Article
Environmental Sciences
Weeberb J. Requia, Ana Maria Vicedo-Cabrera, Evan de Schrijver, Heresh Amini, Antonio Gasparrini
Summary: Further research on the impact of temperature on health in Brazil is needed. This study examines the relationship between high ambient temperature and hospital admissions for circulatory and respiratory diseases in Brazilian municipalities. The findings indicate that respiratory diseases are more strongly associated with high temperature.
ENVIRONMENTAL POLLUTION
(2023)
Article
Urology & Nephrology
Cynthia C. Lim, Dorothy Huang, Zhihua Huang, Li Choo Ng, Ngiap Chuan Tan, Wei Yi Tay, Yong Mong Bee, Andrew Ang, Chieh Suai Tan
Summary: This study evaluated the incidence and risk factors associated with early repeat hospitalization for fluid overload among patients with cardiovascular disease and risks. The results showed that cardiovascular disease, recent hospitalization for fluid overload, recent hospitalization for any cause, and intravenous furosemide use were associated with an increased risk of early repeat hospitalization. Conversely, higher systolic blood pressure on admission and diuretic use at discharge reduced the risk of early hospitalization for fluid overload.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Genetics & Heredity
Diego Lopergolo, Silvia Bianchi, Gian Nicola Gallus, Sara Locci, Barbara Pucci, Valerio Leoni, Daniele Gasparini, Elisa Tardelli, Andrea Chincarini, Stelvio Sestini, Filippo Maria Santorelli, Henrik Zetterberg, Nicola De Stefano, Andrea Mignarri
Summary: NPC1 mutations are associated with Niemann-Pick disease type C, and this study identifies a novel NPC1 mutation in a family with late-onset Alzheimer's disease.
JOURNAL OF MEDICAL GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Foersti, Akseli Hemminki, Xinjun Li
Summary: This study analyzed data from the Swedish Family-Cancer Database to determine the frequency and increased risk for familial cancer, finding that almost all cancers showed a familial risk, with most risks being around two-fold due to family history. High-risk family history should be carefully considered for management, including targeted genetic testing, while medical and behavioral interventions are recommended for familial clustering with no feasible genetic testing.
Review
Endocrinology & Metabolism
Jenny E. Blau, William F. Simonds
Summary: The regulation of serum calcium levels in humans involves the endocrine action of the parathyroid glands, vitamin D, and various target cells and tissues. Primary hyperparathyroidism is a disorder of mineral metabolism typically associated with elevated serum calcium and can be caused by uncontrolled release of parathyroid hormone from abnormal glands, sometimes linked to genetic mutations. Further research into familial HPT lacking known predisposition genes holds promise for the discovery of novel genes related to parathyroid tumor development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Fenghua Li, Xianqi Zhao, Yanni Jiao, Xinglan Duan, Lianlong Yu, Fengjia Zheng, Xiaolin Wang, Lin Wang, Jia-Sheng Wang, Xiulan Zhao, Tianliang Zhang, Wei Li, Jun Zhou
Summary: This study analyzed the exposure level and health risks of aflatoxins (AFs) and zearalenone (ZEA) through cooking oil consumption in Shandong, China. The findings showed that children are facing the highest health risk, and liver cancer incidence is associated with exposure to aflatoxins.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Jin Feng, Dawei Cao, Dashan Zheng, Zhengmin (Min) Qian, Cunrui Huang, Huiqing Shen, Yi Liu, Qiyong Liu, Jimin Sun, Guangyuan Jiao, Xiaoran Yang, Stephen Edward McMillin, Chongjian Wang, Hualiang Lin, Xinri Zhang, Shiyu Zhang
Summary: This study found significant associations between cold spells and hospital admissions, length of hospital stay, and hospitalization expenses for respiratory diseases. Compared with the non-cold spell period, the overall cumulative risk of hospitalization for total respiratory diseases on cold spell days was 1.232 (95% CI: 1.090, 1.394), with increased length of hospital stay and hospitalization expenses of 112.793 (95% CI: 10.755, 214.830) days and 127.568 (95% CI: 40.513, 214.624) thousand Chinese yuan, respectively. The cumulative risks of cold spells on total respiratory diseases and pneumonia were statistically significant. Harvesting effects were also observed in the associations between cold spells and hospital admission, length of hospital stay, and hospitalization expenses for respiratory diseases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Weeberb J. Requia, Ana Maria Vicedo-Cabrera, Evan de Schrijver, Heresh Amini
Summary: This study examines the association between low ambient temperature and daily hospital admissions for cardiovascular and respiratory diseases in Brazil. The findings suggest that low temperatures are associated with an increased risk of hospital admissions for these diseases. This study is important for informing policymakers in implementing measures to protect public health from the effects of cold temperature.
