Article
Biochemistry & Molecular Biology
Jakub Szyller, Mariusz Kozakiewicz, Piotr Siermontowski, Dorota Kaczerska
Summary: Simulated dives have significant effects on the antioxidant system, heat shock protein expression, and nitric oxide synthase, but these changes depend on the diving conditions. There is a relationship between the expression of heat shock proteins and the intensity of oxidative stress.
Article
Biochemistry & Molecular Biology
Paulina Emilia Bastian, Agnieszka Daca, Agata Ploska, Alicja Kuban-Jankowska, Leszek Kalinowski, Magdalena Gorska-Ponikowska
Summary: Gliomas are the most common primary tumors of the central nervous system, and glioblastoma is the most prevalent form of malignant glioma. 2-ME has been found to induce nitro-oxidative stress and modulate heat shock proteins, making it a potential candidate for GBM therapy.
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Fang Yuan, Cuiling Zhang, Xianzhu Luo, Xiaokun Shen, Yuezhong Xian
Summary: ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.
CHEMICAL COMMUNICATIONS
(2023)
Article
Veterinary Sciences
Nicole Verhaar, Nicole de Buhr, Maren von Koeckritz-Blickwede, Marion Hewicker-Trautwein, Christiane Pfarrer, Gemma Mazzuoli-Weber, Henri Schulte, Sabine Kaestner
Summary: The study found a reduced apoptotic cell count in the group subjected to Ischaemic postconditioning (IPoC), but none of the other tested variables were significantly affected by IPoC. The clinical relevance and possible protective mechanism of IPoC in equine intestinal ischaemia remain unclear, highlighting the need for further research on its mechanism of action and effects in clinical cases of strangulating colic.
BMC VETERINARY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Shimaa M. Abou-Zeid, Samira H. Aljuaydi, Huda O. AbuBakr, Enas A. Tahoun, Alessandro Di Cerbo, Mahmoud Alagawany, Samah R. Khalil, Mayada R. Farag
Summary: The study demonstrated that astaxanthin effectively alleviated the toxic effects of thiacloprid on the liver and immune system in rats, by improving antioxidant status and reducing inflammatory response. The results suggest that astaxanthin may serve as a promising therapeutic agent for hepato- and immunoprotection in animals exposed to thiacloprid.
Article
Ophthalmology
Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata
Summary: The study revealed a significant association between higher serum ADMA levels and severe glaucoma, which remained significant after adjusting for potential confounders.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Evangelia Kesidou, Christina Bitsina, Athanasios Chatzisotiriou, Paschalis Theotokis, Evgenia Dandi, Despina A. Tata, Evangelia Spandou
Summary: Research found that administering N-acetylcysteine (NAC) can significantly alleviate sensorimotor deficits caused by neonatal hypoxic ischemic (HI) brain injury and maintain this effect into adulthood. Furthermore, NAC can reduce the severity of brain damage and decrease the short-term expression of inducible nitric oxide synthase (iNOS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huayu Zheng, John M. Weaver, Changjian Feng
Summary: The study found that Hsp90 alpha can significantly increase superoxide generation from nNOS mu and nNOS alpha proteins under L-Arg-depleted conditions, and has varying effects on superoxide production by these two nNOS splice variants.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
M. M. Admiraal, D. C. Velseboer, H. Tjabbes, P. Vis, C. Peeters-Scholte, J. Horn
Summary: This study investigated the safety, tolerability, and pharmacokinetics of 2-IB, a selective inhibitor of neuronal nitric oxide synthase, in patients who survived out-of-hospital cardiac arrest (OHCA). The results showed that the administration of 2-IB to OHCA patients is feasible and safe. Pharmacokinetics can be well predicted with correction for renal function on admission.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Zenghui Liang, Huafang Chen, Xuehao Gong, Binbin Shi, Lili Lin, Fangyi Tao, Qilong Wu, Mingling Fang, Hui Li, Cuitao Lu, Helin Xu, Yingzheng Zhao, Bin Chen
Summary: This study investigated the potential of using nitric oxide-loaded microbubbles and ultrasound to treat thromboembolism. The results showed that this treatment significantly reduced thrombus area, increased recanalization rates and blood flow velocities. The treatment also activated endothelial nitric oxide synthase and mitigated oxidative stress and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Young Dong Yoo, Dae-Hee Lee, Hyunjoo Cha-Molstad, Hyungsin Kim, Su Ran Mun, Changhoon Ji, Seong Hye Park, Ki Sa Sung, Seung Ah Choi, Joonsung Hwang, Deric M. Park, Seung-Ki Kim, Kyung-Jae Park, Shin-Hyuk Kang, Sang Cheul Oh, Aaron Ciechanover, Yong J. Lee, Bo Yeon Kim, Yong Tae Kwon
