Article
Endocrinology & Metabolism
Jiun-Lin Yan, Mao-Yu Chen, Yao-Liang Chen, Chi-Cheng Chuang, Peng-Wei Hsu, Kuo-Chen Wei, Chen-Nen Chang
Summary: This study evaluated the outcomes of the endoscopic transsphenoidal approach as the primary treatment for somatotroph adenomas and investigated patients with suboptimal surgical results. Factors such as tumor size, preoperative GH level, and residual tumors were found to be associated with surgical failure. Octreotide showed good outcomes for treating DGSA patients, while SRS/EXRT generated good results for patients receiving secondary treatments when remission could not be reached after 6 months of TSA operation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Meliha Melin Uygur, Stefano Frara, Luigi di Filippo, Andrea Giustina
Summary: Pituitary hormones play a role in regulating bone health, and high levels can lead to bone remodeling and changes in bone microstructure. Vertebral fractures are an early sign of impaired bone health in pituitary adenoma patients, but they cannot be accurately predicted by bone mineral density. A morphometric approach is considered the gold standard in evaluating bone health, and new tools have been proposed for predicting fractures in pituitary-driven osteopathies. This review focuses on potential biomarkers and diagnostic methods for bone fragility in acromegaly, prolactinomas, and Cushing's disease, including their pathophysiological, clinical, radiological, and therapeutic implications.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Olesja Rogoza, Kaspars Megnis, Marija Kudrjavceva, Aija Gerina-Berzina, Vita Rovite
Summary: Somatostatin receptors play a crucial role in the treatment of neuroendocrine tumors, delaying tumor progression and regulating hormone overproduction. The expression level of SSTRs has predictive value in therapeutic response and patient survival rate. Future research will focus on other epigenetic regulators affecting somatostatin signaling and combination therapy strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Jie Liu, Yamei Yang, Lian Duan, Xiaofeng Chai, Huijuan Zhu, Kan Deng, Xiaolan Lian, Yong Yao
Summary: This study found that the octreotide suppression test can be used as an efficient tool to predict the decline of thyroid-stimulating hormone in patients with thyrotrophin-secreting pituitary adenomas. The 24-hour and 72-hour timepoints were particularly effective in guiding the use of somatostatin analogs.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Caiyan Mo, Han Chen, Ying Guo, Zheng Li, Yao Wang, Liyong Zhong
Summary: The effect and potential mechanism of high growth hormone (GH)/insulin-like growth factor (IGF)-1 on thyroid function were explored by analyzing the changes in thyroid function in patients with growth hormone-secreting pituitary adenoma (GHPA).
ENDOCRINE PRACTICE
(2023)
Article
Endocrinology & Metabolism
Lijun Heng, Xiaoyan Liu, Dong Jia, Wei Guo, Shuo Zhang, Guodong Gao, Li Gong, Yan Qu
Summary: This study aimed to establish a preoperative prediction method for distinguishing sparsely granulated (SG) growth hormone (GH)-secreting pituitary adenoma in acromegaly patients. The study found that SG tumors tend to occur in younger patients with larger diameters and volumes, higher Knosp grades, lower GH indexes, and lower incremental GH% after octreotide treatment.Combining tumor size, Knosp grade, GH index, and GH% increment after octreotide treatment, a grading scale with an AUC of 0.84 was established for predicting SG GH-secreting pituitary adenomas.
