Article
Endocrinology & Metabolism
Laura E. Dichtel, Allison Kimball, Kevin C. J. Yuen, Whitney Woodmansee, Melanie S. Haines, Qiu Xia Guan, Brooke Swearingen, Lisa B. Nachtigall, Nicholas A. Tritos, Julie L. Sharpless, Ursula B. Kaiser, Anu V. Gerweck, Karen K. Miller
Summary: This study investigated the effects of growth hormone receptor antagonism versus somatostatin analog therapy on the quality of life in patients with acromegaly. The results showed that there were no significant differences in quality of life between patients receiving different treatment regimens, but higher HbA1c, BMI, and IGF-1 Z-scores were associated with poorer quality of life in several domains.
CLINICAL ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Emily S. Tonorezos, Richard J. Cohn, Adam W. Glaser, Jeremy Lewin, Eileen Poon, Claire E. Wakefield, Kevin C. Oeffinger
Summary: Worldwide advancements in the treatment and supportive care for children and adolescents with cancer have resulted in a growing population of survivors. However, this population is at a high risk of late occurring health problems due to knowledge gaps and fragmented healthcare during the transition from pediatric to adult care settings.
Article
Endocrinology & Metabolism
Jie Liu, Yamei Yang, Lian Duan, Xiaofeng Chai, Huijuan Zhu, Kan Deng, Xiaolan Lian, Yong Yao
Summary: This study evaluated the efficacy of presurgical somatostatin analogs (SSAs) treatment and long-term remission after surgery for TSH-secreting pituitary adenomas (TSHomas). The results showed that the combination of endoscopic transsphenoidal surgery and presurgical SSAs provided a higher long-term remission for TSHomas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Elizabeth Cespedes M. Feliciano, Sowmya Vasan, Juhua Luo, Alexandra M. Binder, Rowan T. Chlebowski, Charles Quesenberry, Hailey R. Banack, Bette J. Caan, Electra D. Paskett, Grant R. Williams, Ana Barac, Andrea Z. LaCroix, Ulrike Peters, Kerryn W. Reding, Kathy Pan, Aladdin H. Shadyab, Lihong Qi, Garnet L. Anderson
Summary: Patients with cancer experience acute declines in physical function, which may be due to cancer-related symptoms and cancer treatments. This study examined the long-term trajectories of physical function among older cancer survivors and cancer-free controls. The results showed that cancer survivors experienced accelerated declines in physical function after diagnosis, and their physical function remained below that of age-matched controls even years later.
Article
Food Science & Technology
Yilin Li, Kui Zhong, Xue Wang, Houyin Wang, Yongjiu Zhang, Bolin Shi, Huarong Luo, Lei Zhao, Shilong Jiang, Sisi Wang
Summary: The study examined the impact of vacuum packaging and different storage temperatures on the shelf life of fresh corn. Results showed that high-barrier films could effectively preserve the freshness of corn and delay color changes and sourness development.
Article
Clinical Neurology
Anni Rissanen, Mathias Hamalainen, Johan Marjamaa, Jari Siironen, Seppo Koskinen, Juho Konsti, Jussi Numminen, Anniina Koski-Palken
Summary: This study retrospectively analyzed the clinical data of 340 patients who underwent cervical laminectomy for cervical spondylotic myelopathy. The results showed that the rate of further cervical surgeries after laminectomy was low. The patients experienced decreased health-related quality of life, and some patients had cervical misalignments.
WORLD NEUROSURGERY
(2022)
Article
Psychology, Multidisciplinary
Kristina Geue, Anja Mehnert-Theuerkauf, Isabelle Stroske, Hannah Brock, Michael Friedrich, Katja Leuteritz
Summary: This study aims to assess the long-term effects on life satisfaction and psychological distress of young adult cancer survivors by analyzing longitudinal data and cross-sectional topics. It is expected that data from at least 320 participants will be available for analysis after the completion of the sixth survey in 2021.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Medicine, General & Internal
Alexandru Dan Popescu, Mara Carsote, Ana Valea, Andreea Gabriela Nicola, Ionela Teodora Dascalu, Tiberiu Tirca, Jaqueline Abdul-Razzak, Mihaela Jana Tuculina
Summary: Acromegaly-related sub/infertility is associated with suboptimal disease control, hyperprolactinemia, hypogonadotropic hypogonadism, and glucose profile anomalies. This review explores the impact of acromegaly on pregnancy outcomes and discusses management strategies. The level of disease control, family history of diabetes, and body mass index are important predictors of maternal complications. Pharmacotherapy has been shown to be safe and effective in improving pregnancy outcomes.
