Article
Geriatrics & Gerontology
S. Toselli, F. Campa, C. N. Matias, Bruna Spolador de Alencar Silva, Vanessa Ribeiro dos Santos, P. Maietta Latessa, L. A. Gobbo
Summary: In this study, researchers developed and cross-validated a BIA-based equation for estimating ALST, taking into account the impact of body fat distribution. The new formula showed better accuracy and no bias compared to previously published models, providing a practical means to quantify ALST in older adults.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Geriatrics & Gerontology
Seong Rae Kim, Gyeongsil Lee, Seulggie Choi, Yun Hwan Oh, Joung Sik Son, Minseon Park, Sang Min Park
Summary: This study found that increased predicted muscle mass or decreased predicted fat mass were associated with a reduced risk of cardiovascular disease (CVD) in young adults. Conversely, decreased predicted muscle mass or increased predicted fat mass were associated with an elevated risk of CVD.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Ji Hyun Lee, Young Cheol Yoon, Hyun Su Kim, Min Jae Cha, Jae-Hun Kim, Kyunga Kim, Hye Seung Kim
Summary: Obesity is associated with favorable overall survival after surgical excision of lung adenocarcinoma.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Jia-Xing Zhang, Juan Li, Chen Chen, Ting Yin, Qing-An Wang, Xiao-Xia Li, Fa-Xuan Wang, Jian-Hua Zhao, Yi Zhao, Yu-Hong Zhang
Summary: This study established reference values for skeletal muscle mass index, fat mass index, and fat-to-muscle ratio for healthy rural adults in western China. Results showed that men had higher skeletal muscle mass but lower fat mass and fat-to-muscle ratio than women, and there were age-related differences in body composition between men and women.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Medicine, General & Internal
Paivi E. Korhonen, Tuija Mikkola, Hannu Kautiainen, Johan G. Eriksson
Summary: This study found that both fat mass and lean mass index are positively associated with blood pressure levels, independently of other factors. Lean body mass is shown to be an important determinant of blood pressure levels, with a magnitude similar to fat mass. Excess muscle mass may not be beneficial to cardiovascular health.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Oncology
Florian Huemer, Stefan Hecht, Bernhard Scharinger, Verena Schlintl, Gabriel Rinnerthaler, Konstantin Schlick, Ronald Heregger, Thomas Melchardt, Angela Wimmer, Iris Muehlbacher, Oliver Owen Koch, Daniel Neureiter, Eckhard Klieser, Sara Seyedinia, Mohsen Beheshti, Richard Greil, Lukas Weiss
Summary: This study investigated the impact of body composition parameters and dynamics on clinical outcomes in gastric/GEJ cancer patients undergoing perioperative FLOT chemotherapy. The study found that the skeletal muscle index (SMI) was the only body composition parameter that significantly decreased during pre-operative FLOT. Pre-FLOT BMI and SMI were significantly associated with progression-free survival (PFS) in multivariable analysis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Endocrinology & Metabolism
Malou A. H. Nuijten, Thijs M. H. Eijsvogels, Valerie M. Monpellier, Ignace M. C. Janssen, Eric J. Hazebroek, Maria T. E. Hopman
Summary: The meta-analysis revealed significant loss of lean body mass and fat-free mass within the first year post-bariatric surgery, with a majority of the losses occurring within the first 3 months post-surgery. Interventions should be implemented perioperatively to mitigate these losses.
Article
Nutrition & Dietetics
Gyu Seok Oh, Ju-Hak Lee, Kyunghee Byun, Dong-Il Kim, Ki Deok Park
Summary: The study confirmed that combining resistance exercise with leucine-rich protein supplements is more effective in preventing sarcopenia in the elderly than just performing resistance exercise alone.
