Article
Medicine, General & Internal
Hertzel C. Gerstein, Naveed Sattar, Julio Rosenstock, Chinthanie Ramasundarahettige, Richard Pratley, Renato D. Lopes, Carolyn S. P. Lam, Nardev S. Khurmi, Laura Heenan, Stefano Del Prato, Leanne Dyal, Kelley Branch
Summary: The trial compared the cardiovascular and renal outcomes of weekly injections of efpeglenatide versus a placebo in participants with type 2 diabetes and a history of cardiovascular disease or current kidney disease. The study found that the risk of cardiovascular events was lower with efpeglenatide treatment, and a composite renal outcome event was also reduced.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Bertram Pitt, Gerasimos Filippatos, Rajiv Agarwal, Stefan D. Anker, George L. Bakris, Peter Rossing, Amer Joseph, Peter Kolkhof, Christina Nowack, Patrick Schloemer, Luis M. Ruilope
Summary: Finerenone therapy improved cardiovascular outcomes in patients with type 2 diabetes and stage 2 to 4 CKD with moderately elevated albuminuria or stage 1 or 2 CKD with severely elevated albuminuria, compared to placebo. The risk of the primary outcome event was significantly lower in the finerenone group, primarily driven by a reduction in hospitalization for heart failure.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yulia Gennadevna Samoilova, Mariia Vladimirovna Matveeva, Olga Sergeevna Tonkih, Dmitry Anatolievich Kudlay, Oxana Alekseevna Oleynik, Stephen Olaide Aremu, Oksana Yurievna Kilina, Alexander Federovich Kanev, Olga Mihailovna Gerget
Summary: The study focuses on assessing the symmetry of structural, metabolic, and neurovascular changes in the brain in patients with type 1 diabetes and cognitive impairment, using modern neuroimaging methods. Early preclinical predictive diagnostics can help detect impaired vascularization and brain metabolism in this group of patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biology
Botond Antal, Liam P. McMahon, Syed Fahad Sultan, Andrew Lithen, Deborah J. Wexler, Bradford Dickerson, Eva-Maria Ratai, Lilianne R. Mujica-Parodi
Summary: This study analyzed neuroimaging and cognitive data from a large cohort of individuals with type 2 diabetes mellitus (T2DM) and healthy controls. The findings show that T2DM is associated with significant cognitive deficits and structural and functional brain changes, with overlap with aging effects. The duration of the disease is linked to more severe neurodegeneration. Treatment with metformin does not improve neurocognitive outcomes.
Article
Endocrinology & Metabolism
Justin B. Echouffo-Tcheugui, Arnaud D. Kaze, Gregg C. Fonarow, Sam Dagogo-Jack
Summary: In individuals with type 2 diabetes, severe hypoglycemia is independently associated with a higher risk of incident heart failure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Anna Frey, Gyorgy A. Homola, Carsten Henneges, Larissa Muhlbauer, Roxane Sell, Peter Kraft, Maximilian Franke, Caroline Morbach, Marius Vogt, Wolfgang Mullges, Georg Ertl, Laszlo Solymosi, Lukas Pirpamer, Reinhold Schmidt, Mirko Pham, Stefan Stork, Guido Stoll
Summary: In patients with mild HF, reduced hippocampal volume at baseline was associated with impaired cognitive function, but no accelerated deterioration in cognition and brain atrophy was observed over a mid-term period of three years. The only decline in cognition during this period was in the domain of intensity of attention.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Anna Frey, Gyoergy A. Homola, Carsten Henneges, Larissa Muewhlbauer, Roxane Sell, Peter Kraft, Maximilian Franke, Caroline Morbach, Marius Vogt, Wolfgang Muellges, Georg Ertl, Laszlo Solymosi, Lukas Pirpamer, Reinhold Schmidt, Mirko Pham, Stefan Stoerk, Guido Stoll
Summary: In patients with chronic heart failure, reduced hippocampal volume at baseline is associated with impaired cognitive function, but no accelerated deterioration in cognition and brain atrophy was evident over a three-year mid-term period. Cognitive function remained stable during the observation period, with only a slight decline in attention intensity.
