Review
Pediatrics
Irene Netchine, Manouk van der Steen, Abel Lopez-Bermejo, Ekaterina Koledova, Mohamad Maghnie
Summary: Children born small for gestational age (SGA) face a range of growth and metabolic issues, with some potentially needing growth hormone treatment to promote linear growth and address metabolic abnormalities.
FRONTIERS IN PEDIATRICS
(2021)
Article
Pediatrics
Lan Ling, Ting Chen, Xin-Hua Zhang, Min-Hong Pan, Hai-Hong Gong, Li-Na Zhang, Meng Zhao, Xiao-Qing Chen, Shu-Dong Cui, Chao Lu
Summary: This study aimed to identify the risk factors associated with short stature in children born small for gestational age (SGA) at full-term. The findings suggest that a decrease in placental perfusion, chromosomal abnormalities, short parental height, and absence of catch-up growth are risk factors for short stature in these children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Justyna Zamojska, Katarzyna Niewiadomska-Jarosik, Beata Kierzkowska, Marta Gruca, Agnieszka Wosiak, Elzbieta Smolewska
Summary: This study aimed to evaluate the lipid profile in early childhood in SGA children and found that even without overweight or obesity in early childhood, SGA children had abnormal lipid profiles, which may contribute to the development of cardiovascular diseases in adulthood.
Review
Pediatrics
Wayne Cutfield, Ahila Ayyavoo
Summary: 'Small for Gestational Age' (SGA) refers to children born with low birth weight and/or short birth length, most of whom experience catch-up growth within 6 months of age. Treatment with recombinant human growth hormone (rhGH) can help SGA children achieve normal adult height, although they may still face long-term consequences such as insulin resistance, abdominal fat accumulation, and metabolic disorders.
INDIAN JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Alice Maguolo, Francesca Olivieri, Chiara Zusi, Emanuele Miraglia Del Giudice, Anita Morandi, Claudio Maffeis
Summary: The birth weight of overweight and obese children and adolescents is associated with cardiometabolic derangements, with those born SGA at higher risk of prediabetes and high cholesterol.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Obstetrics & Gynecology
Gabriela Luiza Nogueira Vitral, Roberta Maia de Castro Romanelli, Tiago Alves Leonel, Juliano de Souza Gaspar, Regina Amelia Lopes Pessoa de Aguiar, Zilma Silveira Nogueira Reis
Summary: This systematic review compares the influence of last menstrual period (LMP) and ultrasound (USG) on prematurity and small-for-gestational-age (SGA) proportions. The study found that LMP-based gestational age estimation has little effect on prematurity proportions compared to USG, but there is limited data on the influence on SGA proportions.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Nutrition & Dietetics
Alejandro Avila-Alvarez, Helena Perez Tato, Andrea Sucasas Alonso, Ana Prado Carro, Jesus Fuentes Carballal
Summary: In preterm newborns, secondary hyperparathyroidism is a frequently occurring but often unrecognized condition. Detecting this condition may be important in guiding nutritional treatment. This study found that cesarean section, oxygen use during resuscitation, invasive mechanical ventilation, and anemia requiring transfusion were independent risk factors for secondary hyperparathyroidism in preterm infants. Additionally, serum calcium, serum phosphate, vitamin D, and the calcium/creatinine ratio in urine were associated with secondary hyperparathyroidism. Furthermore, a predictive model using gestational age and calcium/creatinine ratio in urine demonstrated good accuracy.
Review
Biology
Zhongjie Fu, Anders K. Nilsson, Ann Hellstrom, Lois E. H. Smith
Summary: Retinopathy of prematurity (ROP) is caused by the suppression of physiological retinal vascular development, leading to compensatory but pathological neovascularization. Promoting normal vessel growth can prevent ROP. Early perinatal metabolic dysregulation is a risk factor for ROP and other long-term sequelae. Controlling postnatal hyperglycemia, dyslipidemia, and hyperoxia can promote normal retinal development.
Article
Pediatrics
Fang Fang, Yan Chen, Qian Chen, Jiong Li, Zhong-Cheng Luo, Fei Li, Yongjun Zhang, Fan Jiang, Jun Zhang
Summary: This study aimed to explore the health outcomes of term small-for-gestational-age (SGA) children with different etiologies. The results showed that SGA children due to fetal factors had the highest risk of low IQ, while SGA infants due to physiological factors had the highest risk of growth restriction. Term SGA babies should be managed differently based on their etiology and the number of risk factors.
