Article
Nutrition & Dietetics
Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Agnieszka Wosiak, Marta Gruca, Elzbieta Smolewska
Summary: This study aimed to estimate the serum levels of adiponectin, leptin, and resistin in children born small for gestational age (SGA) compared to children born with appropriate birthweight. The results showed that SGA children had significantly higher levels of adiponectin and leptin, while resistin levels were comparable. There were correlations between body weight, blood pressure, and adiponectin and leptin levels in SGA children.
Review
Pediatrics
Irene Netchine, Manouk van der Steen, Abel Lopez-Bermejo, Ekaterina Koledova, Mohamad Maghnie
Summary: Children born small for gestational age (SGA) face a range of growth and metabolic issues, with some potentially needing growth hormone treatment to promote linear growth and address metabolic abnormalities.
FRONTIERS IN PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Fatima Crispi, Merida Rodriguez-Lopez, Gabriel Bernardino, Alvaro Sepulveda-Martinez, Susanna Prat-Gonzalez, Carolina Pajuelo, Rosario J. Perea, Maria T. Caralt, Giulia Casu, Kilian Vellve, Francesca Crovetto, Felip Burgos, Mathieu De Craene, Constantine Butakoff, Miguel A. Gonzalez Ballester, Isabel Blanco, Marta Sitges, Bart Bijnens, Eduard Gratacos
Summary: This study evaluated the baseline cardiac function and structure as well as exercise capacity in young adults born small for gestational age (SGA). The results showed that these young adults had markedly reduced exercise capacity, indicating potential association with increased cardiovascular mortality.
Article
Cardiac & Cardiovascular Systems
Merida Rodriguez-Lopez, Alvaro Sepulveda-Martinez, Gabriel Bernardino, Francesca Crovetto, Carolina Pajuelo, Marta Sitges, Bart Bijnens, Eduard Gratacos, Fatima Crispi
Summary: This study assessed the differences in cardiometabolic health between adults born small for gestational age. The results showed that females born small for gestational age are more prone to cardiac dysfunction, while males are more likely to experience changes in electrocardiography, vascular health, and metabolism.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Beata Kierzkowska, Marta Gruca, Agnieszka Wosiak, Elzbieta Smolewska
Summary: This study aimed to evaluate the lipid profile in early childhood in SGA children and found that even without overweight or obesity in early childhood, SGA children had abnormal lipid profiles, which may contribute to the development of cardiovascular diseases in adulthood.
Article
Endocrinology & Metabolism
Hua He, Wen-Ting Zhu, Anne Monique Nuyt, Isabelle Marc, Pierre Julien, Rong Huang, Lise Dubois, Shu-Qin Wei, Jun Zhang, Emile Levy, William D. Fraser, Zhong-Cheng Luo
Summary: This study examined the differences in neonatal endocrine metabolic health biomarkers in SGA infants with either stunting or wasting in the 3D birth cohort in Canada. The results showed that SGA infants with either stunting only or wasting only had lower cord plasma IGF-I and leptin concentrations, while those with both stunting and wasting had substantially lower proinsulin and higher ghrelin concentrations. This study highlights the importance of considering different SGA subtypes in understanding endocrine characteristics in early life.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Achim Fiess, Jana C. Riedl, Sandra Gissler, Eva Mildenberger, Michael S. Urschitz, Bernhard Stoffelns, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study found an association between restricted prenatal growth and increased higher-order aberrations in adulthood.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Lan Ling, Ting Chen, Xin-Hua Zhang, Min-Hong Pan, Hai-Hong Gong, Li-Na Zhang, Meng Zhao, Xiao-Qing Chen, Shu-Dong Cui, Chao Lu
Summary: This study aimed to identify the risk factors associated with short stature in children born small for gestational age (SGA) at full-term. The findings suggest that a decrease in placental perfusion, chromosomal abnormalities, short parental height, and absence of catch-up growth are risk factors for short stature in these children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Jose Manuel Rial Rodrigez, Lourdes Ibanez Toda, Ignacio Diez Lopez, Jordi Bosch Munoz, Luis Salamanca Fresno, Eugenio Fernandez Hernandez, Antonio de Arriba Munoz
Summary: It is found that adult patients born small for gestational age who received recombinant human growth hormone treatment, especially those without catch up growth, have impaired health related quality of life, particularly in mental health domains.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Emmie N. Upners, Lars Lau Raket, Jorgen H. Petersen, Ajay Thankamony, Edna Roche, Guftar Shaikh, Jeremy Kirk, Hilary Hoey, Sten-A Ivarsson, Olle Soder, Anders Juul, Rikke Beck Jensen
Summary: GH treatment improves adult height in short SGA children, with decreased peak height velocity, and earlier pubertal onset in SGA boys.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Jennia Michaeli, Ofir Michaeli, Ariel Rozitzky, Sorina Grisaru-Granovsky, Naomi Feldman, Naama Srebnik
Summary: This study revealed that antenatal diagnosis of FGR was independently associated with a 70% increased risk of cesarean delivery in AGA neonates without improving neonatal outcomes. These findings suggest that the outcomes may be due to prospect theory application and cognitive bias in clinical decision-making.