Article
Oncology
Ashok K. Dilly, Brendon D. Honick, Yong J. Lee, Zong S. Guo, Herbert J. Zeh, David L. Bartlett, Haroon A. Choudry
Meeting Abstract
Oncology
Young-Sun Lee, Se Hoon Hong, Dae-Hee Lee, Min J. Jo, Yoo A. Jeong, William T. Kwon, Haroon A. Choudry, David L. Bartlett, Yong J. Lee
Article
Biochemistry & Molecular Biology
Young-Sun Lee, Dae-Hee Lee, So Yeon Jeong, Seong Hye Park, Sang Cheul Oh, Yong Seok Park, Jian Yu, Haroon A. Choudry, David L. Bartlett, Yong J. Lee
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Hima Makala, Simon C. Watkins, M. Haroon A. Choudry, David L. Bartlett, Yong Tae Kwon, Yong J. Lee
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Oncology
Ashokkumar Dilly, Brendon D. Honick, Yong J. Lee, David L. Bartlett, Haroon A. Choudry
Article
Biochemistry & Molecular Biology
Young-Sun Lee, Kalishwaralal Kalimuthu, Yong Seok Park, Xu Luo, M. Haroon A. Choudry, David L. Bartlett, Yong J. Lee
Article
Genetics & Heredity
Ashok K. Dilly, Brendon D. Honick, Yong J. Lee, David L. Bartlett, Haroon A. Choudry
ORPHANET JOURNAL OF RARE DISEASES
(2020)
Article
Medical Laboratory Technology
Ashok K. Dilly, Brendon D. Honick, Robin Frederick, Anulekha Elapavaluru, Sachin Velankar, Hima Makala, T. Kevin Hitchens, Lesley M. Foley, Jianxia Guo, Jan H. Beumer, Lora Heather Rigatti, Yong J. Lee, David L. Bartlett, Haroon A. Choudry
Summary: In patients with appendiceal mucinous carcinoma peritonei, abundant intraperitoneal accumulation of extracellular mucus causes organ dysfunction and hampers chemotherapeutic drug delivery. Combination of bromelain and N-acetylcysteine efficiently lyses extracellular mucus, reduces tumor-related symptoms, and enhances the efficacy of chemotherapy.
TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Kalishwaralal Kalimuthu, Jin Hong Kim, Yong Seok Park, Xu Luo, Lin Zhang, Ja-Lok Ku, M. Haroon A. Choudry, Yong J. Lee
Summary: The combination treatment of glucose deprivation and TRAIL can induce apoptosis in tumor cells through the activation of various caspases, involving the ER stress response pathway and the mitochondria-dependent pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yue Xi, Yanping Li, Pengfei Xu, Sihan Li, Zhengsheng Liu, Hung-Chun Tung, Xinran Cai, Jingyuan Wang, Haozhe Huang, Menglin Wang, Meishu Xu, Songrong Ren, Song Li, Min Zhang, Yong J. Lee, Leaf Huang, Da Yang, Jinhan He, Zhiying Huang, Wen Xie
Summary: The study demonstrates that GLRX reverses PSSG by liberating GSH, inhibiting activation of hepatic stellate cells and liver fibrosis. GLRX depletion exacerbates liver fibrosis, while overexpression of GLRX inhibits PSSG and liver fibrosis development.
Review
Biochemistry & Molecular Biology
Kalishwaralal Kalimuthu, Chenicheri K. Keerthana, Manikandan Mohan, Jaison Arivalagan, Johnson Retnaraj Samuel Selvan Christyraj, Michael A. Firer, Mohammad Haroon Asif Choudry, Ruby John Anto, Yong J. Lee
Summary: This review critically analyzes the molecular mechanisms of selenium metabolism and its potential as a therapeutic target for cancer, highlighting SECISBP2 as a novel prognostic predictor and an alternative target for cancer. Strategies to develop a novel selenium metabolism-based approach for cancer therapy are emphasized, with expectations for extensive clinical use of SECISBP2 as a specific biomarker in cancer therapy. Scientists face additional challenges, including research on anticancer peptides targeting the intracellular protein SECISBP2.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Weilin Liu, Hongqi Chen, Zhi Zhu, Zuqiang Liu, Congrong Ma, Yong J. Lee, David L. Bartlett, Zong-Sheng Guo
Summary: The study found that the combination of the ferroptosis activator Erastin with the oncolytic vaccinia virus could effectively inhibit tumor growth, prolong host survival, and enhance antitumoral immunity in hepatocellular carcinoma and colon cancer models.
Article
Cell Biology
Jin Hong Kim, Abdo J. Najy, Jian Li, Xu Luo, Hyeong-Reh C. Kim, Mohammad Haroon Asif Choudry, Yong J. Lee
Summary: This study investigated the crosstalk between the ferroptotic agent-induced endoplasmic reticulum (ER) stress response and TRAIL-induced apoptosis, and found that Bid plays a critical role in this process.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Letter
Biochemistry & Molecular Biology
Yong J. Lee
