Review
Immunology
Rui Qin, Gengren Tian, Junbao Liu, Lu Cao
Summary: Endometriosis is a common gynecological disease that is associated with an imbalance of sex hormones, immune inflammation, and tumor characteristics. Recent studies have shown an association between the gut microbiota and endometriosis, suggesting that regulating gut microbiota may be beneficial for the treatment of endometriosis patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Radhika Kapoor, Christina Anna Stratopoulou, Marie-Madeleine Dolmans
Summary: Endometriosis is a female reproductive disorder with a low rate of early detection, the treatment mainly involves hormone therapies, thus there is a need to study alternative strategies that are more effective and have fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Vaishnavi Balasubramanian, Roshni Saravanan, Leena Dennis Joseph, Bhawna Dev, Shanmugasundaram Gouthaman, Bhuvana Srinivasan, Arun Dharmarajan, Suresh Kumar Rayala, Ganesh Venkatraman
Summary: Endometriosis is a common disease affecting some women of reproductive age, characterized by infertility and pelvic pain. Although the exact pathogenesis is not fully understood, exploring the molecular elements involved may lead to breakthroughs in treatment of the illness.
CELLULAR SIGNALLING
(2021)
Article
Obstetrics & Gynecology
Willem Jan van Weelden, Roy I. Lalisang, Johan Bulten, Kristina Lindemann, Heleen J. van Beekhuizen, Hans Trum, Dorry Boll, Henrica M. J. Werner, Luc R. C. W. van Lonkhuijzen, Refika Yigit, David Forsse, Petronella O. Witteveen, Khadra Galaal, Alexandra van Ginkel, Eliana Bignotti, Vit Weinberger, Sanne Sweegers, Judith R. Kroep, Silvia Cabrera, Marc P. L. M. Snijders, Marcia A. Inda, Ane Gerda Z. Eriksson, Camilla Krakstad, Andrea Romano, Anja van de Stolpe, Johanna M. A. Pijnenborg
Summary: This study aimed to improve the efficacy of hormonal therapy in advanced or recurrent endometrial cancer by analyzing hormone receptor expressions and pathway activity. Results showed that using a 50% cutoff level for hormone receptor expression significantly enhanced the prediction of response to hormonal treatment.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Essam R. Othman, Ahmad Abo Markeb, Maha Y. Khashbah, Ibrahim I. Abdelaal, Tarek T. ElMelegy, Ahmed N. Fetih, Lisette E. Van der Houwen, Cornelis B. Lambalk, Velja Mijatovic
Summary: The study found that endometriosis patients' eutopic endometrial tissue contained higher levels of certain estrogen metabolites, and the concentration of one metabolite was also higher in urine. This suggests that endometriosis patients preferentially metabolize estrogen through specific pathways.
REPRODUCTIVE SCIENCES
(2021)
Article
Oncology
Han Cai, Jinghe Lang
Summary: This study explores the role of lncRNA LINC01960-201 in in vitro decidualization of endometrial stromal cells in endometriosis during the window of implantation, as well as the regulation of hsa-miR-608 and hsa-miR-760 in the decidualization process. The results suggest that LINC01960-201 may play a significant regulatory role in the decidualization of endometrial stromal cells.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Endocrinology & Metabolism
Yi-Kong Lin, Yun-Yun Li, Yue Li, Da-Jin Li, Xiao-Lin Wang, Li Wang, Min Yu, Yi-Zhun Zhu, Jia-Jing Cheng, Mei-Rong Du
Summary: This study suggests that the interaction between inflammation and endocrine imbalance plays a significant role in the development of endometriosis (EMS). SCM-198 inhibits the progression of EMS by regulating the inflammation-endocrine-autophagy axis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pathology
Shiho Asaka, Ying Liu, Zheng-Cheng Yu, Yohan Suryo Rahmanto, Motoki Ono, Ryoichi Asaka, Tsutomu Miyamoto, Ting -Tai Yen, Ayse Ayhan, Tian -Li Wang, Ie-Ming Shih
Summary: Loss of ARID1A expression is associated with decreased PR expression in human and murine endometrial epithelial neoplasia, suggesting that ARID1A regulates PR transcription by modulating the PgR enhancer region during early tumor development.
Article
Biochemistry & Molecular Biology
Hai-Yan Peng, Sha-Ting Lei, Shu-Hui Hou, Li-Chun Weng, Qing Yuan, Ming-Qing Li, Dong Zhao
Summary: The study reveals that disturbed cholesterol metabolism and estrogen-converting enzymes in EMs lesions lead to increased cellular cholesterol concentration and local estradiol level. PrPC promotes the proliferative, migratory, and invasive abilities of ESC in endometrial stromal cells and accelerates EMs progression in mouse models. Furthermore, PrPC promotes cholesterol accumulation and activates estrogen biosynthesis of ESC in a PPAR alpha pathway-dependent manner, suggesting potential therapeutic targets for EMs intervention.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Irina V. Menzhinskaya, Stanislav V. Pavlovich, Arika G. Melkumyan, Vladimir D. Chuprynin, Ekaterina L. Yarotskaya, Gennady T. Sukhikh
Summary: The study evaluates the characteristics and significance of serum autoantibodies in ovarian endometrioma and deep infiltrative endometriosis. The results show that endometriosis is associated with autoantibodies to endometrial antigens, hormones, and alpha-enolase. These antibodies have high diagnostic value for identifying ovarian endometrioma and deep infiltrative endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Yanqing Ren, Xinru Wang, Jinyu Guo, Di Wang, Xinhua Li, Xiumei Cheng, Xinguo Wang
Summary: Increased expression of CHCHD2 in endometriotic tissues may contribute to the pathogenesis of endometriosis via regulating mitochondrial function and apoptosis, and CHCHD2 may be a potential target for interrupting the development of endometriosis.
