Article
Biochemistry & Molecular Biology
Shuting Liu, Fa Yuan, Mengqing Xiang
Summary: In this study, the effects of multiple factors on ERG were analyzed and compared. The results showed that ERG was influenced by active electrode locations and differences between day and night, while OPs were not affected. Additionally, there were significant differences in visual responses between different mouse strains. These findings provide valuable references for future studies of mammalian visual electrophysiology.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Ophthalmology
Luzia Diegues Silva, Adriana Berezovsky, Solange Rios Salomao, Nivea Nunes Ferraz, Carina Verna, Tarciana de Souza Soares, Lauro Augusto de Oliveira
Summary: This study investigated the impact of BI-Kpro implantation on retinal and visual pathway function using ERG and VEPs. The results showed that the majority of patients had significant improvement in visual function as assessed by electrophysiological testing, indicating a positive effect of BI-Kpro implantation on visual function.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Lucia Ziccardi, Lucilla Barbano, Giulio Antonelli, Ettore Cioffi, Antonio Di Renzo, Valeria Gioiosa, Christian Marcotulli, Andrzej Grzybowski, Carlo Casali, Vincenzo Parisi
Summary: This study found that healthy heterozygous carriers of Friedreich's ataxia (C-FRDA) exhibit dysfunction of retinal elements and abnormal neural conduction along the visual pathways. Several ophthalmological parameters showed significant differences between C-FRDA subjects and the control group.
Article
Clinical Neurology
Marwa A. Elgaly, Hanan Hosny, Hala R. El Habashy, Mona Hussein, Rehab Magdy, Rehab Elanwar
Summary: This study aimed to investigate the effect of chronic increased intracranial pressure (ICP) on the retina and optic nerve in chronic idiopathic intracranial hypertension (IIH) patients. The results showed delayed P100 latencies, decreased amplitudes, and delayed peak times in IIH patients compared to controls. Both optic nerve dysfunction and central retinal changes were identified in chronic IIH patients.
Article
Multidisciplinary Sciences
Sonal Aswin Vyas, Yamunadevi Lakshmanan, Henry Ho-Lung Chan, Tsz-Wing Leung, Chea-Su Kee
Summary: Myopia and astigmatism are major causes of visual impairment. This study used chickens as an animal model to investigate the effects of experimentally induced myopia and astigmatism on retinal functions. The results showed that astigmatism plays a significant role in retinal physiology.
SCIENTIFIC REPORTS
(2022)
Review
Psychiatry
Katelyne Tursini, Irving Remy, Steven Le Cam, Valerie Louis-Dorr, Helene Malka-Mahieu, Raymund Schwan, Gregory Gross, Vincent Laprevote, Thomas Schwitzer
Summary: This study reviews the existing literature to identify key alterations in ERGs and VEP-EEGs of subjects with neurodegenerative and psychiatric disorders, emphasizing the functional role of the visual system. The results showed deficits mainly in the N95 ERG wave and the P100 VEP-EEG wave in Parkinson's, Alzheimer's, and major depressive disorder, reinforcing the link between the retina and the visual cortex for the diagnosis of psychiatric and neurodegenerative diseases.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Ophthalmology
Andrey V. Dmitriev, Alexander A. Dmitriev, Robert A. Linsenmeier
Summary: Retinal neurons utilize a considerable amount of energy for ion movement, and changes in metabolism occur as a result of ion redistribution induced by light. This study compares the effects of steady and flickering light on extracellular potassium concentration ([K+](o)) in the distal and proximal retina. The results demonstrate that steady light decreases metabolism in the distal retina, while flickering light leads to sustained increase of [K+](o) in the proximal retina, indicating enhanced metabolic demand and neurovascular coupling.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Neurosciences
Paul A. A. Constable, Jeremiah K. H. Lim, Dorothy A. A. Thompson
Summary: The retina and brain have similar neurochemistry and neurodevelopmental origins. Retinal findings are being used as potential biomarkers for central nervous system disorders. Despite limitations, functional retinal biomarkers show promise in neurological disorders. This review summarizes functional retinal findings, retinal neurotransmitters, and electrophysiological tests, and suggests that future applications of signal analysis and machine learning algorithms could provide new insights into the pathophysiology and classification of various clinical disorders.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Irving Remy, Florent Bernardin, Fabienne Ligier, Julien Krieg, Louis Maillard, Raymund Schwan, Thomas Schwitzer, Vincent Laprevote
Summary: This study aimed to compare the electrophysiological impairments in retinal and cortical visual functions between patients with schizophrenia and healthy controls. The results showed that patients with schizophrenia exhibited decreased P100 amplitude and increased P100 latency compared to healthy controls. Moreover, a positive correlation was found between P100 latency and retinal N95 latency in the schizophrenia group.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Giulia Righetti, Melanie Kempf, Christoph Braun, Ronja Jung, Susanne Kohl, Bernd Wissinger, Eberhart Zrenner, Katarina Stingl, Krunoslav Stingl
Summary: By characterizing the time-frequency representation of OPs in ACHM individuals and controls, this study found a significantly reduced relative power in ACHM individuals compared to controls, particularly in the time-frequency window >100 Hz. This suggests that the activity of OPs above 100 Hz in ACHM individuals is mainly driven by cones rather than rods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Arne Brombas, Xiangyu Zhou, Stephen R. Williams
Summary: This study reveals the different roles of dendritic excitability in different cell types and its impact on neuronal and circuit computations. Sustained OFF-GCs generate dendritic spikes to transmit the motion signals of visual stimuli, producing a continuous wave of action potential firing, while transient OFF-GCs have passive dendrites and cannot generate dendritic spikes, leading to fragmented signal representation.