Review
Clinical Neurology
Heidemarie Lex, Steven W. Nevers, Erica L. Jensen, Yarden Ginsburg, Daniel F. Maixner, Brian J. Mickey
Summary: Long-term quality of life outcomes after ECT vary widely, with individuals responding well to initial treatment, being married, and having a less chronic course of illness experiencing the best outcomes. Approximately 40-50% of individuals experienced clinically meaningful improvements after ECT.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Food Science & Technology
Ciara K. McDonnell, Adam G. Fitzgerald, Paul Burt, Joanne Hughes, Glen E. Mellor, Robert S. Barlow, Anita L. Sikes, Yutao Li, Aarti B. Tobin
Summary: The study found that shockwaves did not affect the microbiological counts of meat samples, but significantly reduced the peak force of striploin and had no effect on the texture of brisket. Additionally, shockwave treatment led to increased moisture loss in both striploin and brisket at the beginning of storage, which decreased over time. The results suggest that shockwave technology does not impact meat shelf-life and has potential for tenderizing beef.
INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES
(2021)
Article
Endocrinology & Metabolism
Iris C. M. Pelsma, Nienke R. Biermasz, Wouter R. van Furth, Alberto M. Pereira, Herman M. Kroon, Margreet Kloppenburg, Kim M. J. A. Claessen
Summary: This study evaluated the long-term course of acromegalic arthropathy, revealing significant radiographic progression over 9.1 years in patients in remission, while clinical progression was observed less frequently.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Surgery
Henk-Thijs Brandsma, Birgitta ME. Hansson, Theo J. Aufenacker, Nienke de Jong, Klaas CA. Engelenburg, Chander Mahabier, Rogier Donders, Pascal Steenvoorde, Tammo de Vries S. Reilingh, Hendrik Leendert van Westreenen, Marinus J. Wiezer, Johannes H. W. de Wilt, Maroeska Rovers, Camiel Rosman, Dutch Prevent Study Grp
Summary: The aim of this study was to determine the effectiveness, safety, and cost-effectiveness of prophylactic mesh placement in preventing parastomal hernia formation in the long term. The results showed that while the procedure did not reduce the incidence of parastomal hernia after 5 years of follow-up, it did delay its onset without significant differences in morbidity, mortality, or quality of life. Additionally, it was found to be a cost-effective option.
Article
Orthopedics
Lisa M. J. Esteban Lopez, Lisa Hoogendam, Guus M. Vermeulen, Jonathan Tsehaie, Harm P. Slijper, Ruud W. Selles, Robbert M. Wouters
Summary: In the nonsurgical treatment of thumb carpometacarpal (CMC-1) osteoarthritis (OA), pain and limitations in activities of daily living (ADL) did not worsen after 12 months of follow-up. Patient satisfaction with treatment results was high, supporting the sustainability of nonsurgical treatment.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Multidisciplinary Sciences
Mostafa M. Khodeir, Hassan A. Shabana, Zafar Rasheed, Abdullah S. Alkhamiss, Mohamed Khodeir, Mohammad S. Alkhowailed, Sami Alharbi, Mansour Alsoghair, Suliman A. Alsagaby, Waleed Al Abdulmonem
Summary: Long-term symptoms after recovery from COVID-19 are common, including general fatigue, weakness, neurological symptoms like mood changes and insomnia, and sensory symptoms like loss of taste and smell. Further studies are needed to fully understand the recovery process from COVID-19.
Article
Surgery
Dina M. Filiberto, Brian F. Jimenez, Emily K. Lenart, Dih Dih Huang, Marion E. Hare, Elizabeth A. Tolley, Louis J. Magnotti
Summary: Traumatic spine fractures have long-term effects on patients' functional outcomes. Age, thoracic fractures, lower extremity fractures, discharge location, and time to operative fixation are associated with poor functional outcomes.
Article
Clinical Neurology
Juan A. Aibar-Duran, Michael Oladotun-Anka, Carlos Asencio-Cortes, Elena Valassi, Susan Webb, Juan R. Gras-Cabrerizo, Joan Monserrat-Gili, Pere Tresserras Ribo, Fernando Munoz-Hernandez
Summary: The study found that patients with ACTH-secreting pituitary adenomas had higher rates of transient diabetes insipidus and postsurgical bacterial sinusitis postoperatively, but overall complication rates were similar to the other two groups (GH group and nonfunctioning group).