ENVIRONMENTAL RESEARCH
(2023)
Article
Sport Sciences
Hamish Reid, Ashley Jane Ridout, Simone Annabella Tomaz, Paul Kelly, Natasha Jones
Summary: The benefits of physical activity for people living with long-term conditions (LTCs) are well established, while the risks are lower but perceived to be higher. Clear, consistent messaging on risk, individualized conversations, and gradual progression in activity levels are crucial in promoting physical activity in this population. Healthcare professionals should focus on addressing perceived risks and encouraging meaningful behavioral change in day-to-day practice.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Review
Microbiology
Magloire Pandoua Nekoua, Cyril Debuysschere, Ines Vergez, Corentin Morvan, Chaldam Jespere Mbani, Famara Sane, Enagnon Kazali Alidjinou, Didier Hober
Summary: Viral infections have long been associated with physiological and pathological changes in the endocrine system. The current pandemic of COVID-19 has revealed numerous endocrine complications, highlighting the need to better understand the impact of viral infections on the endocrine system. Several viruses can directly damage endocrine cells or indirectly disrupt the system through the activation of the host antiviral immune response, leading to inflammation or organ-specific autoimmunity. Furthermore, endocrine disorders can also impact susceptibility to viral infections due to the immunoregulatory functions of endocrine hormones.
Article
Rheumatology
Zafer Gunendi, Fatma Gul Yurdakul, Hatice Bodur, Ahmet Kivanc Cengiz, Ulku Ucar, Hasan Fatih Cay, Nesrin Sen, Yasar Keskin, Gulcan Gurer, Meltem Alkan Melikoglu, Duygu Altintas, Hulya Deveci, Merve Baykul, Kemal Nas, Remzi Cevik, Ali Yavuz Karahan, Murat Toprak, Sertac Ketenci, Mehmet Nayimoglu, Ilhan Sezer, Ali Nail Demir, Hilal Ecesoy, Mehmet Tuncay Duruoz, Ozan Volkan Yurdakul, Ayse Banu Sarifakioglu, Sebnem Ataman
Summary: This study evaluated the impact of COVID-19 in FMF patients and found that FMF may not be a risk factor for poor outcomes in COVID-19. Most FMF patients with COVID-19 had mild to moderate disease activity.
RHEUMATOLOGY INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Andrea Crafa, Aldo E. Calogero, Rossella Cannarella, Laura M. Mongioi', Rosita A. Condorelli, Emanuela A. Greco, Antonio Aversa, Sandro La Vignera
Summary: Endocrine diseases have a significant impact on public health, potentially causing long-term disabilities and affecting the quality of life of patients. This extensive literature review evaluates the prevalence of endocrine disorders in the world and Italy, highlighting their epidemiological, clinical, and economic impact.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Bengt Zoller, MirNabi Pirouzifard, Magnus P. Lindgren, Jan Sundquist, Kristina Sundquist
Summary: This study found that a family history of short sibling survival after IS is associated with mortality after IS for younger male subjects.
Article
Endocrinology & Metabolism
Isabel Mazarico-Altisent, Ismael Capel, Neus Baena, Maria Rosa Bella-Cueto, Santi Barcons, Xavier Guirao, Rocio Pareja, Andreea Muntean, Valeria Arsentales, Assumpta Caixas, Mercedes Rigla
Summary: Genetic screening in a Mediterranean cohort of suspected familial hyperparathyroidism revealed a high prevalence of germline variants, leading to early diagnosis and treatment for patients and early intervention in their relatives. It is recommended to conduct genetic testing for patients with primary hyperparathyroidism who present high-risk features.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Communication
Yi-Hui Christine Huang, Yu Hong, Fen Lin, Zhao Alexandre Huang, Jian Lin
COMMUNICATION AND THE PUBLIC
(2022)
Article
Biotechnology & Applied Microbiology
Li-Peng Hu, Wuqing Huang, Xu Wang, Chunjie Xu, Wei -Ting Qin, Dongxue Li, Guangang Tian, Qing Li, Yaoqi Zhou, Suyuan Chen, Hui-Zhen Nie, Yujun Hao, Jian Song, Xue-Li Zhang, Jan Sundquist, Kristina Sundquist, Jun Li, Shu-Heng Jiang, Zhi-Gang Zhang, Jianguang Ji
Summary: Research suggests that reversing gut fungal dysbiosis with terbinafine can inhibit the development of colorectal cancer (CRC). Terbinafine reduces fungal load, suppresses tumor cell proliferation, inhibits fungus-induced myeloid-derived suppressor cell expansion, and restores antitumor immune response.
Article
Obstetrics & Gynecology
Filip Jansaker, Xinjun Li, Avalon Sundqvist, Kristina Sundquist, Christer Borgfeldt
Summary: This study aimed to estimate the association between sociodemographic factors and cervical neoplasia. The results showed that women with low education and women from Eastern Europe are more likely to suffer from cervical cancer, while women from non-Western regions have a lower risk of cervical cancer and carcinoma in situ. Women with chronic obstructive pulmonary disease (COPD) as a proxy for tobacco abuse are more susceptible to cervical cancer compared to women with a high education level.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Medicine, General & Internal
Deqiang Zheng, Ning Li, Rui Hou, Xiaoyu Zhang, Lijuan Wu, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: By combining observational and mendelian randomization studies, this research found that the use of GLP-1 RAs significantly decreases the risk of diabetic retinopathy in patients with type 2 diabetes.
