Article
Medicine, General & Internal
Hsuan-Wen Chou, Hao-Chang Hung, Ching-Han Lin, An-Chi Lin, Ye-Fong Du, Kai-Pi Cheng, Chung-Hao Li, Chih-Jen Chang, Hung-Tsung Wu, Horng-Yih Ou
Summary: The study revealed a negative association between Hhip concentrations and BMI, with overweight and obese individuals having lower Hhip levels. Overweight and obesity were independently associated with lower Hhip concentrations, suggesting Hhip may play a role in linking obesity and diabetes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Tanja M. Mueller, Emily Becker, Maximilian Wiendl, Lisa Lou Schulze, Caroline Voskens, Simon Voelkl, Andreas E. Kremer, Markus F. Neurath, Sebastian Zundler
Summary: COVID-19 is associated with a decrease in circulating adaptive immune cells expressing the key gut homing marker alpha 4 beta 7, while the total number of IgA-expressing B cells is increased. This suggests that the systemic immune response against SARS-CoV-2 may be dominated by extraintestinal, particularly pulmonary, immune cell priming.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Tomasello, Maria Pitrone, Valentina Guarnotta, Carla Giordano, Giuseppe Pizzolanti
Summary: This study investigated the contributions of adipose progenitors (ASCs) and adipocytes (AMCs) to TNF-alpha-induced extracellular matrix (ECM) remodeling and the potential involvement of irisin in AT impairment in obesity. The results showed that inflamed adipocytes exhibited impaired protein metabolism and lipid storage ability, accompanied by increased matrix metalloproteinase activity. In vitro and ex vivo measurements revealed a positive correlation between inflammation, adipose secretion of irisin, and circulating irisin levels in patients with visceral obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Isabel Huber-Ruano, Enrique Calvo, Jordi Mayneris-Perxachs, M-Mar Rodriguez-Pena, Victoria Ceperuelo-Mallafre, Lidia Cedo, Catalina Nunez-Roa, Joan Miro-Blanch, Maria Arnoriaga-Rodriguez, Aurelie Balvay, Claire Maudet, Pablo Garcia-Roves, Oscar Yanes, Sylvie Rabot, Ghjuvan Micaelu Grimaud, Annachiara De Prisco, Angela Amoruso, Jose Manuel Fernandez-Real, Joan Vendrell, Sonia Fernandez-Veledo
Summary: The study reveals that gut microbiota is a significant source of elevated succinate in obese individuals. Therapeutic treatments with selected bacteria can reduce circulating succinate levels in obese mice, and Odoribacter laneus shows promise as a probiotic to deplete succinate and improve glucose tolerance.
Article
Developmental Biology
Lanting Chen, Fengrun Sun, Mengdie Li, Jinfeng Qian, Meirong Du, Dajin Li, Songcun Wang
Summary: The study found that during pregnancy, Eomes plays an important role in the function of CD8(+)T cells, particularly in the case of miscarriage where the number of Eomes(+)dCD8(+)T cells decreases, showing a pro-inflammatory phenotype.
Article
Biochemistry & Molecular Biology
Alphons J. M. Vermorken, Jingjing Zhu, Paul Holvoet, Yali Cui
Summary: Iron deficiency exacerbates the prognosis of patients with heart failure, leading to functional deficiencies. Treatments targeting mitochondrial and lysosomal function may improve the prognosis of a subgroup of heart failure patients with skeletal muscle wasting. Monitoring methylmalonic acid levels can help identify patients who may benefit from treatment.