CLINICAL ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giacomo Voltan, Pierluigi Mazzeo, Daniela Regazzo, Carla Scaroni, Filippo Ceccato
Summary: Acromegaly is a rare disease with systemic complications and incomplete hormonal control in some cases. Estrogens were previously used to treat acromegaly, but abandoned due to side effects. Recent studies have re-evaluated the role of estrogens and SERMs in acromegaly treatment, focusing on the GH/IGF1 axis and potential implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Federico Gatto, Richard A. Feelders, Peter M. van Koetsveld, Fadime Dogan, Sebastian J. C. M. M. Neggers, Aart-Jan van der Lelij, Jessica Amaru, Diego Ferone, Leo J. Hofland
Summary: Cabergoline (CAB) is an off-label medical therapy for acromegaly, but it is overshadowed by first-generation somatostatin receptor ligands like octreotide (OCT). In this study, OCT was found to be slightly more effective than CAB in inhibiting growth hormone (GH) secretion in vitro. Additionally, the response to CAB treatment was shown to be better in GH/prolactin (PRL) co-secreting tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Artak Labadzhyan, L. B. Nachtigall, M. Fleseriu, M. B. Gordon, M. Molitch, L. Kennedy, S. L. Samson, Y. Greenman, N. Biermasz, M. Bolanowski, A. Haviv, W. Ludlam, G. Patou, C. J. Strasburger
Summary: Results from trials investigating oral octreotide capsules as an alternative treatment for acromegaly showed consistent biochemical response, durability of response, and patient preference for oral treatment, despite differences in trial design.
Review
Biochemistry & Molecular Biology
Sofie Eline Tollefsen, Ole Solheim, Patricia Mjones, Sverre Helge Torp
Summary: Meningioma is a common brain tumor without approved specific drugs. This study aims to compile the current insights of somatostatin analogs for treating patients with meningioma. A systematic search was conducted, and 17 eligible studies were evaluated. Although the efficacy of somatostatin analogs remains unclear, some studies suggest that they may be a last-option treatment for severely ill-patients. However, a controlled study or randomized clinical trial is needed to establish their efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yin Zhang, Lei Zhang, Kexia Fan, Yajun Gou, Zhenle Zang, Xiao Ding, Hui Yang, Song Li
Summary: The invasiveness and high proliferation rate of growth hormone-secreting pituitary adenomas (GHPAs) are associated with abnormal mitochondrial dynamics. In this study, it was found that invasive GHPA samples had decreased numbers, volumes, and membrane areas of mitochondria compared to noninvasive samples. Downregulation of Drp1 protein may contribute to this abnormal mitochondrial dynamics, leading to enhanced invasion and proliferation of tumor cells. Mitochondrial hypofission might activate the STAT3 pathway to regulate tumor cell functions.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Andrea Giustina, Luigi di Filippo, Melin M. Uygur, Stefano Frara
Summary: A personalized approach to acromegaly treatment, utilizing novel clinical and molecular biomarkers, has shown promising results in predicting responsiveness to second-line medical treatments. Integrating these findings into existing guidelines may significantly improve the management of difficult acromegaly patients.
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonio Bianchi, Antonella Giampietro, Alfredo Pontecorvi, Gerald Raverot, Laura De Marinis
Summary: This review provides an overview of the second-line therapies for acromegaly, summarizing the evidence on clinical, molecular, and morphological aspects that can predict the response to these treatments and advocating for a patient-tailored therapeutic approach in clinical practice.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Francesca Pecori Giraldi, Maria Francesca Cassarino, Antonella Sesta, Giovanni Lasio, Marco Losa
Summary: The study investigates the effect of silibinin on human corticotroph adenomas. It is found that silibinin can inhibit ACTH synthesis and secretion in individual adenomas and directly affects NR3C1 gene expression. These results reveal promising effects of silibinin as an innovative target treatment for patients with Cushing's disease.
NEUROENDOCRINOLOGY
(2023)
Article
Ophthalmology
Bastian Grundel, Marc-Antoine Bernardeau, Holger Langner, Christoph Schmidt, Daniel Boehringer, Marc Ritter, Paul Rosenthal, Andrea Grandjean, Stefan Schulz, Philipp Daumke, Andreas Stahl
Summary: This study utilized text mining to extract information from clinical texts and found that the extraction performance was good for certain data such as visual acuity, intraocular pressure, and accompanying diagnoses, showing potential for future applications. However, manual adjustments are still necessary to improve accuracy.