Article
Nutrition & Dietetics
Laura E. Lach, Katherine E. Chetta, Amy L. Ruddy-Humphries, Myla D. Ebeling, Mathew J. Gregoski, Lakshmi D. Katikaneni
Summary: This study examined the growth and body composition of SGA and AGA VLBW infants, as well as their outpatient neurodevelopmental outcomes. The results showed significant differences in percentage of body fat, percentage of lean mass, and weight gain between SGA and AGA groups at the first ADP assessment. However, there was no difference in outpatient neurodevelopmental testing between the two groups. The study found that weight gain as catch-up body fat accrual is associated with normal neurodevelopment in SGA preterm infants compared to AGA preterm infants.
Article
Multidisciplinary Sciences
Maria Matre, Cathrin Vano Mehl, Silje Dahl Benum, Laura Jussinniemi, Eero Kajantie, Kari Anne I. Evensen
Summary: There is a lack of research on the body composition and physical fitness of individuals born small for gestational age (SGA) at term entering mid-adulthood. This study aimed to investigate these outcomes in adults born SGA at term. The results showed that body composition and physical fitness were similar in adults born SGA and non-SGA at term, with the exception of reduced grip strength in men born SGA, which may require further investigation.
SCIENTIFIC REPORTS
(2023)
Article
Acoustics
R. L. Deter, W. Lee, P. Dicker, E. C. Tully, F. Cody, F. D. Malone, K. M. Flood
Summary: This study found that there are seven growth restriction patterns in small fetuses with delayed growth in the third trimester. 37% of fetuses without evidence of growth restriction had vascular abnormalities. The distribution and types of normal growth and growth restriction patterns in the AGA cohort were different compared to the SGA cohort.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Ophthalmology
Achim Fiess, Anna Schultheis, Eva Mildenberger, Michael S. Urschitz, Bernhard Stoffelns, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study aimed to determine the effects of being small (SGA) or large for gestational age (LGA) on the ocular geometry of adults born at term. The results showed that severe and moderate prenatal growth restriction led to an altered ocular geometry, including a steepening of the cornea and a smaller corneal diameter.
ACTA OPHTHALMOLOGICA
(2023)
Article
Endocrinology & Metabolism
Anna Prats-Puig, Silvia Xargay-Torrent, Gemma Carreras-Badosa, Berta Mas-Pares, Judit Bassols, Clive J. Petry, Michael Girardot, Francis D. E. Zegher, Lourdes Ibanez, David B. Dunger, Robert Feil, Abel Lopez-Bermejo
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Genetics & Heredity
Antonio F. Martinez-Monseny, Didac Casas-Alba, Cesar Arjona, Merce Bolasell, Paula Casano, Jordi Muchart, Federico Ramos, Loreto Martorell, Francesc Palau, Alfredo Garcia-Alix, Mercedes Serrano
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2020)
Article
Endocrinology & Metabolism
Gerhard Binder, Thomas Reinehr, Lourdes Ibanez, Susanne Thiele, Agnes Linglart, Joachim Woelfle, Paul Saenger, Markus Bettendorf, Agnieszka Zachurzok, Bettina Gohlke, Tabitha Randell, Berthold P. Hauffa, Hedi L. Claahsen van der Grinten, Paul-Martin Holterhus, Anders Juul, Roland Pfaeffle, Stefano Cinafarani
HORMONE RESEARCH IN PAEDIATRICS
(2020)
Article
Endocrinology & Metabolism
Marta Diaz, Judit Bassols, Abel Lopez-Bermejo, Francis de Zegher, Lourdes Ibanez
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Pediatrics
Marta Diaz, Laura Campderros, Mariana P. Guimaraes, Abel Lopez-Bermejo, Francis de Zegher, Francesc Villarroya, Lourdes Ibanez
PEDIATRIC RESEARCH
(2020)
Article
Pediatrics
Lourdes Ibanez, Francis de Zegher
Article
Endocrinology & Metabolism
