gut microbiota and microglia plays a crucial role in age-related cognitive declines. This review discusses the changes in gut microbiota compositions, brain changes, especially morphology and functions of microglia, and highlights the role of microbiota-microglia connections in neurodegenerative diseases.
Article
Geriatrics & Gerontology
Pankaja Desai, Kristin R. Krueger, Carlos Mendes de Leon, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study investigates the impact of depressive symptoms and glial fibrillary acid protein (GFAP) concentrations on cognitive functioning. The results show that depressive symptoms and high GFAP concentrations contribute to cognitive decline, while depressive symptoms and low GFAP concentrations have a smaller effect.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ting Wang, Bo Ruan, Jinxin Wang, Zhiyong Zhou, Xulan Zhang, Changcheng Zhang, Haixia Zhao, Yuanjian Yang, Ding Yuan
Summary: Aging is associated with cognitive decline and neuroinflammation, with the NLRP3 inflammasome playing a critical role in this process. Inhibiting the NLRP3 inflammasome may represent a novel therapeutic intervention for aging-related cognitive impairment.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Giovanni Lauretta, Silvia Ravalli, Grazia Maugeri, Velia D'Agata, Michelino Di Rosa, Giuseppe Musumeci
Summary: Physical exercise promotes general well-being and can prevent diseases, as well as reduce cognitive impairments and the risk of neurodegenerative diseases.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jenni Harvey
Summary: It has been well established that leptin plays a crucial role in controlling energy homeostasis by signaling to specific hypothalamic nuclei. However, recent studies have revealed that leptin also acts on hippocampal synapses and significantly impacts cognitive processes, particularly hippocampal-dependent learning and memory.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Kacie D. Deters, Elizabeth C. Mormino, Lei Yu, Michael W. Lutz, David A. Bennett, Lisa L. Barnes
Summary: The study investigated the effects of APOE-TOMM40-'523 haplotypes on cognitive decline in non-demented non-Hispanic Blacks (NHB) and compared these effects to non-Hispanic Whites (NHW). Results showed that the '523-S/S haplotype had different effects on cognitive decline in NHB depending on APOE allele, and that differences in the effect of epsilon 4-'523-S in NHB may explain previous mixed findings on epsilon 4 and decline in this population.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
S. Duke Han, Debra A. Fleischman, Lei Yu, Victoria Poole, Melissa Lamar, Namhee Kim, Sue E. Leurgans, David A. Bennett, Konstantinos Arfanakis, Lisa L. Barnes
Summary: This study investigated neuroimaging correlates of cognitive decline in older Black adults and found that global cognitive decline was associated with functional connectivity of the hippocampus to the dorsolateral prefrontal cortex. Decline in semantic memory was associated with connectivity of the hippocampus to the precentral gyrus, and decline in perceptual speed was inversely associated with connectivity of the hippocampus to the intracalcarine cortex and the fusiform gyrus.
HUMAN BRAIN MAPPING
(2022)
Article
Behavioral Sciences
Frank Raven, Iris W. Riemersma, Martha F. Olthuis, Ieva Rybakovaite, Elroy L. Meijer, Peter Meerlo, Eddy A. van der Zee, Robbert Havekes
Summary: Many organisms in the animal kingdom have the ability to form and retrieve memories. Synaptic plasticity is crucial for memory storage. Overactivating cofilin improves short-term memory formation.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Chen Hong, Zhi Wang, Si-li Zheng, Wen-jun Hu, Shu-na Wang, Yan Zhao, Chao-yu Miao
Summary: Aging is a main risk factor for cognitive dysfunction, and Metrnl, a neurotrophic factor, has been found to regulate cognitive functions and hippocampal BDNF levels during the aging process. Metrnl may become a new candidate for the treatment or alleviation of aging-related cognitive dysfunction.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Neurosciences