REPRODUCTIVE SCIENCES
(2022)
Article
Environmental Sciences
Zhifang Sun, Rufei Gao, Xuemei Chen, Xueqing Liu, Yubin Ding, Yanqing Geng, Xinyi Mu, Taihang Liu, Fangfang Li, Yingxiong Wang, Junlin He
Summary: This study found that gestational exposure to BHT inhibits decidualization of mouse endometrium during early pregnancy, resulting in a decrease in the number of implantation sites and uterine weight. Additionally, BHT suppressed the decidual morphology of endometrial stromal cells and significantly decreased the expression of decidual markers. Furthermore, BHT exposure led to upregulation of reproductive hormones and hormone receptor signals in early pregnancy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Obstetrics & Gynecology
A. Nenicu, K. Yordanova, Y. Gu, M. D. Menger, M. W. Laschke
Summary: The study found that there were no differences in growth, microvessel density, and cell proliferation between endometriotic lesions forming from menstrual and non-menstrual tissue fragments in non-ovariectomized mice. However, lesion formation from non-menstrual tissue fragments was suppressed in ovariectomized mice, which could be reversed by estrogen supplementation. On the other hand, endometriotic lesions from menstrual tissue fragments showed smaller volume in ovxthornE2 mice, indicating reduced hormone sensitivity.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Roberto Gonzalez-Martin, Andrea Palomar, Yassmin Medina-Laver, Alicia Quinonero, Francisco Dominguez
Summary: This study aimed to investigate the effects of DEHP exposure on primary endometrial cells and endometrial adenocarcinoma cells. DEHP exposure did not significantly affect cell viability and endometriosis markers, but significantly increased the invasive capacity of primary endometrial stromal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Sara Caceres, Beatriz Monsalve, Angela Alonso-Diez, Belen Crespo, Maria Jose Illera, Paloma Jimena de Andres, Gema Silvan, Juan Carlos Illera
Summary: Through experimental studies on canine and human inflammatory breast cancer, it was found that anti-aromatase and anti-sulfatase therapies have inhibitory effects on tumors in vitro, while anti-sulfatase can increase tumor progression; letrozole effectively reduces tumor progression by decreasing estrogen levels.
Article
Pharmacology & Pharmacy
Ruud A. W. Veldhuizen, Brandon Baer, Lynda A. McCaig, Lauren A. Solomon, Lisa Cameron, Daniel B. Hardy
Summary: Fetal growth restriction affects the response to pulmonary inflammatory insult, resulting in decreased neutrophil infiltration and increased surfactant production in growth-restricted rats compared to healthy control rats.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Review
Physiology
Daniel J. Hoffman, Theresa L. Powell, Emily S. Barrett, Daniel B. Hardy
Summary: Nearly 2 billion adults worldwide are overweight, with over half classified as obese, and nearly one-third of global children experience poor growth and development. The global epidemic of obesity and double burden of malnutrition, where overweight coexists with underweight and micronutrient deficiencies, poses a significant challenge to human health. Understanding the developmental origins of health and disease (DOHaD) is crucial in addressing the global issues of obesity and chronic diseases.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Annia A. Martinez-Pena, Kendrick Lee, James J. Petrik, Daniel B. Hardy, Alison C. Holloway
Summary: Research shows that prenatal exposure to Delta(9)-THC affects ovarian health in adult rat offspring, leading to abnormal follicular development and decreased blood vessel density, highlighting the potential long-term impact of this component on female reproductive health.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Public, Environmental & Occupational Health
Reza Khazaee, Anastasiya Vinokurtseva, Lynda A. McCaig, Cory Yamashita, Daniel B. Hardy, Edith Arany, Ruud A. W. Veldhuizen
Summary: The study found that fetal growth restriction induced by maternal protein restriction did not affect liver and lung inflammatory responses to sepsis in both male and female adult rats. However, male FGR offspring showed a significant decrease in the relative amount of pulmonary surfactant, potentially contributing to lung dysfunction.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Review
Psychiatry
Mina G. Nashed, Daniel B. Hardy, Steven R. Laviolette
Summary: The prevalence of cannabis use during pregnancy varies widely in North America, with disparities likely due to underestimates and lack of evidence-based policy. Prenatal cannabis exposure has been linked to issues such as low birth weight, and emerging evidence suggests wide-ranging physiological and neurodevelopmental consequences. More rigorous investigation into the long-term effects of prenatal cannabis exposure is needed, especially considering the increase in potency and potential risks associated with THC exposure during pregnancy.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Substance Abuse