PEDIATRIC RESEARCH
(2023)
Article
Endocrinology & Metabolism
Eran Lavi, Asher Shafrir, Rana Halloun, Itai Basel, Smadar Eventov Friedman, Abdulsalam Abu-Libdeh, Hanna Shoob, Chen Stein-Zamir, David Haim Zangen
Summary: The study found that the actual incidence of SGA newborns and ACUG was lower than expected, with the actual prevalence of ACUG significantly higher than previously reported. Term children had a higher rate of ACUG achievement compared to preterm children.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Maleesa M. Pathirana, Prabha H. Andraweera, Emily Aldridge, Shalem Y. Leemaqz, Madeline Harrison, Jade Harrison, Petra E. Verburg, Margaret A. Arstall, Gustaaf A. Dekker, Claire T. Roberts
Summary: Gestational diabetes mellitus may lead to abnormal cardio-metabolic risk factors in women and their children three years after childbirth, but early pregnancy BMI and socioeconomic index may act as mediators.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Emmie N. Upners, Lars Lau Raket, Jorgen H. Petersen, Ajay Thankamony, Edna Roche, Guftar Shaikh, Jeremy Kirk, Hilary Hoey, Sten-A Ivarsson, Olle Soder, Anders Juul, Rikke Beck Jensen
Summary: GH treatment improves adult height in short SGA children, with decreased peak height velocity, and earlier pubertal onset in SGA boys.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Merida Rodriguez-Lopez, Alvaro Sepulveda-Martinez, Gabriel Bernardino, Francesca Crovetto, Carolina Pajuelo, Marta Sitges, Bart Bijnens, Eduard Gratacos, Fatima Crispi
Summary: This study assessed the differences in cardiometabolic health between adults born small for gestational age. The results showed that females born small for gestational age are more prone to cardiac dysfunction, while males are more likely to experience changes in electrocardiography, vascular health, and metabolism.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Ioanna Kakatsaki, Styliani Papanikolaou, Theano Roumeliotaki, Nicolina Hilda Anagnostatou, Ioanna Lygerou, Eleftheria Hatzidaki
Summary: Monitoring the growth of neonates in the NICU using growth charts is crucial for preterm infant care. This study compared the prevalence of SGA at birth and EUGR at discharge in extremely and very preterm neonates using different growth curves and examined the associated factors. The study found that the prevalence of SGA and EUGR neonates differs between the two growth references, indicating a need for further evaluation of these charts to determine the most appropriate way to monitor infant growth.
Article
Pharmacology & Pharmacy
Jessica Gorgui, Odile Sheehy, Jacquetta Trasler, Anick Berard
Summary: This study aimed to evaluate the association between medically assisted reproduction (MAR) and the risk of small for gestational age (SGA) and very small for gestational age (VSGA). The results showed that MAR was associated with an increased risk of SGA among preterm pregnancies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
J. S. Renes, R. H. Willemsen, J. C. Mulder, W. M. Bakker-van Waarde, J. Rotteveel, W. Oostdijk, E. C. A. M. Houdijk, C. Westerlaken, C. Noordam, A. A. Verrijn Stuart, R. J. Odink, M. A. J. de Ridder, A. C. S. Hokken-Koelega
CLINICAL ENDOCRINOLOGY
(2015)
Article
Endocrinology & Metabolism
R. H. Willemsen, L. van Leeuwen, T. A. S. Voorend-van Bergen, Y. B. de Rijke, M. W. Pijnenburg, E. L. T. van den Akker
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2016)
Article
Endocrinology & Metabolism
G. F. Kerkhof, R. W. J. Leunissen, R. H. Willemsen, F. H. de Jong, J. A. Visser, J. S. E. Laven, A. C. S. Hokken-Koelega
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2010)
Article
Endocrinology & Metabolism
L. Manenschijn, E. L. T. van den Akker, W. A. Ester, R. W. J. Leunissen, R. H. Willemsen, E. F. C. van Rossum, J. W. Koper, S. W. J. Lamberts, A. C. S. Hokken-Koelega
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2010)
Article
Endocrinology & Metabolism
Petra E. Breukhoven, Ralph W. J. Leunissen, Sandra W. K. de Kort, Ruben H. Willemsen, Anita C. S. Hokken-Koelega
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2011)
Article
Cell Biology
D. C. M. van der Kaay, A. E. J. Hendriks, W. A. Ester, R. W. J. Leunissen, R. H. Willemsen, S. W. K. de Kort, J. R. Paquette, A. C. S. Hokken-Koelega, C. L. Deal
GROWTH HORMONE & IGF RESEARCH
(2009)
Article
Endocrinology & Metabolism
Gerthe F. Kerkhof, Ralph W. J. Leunissen, Ruben H. Willemsen, Frank H. de Jong, Theo Stijnen, Anita C. S. Hokken-Koelega
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2009)
Article
Endocrinology & Metabolism
Danielle van der Kaay, Cheri Deal, Sandra de Kort, Ruben Willemsen, Ralph Leunissen, Wietske Ester, Jean Paquette, Jaap van Doorn, Anita Hokken-Koelega
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2009)
Article
Endocrinology & Metabolism
Ruben H. Willemsen, Ralph W. J. Leunissen, Theo Stijnen, Anita C. S. Hokken-Koelega
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2009)
Article
Endocrinology & Metabolism
Gerthe F. Kerkhof, Ruben H. Willemsen, Ralph W. J. Leunissen, Petra E. Breukhoven, Anita C. S. Hokken-Koelega
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2012)
Article
Endocrinology & Metabolism
P. E. Breukhoven, G. F. Kerkhof, R. H. Willemsen, A. C. S. Hokken-Koelega
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2012)
Article
Endocrinology & Metabolism
Judith S. Renes, Ruben H. Willemsen, Anja Wagner, Martijn J. J. Finken, Anita C. S. Hokken-Koelega
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2013)
Article
Pediatrics
Gerthe F. Kerkhof, Petra E. Breukhoven, Ralph W. J. Leunissen, Ruben H. Willemsen, Anita C. S. Hokken-Koelega
JOURNAL OF PEDIATRICS
(2012)
Review
Endocrinology & Metabolism
Ruben H. Willemsen, Daniela Elleri, Rachel M. Williams, Ken K. Ong, David B. Dunger
NATURE REVIEWS ENDOCRINOLOGY
(2014)
Article
Pediatrics
Gemma White, Shakira Cosier, Afiya Andrews, Lee Martin, Ruben Willemsen, Martin O. Savage, Helen L. Storr
Summary: This observational study evaluated the sensitivity and specificity of UK and Dutch referral criteria for predicting pathological short stature. The UK criteria showed limited sensitivity and specificity, while the Dutch criteria had higher sensitivity. Considering the child's genetic height potential before referral can prevent unnecessary assessments.
BMJ PAEDIATRICS OPEN
(2022)