Article
Endocrinology & Metabolism
Sang Ouk Chin, You-Cheol Hwang, In-Jin Cho, In-Kyung Jeong, Kyu Jeung Ahn, Ho Yeon Chung
Summary: The study aimed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity, as well as glucose tolerance, in Korean adults. Results showed that as glucose tolerance deteriorated, PFC increased, and parameters related to insulin secretion decreased. The study found that PFC was higher in participants diagnosed with diabetes compared to those with normal glucose tolerance, and there was a significant negative correlation between PFC and indices reflecting beta cell function.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Alexandra Hoepfinger, Thomas Karrasch, Andreas Schaeffler, Andreas Schmid
Summary: Recent investigation has found that Cathelicidin antimicrobial peptide (CAMP) plays a significant role in infection defense and innate immunity processes in adipose tissue. However, its regulation and functions as an adipokine in metabolic contexts are not well understood. This study examined the regulation of CAMP levels during oral glucose tolerance tests (OGTTs) and found that glucose positively regulates systemic CAMP in a postprandial manner, independent of its impact on adipocyte CAMP expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Jingna Xun, Shuyan Guo, Yumin Xu, Rong Chen, Qi Tang, Xinyu Zhang, Danping Liu, Renfang Zhang, Yinzhong Shen, Li Liu, Jiangrong Wan, Jun Chen, Hongzhou Lu
Summary: This study assessed the association of plasma beta DG levels with inflammation and immune activation in people living with HIV (PLWH) and the effect of antiretroviral therapy (ART) on beta DG levels. The results showed that beta DG levels were positively correlated with immune activation markers and decreased significantly after 1 year of ART, suggesting it could serve as a biomarker of immune activation and efficacy monitoring in PLWH.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Immunology
Mohammad Afzal Khan, Christine L. Lau, Alexander Sasha Krupnick
Summary: By studying the levels of Tregs/FOXP3 gene expression, it can serve as a crucial prognostic biomarker for the progression of chronic lung allograft dysfunction (CLAD) in lung transplant recipients, and provide potential therapeutic options to improve lung transplant survival rates.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Samuel Furse, Albert Koulman, Susan E. Ozanne, Lucilla Poston, Sara L. White, Claire L. Meek
Summary: Gestational diabetes in obese women is associated with elevated levels of specific lipids related to de novo lipogenesis, which are also correlated with measures of offspring adiposity. These findings suggest that the effects of GDM on neonatal body composition may not be solely due to hyperglycemia, but may involve other pathways.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Saikat Dewanjee, Pratik Chakraborty, Hiranmoy Bhattacharya, Leena Chacko, Birbal Singh, Anupama Chaudhary, Kalpana Javvaji, Saumya Ranjan Pradhan, Jayalakshmi Vallamkondu, Abhijit Dey, Rajkumar Singh Kalra, Niraj Kumar Jha, Saurabh Kumar Jha, P. Hemachandra Reddy, Ramesh Kandimalla
Summary: This article systematically evaluates the abnormal glucose metabolism associated with amyloid beta and phosphorylated tau accumulation in AD, and discusses the role of insulin signaling and mitochondrial dysfunction in the progression of AD pathology.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Samantha J. Donkel, Frank J. Wolters, M. Arfan Ikram, Moniek P. M. de Maat
Summary: The study investigated the association of demographic and cardiovascular risk factors with NETs in a general population, finding weak correlations with age, history of coronary heart disease, lipid-lowering drug use, and HDL-cholesterol levels. The findings suggest that CVD risk factors have only a small impact on NETs levels in the general population and may be more relevant in acute disease phases.