EUROPEAN HEART JOURNAL
(2021)
Article
Endocrinology & Metabolism
Hertzel C. Gerstein, Sibylle Hess, Brian Claggett, Kenneth Dickstein, Lars Kober, Aldo P. Maggioni, John J. V. McMurray, Jeffrey L. Probstfield, Matthew C. Riddle, Jean-Claude Tardif, Marc A. Pfeffer
Summary: This study used protein biomarkers to identify individuals with type 2 diabetes who are at high risk for cardiovascular outcomes and death. The results showed that NT-proBNP and other proteins can independently predict these outcomes in this population. Adding additional biomarkers only slightly improved the predictive value of NT-proBNP.
Article
Medicine, General & Internal
Mi Zhou, Duo Huang, Yangyang Cheng, Yee Man Lau, Wing Hon Lai, Yuk-Ming Lau, JoJo Hai, Chu Pak Lau, Esther W. Chan, Wen Sheng Yue, Ming-Liang Zuo, Li Xue Yin, Yingqing Feng, Ning Tan, Jiyan Chen, Xin Li Li, Hung Fat Tse, Chi Ho Lee, Wing-Sun Chow, Chung Wah Siu, Chun Ka Wong
Summary: This study implemented screening for left ventricular dysfunction in patients with type 2 diabetes mellitus and found a small percentage of patients at high risk for heart failure. Male gender, prior stroke, chronic kidney disease, and newly detected atrial fibrillation were significantly associated with elevated NT-proBNP levels. The study suggests that NT-proBNP and ECG screening can aid in early detection of cardiovascular complications and improve long-term outcomes.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Sanjoy K. Paul, Jonathan E. Shaw, Peter Fenici, Olga Montvida
Summary: This study aimed to explore the risks and mediation effects of developing chronic kidney disease (CKD) and heart failure (HF) in young- and usual-onset type 2 diabetes (T2D) among White Americans (WAs) and African Americans (AAs). The study found that AAs had a higher risk of developing CKD and HF compared to WAs, and CKD had a greater mediation effect on the HF risk difference between ethnicities compared to HF on CKD risk difference.
Article
Cardiac & Cardiovascular Systems
C. H. Lee, M. Z. Wu, D. T. W. Lui, C. H. Y. Fong, Q. W. Ren, S. Y. Yu, M. M. A. Yuen, W. S. Chow, J. Y. Huang, A. Xu, K. H. Yiu, K. S. L. Lam
Summary: This study found that serum TSP2 levels were independently associated with incident heart failure and deterioration in diastolic function in patients with type 2 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Neurosciences
Joana Crisostomo, Joao V. Duarte, Nadia Canario, Carolina Moreno, Leonor Gomes, Miguel Castelo-Branco
Summary: Type 2 diabetes affects brain structure, specifically cortical gyrification. This study investigated the impact of variations in glycemic profile over time on gyrification in individuals with type 2 diabetes. The findings suggest that glycemic control might influence gyrification in this metabolic disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Tianqi Zhang, Marnie Shaw, Nicolas Cherbuin
Summary: This study systematically reviews and estimates the association between type 2 diabetes mellitus (T2DM) and brain volumetric differences and atrophy. The results show that individuals with T2DM have smaller total and regional brain volumes, as well as greater brain atrophy over time. Meta-regression analysis suggests that diabetes-related brain volume differences start occurring in early adulthood, decrease with age, and increase with diabetes duration. These findings highlight the urgent need to develop interventions to reduce the risk of T2DM for brain health.
DIABETES & METABOLISM JOURNAL
(2022)
Review
Endocrinology & Metabolism
Mads C. J. Barloese, Christian Bauer, Esben Thade Petersen, Christian Stevns Hansen, Sten Madsbad, Hartwig Roman Siebner
Summary: Type 2 diabetes causes long-term damage in multiple organs, including the brain. Cognitive decline is an independent risk factor for diabetes, and changes in neurovascular coupling may serve as a clinical marker for the development of cognitive decline.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Min Zhuo, Elvira D'Andrea, Julie M. Paik, Deborah J. Wexler, Brendan M. Everett, Robert J. Glynn, Seoyoung C. Kim, Elisabetta Patorno
Summary: The use of SGLT-2 inhibitors is associated with a reduced risk of incident atrial fibrillation in older adults with type 2 diabetes.