Lucia Sentchordi-Montane, Sara Benito-Sanz, Miriam Aza-Carmona, Arrate Pereda, Manuel Parron-Pajares, Carolina de la Torre, Gabriela A. Vasques, Mariana F. A. Funari, Andre M. Travessa, Patricia Dias, Larisa Suarez-Ortega, Jesus Gonzalez-Buitrago, Nancy Elizabeth Portillo-Najera, Isabel Llano-Rivas, Maria Martin-Frias, Joaquin Ramirez-Fernandez, Jaime Sanchez del Pozo, Lucia Garzon-Lorenzo, Gabriel A. Martos-Moreno, Cristina Alfaro-Iznaola, Ines Mulero-Collantes, Pablo Ruiz-Ocana, Paula Casano-Sancho, Ana Portela, Lorea Ruiz-Perez, Angela del Pozo, Elena Vallespin, Mario Solis, Antonio M. Lerario, Isabel Gonzalez-Casado, Purificacion Ros-Perez, Guiomar Perez de Nanclares, Alexander A. L. Jorge, Karen E. Heath
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Article
Endocrinology & Metabolism
Joan Gil, Montserrat Marques-Pamies, Mireia Jorda, Carmen Fajardo-Montanana, Araceli Garcia-Martinez, Miguel Sampedro, Guillermo Serra, Isabel Salinas, Alberto Blanco, Elena Valassi, Gemma Sesmilo, Cristina Carrato, Rosa Camara, Cristina Lamas, Paula Casano-Sancho, Clara V. Alvarez, Ignacio Bernabeu, Susan M. Webb, Antonio Pico, Monica Marazuela, Manel Puig-Domingo
Summary: Only two out of 21 molecular markers studied could predict enhanced SRLs response after surgical debulking in large GH-producing tumors. Tumors with improved response to SRLs post-surgery showed lower Ki-67 levels (MKI67, FC = 0.17 and P = .008) and higher levels of RAR-related orphan receptor C (RORC) (FC = 3.1 and P < .001).
CLINICAL ENDOCRINOLOGY
(2021)
Article
Pediatrics
Cristina Garcia-Beltran, Rita Malpique, Belen Carbonetto, Pedro Gonzalez-Torres, Desiree Henares, Pedro Brotons, Carmen Munoz-Almagro, Abel Lopez-Bermejo, Francis de Zegher, Lourdes Ibanez
Summary: The gut microbiota composition in girls with PCOS differs significantly from healthy controls, with SPIOMET treatment showing the potential to normalize some of these anomalies.
Article
Multidisciplinary Sciences
Francis de Zegher, Marta Diaz, Joan Villarroya, Montserrat Cairo, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
Summary: The study found that young patients with early PCOS may have a relative deficit of GDF15, explaining their difficulties in controlling body adiposity. SPIOMET treatment can increase GDF15 concentrations and reduce inflammation levels.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Cristina Garcia-Beltran, Ruben Cereijo, Cristina Plou, Aleix Gavalda-Navarro, Rita Malpique, Joan Villarroya, Abel Lopez-Bermejo, Francis de Zegher, Lourdes Ibanez, Francesc Villarroya
Summary: This study reveals the relationship between brown adipose tissue (BAT) activity and adiposity measures and metabolic health in early infancy. The study found gender-specific differences in BAT activity and CXCL14 levels, which were negatively associated with adiposity measures in girls.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Correction
Multidisciplinary Sciences
Francis de Zegher, Marta Diaz, Joan Villarroya, Montserrat Cairo, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Marta Diaz, Gemma Carreras-Badosa, Joan Villarroya, Aleix Gavalda-Navarro, Judit Bassols, Francis de Zegher, Abel Lopez-Bermejo, Francesc Villarroya, Lourdes Ibanez
Summary: Circulating GDF15 concentrations significantly increase in LBW/catch-up girls after long-term metformin treatment, and are negatively associated with insulin, androgens, body fat, and visceral fat. Prepubertal intervention with metformin reduces central adiposity and insulin resistance.
PEDIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
F. de Zegher, M. Diaz, L. Ibanez
Summary: This study found that the HOTAIR rs1443512 genotype not only influences the distribution of fat mass in adolescent girls with PCOS-without-obesity, but also the redistribution of fat mass during prolonged treatment with low-dose pioglitazone.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Silvia Xargay-Torrent, Estefania Dorado-Ceballos, Anna Benavides-Boixader, Esther Lizarraga-Mollinedo, Berta Mas-Pares, Merce Montesinos-Costa, Francis De Zegher, Lourdes Ibanez, Judit Bassols, Abel Lopez-Bermejo
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)