Article
Endocrinology & Metabolism
Nicholas A. Tritos, Pouneh K. Fazeli, Ann McCormack, Susana M. Mallea-Gil, Maria M. Pineyro, Mirjam Christ-Crain, Stefano Frara, Artak Labadzhyan, Adriana G. Ioachimescu, Ilan Shimon, Yutaka Takahashi, Mark Gurnell, Maria Fleseriu
Summary: Using the Delphi process, consensus was achieved on most items related to perioperative endocrine evaluation and management in adults undergoing TSS. This international expert perspective provides a framework for future guideline development. Areas where consensus was not reached, such as immediate postoperative remission in acromegaly or Cushing's disease, highlight the need for further research.
Article
Biochemistry & Molecular Biology
Martin Kuiper, Joseph Bonello, Jesualdo T. Fernandez-Breis, Philipp Bucher, Matthias E. Futschik, Pascale Gaudet, Ivan V. Kulakovskiy, Luana Licata, Colin Logie, Ruth C. Lovering, Vsevolod J. Makeev, Sandra Orchard, Simona Panni, Livia Perfetto, David Sant, Stefan Schulz, Steven Vercruysse, Daniel R. Zerbino, Astrid Laegreid
Summary: Following nine workshops organized by GREEKC, experts from around the world worked to improve the Gene Regulation Knowledge Commons (GRKC) by standardizing and updating workflows, as well as involving end-users in the design process, leading to significant achievements in enhancing the GRKC.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Article
Endocrinology & Metabolism
Maria Fleseriu, Ariel Barkan, Maria del Pilar Schneider, Yannis Darhi, Amicie de Pierrefeu, Antonio Ribeiro-Oliveira, Stephan Petersenn, Sebastian Neggers, Shlomo Melmed
Summary: Patients with acromegaly have a higher prevalence of comorbidities and are prescribed more concomitant medications compared to patients without acromegaly. Physicians should consider the number and type of ongoing medications for individual patients before prescribing additional acromegaly treatments.
Review
Endocrinology & Metabolism
Maria Fleseriu, Richard Auchus, Irina Bancos, Anat Ben-Shlomo, Jerome Bertherat, Nienke R. Biermasz, Cesar L. Boguszewski, Marcello D. Bronstein, Michael Buchfelder, John D. Carmichael, Felipe F. Casanueva, Frederic Castinetti, Philippe Chanson, James Findling, Monica Gadelha, Eliza B. Geer, Andrea Giustina, Ashley Grossman, Mark Gurnell, Ken Ho, Adriana G. Ioachimescu, Ursula B. Kaiser, Niki Karavitaki, Laurence Katznelson, Daniel F. Kelly, Andre Lacroix, Ann McCormack, Shlomo Melmed, Mark Molitch, Pietro Mortini, John Newell-Price, Lynnette Nieman, Alberto M. Pereira, Stephan Petersenn, Rosario Pivonello, Hershel Raff, Martin Reincke, Roberto Salvatori, Carla Scaroni, Ilan Shimon, Constantine A. Stratakis, Brooke Swearingen, Antoine Tabarin, Yutaka Takahashi, Marily Theodoropoulou, Stylianos Tsagarakis, Elena Valassi, Elena V. Varlamov, Greisa Vila, John Wass, Susan M. Webb, Maria C. Zatelli, Beverly M. K. Biller
Summary: Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management. The Pituitary Society convened a consensus workshop to discuss recent evidence and clinical practice. Recommendations regarding lab tests, imaging, and treatment options were collated and discussed, with focus on future research topics.
LANCET DIABETES & ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Bubb, Anna-Sophia Lieselott Beyer, Pooja Dasgupta, Daniel Kaemmerer, Joerg Saenger, Katja Evert, Ralph M. Wirtz, Stefan Schulz, Amelie Lupp
Summary: GPER is widely expressed in human non-neoplastic and neoplastic tissues and a novel antibody has been developed to detect GPER-expressing tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Francesco Fallo, Guido Di Dalmazi, Felix Beuschlein, Nienke R. Biermasz, Frederic Castinetti, Atanaska Elenkova, Martin Fassnacht, Andrea M. Isidori, Darko Kastelan, Marta Korbonits, John Newell-Price, Gianfranco Parati, Stephan Petersenn, Rosario Pivonello, Oskar Ragnarsson, Antoine Tabarin, Marily Theodoropoulou, Stylianos Tsagarakis, Elena Valassi, Przemyslaw Witek, Martin Reincke
Summary: Cushing's syndrome, characterized by excessive cortisol levels, leads to systemic manifestations and increased cardiovascular risk, particularly hypertension. Early diagnosis and tailored management are crucial in mitigating the negative effects of Cushing's syndrome, including addressing the underlying cause and using individualized antihypertensive drugs. A consensus document prepared by experts in endocrine hypertension provides a summary of the latest knowledge on the epidemiology, genetics, diagnosis, and treatment of hypertension in Cushing's syndrome.
