Article
Cell & Tissue Engineering
H. Xie, N. Wang, H. He, Z. Yang, J. Wu, T. Yang, Y. Wang
Summary: In this meta-analysis, the association between selenium status and bone health indicators was investigated. The results demonstrate a positive correlation between selenium intake and bone mineral density, as well as an inverse relationship with osteoporosis and hip fracture risk.
BONE & JOINT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Dongfeng Chen, Ying Li, Qiang Wang, Peng Zhan
Summary: This study compared the transcriptome data of osteoblasts from men and women, identifying differentially expressed genes associated with immune response, development, and collagen metabolism. By incorporating multi-omics data and transcriptome data, 9 key genes related to osteoporosis were identified and potential therapeutic targets for osteoporosis were found.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Jesus Francisco Garcia-Gavilan, Alfredo Martinez, Jadwiga Konieczna, Rafael Mico-Perez, Ana Garcia-Arellano, Josep Basora, Laura Barrubes, Alberto Goday, Silvia Canudas, Jordi Salas-Salvado, Monica Bullo
Summary: The study found that both high and low dietary acid were associated with an increased risk of osteoporotic fractures, but only high dietary acid had a negative relation to bone mineral density in senior adults with existing chronic health conditions.
JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Diana Jedrzejuk, Pawel Poznanski, Pawel Szewczyk, Oktawia Mazanowska, Marek Bolanowski, Magdalena Krajewska, Dorota Kaminska
Summary: The popularity of living-donor organ donation has increased recently due to the growing need for organs and a shortage of deceased-donor organs. This procedure requires a comprehensive health assessment of candidates, who must be in good physical and mental health. We present a case of a potential living-kidney donor who was withdrawn from donation due to Paget's disease of bone, and various imaging and assessment techniques were used to thoroughly evaluate the affected vertebra.
Article
Endocrinology & Metabolism
Toshio Matsumoto, Teruki Sone, Satoshi Soen, Sakae Tanaka, Akiko Yamashita, Tetsuo Inoue
Summary: This study aimed to determine the efficacy and safety of abaloparatide in increasing bone mineral density (BMD) in Japanese patients with osteoporosis at high fracture risk. The results showed that abaloparatide significantly increased BMD and prevented new vertebral fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
JJ. Liu, SB. Fu, J. Jiang, XL. Tang
Summary: Exposure to air pollution, specifically PM2.5 and NO2, was associated with an increased risk of osteoporosis, while PM10, NO, and O-3 did not show a significant excess risk. Despite the limited number of epidemiological studies, this research suggests a positive correlation between increased exposure to air pollutants and a higher osteoporosis risk. Further large cohort studies are needed to investigate the impact of different constituents and duration of air pollutants exposure.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Dan He, Huan Liu, Wenming Wei, Yijing Zhao, Qingqing Cai, Sirong Shi, Xiaoge Chu, Xiaoyue Qin, Na Zhang, Peng Xu, Feng Zhang
Summary: This study conducted a genome-wide trajectory analysis and identified the CPED1-WNT16-FAM3C locus as playing a significant role in bone mineral density (BMD) mean trajectories. They also discovered several novel candidate genes associated with BMD within-subject variability.
OSTEOPOROSIS INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Jiangbi Li, Yang Sun, Zhuo Chen, Xiaoping Xie, Feng Gu, Songqi Bi, Tiecheng Yu
Summary: This review examined the effects of bisphosphonates on bone density, fractures, and bone markers in osteopenic older women. The study found that bisphosphonates had significant positive effects on bone density and bone markers, as well as reducing the risk of fractures. However, further research is needed to determine their safety.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Mathematical & Computational Biology
Xianglu Li, Zhaohua Zhong, Enguang Ma, Xiaowei Wu
Summary: This study identified key genes and miRNA regulatory mechanisms involved in the fracture healing process through differential analysis, enrichment analysis, and network analysis, suggesting Cd19 and Col6a1 as candidate markers regulated by miRNAs.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Cell & Tissue Engineering
Y. Jia, X. Qi, M. Ma, S. Cheng, B. Cheng, C. Liang, X. Guo, F. Zhang
Summary: This study aimed to explore novel regulatory genetic variants associated with bone mineral density (BMD). Through an integrative analysis of BMD genome-wide association study and regulatory single nucleotide polymorphism (rSNP) annotation information, we identified 36 common genes associated with BMD, such as FAM3C, CCDC170, and SOX6. Additionally, multiple gene ontology terms related to BMD were detected. These findings support the implication of regulatory genetic variants in the development of osteoporosis.