Federico Gallo, Vincent DeLuca, Yanina Prystauka, Toms Voits, Jason Rothman, Jubin Abutalebi
Summary: Due to advances in healthcare, global life expectancy is increasing steadily. This can, however, result in a higher incidence of age-related diseases like dementia. Research has found that healthy lifestyle factors such as a nutritious diet, physical exercise, and occupational achievement can positively influence cognitive aging. This article critically reviews the neuroscientific evidence for another potential factor - bilingualism - and highlights its importance in understanding cognitive aging trajectories and its socio-economic impact.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Geriatrics & Gerontology
Caroline Machado Dartora, Wyllians Vendramini Borelli, Michel Koole, Ana Maria Marques da Silva
Summary: The review discusses the assessment of cognitive decline based on imaging differences and the relationship between imaging markers and their patterns with aging. However, there is currently no consensus among biomarkers regarding the relationship with cognitive decline and its trajectory. Further research and improvements are needed to better understand cognitive decline and develop effective treatment strategies.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Xun-Hu Gu, Li Jun Xu, Zhi-Qiang Liu, Bo Wei, Yuan-Jian Yang, Guo-Gang Xu, Xiao-Ping Yin, Wei Wang
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Plant Sciences
Tao Chen, Yuan-Jian Yang, Yan-Kun Li, Jing Liu, Peng-Fei Wu, Fang Wang, Jian-Guo Chen, Li-Hong Long
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Neurosciences
Yuan-Jian Yang, Ying Zhao, Bin Yu, Guo-Gang Xu, Wei Wang, Jin-Qiong Zhan, Zhen-Yu Tang, Ting Wang, Bo Wei
Article
Behavioral Sciences
Zhi-Qiang Liu, Xun-Hu Gu, Yuan-Jian Yang, Xiao-ping Yin, Li-Jun Xu, Wei Wang
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2016)
Article
Psychiatry
Yuan-Jian Yang, Jian-Wen Xiong, Ying Zhao, Jin-Qiong Zhan, Hai-Bo Chen, Kun Yan, Mao-Rong Hu, Bin Yu, Bo Wei
PSYCHIATRY RESEARCH
(2016)
Article
Behavioral Sciences
Hai-Bo Chen, Wen-Ning Wu, Wei Wang, Xun-Hu Gu, Bin Yu, Bo Wei, Yuan-Jian Yang
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2017)
Article
Neurosciences
Jian-wen Xiong, Bo Wei, Yan-kun Li, Jin-qiong Zhan, Shu-zhen Jiang, Hai-bo Chen, Kun Yan, Bin Yu, Yuan-jian Yang
PSYCHOPHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Wei Wang, Fang Wang, Yuan-Jian Yang, Zhuang-Li Hu, Li-Hong Long, Hui Fu, Na Xie, Jian-Guo Chen
BRITISH JOURNAL OF PHARMACOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Can-Ming Wang, Yuan-Jian Yang, Jie-Ting Zhang, Jue Liu, Xin-Lei Guan, Ming-Xing Li, Hai-Feng Lu, Peng-Fei Wu, Jian-Guo Chen, Fang Wang
JOURNAL OF NEUROCHEMISTRY
(2015)
Article
Neurosciences
Hai-Feng Lu, Peng-Fei Wu, Yuan-Jian Yang, Wen Xiao, Jun Fan, Jing Liu, Yuan-Long Li, Yi Luo, Zhuang-Li Hu, You Jin, Fang Wang, Jian-Guo Chen
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Dan-Fang Yu, Peng-Fei Wu, Hui Fu, Jin Cheng, Yuan-Jian Yang, Tao Chen, Li-Hong Long, Jian-Guo Chen, Fang Wang
NEUROSCIENCE LETTERS
(2011)
Article
Behavioral Sciences
Yuan-Jian Yang, Yan-Kun Li, Wei Wang, Jian-Guo Wan, Bin Yu, Mei-Zhen Wang, Bin Hu
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2014)
Article
Biochemistry & Molecular Biology
Jin-Qiong Zhan, Chun-Nuan Chen, Si-Xian Wu, Han-Jun Wu, Ke Zou, Jian-Wen Xiong, Bo Wei, Yuan-Jian Yang
Summary: The study shows that fisetin treatment can reverse deficits in hippocampal synaptic plasticity and memory in a male rat model of schizophrenia by restoring the phosphorylation and surface expression of AMPAR GluA1 subunit, indicating fisetin as a promising therapeutic candidate for schizophrenia-associated cognitive deficits.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Wen-Ning Wu, Peng-Fei Wu, Jun Zhou, Xin-Lei Guan, Zui Zhang, Yuan-Jian Yang, Li-Hong Long, Na Xie, Jian-Guo Chen, Fang Wang
MOLECULAR PHARMACOLOGY
(2013)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
