Article
Biochemistry & Molecular Biology
Xinxin Huang, Juncheng Hao, Yan Qin Tan, Tao Zhu, Vijay Pandey, Peter E. Lobie
Summary: Patients with epithelial ovarian cancer are often diagnosed at an advanced stage, leading to poor overall prognosis. This review summarizes the functional significance of CXCL/CXCR chemokines in modulating EOC progression and discusses the current status and prospects of CXCR/CXCL-based theranostic strategies in EOC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hai-Hui Xie, Hong-Yan Ma, Shu Zhang, Jian-Wen Li, Qi Han, Hui-Qun Chen, Bo-Qin Su, Jian-Ping Zhou
Summary: The study demonstrates that EDA can significantly lower the serum concentrations of CXCL13 and IL-6, improve PND symptoms in elderly patients, and reduce the incidence of post-operative delirium.
CHINESE MEDICAL JOURNAL
(2021)
Article
Nanoscience & Nanotechnology
Peng Zhao, Jun Wang, Behnaz Karkheiran, Samira Alesaeidi, Ehsan Nourbakhsh, Mohammad Saeed Kahrizi, Asal Mir
Summary: This study developed a new nano-liposome that can modulate the tumor microenvironment and enhance the efficacy of immune checkpoint inhibitors, leading to improved anti-tumor immune response.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Oncology
Sven H. Loosen, Tom F. Ulmer, Simon Labuhn, Jan Bednarsch, Sven A. Lang, Patrick H. Alizai, Anne T. Schneider, Mihael Vucur, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Summary: This study identified circulating levels of CXCL13 as a previously unrecognized marker for predicting outcomes following the resection of BTC, highlighting the potential role of the CXC chemokine family in BTC pathogenesis.
Article
Immunology
Zeyu Sun, Wenhua Huang, Yuling Zheng, Peng Liu, Wenbo Yang, Zinan Guo, Decong Kong, Qingyu Lv, Xinyu Zhou, Zongmin Du, Hua Jiang, Yongqiang Jiang
Summary: The research discovered that mice without the Fpr2 receptor were highly susceptible to GBS infections, showing decreased chemotaxis of neutrophils, decreased bactericidal ability of neutrophils, and high mortality.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chunlei Zhang, Yindong Kang, Pengcheng Miao, Dehui Chang
Summary: This study identifies CXCL9/10 gene expression levels as potential molecular markers for predicting the efficacy and prognosis of bladder cancer patients treated with Atezolizumab, based on clinical trial data.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Aleksandra Rymarz, Magdalena Mosakowska, Stanislaw Niemczyk
Summary: The study evaluated the significance of MMP-3, CXCL-13, and C5a in different stages of AAV. The three markers showed potential in distinguishing active vasculitis from other pathologies, with CXCL-13 being a potential marker in distinguishing active vasculitis from long term remission. MMP-3 levels were related to kidney function expressed by eGFR and caution should be taken in interpreting its elevation in patients with kidney failure.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Chuanjie Qin, Nazakat Hussain Memon, Quan Gong, Qinchao Shi, Qingfa Yang
Summary: The interaction of CXC chemokine ligand 12/CXC receptor 4 ligand/receptor in the immune system plays a crucial role in response against bacterial infection in vertebrates. The study on Pelteobagrus vachellii revealed a 24-hour variation in the expression of CXCR4 and CXCL12 genes, highlighting the importance of understanding the immune rhythm in teleosts.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Article
Oncology
Sung-Tai Wei, Jung-Ying Chiang, Hwai-Lee Wang, Fu-Ju Lei, Yen-Chih Huang, Chi-Chung Wang, Der-Yang Cho, Chia-Hung Hsieh
Summary: Hypoxic tumor microenvironment (HTM) promotes a more aggressive and malignant state in glioblastoma. In this study, the researchers found that CXCL14, regulated by HIF and activated IGF-1R signaling pathway, plays a role in HTM-mediated glioblastoma progression. Targeting CXCL14 with siRNA nanoparticles can inhibit glioblastoma growth and extend survival time.