JOURNAL OF HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Stephan Petersenn
Summary: Diagnosis of Cushing's syndrome is often delayed due to its rarity and variable clinical features. Simple and accurate screening tests, such as overnight dexamethasone suppression test and urinary free cortisol test, are necessary to enhance screening for hypercortisolism.
Article
Endocrinology & Metabolism
Pia Burman, Jacqueline Trouillas, Marco Losa, Ann McCormack, Stephan Petersenn, Vera Popovic, Marily Theodoropoulou, Gerald Raverot, Olaf M. Dekkers
Summary: This study describes the characteristics and treatment outcomes of aggressive pituitary tumors (APT) and pituitary carcinomas (PC). Temozolomide is the first-line chemotherapy, but other therapies are also emerging. Predicting treatment response remains challenging with current biomarkers.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Stephan Petersenn
Summary: Hyperprolactinemia should be actively investigated as a potential cause of infertility. Dopamine agonists can successfully treat underlying prolactinomas. However, patients with micro- or well-circumscribed macroprolactinomas (Knosp 0 or 1) should also be informed about the possibility of cure through transsphenoidal surgery instead of long-term medical therapy. Management during pregnancy is usually uncomplicated but may present some specific challenges.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2023)
Editorial Material
Endocrinology & Metabolism
Jacqueline Trouillas, Pia Burman, Marco Losa, Ann McCormack, Stephan Petersenn, Vera Popovic, Marily Theodoropoulou, Olaf M. Dekkers, Gerald Raverot
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Benjamin Wende, Anna-Sophia Liselott Beyer, Niklas Ruhnke, Daniel Kaemmerer, Joerg Saenger, Stefan Schulz, Amelie Lupp
Summary: A rabbit monoclonal antibody, 8H9L8, was developed for studying the protein expression of CALCRL. The antibody was confirmed to be specific and used for immunohistochemical analyses of normal and neoplastic tissues. CALCRL was found to be expressed in various tissues and showed strong expression in certain tumors, potentially serving as a useful target for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Markus Kreuzthaler, Mathias Brochhausen, Cilia Zayas, Bernd Blobel, Stefan Schulz
Summary: This paper provides an overview of the linguistic and ontological challenges in transforming health ecosystems for precision medicine. It discusses the need for standardization and interoperability in clinical and research data representation, as well as smart support for content comprehension by humans and machines. The paper explores the current use of natural language processing in extracting information from healthcare texts and highlights the importance of biomedical ontologies in integrating heterogeneous data sources. It also addresses misconceptions and shortcomings in the field and suggests future steps for data interoperability.
FRONTIERS IN MEDICINE
(2023)
Article
Biology
Sebastian Fritzwanker, Falko Nagel, Andrea Kliewer, Viviane Stammer, Stefan Schulz
Summary: Phosphorylation of receptors is unstable during routine immunohistochemical procedures, requiring the use of phosphatase inhibitors for specific GPCR antibodies. We showed that phosphorylation of receptors is highly unstable during routine immunohistochemical procedures, and the use of phosphatase inhibitors is necessary for specific GPCR antibodies. Our findings were confirmed using phosphorylation state-specific MOP and CB1 antibodies.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Behavioral Sciences
Masao Miyazaki, Jana Caspers, Tamako Miyazaki, Reiko Uenoyama, Shota Ichizawa, Stefan Schulz