Article
Geriatrics & Gerontology
Marie-Theres Huemer, Alina Bauer, Agnese Petrera, Markus Scholz, Stefanie M. Hauck, Michael Drey, Annette Peters, Barbara Thorand
Summary: This study utilized proteomic profiling to identify novel biomarkers associated with low muscle mass, high fat mass, and their combination. Key findings included previously unknown biomarkers such as kallikrein-6, CCL28, and NT-proBNP as potential indicators of declining health status related to muscle and fat composition. The high-throughput proteomics approach accelerated biomarker discovery in muscle research.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Nutrition & Dietetics
Feng-Min Zhang, Xiao-Lei Chen, Qian Wu, Wen-Xi Dong, Qian-Tong Dong, Xian Shen, Han-Ping Shi, Zhen Yu, Cheng-Le Zhuang
Summary: This study developed and validated nomograms for predicting low muscle mass and muscle radiodensity based on preoperative data in gastric cancer patients. The nomograms showed good discrimination and calibration in diagnosing sarcopenia and malnutrition, with high agreement ratios between the nomograms and actual observations. These diagnostic tools can facilitate early identification and interventions for at-risk populations.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Katsuhiko Ohori, Toshiyuki Yano, Satoshi Katano, Hidemichi Kouzu, Suguru Honma, Kanako Shimomura, Takuya Inoue, Yuhei Takamura, Ryohei Nagaoka, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Tomoyuki Ishigo, Ayako Watanabe, Akiyoshi Hashimoto, Tetsuji Miura
Summary: The study retrospectively analyzed data from 198 HF patients and found that higher body fat mass was associated with lower short-term cardiac event risk in HF patients, while muscle wasting was not significantly associated with cardiac events.
Article
Geriatrics & Gerontology
Masaaki Konishi, Eiichi Akiyama, Yasushi Matsuzawa, Ryosuke Sato, Shinnosuke Kikuchi, Hidefumi Nakahashi, Nobuhiko Maejima, Noriaki Iwahashi, Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Toshihiro Misumi, Stephan von Haehling, Stefan D. Anker, Kouichi Tamura, Kazuo Kimura
Summary: The study found that more than half of heart failure patients had reduced muscle mass, and lower values of both muscle and fat mass were associated with higher mortality in heart failure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Oncology
Livingstone Aduse-Poku, Shama D. D. Karanth, Meghann Wheeler, Danting Yang, Caretia Washington, Young-Rock Hong, Todd M. M. Manini, Jesus C. C. Fabregas, Ting-Yuan David Cheng, Dejana Braithwaite
Summary: Using a nationally representative sample of cancer survivors, this study found that higher fat mass and sarcopenia were associated with increased risk of mortality. The results have significant clinical implications and emphasize the importance of healthy body composition in cancer patients. Further research is needed to explore specific interventions to reduce fat mass and prevent muscle loss.
Article
Endocrinology & Metabolism
Reshma Aziz Merchant, Santhosh Seetharaman, Lydia Au, Michael Wai Kit Wong, Beatrix Ling Ling Wong, Li Feng Tan, Matthew Zhixuan Chen, Shu Ee Ng, John Tshon Yit Soong, Richard Jor Yeong Hui, Sing Cheer Kwek, John E. Morley
Summary: This study found that higher FFMI and lower FM/FFM in the high BMI group were associated with better functional outcomes. The prevalence of low muscle mass was higher in the normal BMI group. Females had significantly higher FMI and FM/FFM, while males had significantly higher FFMI. Additionally, the highest FFMI tertile group had better physical function and lower prevalence of sarcopenic obesity and sarcopenia.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuxin Li, Zhen Huang, Yan Gong, Yansong Zheng, Qiang Zeng
Summary: This study explores the relationship between bone mineral density and body composition indicators in Chinese adults aged 50 and above. It found that age, smoking, homocysteine levels, and blood glucose levels are independent risk factors for osteoporosis. Increasing body weight, particularly lean muscle mass, while controlling body fat percentage, can reduce the risk of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Linsey U. Gani, Chanika Sritara, Robert D. Blank, Weiwen Chen, Julia Gilmour, Ruban Dhaliwal, Ranjodh Gill
Summary: Dual-energy X-ray absorptiometry (DXA) is the gold standard method for measuring bone mineral density (BMD), which is strongly associated with fracture risk. The International Society for Clinical Densitometry (ISCD) has released new official positions on follow-up DXA examinations, highlighting the importance of considering the clinical context and individualized testing intervals.
JOURNAL OF CLINICAL DENSITOMETRY
(2024)
Article
Endocrinology & Metabolism
Andia Cheneymann, Josephine Therkildsen, Simon Winther, Louise Nissen, Jesper Thygesen, Bente L. Langdahl, Ellen-Margrethe Hauge, Morten Bottcher
Summary: Osteoporosis is often overlooked, and contrast-enhanced CT scans used for other diseases may overestimate bone mineral density. Adjustments for this effect are necessary before contrast-enhanced images can be clinically utilized for BMD screening.
JOURNAL OF CLINICAL DENSITOMETRY
(2024)