Review
Oncology
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yang Wang, Zhentao Yu
Summary: Esophageal squamous cell carcinoma is the main type of esophageal cancer, where abnormal expression of CXCL12 and CXCR4 contributes to tumor proliferation, distant metastases, and worsening prognosis. Antagonists and imaging agents targeting CXCL12/CXCR4 have been developed to interfere with and monitor tumor metastasis.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Immunology
Rusan Ali Catar, Maria Bartosova, Edyta Kawka, Lei Chen, Iva Marinovic, Conghui Zhang, Hongfan Zhao, Dashan Wu, Daniel Zickler, Honorata Stadnik, Marek Karczewski, Julian Kamhieh-Milz, Achim Jorres, Guido Moll, Claus Peter Schmitt, Janusz Witowski
Summary: Peritoneal dialysis (PD) is a valuable 'home treatment' option, especially during the Coronavirus pandemic. However, the long-term use of PD is limited by unfavorable tissue remodeling in the peritoneal membrane, which is associated with inflammation-induced angiogenesis. This study identifies the crucial contribution of mesothelial cell-derived angiogenic CXC chemokine ligand 1 (CXCL1) to peritoneal angiogenesis in PD, suggesting new therapeutic targets to prolong PD therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Se-Hoon Lee, Yeongmin Kim, Bu-Nam Jeon, Gihyeon Kim, Jinyoung Sohn, Youngmin Yoon, Sujeong Kim, Yunjae Kim, Hyemin Kim, Hongui Cha, Na-Eun Lee, Hyunsuk Yang, Joo-Yeon Chung, A-Reum Jeong, Yun Yeon Kim, Sang Gyun Kim, Yeonhee Seo, Sehhoon Park, Hyun Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Hansoo Park, Kyoung Wan Yoon
Summary: High levels of ICAM-1 in tumors and plasma are associated with prolonged survival in non-small cell lung cancer patients treated with anti-PD-1 or anti-PD-L1. Further studies reveal that sICAM-1 enhances the efficacy of anti-PD-1 by activating cytotoxic T cells, and CXCL13 might be involved in the ICAM-1-mediated anti-tumor pathway. Combinatorial therapy with sICAM-1 and anti-PD-1 shows promise in converting anti-PD-1-resistant tumors to responsive ones in preclinical studies.
Article
Immunology
Rui-Bin Zhang, Long-Cong Dong, Yuan Shen, Hong-Ying Li, Qin Huang, Shu-Guang Yu, Qiao-Feng Wu
Summary: This study used transcriptomics, bioinformatics analysis, and core gene validation to identify the core gene and potential mechanisms for electroacupuncture (EA) treatment of ulcerative colitis (UC). The results showed that EA could improve the symptoms of UC mice and regulate the activity of immune infiltrating cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Yang Zhao, Haohang Sun, Weidong Zhang, Yuanlin Xi, Xuezhong Shi, Yongli Yang, Jie Lu, Ming Zhang, Liang Sun, Dongsheng Hu
Summary: This study aimed to investigate the association between triglyceride-glucose (TyG) and incident ischemic stroke, as well as assess the potential modification effect by known risk factors of stroke. The results showed that elevated TyG index is an independent predictor of ischemic stroke in the general population, and insulin resistance may be positively associated with future stroke risk.
DIABETES & METABOLISM
(2021)
Article
Oncology
Lingwei Kong, Rushan Qi, Guangchun Zhou, Sentai Ding
Summary: The study found that Survivin, CXCL8, and VEGF were highly expressed, while ING4 was lowly expressed in prostate cancer tissues, and this expression was correlated with clinical stage; in addition, these factors played a synergistic role in the development and progression of prostate cancer.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N. William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R. Robertson, Paul M. McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio, Robert P. Igo, Rany M. Salem, Norberto Perico, Maria Lajer, Annemari Karajamak, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M. van Dam, Guozhi Jiang, Claudia H. T. Tam, Andrea O. Y. Luk, Heung Man Lee, Cadmon K. P. Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C. N. Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, Marcus G. Pezzolesi, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T. Hiraki, Tarunveer S. Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R. Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D. Paterson, David Tregouet, Alexander P. Maxwell, Su Chi Lim, Ronald C. W. Ma, E. Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S. Krolewski, Stephen S. Rich, Joel N. Hirschhorn, Jose C. Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, Mary Julia Brosnan, Colin N. A. Palmer, Per-Henrik Groop, Helen M. Colhoun, Leif C. Groop, Mark I. McCarthy