BONE & JOINT RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xin Huang, Tianxin Zhang, Ping Guo, Weiming Gong, Hengchao Zhu, Meng Zhao, Zhongshang Yuan
Summary: In this study, researchers conducted a comprehensive drug-target Mendelian randomization analysis to explore the associations between genetic proxies for antihypertensive drugs and bone health-related traits. The results showed that genetic proxies for angiotensin receptor blockers (ARBs) were associated with a reduced risk of fracture and higher bone mineral density (BMD). On the other hand, genetic proxies for calcium channel blockers (CCBs) were associated with an increased risk of fracture, while genetic proxies for potassium sparing diuretics (PSDs) were associated with lower BMD. The study highlights the potential effects of different antihypertensive drugs on bone health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Huajie Dai, Longyi Zheng, Zheng Zhu, Xin Geng, Tianzhichao Hou, Qi Wang, Yijie Zhu, Hong Lin, Shuangyuan Wang, Ruizhi Zheng, Zhiyun Zhao, Mian Li, Jieli Lu, Yu Xu, Tiange Wang, Jianmin Liu, Guang Ning, Weiqing Wang, Yufang Bi, Jie Zheng, Min Xu
Summary: This study aimed to evaluate the causal effect of SGLT2 inhibition on BMD, osteoporosis, and fracture risk using genetics. The results showed little evidence of association between genetically proxied SGLT2 inhibition and BMD, osteoporosis, or most types of fracture. Only a nominal significance was found for fracture of the lower leg and shoulder and upper arm. This study does not support an effect of genetically proxied SGLT2 inhibition on fracture risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Orthopedics
Xiaozhi Sun, Xiaotao Wu
Summary: Higher levels of apolipoprotein A1 (ApoA1) are associated with increased risk of osteoporosis, indicating the involvement of lipid metabolism in bone metabolism.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Urology & Nephrology
David A. Jaques, Scott Henderson, Andrew Davenport
Summary: In patients requiring renal replacement therapy (RRT), bone mineral density (BMD) measured at the femoral neck is a predictor of mortality and fracture risk. This suggests that FNBMD can serve as an overall prognostic marker in this population.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Immunology
Youfeng Guo, Haihong Zhao, Feng Wang, Haowei Xu, Xiaowei Liu, Tao Hu, Desheng Wu
Summary: This study investigated the correlation between body composition, fractures, and telomere length (TL). The results indicated that TL was positively and negatively associated with bone mineral density (BMD) and bone mineral content (BMC) in different body parts. TL was also found to be related to the occurrence of wrist and spine fractures, and this correlation showed some sex specificity. Further research is needed to validate these associations in the skull, upper limbs, and wrists.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Philip C. M. Au, Kathryn C. B. Tan, Bernard M. Y. Cheung, Ian C. K. Wong, Ying Wong, Ching-Lung Cheung
Summary: Analysis of data on the use of SGLT2 inhibitors and DPP4is in diabetic patients revealed that SGLT2 inhibitors were associated with a lower risk of pneumonia and pneumonia mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Geriatrics & Gerontology
Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Bernard M. Y. Cheung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study found a higher immediate risk of major adverse cardiovascular events (MACEs) in patients with hip fractures compared to those without. The risk was highest in the first 90 days post-fracture and decreased over time, suggesting the importance of early evaluation and management in older adults with hip fractures to reduce subsequent MACE risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Philip C. M. Au, Kathryn C. B. Tan, Bernard M. Y. Cheung, Ian C. K. Wong, Hang-Long Li, Ching-Lung Cheung
Summary: In a study conducted in Hong Kong, it was found that compared to dipeptidyl peptidase-4 inhibitors (DPP4is), the use of sodium-glucose cotransporter 2 inhibitors (SGLT2is) in patients with type 2 diabetes was associated with a reduced risk of end-stage renal disease and acute renal failure, as well as a slower decline in estimated glomerular filtration rate.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Man-Fung Tsoi, Hang-Long Li, Qi Feng, Ching-Lung Cheung, Tommy T. Cheung, Bernard M. Y. Cheung
Summary: The prevalence of childhood obesity in the USA has been increasing from 1999 to 2018, with higher rates among children from Spanish-speaking households. Targeted public health intervention strategies are urgently needed to address this rising epidemic.