Article
Endocrinology & Metabolism
Ran Liu, Shilin Guan, Zhongai Gao, Jingyu Wang, Jie Xu, Zhaohu Hao, Yi Zhang, Shaohua Yang, Zhenhong Guo, Juhong Yang, Hailin Shao, Baocheng Chang
Summary: In the prediabetic stage of IGT, high concentrations of insulin and glucose regulate the secretory function of glomerular endothelial cells in opposite ways by modulating the expression of miRNA-21, potentially leading to renal tubule ischemia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Alvaro Gonzalez-Dominguez, Thalia Belmonte, Jesus Dominguez-Riscart, Pablo Ruiz-Ocana, Ines Muela-Zarzuela, Ana Saez-Benito, Raul Montanez-Martinez, Rosa M. M. Mateos, Alfonso M. M. Lechuga-Sancho
Summary: This study found that insulin response is associated with oxidative stress and inflammation in children, and children with impaired insulin response have worse lipid and carbohydrate metabolism and are more likely to develop type 2 diabetes. Uric acid may mediate pathological inflammatory response by activating NLRP3 in peripheral blood mononuclear cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Milton Fabian Suarez-Ortegon, Alejandra Arbelaez, Jose Maria Moreno-Navarrete, Jose Guillermo Ortega-Avila, Mildrey Mosquera, Jose Manuel Fernandez-Real
Summary: Excessive body iron levels are associated with insulin resistance and cardiometabolic risk, and oxidative stress may play a role in this relationship. This study investigated the association between soluble transferrin receptor (sTfR) levels, antioxidant status, and cardiometabolic risk markers. The results showed that sTfR levels were positively correlated with total antioxidant capacity (TAC) in both men and women. In men, sTfR levels were inversely associated with waist circumference and fasting glucose, and positively associated with LDL cholesterol. The findings suggest that sTfR levels are associated with antioxidant status and specific cardiometabolic risk variables, independent of other factors such as serum ferritin and hepcidin.
Review
Endocrinology & Metabolism
Miguel Lopez, Manuel Fernandez-Real, Stanislav I. Tomarev
Summary: Classically, the regulation of energy balance has been based on central and peripheral mechanisms sensing energy, nutrients, metabolites, and hormonal cues. Recent data have added more complexity to the homeostatic regulation of metabolism by introducing the key role of olfaction in energy homeostasis. Olfactory inputs contribute to the regulation of feeding, energy expenditure, and whole body metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ariadna Gomez-Vilarrubla, Berta Mas-Pares, Gemma Carreras-Badosa, Mariona Jove, Rebeca Berdun, Alexandra Bonmati-Santane, Francis de Zegher, Lourdes Ibanez, Abel Lopez-Bermejo, Judit Bassols
Summary: During pregnancy, the transfer of maternal polyunsaturated fatty acids (PUFA) to the fetus through the placenta plays a role in the development of obesity. This study examined the associations between long chain PUFA (LC-PUFA) measured in the placenta at birth and obesity-related parameters in offspring at 6 years of age. A higher placental arachidonic acid/eicosapentaenoic acid ratio was found to be positively associated with visceral adiposity and obesity risk parameters, especially in subjects with higher expressions of placental fatty acid transporters. These findings emphasize the potential role of n-6 and n-3 LC-PUFA in the fetal programming of obesity risk in childhood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Maria Arnoriaga-Rodriguez, Yenny Leal, Jordi Mayneris-Perxachs, Vicente Perez-Brocal, Andres Moya, Wifredo Ricart, Merce Fernandez-Balsells, Jose Manuel Fernandez-Real
Summary: Sleep disruption is associated with worse glucose metabolic control and altered gut microbiota. This study found an association between rapid eye movement (REM) sleep duration and glucose levels as well as gut microbiota composition. Sleep deprivation can lead to poor glucose control and microbiota imbalance, negatively impacting metabolic health.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Luca Valenti, Elena Corradini, Leon A. Adams, Elmar Aigner, Saleh Alqahtani, Marco Arrese, Edouard Bardou-Jacquet, Elisabetta Bugianesi, Jose-Manuel Fernandez-Real, Domenico Girelli, Hannes Hagstrom, Benjamin Henninger, Kris Kowdley, Guido Ligabue, Donald McClain, Fabrice Laine, Koji Miyanishi, Martina U. Muckenthaler, Alessia Pagani, Patrizia Pedrotti, Antonello Pietrangelo, Daniele Prati, John D. Ryan, Laura Silvestri, C. Wendy Spearman, Per Stal, Emmanuel A. Tsochatzis, Francesca Vinchi, Ming-Hua Zheng, Heinz Zoller
Summary: Hyperferritinaemia is often associated with metabolic dysfunction and fatty liver and is linked to an increased risk of cardiometabolic and liver diseases. The main determinants of ferritin levels in individuals with metabolic dysfunction are genetic variants that affect iron metabolism. However, there is currently a lack of validated criteria for the diagnosis and staging of metabolic hyperferritinaemia, and the benefits of iron depletion therapy remain unclear. In this article, the authors provide an overview of the relationship between hyperferritinaemia and iron accumulation in individuals with metabolic dysfunction and propose updated definitions and staging systems, highlighting research gaps and suggesting future study designs and outcome measures.