Article
Endocrinology & Metabolism
Mahboubeh Daneshpajooh, Lena Eliasson, Karl Bacos, Charlotte Ling
ACTA DIABETOLOGICA
(2018)
Article
Endocrinology & Metabolism
Emma Nilsson, Anna Benrick, Milana Kokosar, Anna Krook, Eva Lindgren, Thomas Kallman, Mihaela M. Martis, Kurt Hojlund, Charlotte Ling, Elisabet Stener-Victorin
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2018)
Article
Cell & Tissue Engineering
Cajsa Davegardh, Elin Hall Wedin, Christa Broholm, Tora Ida Henriksen, Maria Pedersen, Bente Klarlund Pedersen, Camilla Scheele, Charlotte Ling
STEM CELL RESEARCH & THERAPY
(2019)
Article
Oncology
Paula Walle, Ville Mannisto, Vanessa Derenji de Mello, Maija Vaittinen, Alexander Perfilyev, Kati Hanhineva, Charlotte Ling, Jussi Pihlajamaki
CLINICAL EPIGENETICS
(2019)
Review
Cell Biology
Charlotte Ling, Tina Ronn
Article
Endocrinology & Metabolism
Elfin Hall, Josefine Jonsson, Jones K. Ofori, Petr Volkov, Alexander Perfilyev, Marloes Dekker Nitert, Lena Eliasson, Charlotte Ling, Karl Bacos
Review
Medicine, General & Internal
C. Ling
JOURNAL OF INTERNAL MEDICINE
(2020)
Article
Endocrinology & Metabolism
Meriem Ouni, Sophie Saussenthaler, Fabian Eichelmann, Markus Jaehnert, Mandy Stadion, Clemens Wittenbecher, Tina Ronn, Lisa Zellner, Pascal Gottmann, Charlotte Ling, Matthias B. Schulze, Annette Schuermann
Article
Cell Biology
Sonia Garcia-Calzon, Alexander Perfilyev, Mats Martinell, Monta Ustinova, Sebastian Kalamajski, Paul W. Franks, Karl Bacos, Ilze Elbere, Jussi Pihlajamaki, Petr Volkov, Allan Vaag, Leif Groop, Rlena Maziarz, Janis Klovins, Emma Ahlqvist, Charlotte Ling
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Endocrinology & Metabolism
Josefine Jonsson, Kristina M. Renault, Sonia Garcia-Calzon, Alexander Perfilyev, Angela C. Estampador, Kirsten Norgaard, Mads Vendelbo Lind, Allan Vaag, Line Hjort, Kim F. Michaelsen, Emma Malchau Carlsen, Paul W. Franks, Charlotte Ling
Summary: Maternal obesity can lead to epigenetic changes in offspring, impacting growth and disease risk. Lifestyle interventions during pregnancy may alter DNA methylation in offspring, influencing lean mass and growth.
Article
Genetics & Heredity
Silja Schrader, Alexander Perfilyev, Mats Martinell, Sonia Garcia-Calzon, Charlotte Ling
Summary: The study found an association between statin therapy and epigenetic modifications in patients with type 2 diabetes, identifying differential methylation sites related to cholesterol biosynthesis and immune response through analysis of blood DNA methylation.
Article
Multidisciplinary Sciences
Cajsa Davegardh, Johanna Sall, Anna Benrick, Christa Broholm, Petr Volkov, Alexander Perfilyev, Tora Ida Henriksen, Yanling Wu, Line Hjort, Charlotte Brons, Ola Hansson, Maria Pedersen, Jens U. Wurthner, Klaus Pfeffer, Emma Nilsson, Allan Vaag, Elisabet Stener-Victorin, Karolina Pircs, Camilla Scheele, Charlotte Ling
Summary: The study reports that downregulation of VPS39 in muscle stem cells from individuals with type 2 diabetes may contribute to insulin resistance and lower muscle quality through effects on autophagy and epigenetics.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Silja Schrader, Alexander Perfilyev, Emma Ahlqvist, Leif Groop, Allan Vaag, Mats Martinell, Sonia Garcia-Calzon, Charlotte Ling
Summary: This study identified differential epigenetic patterns between subgroups of T2D and developed subgroup-specific methylation risk scores (MRSs). These MRSs can predict diabetic complications. Different MRSs are associated with different risks of cardiovascular and renal diseases.
Article
Endocrinology & Metabolism
Charlotte Ling
Summary: Data suggests that epigenetic modifications and mechanisms play a significant role in the pathogenesis of type 2 diabetes. However, the role of pharmacoepigenetics in type 2 diabetes is not well-established. Blood-based epigenetic biomarkers may be useful in distinguishing responders from non-responders to glucose-lowering therapies. Furthermore, there is a need for further research on whether existing therapies exert their effects through therapy-induced epigenetic alterations. Finally, epigenetic enzymes may be potential drug targets for type 2 diabetes.