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Review
Genetics & Heredity
Juan Luque, Ingrid Mendes, Beatriz Gomez, Beatriz Morte, Miguel Lopez de Heredia, Enrique Herreras, Virginia Corrochano, Juan Bueren, Pia Gallano, Rafael Artuch, Cristina Fillat, Luis A. Perez-Jurado, Lluis Montoliu, Angel Carracedo, Jose M. Millan, Susan M. Webb, Francesc Palau, Pablo Lapunzina
Summary: CIBERER, a thematic area of CIBER, focuses on rare disease research. It aims to facilitate collaboration between biomedical and clinical research groups and provide new tools for the diagnosis and therapy of low-prevalence diseases.
Article
Endocrinology & Metabolism
Leonard Girnita, Terry J. Smith, Joseph A. M. J. L. Janssen
Summary: This article reviews the generation of autoantibodies in thyroid eye disease (TED) and their direct effects on orbital fibroblast responses through the TSH receptor (TSHR), IGF-I receptor (IGF-IR), or both. Evidence suggests that IGF-IR functions not only as a typical tyrosine kinase receptor, but also as a functional receptor tyrosine kinase/G-protein-coupled receptor hybrid. Teprotumumab, a monoclonal IGF-IR antibody, effectively reduces TED disease activity and its in vitro actions on fibrocytes and orbital fibroblasts. The article proposes four possible IGF-IR activation models underlying the clinical responses to teprotumumab in TED patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Joan Gil, Montserrat Marques-Pamies, Miguel Sampedro, Susan M. Webb, Guillermo Serra, Isabel Salinas, Alberto Blanco, Elena Valassi, Cristina Carrato, Antonio Pico, Araceli Garcia-Martinez, Luciana Martel-Duguech, Teresa Sardon, Andreu Simo-Servat, Betina Biagetti, Carles Villabona, Rosa Camara, Carmen Fajardo-Montanana, Cristina Alvarez-Escola, Cristina Lamas, Clara V. Alvarez, Ignacio Bernabeu, Monica Marazuela, Mireia Jorda, Manel Puig-Domingo
Summary: This study aimed to predict the response of acromegaly patients to somatostatin receptor ligands (SRL) using mathematical modeling and clinical information. Accuracy of patient stratification was significantly improved when the cohort was fragmented based on relevant clinical characteristics. The proposed stratification method based on tumor characteristics, sex, age, and multiple biomarkers achieved accuracies ranging from 71% to 95%. The use of data mining offers a promising approach for personalized medicine in acromegaly.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Queralt Asla, Helena Sarda, Enrique Lerma, Felicia A. Hanzu, Maria Teresa Rodrigo, Eulalia Urgell, Jose Ignacio Perez, Susan M. Webb, Anna Aulinas
Summary: 11-deoxycorticosterone-producing adrenal lesions are a very rare cause of mineralocorticoid-induced hypertension. This condition primarily affects middle-aged women and presents with high blood pressure and hypokalemia. The tumors are typically malignant and may differ in size, 11-deoxycorticosterone levels, and time of evolution compared to benign tumors.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Joseph A. M. J. L. Janssen
Summary: Recent data suggests that the onset of metabolic syndrome and related diseases is often preceded by a period of hyperinsulinemia. Hyperinsulinemia may be caused by factors such as diet, over-nutrition, genetic background, and fetal/metabolic programming. The synergistic effects of hyperinsulinemia and functional hypercortisolism may promote abdominal visceral obesity and insulin resistance, which are key components of metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Susan M. Webb, Elena Valassi
Summary: This brief review focuses on recent publications in the last five years that discuss health-related quality of life (QoL) in individuals diagnosed with endogenous hypercortisolism, specifically pituitary-dependent Cushing's disease (CD) or any other cause of Cushing syndrome (CS). Despite improvements from treatment, individuals still experience physical morbidity, neurocognitive problems, and decreased stress tolerance, leading to long-term impairment of QoL.