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Forsti, Vaclav Liska, Akseli Hemminki, Xinjun Li
Summary: This study found a significant association between autoimmune diseases and hepatobiliary cancers through long-term tracking in the Swedish population. Several autoimmune diseases, particularly autoimmune hepatitis and primary biliary cirrhosis, were strongly linked with hepatobiliary cancers. Therefore, it is important to manage autoimmune disease symptoms carefully in each patient and promote a healthy lifestyle.
Article
Cardiac & Cardiovascular Systems
Jun Xiao, Jianguang Ji, Naiqi Zhang, Xi Yang, Keyuan Chen, Liangwan Chen, Wuqing Huang
Summary: This study assessed the association between genetically predicted lipid traits, their modification through licensed or investigational targets, and heart failure. The results showed a significant relationship between genetically predicted LDL-C, TG, HDL-C, and ApoB levels and heart failure, mainly mediated by coronary heart disease. Drug target analysis identified PCSK9, CETP, and LPL as potential targets for heart failure prevention.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Yishan Liu, Jan Sundquist, Kristina Sundquist, Deqiang Zheng, Jianguang Ji
Summary: This study examined the long-term impact of childhood cancer on parental mental health, with a focus on potential sex differences between mothers and fathers. The results showed that the mental health of both parents was continuously affected by the diagnosis, but the impact was more severe for mothers. Therefore, tailored psychological services or interventions are necessary to support parents of children with cancer.
Article
Cardiac & Cardiovascular Systems
Ning Li, Xiaoyu Zhang, Meng Zhang, Lijuan Wu, Changwei Li, Yuesong Pan, Wei Wang, Jianguang Ji, Deqiang Zheng
Summary: This study used Mendelian randomization analysis to investigate the association between dyslipidemia and diabetic retinopathy (DR). The findings suggest a negative association between high-density lipoprotein cholesterol (HDL-C) levels and the development of DR, while CETP inhibitors were not found to be associated with DR. These results indicate a potential protective role of HDL-C in preventing DR.
Article
Clinical Neurology
Filip Jansaker, Jan Sundquist, Kristina Sundquist, Xinjun Li
Summary: This study aimed to explore the association between neighborhood deprivation and mortality in patients with schizophrenia and bipolar disorder. The findings revealed a significant association between neighborhood deprivation and all-cause mortality, as well as cause-specific mortalities, in both patient groups. These findings have implications for healthcare resource allocation and clinical management in deprived neighborhoods.
Article
Oncology
Shan Huang, Nai-Qi Zhang, Chun-Jie Xu, Wu-Qing Huang, Dong-Xue Li, Jun Li, Lin-Li Yao, Kristina Sundquist, Jan Sundquist, Shu-Heng Jiang, Xin Xing, Li-Peng Hu, Zhi-Gang Zhang, Jianguang Ji, Xue-Li Zhang
Summary: Combined administration of dipyridamole and aspirin enhances the anti-cancer effect of aspirin against colorectal cancer by inducing endoplasmic reticulum stress and apoptosis.
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Foersti, Vaclav Liska, Akseli Hemminki, Xinjun Li
Summary: Liver cancer, including hepatocellular carcinoma, gallbladder cancer, and bile duct cancer, is influenced by various risk factors such as alcohol, viral hepatitis, gallstones, infections, autoimmune diseases, and diabetes. This study demonstrates that the combination of these risk factors can account for at least 50% of the causes of these cancers, highlighting the significance of chronic inflammation as an underlying mechanism. The use of national hospital records in Sweden provides valuable insights into the potential comorbidities associated with hepatobiliary cancers.
Letter
Urology & Nephrology
Kari Hemminki, Jianguang Ji, Jan Sundquist
Article
Psychology, Applied
Xinjun Li, Filip Jansaker, Jan Sundquist, Kristina Sundquist
Summary: Patients with bipolar disorder living in high deprivation neighbourhoods have a significantly higher risk of developing type 2 diabetes compared to those living in low deprivation neighbourhoods.
Article
Public, Environmental & Occupational Health
Yuying Wang, Yujie Zhang, Meng Zhang, Xiaoyu Zhang, Haibin Li, Youxin Wang, Wei Wang, Jianguang Ji, Lijuan Wu, Deqiang Zheng
Summary: This study aimed to explore the prevalence of adverse reactions to COVID-19 vaccination and provide direct evidence of vaccine safety for the elderly and those with underlying medical conditions. The prevalence of adverse reactions in these populations was found to be similar to that of the general population, suggesting that vaccination is safe for them.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Naiqi Zhang, Yanni Li, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This study identified eight druggable target genes for breast cancer and suggested that raloxifene is an effective chemoprevention against breast cancer, using Mendelian randomization analysis and population-based validation.