Diana Draghici, Kevin Barr, Daniel B. Hardy, Brian L. Allman, Katherine E. Willmore
Summary: The study found that prenatal alcohol exposure (PAE) and maternal age both increased the risk of low birthweight and growth restriction in offspring, and also affected craniofacial morphology. However, when combined, the effects of PAE and advanced maternal age on offspring outcomes were more complex than simply scaling the effects of either factor.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Sport Sciences
Daniel B. Hardy, Xin Mu, Katelyn S. Marchiori, Michelle F. Mottola
Summary: This study found that mild- and moderate-intensity exercise during pregnancy increases placental angiogenesis but does not increase placental oxidative or ER stress in healthy pregnancies, supporting routine exercise as part of standard care for pregnant women. Further research is warranted to explore the potential benefits of exercise on ANG1 in pathological pregnancies.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Pediatrics
Ousseynou Sarr, Katherine E. Mathers, Christina Vanderboor, Kristina Wiggers, Aditya Devgan, Daniel B. Hardy, Lin Zhao, Timothy R. H. Regnault
Summary: The study found that male guinea pigs with intrauterine growth restriction and low birth weight had hepatic cholesterol accumulation in later life, while females did not show the same effect. The increased hepatic cholesterol in LBW male guinea pigs, along with the decreased expression of cholesterol metabolism-related proteins, may contribute to hepatic lipotoxicity.
PEDIATRIC RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Sergio Raez-Villanueva, Amrita Debnath, Daniel B. Hardy, Alison C. Holloway
Summary: This study suggests that upregulation of p66shc through posttranslational histone modifications may underlie the reported adverse outcomes of nicotine exposure on pancreatic function.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Endocrinology & Metabolism
Kyunghee Hong, Sribalasubashini Muralimanoharan, Youn-Tae Kwak, Carole R. Mendelson
Summary: Through the differentiation and gene expression analysis of trophoblast stem cells, it was found that NRF2 plays a crucial role in the formation of multinucleated syncytiotrophoblast, serving as a key regulator in the maintenance of pregnancy.
Article
Endocrinology & Metabolism
Farzad Asadi, Juan Andres Fernandez Andrade, Ryan Gillies, Kendrick Lee, Savita Dhanvantari, Daniel Barry Hardy, Edith Juliana Arany
Summary: Administration of A9-tetrahydrocannabinol to pregnant rats resulted in glucose intolerance, insulin resistance, and reduced islet mass in female offspring, with no significant effects observed in male offspring. The study also showed that A9-THC may affect alpha-cell function through its impact on Stmn2 levels.
CANADIAN JOURNAL OF DIABETES
(2022)
Article
Reproductive Biology
Annia A. Martinez-Pen, James J. Petrik, Daniel B. Hardy, Alison C. Holloway
Summary: This study aimed to assess the effects of delta-9-tetrahydrocannabinol (THC), the psychoactive component of cannabis, on the expression and secretion of the angiogenic factor vascular endothelial growth factor (VEGF) in the ovary. Results showed that THC exposure increased the secretion of VEGF and prostaglandin E2 (PGE2), and promoted cell proliferation and survival. These changes may impact essential ovarian processes and potentially affect female reproductive health and fertility. Further research on the impact of cannabis and its constituents on female reproductive health is necessary.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Neurosciences
Mohammed H. Sarikahya, Samantha Cousineau, Marta De Felice, Kendrick Lee, Karen Kw Wong, Marieka V. DeVuono, Tony Jung, Mar Rodriguez-Ruiz, Tsun Hay Jason Ng, Dana Gummerson, Emma Proud, Daniel B. Hardy, Ken K-C Yeung, Walter Rushlow, Steven R. Laviolette
Summary: Despite increased prevalence of maternal cannabis use, little is understood regarding potential long-term effects of prenatal cannabis exposure (PCE) on neurodevelopmental outcomes. This study found that PCE induces behavioral, neuronal, and molecular alterations in the mesolimbic system in male and female offspring, resembling neuropsychiatric endophenotypes. Moreover, PCE resulted in profound dysregulation of critical fatty acid pathways in the developing brain lipidome.
Article
Biochemistry & Molecular Biology
Annia A. Martinez-Pena, Kendrick Lee, Madison Pereira, Ahmed Ayyash, James J. Petrik, Daniel B. Hardy, Alison C. Holloway
Summary: As cannabis use during pregnancy increases, understanding its effects on the developing fetus becomes important. This study found that gestational THC exposure can impact the miRNA profile in adult rat ovaries and have negative consequences on ovarian health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Obstetrics & Gynecology
Kendrick Lee, Mohammed H. Sarikahya, Tony Jung, Samantha L. Cousineau, Ken K. -C. Yeung, Steven R. Laviolette, Daniel B. Hardy
REPRODUCTIVE SCIENCES
(2022)