Article
Ophthalmology
Julie Racine, Richard Golden
Summary: Galloway-Mowat syndrome (GAMOS) is a rare condition characterized by nephrotic syndrome, brain anomaly, and developmental delays. This study investigated abnormal retinal function in a female patient diagnosed with GAMOS due to a mutation in the WDR73 gene, revealing significant deficits affecting both cone and rod photoreceptor pathways. These findings suggest that retinal functional anomalies may serve as a potential biomarker in patients with GAMOS.
DOCUMENTA OPHTHALMOLOGICA
(2021)
Article
Neurosciences
Xin Xie, Kang Feng, Juan Wang, Min Zhang, Jing Hong, Haolin Zhang
Summary: Alcohol addiction can impair the visual pathway and cause vision decline. Visual electrophysiology tests can detect early retinal and optic nerve dysfunction caused by alcohol addiction. Our study found significant changes in visual electrophysiological parameters in alcohol addicts, providing a non-invasive tool to evaluate their visual pathway conditions and guide treatment.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Article
Ophthalmology
Tarciana de Souza Soares, Adriana Berezovsky, Paula Yuri Sacai, Arthur Gustavo Fernandes, Daniel Martins Rocha, Carina Verna, Patricia de Freitas Dotto, Sung Eun Song Watanabe, Solange Rios Salomao
Summary: This study investigated the diagnostic contribution of grating visual acuity (GVA) measured by sweep pattern-reversal visually evoked potentials (SPRVEP) in unexplained visual loss (UVL). The results showed that GVA had good diagnostic validity in discriminating UVL patients from healthy controls and patients with organic visual loss.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Katie K. N. Tran, Vickie H. Y. Wong, Jeremiah K. H. Lim, Ali Shahandeh, Anh Hoang, David Finkelstein, Bang Bui, Christine T. O. Nguyen
Summary: This study aims to characterize the retinal phenotype in a mouse model of PD and investigate the effectiveness of levodopa treatment. The results show that dopaminergic cell number decreases and retinal function deficits are similar to those seen in PD patients. However, structural thinning of the retina is not improved with levodopa treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Livio Narici, Maurizio Paci, Valentina Brunetti, Adele Rinaldi, Walter G. Sannita, Simone Carozzo, Angelo DeMartino
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2013)
Article
Oncology
Simone Carozzo, Dieter Schardt, Livio Narici, Stephanie E. Combs, Juergen Debus, Walter G. Sannita
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2013)
Article
Psychology, Biological
Simone Carozzo, Cristina Martinoli, Walter G. Sannita
JOURNAL OF PSYCHOPHYSIOLOGY
(2014)
Article
Engineering, Biomedical
C. La Tessa, T. Berger, R. Kaderka, D. Schardt, S. Burmeister, J. Labrenz, G. Reitz, M. Durante
PHYSICS IN MEDICINE AND BIOLOGY
(2014)
Review
Clinical Neurology
Antonio Cerasa, Francesco Arcuri, Luigina Maria Pignataro, Sebastiano Serra, Demetrio Messina, Simone Carozzo, Antonio Biafora, Caterina Ceraudo, Luca Abbruzzino, Loris Pignolo, Giuseppina Basta, Paolo Tonin
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Engineering, Biomedical
Simone Carozzo, Sebastiano Serra, Loris Pignolo, Paolo Tonin, Antonio Cerasa
MEDICAL ENGINEERING & PHYSICS
(2020)
Article
Neurosciences
Loris Pignolo, Giuseppina Basta, Simone Carozzo, MariaConcetta Bilotta, Maria Rosaria Todaro, Sebastiano Serra, Irene Ciancarelli, Paolo Tonin, Antonio Cerasa
Article
Neurosciences
Francesco Riganello, Martina Vatrano, Simone Carozzo, Miriam Russo, Lucia Francesca Lucca, Maria Ursino, Valentina Ruggiero, Antonio Cerasa, Camillo Porcaro
Summary: This study aimed to observe fluctuations in EEG and HRV parameters, finding higher values of PSDalpha, alpha/theta, etc for HC individuals in the morning, and significant differences between groups in CI, PSDalpha, PSDtheta, etc in the afternoon.
Article
Neurosciences
Simone Carozzo, Walter G. Sannita
Summary: The study observed linear and inverted-U distributions of electrophysiological responses to visual contrast stimulation in humans, possibly related to stochastic resonance models. Replication in larger samples is needed, further research on the mechanisms of neuronal synchronization and visual processing is warranted.
IBRO NEUROSCIENCE REPORTS
(2021)
Article
Medicine, General & Internal
Simone Carozzo, Martina Vatrano, Francesco Coschignano, Riccardo Battaglia, Rocco Salvatore Calabro, Loris Pignolo, Marianna Contrada, Paolo Tonin, Antonio Cerasa, Andrea Demeco
Summary: This study evaluated the effects of visual feedback training on motor recovery in postoperative patients with a total knee replacement (TKR). The results showed that applying visual feedback training in addition to traditional rehabilitation strategies improved knee function and motor control in TKR patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Loris Pignolo, Sebastiano Serra, Giuseppina Basta, Simone Carozzo, Francesco Arcuri, Luigina Maria Pignataro, Irene Ciancarelli, Paolo Tonin, Antonio Cerasa
Article
Health Policy & Services
Sherry Ball, Michelle Montpetite, Christine Kowalski, Zach Gerdes, Glenn Graham, Susan Kirsh, Julie Lowery
JOURNAL OF INTEGRATED CARE
(2017)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)