期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 55, 期 -, 页码 612-626出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.05.014
关键词
Schizophrenia; Psychosis; Inflammation; Oxidative stress; Immune system; Antiinflammatory drugs
资金
- Univ. Complutense de Madrid
- Univ. de Barcelona
- Spanish Ministries of Science and Innovation and of Economy and Competitiveness, Health - ISCIII (CIBERSAM, FIS, Instituto de Investigacion Sanitaria) [Imas12]
- Fondo Europeo de Desarrollo Regional FEDER, Union Europea, Un manera de hacer Europa
- Autonomous Government of Madrid [2014SGR441]
- Autonomous Government of Catalonia [2014SGR441]
- Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS)
- European Union
- Foundation Mutua Madrilena
- Foundation Alicia Koplowitz
- Foundation Centre Esther Koplowitz
- Foundation Caja Navarra
- National Center of Competence in Research (NCCR) SYNAPSY - The Synaptic Bases of Mental Diseases - Swiss National Science Foundation
- Avina Foundation
In the past decade, there has been renewed interest in immune/inflammatory changes and their associated oxidative/nitrosative consequences as key pathophysiological mechanisms in schizophrenia and related disorders. Both brain cell components (microglia, astrocytes, and neurons) and peripheral immune cells have been implicated in inflammation and the resulting oxidative/nitrosative stress (O&NS) in schizophrenia. Furthermore, down-regulation of endogenous antioxidant and anti-inflammatory mechanisms has been identified in biological samples from patients, although the degree and progression of the inflammatory process and the nature of its self-regulatory mechanisms vary from early onset to full-blown disease. This review focuses on the interactions between inflammation and O&NS, their damaging consequences for brain cells in schizophrenia, the possible origins of inflammation and increased O&NS in the disorder, and current pharmacological strategies to deal with these processes (mainly treatments with anti-inflammatory or antioxidant drugs as add-ons to antipsychotics). (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据