NATURE REVIEWS ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lidia Sojo, Elena Santos-Gonzalez, Lidia Riera, Alex Aguilera, Rebeca Barahona, Paula Pellicer, Maria Buxo, Jordi Mayneris-Perxachs, Merce Fernandez-Balsells, Jose-Manuel Fernandez-Real
Summary: In this study, we investigated the plasma lipidomics profiles of patients with T1DM and explored potential associations. We found significant associations between certain lipid species and subclinical atherosclerosis, as well as differences according to overweight status. Our findings suggest that personalized approaches targeting specific lipid molecules may be useful in preventing cardiovascular disease in T1DM patients.
Review
Endocrinology & Metabolism
Marisel Rosell-Diaz, Jose Manuel Fernandez-Real
Summary: The decline in cognitive function and the prevalence of neurodegenerative disorders are serious threats to health in old age, with dementia affecting 50 million people worldwide. Type 2 diabetes is linked to an increased risk of cognitive impairment and dementia. Studies have shown that metformin, a medication used to treat type 2 diabetes, may partially restore gut dysbiosis related to diabetes and potentially improve cognitive function.
Article
Endocrinology & Metabolism
Jiuwen Sun, Alberic Germain, Gracia Kaglan, Florence Servant, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez Real, Daniela Tatiana Sala, Radu Mircea Neagoe, Anne Bouloumie, Remy Burcelin
Summary: This study found that specific bacterial families in the visceral adipose tissue of obese patients can trigger inflammation and adipose depot development. There are significant differences in the bacterial composition between obese patients and non-obese individuals. These findings generate new hypotheses regarding the relationship between obesity and gut tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Milton Fabian Suarez-Ortegon, Jenny Elizabeth Ordonez-Betancourth, Jose Guillermo Ortega-Avila, Ana Yibby Forero, Jose Manuel Fernandez-Real
Summary: This study evaluated the relationship between three adiposity markers and iron-deficient status in reproductive-age women. The results showed that waist circumference, waist-to-height ratio, and BMI were inversely associated with iron deficiency. Among them, waist-to-height ratio had the strongest correlation.
Review
Endocrinology & Metabolism
Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Iron regulation is crucial for maintaining healthy adipose tissue function. Excessive accumulation of iron in adipose tissue can lead to dysfunction. Understanding the interplay between iron and adipose tissue is important for developing new therapeutic approaches to improve and prevent adipose tissue dysfunction.
Article
Multidisciplinary Sciences
Aina Lluch, Jessica Latorre, Angela Serena-Maione, Isabel Espadas, Estefania Caballano-Infantes, Jose M. Moreno-Navarrete, Nuria Oliveras-Canellas, Wifredo Ricart, Maria M. Malagon, Alejandro Martin-Montalvo, Walter Birchmeier, Witold Szymanski, Johannes Graumann, Maria Gomez-Serrano, Elena Sommariva, Jose M. Fernandez-Real, Francisco J. J. Ortega
Summary: This study reveals that levels of Plakophilin-2 (PKP2) steadily increase during fat cell differentiation, but are compromised in the presence of inflammation. Expression of PKP2 in subcutaneous adipose tissue diminishes in patients with obesity and normalizes upon weight loss. The impaired PKP2 leads to cell cycle dysfunction and premature senescence in adipocytes.
NATURE COMMUNICATIONS
(2023)