Article
Virology
Suhas Krishnamoorthy, Gloria H-Y Li, Ching-Lung Cheung
Summary: This study used summary data-based Mendelian randomization analysis to identify 309 significant gene-trait associations potentially causally associated with severe COVID-19. These genes are involved in multiple biological processes and improve our understanding of the mechanism of COVID-19, providing insights for the development of therapeutic agents for treating severe COVID-19. Additionally, unique genes and biological processes were identified for hospitalized COVID-19 and SARS-CoV-2 infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Genetics & Heredity
Lei Sun, Zhong Wang, Tianyuan Lu, Teri A. Manolio, Andrew D. Paterson
Summary: A study conducted 10 years ago found that only 33% of GWAS results included the X chromosome, leading to recommendations to address this exclusion. However, a recent survey showed that in the NHGRI-EBI GWAS Catalog of 2021, only 25% of the reported results included the X chromosome and 3% included the Y chromosome, indicating that the exclusion persists and has become a more significant problem.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Public, Environmental & Occupational Health
Wang Chun Kwok, Terence Chi Chun Tam, Chor Wing Sing, Esther Wai Yin Chan, Ching-Lung Cheung
Summary: This study evaluated the validity of the ICD-9 code algorithm for identifying bronchiectasis in the CDARS database in Hong Kong. Among 19,617 patients in public hospitals and 1,866 patients in Queen Mary Hospital, the overall positive predictive value (PPV) for the ICD-9 code 494 diagnosis of bronchiectasis was 92.7%.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Multidisciplinary Sciences
Francisco Tsz Tsun Lai, Min Fan, Caige Huang, Celine Sze Ling Chui, Eric Yuk Fai Wan, Xue Li, Carlos King Ho Wong, Ching-Lung Cheung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: Extending the interval between doses of mRNA Covid-19 vaccines has been linked with a reduced risk of myocarditis in children and adolescents, but impacts on vaccine effectiveness are not known.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Kat-Tik Lau, Suhas Krishnamoorthy, Chor-Wing Sing, Ching Lung Cheung
Summary: The purpose of this review was to systematically examine recent studies on the association between metabolites and bone mineral density (BMD) in humans. A total of 16 articles were included in this review after screening 170 studies. More than 400 unique metabolites in blood were found to be significantly associated with BMD, and valine and glycine were consistently associated with BMD, while leucine showed inconsistent associations.
CURRENT OSTEOPOROSIS REPORTS
(2023)
Article
Medicine, General & Internal
Gloria Hoi-Yee Li, Ching -Lung Cheung, Kathryn Choon-Beng Tan, Annie Wai-Chee Kung, Timothy Chi-Yui Kwok, Wallis Cheuk-Yin Lau, Janus Siu-Him Wong, Warrington W. Q. Hsu, Christian Fang, Ian Chi-Kei Wong
Summary: Sex-specific hip fracture prediction models were developed using electronic health records (EHR) without bone mineral density (BMD) data. The logistic regression (LR) model showed better discrimination and classification performance than machine learning (ML) algorithms in both internal and independent validation cohorts for both females and males. The LR models could be integrated into routine clinical workflow to identify high-risk individuals for DXA scan.
Article
Endocrinology & Metabolism
Ching-Lung Cheung, Gloria HY. Li, Hang-Long Li, Constance Mak, Kathryn CB. Tan, Annie WC. Kung
Summary: To enhance public awareness and facilitate diagnosis of osteoporosis, a new Chinese Osteoporosis Screening Algorithm (COSA) was developed to identify individuals at high risk of osteoporosis. This algorithm demonstrated improved reclassification performance compared to existing tools and showed significant associations with fracture risk. The COSA was specific for Hong Kong Chinese and can serve as an effective screening tool in this population.
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Multidisciplinary Sciences
Andrew D. Paterson, Sang-Cheol Seok, Veronica J. Vieland
Summary: Next-generation sequencing has revolutionized genetic discoveries for rare diseases. However, most identified variants are rare and found in small pedigrees, posing challenges for estimating penetrance and providing genetic counseling.
Article
Medicine, General & Internal
Xi Xiong, David Tak Wai Lui, Matthew Shing Hin Chung, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Celine Sze Ling Chui, Xue Li, Franco Wing Tak Cheng, Ching-Lung Cheung, Esther Wai Yin Chan, Chi Ho Lee, Yu Cho Woo, Kathryn Choon Beng Tan, Carlos King Ho Wong, Ian Chi Kei Wong
Summary: This study aimed to investigate the risk of incident diabetes following COVID-19 vaccination. The results showed no increased risk of incident diabetes after COVID-19 vaccination. However, SARS-CoV-2 infection was associated with a significantly higher risk of incident diabetes, especially type 2 diabetes.
Letter
Endocrinology & Metabolism
Ching-Lung Cheung
OSTEOPOROSIS AND SARCOPENIA
(2023)
Article
Biochemistry & Molecular Biology
Desmond Zeya Chen, Delnaz Roshandel, Zhong Wang, Lei Sun, Andrew D. Paterson
Summary: The UK Biobank has been widely used for genome-wide association studies (GWAS), but the study of the X chromosome has been limited. Recent research has found significant differences in minor allele frequencies on the X chromosome, particularly at the boundaries between the pseudo-autosomal regions and the non-pseudo-autosomal regions. Additionally, a small fraction of sex chromosomes and some autosomal SNPs also showed significant differences in minor allele frequencies.
HUMAN MOLECULAR GENETICS
(2023)