Article
Endocrinology & Metabolism
Emilie Pupier, Alicia Santos, Nicole Etchamendy, Aurelie Lavielle, Amandine Ferriere, Aline Marighetto, Eugenia Resmini, Daniela Cota, Susan M. Webb, Antoine Tabarin
Summary: Cognitive impairments and altered quality of life may persist in patients with long-term remission of Cushing's disease, even in the absence of other comorbidities. Memory tests revealed similar performance between patients and controls, but patients had worse quality of life despite no depression or residual clinical symptoms of Cushing's disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Betina Biagetti, Pedro Iglesias, Rocio Villar-Taibo, Maria-Dolores Moure, Miguel Paja, Marta Araujo-Castro, Jessica Ares, Cristina Alvarez-Escola, Almudena Vicente, Elia Alvarez Guivernau, Iria Novoa-Testa, Fernando Guerrero Perez, Rosa Camara, Beatriz Lecumberri, Carlos Garcia Gomez, Ignacio Bernabeu, Laura Manjon, Sonia Gaztambide, Fernando Cordido, Susan M. Webb, Edelmiro Luis Menendez-Torre, Juan J. Diez, Rafael Simo, Manel Puig-Domingo
Summary: The study found that the most common phenotype in elderly patients newly diagnosed with acromegaly includes small adenomas and moderately high IGF-1 levels. GH <= 6 ng/ml at diagnosis and female gender, rather than age per se, were associated with a greater chance of response to SRL.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Susan M. Webb, Jette Kristensen, Anna Nordenstrom, Diana Vitali, Vincent Amodru, Lenja Katharina Wiehe, Matt Bolz-Johnson
Summary: Patient journeys are instruments that collect patients' experiences and improve the clinical evaluation and management of rare diseases, helping patients adapt to chronic conditions.
ENDOCRINE CONNECTIONS
(2022)
Article
Medicine, Research & Experimental
Dermot O'Toole, Pamela L. Kunz, Susan M. Webb, Grace Goldstein, Sheila Khawaja, Mark McDonnell, Sandra Boiziau, Delphine Gueguen, Aude Houchard, Antonio Ribeiro-Oliveira, Ally Prebtani
Summary: In patients with neuroendocrine tumors or acromegaly treated with long-acting somatostatin analogs, LAN demonstrated reduced injection-site pain and technical problems compared to OCT.
ADVANCES IN THERAPY
(2023)
Article
Endocrinology & Metabolism
Alicia Santos, Chiara Nalin, GianMario Bortolotti, Elisabet Dominguez-Clave, Gianola Daniela, Liana Cortesi, Marina Pagani, Maria A. M. Momblan, Ignasi Gich, Susan M. Webb, Roberto Trevisan, Eugenia Resmini
Summary: This study demonstrates the value of a mindfulness program in patients with acromegaly, showing improvements in sleep, reduction in pain, and increased self-compassion.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Oncology
Elena Valassi, Frederic Castinetti, Amandine Ferriere, Stylianos Tsagarakis, Richard A. Feelders, Romana T. Netea-Maier, Michael Droste, Christian J. Strasburger, Dominique Maiter, Darko Kastelan, Philippe Chanson, Susan M. Webb, Frank Demtroder, Valdis Pirags, Olivier Chabre, Holger Franz, Alicia Santos, Martin Reincke
Summary: This study investigated the prevalence, presentation, and outcome of CTP-BADX/NS in Cushing's disease patients included in the ERCUSYN database. The results showed that 45% of BADX patients developed CTP-BADX/NS and only half of them were able to control tumor progression. Further studies are needed to establish effective strategies for prevention and treatment.
ENDOCRINE-RELATED CANCER
(2022)
Review
Biochemistry & Molecular Biology
Joseph A. M. J. L. Janssen
Summary: The metabolic syndrome is a collection of conditions that increase the risk of type 2 diabetes, cardiovascular disease, and cancer. The prevalence of metabolic syndrome in the Western world has reached epidemic levels, likely due to changes in diet, environment, and decreased physical activity. This review highlights how the Western diet and lifestyle have contributed to the development of metabolic syndrome through negative effects on the insulin-IGF-I system. It suggests that interventions targeting the insulin-IGF-I system may be key in preventing and treating metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Endocrinology & Metabolism
L. Martel-Duguech, A. Alonso-Jimenez, H. Bascunana, J. Diaz-Manera, J. Llauger, C. Nunez-Peralta, B. Biagetti, P. Montesinos, S. M. Webb, E. Valassi
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)