Article
Cardiac & Cardiovascular Systems
Tracy L. Hammonds, Emily C. Gathright, Carly M. Goldstein, Marc S. Penn, Joel W. Hughes
Article
Cardiac & Cardiovascular Systems
Michael L. Alosco, Mary Beth Spitznagel, Ronald Cohen, Lawrence H. Sweet, Lisa H. Colbert, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2014)
Article
Psychology, Clinical
Krysten K. Fulcher, Michael L. Alosco, Lindsay Miller, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence Sweet, Lisa H. Colbert, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad
Article
Cardiac & Cardiovascular Systems
Misty A. W. Hawkins, Emily C. Gathright, John Gunstad, Mary A. Dolansky, Joseph D. Redle, Richard Josephson, Shirley M. Moore, Joel W. Hughes
Article
Peripheral Vascular Disease
Robert D. Brook, Lawrence J. Appel, Melvyn Rubenfire, Gbenga Ogedegbe, John D. Bisognano, William J. Elliott, Flavio D. Fuchs, Joel W. Hughes, Daniel T. Lackland, Beth A. Staffileno, Raymond R. Townsend, Sanjay Rajagopalan
Article
Geriatrics & Gerontology
Michael L. Alosco, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence H. Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2014)
Article
Cardiac & Cardiovascular Systems
Misty A. W. Hawkins, John Gunstad, Mary A. Dolansky, Joseph D. Redle, Richard Josephson, Shirley M. Moore, Joel W. Hughes
JOURNAL OF CARDIAC FAILURE
(2014)
Article
Cardiac & Cardiovascular Systems
James S. Rosneck, Joel Hughes, John Gunstad, Richard Josephson, Donald A. Noe, Donna Waechter
JOURNAL OF CARDIOVASCULAR NURSING
(2014)
Article
Nursing
Michael L. Alosco, Mary Beth Spitznagel, Naftali Raz, Ronald Cohen, Lawrence H. Sweet, Lisa H. Colbert, Richard Josephson, Manfred van Dulmen, Joel Hughes, Jim Rosneck, John Gunstad
JOURNAL OF CLINICAL NURSING
(2014)
Article
Health Care Sciences & Services
Carly M. Goldstein, Emily C. Gathright, Mary A. Dolansky, John Gunstad, Anthony Sterns, Joseph D. Redle, Richard Josephson, Joel W. Hughes
JOURNAL OF TELEMEDICINE AND TELECARE
(2014)
Article
Clinical Neurology
Michael L. Alosco, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence H. Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2014)
Article
Health Care Sciences & Services
Amy B. Petrinec, Joel W. Hughes, Melissa D. Zullo, Cindy Wilk, Richard L. George
Summary: The pilot study aims to examine the efficacy of delivering cognitive behavioral therapy through a smartphone mobile health app to reduce PICS-F symptoms in family members of critically ill patients. The study utilizes a repeated-measures longitudinal design, with Bandura's social cognitive theory and a focus on mental health self-efficacy forming the theoretical framework.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Psychology
Cynthia Hunt, Gregory C. Gibson, Anthony Vander Horst, Kimberly A. Cleveland, Craig Wawrosch, Maya Granot, Tyler Kuhn, Christopher J. Woolverton, Joel W. Hughes
Summary: During the pandemic of COVID-19, gender diverse students exhibited lower psychological resilience, higher distress levels, and similar perceived risk compared to their male and female peers, indicating a need for additional support and expanded access to treatment.
PSYCHOLOGY OF SEXUAL ORIENTATION AND GENDER DIVERSITY
(2021)
Article
Psychology, Clinical
David E. Ede, Fawn A. Walter, Joel W. Hughes
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2020)
Article
Psychology, Developmental
Michael L. Alosco, Sarah Garcia, Mary Beth Spitznagel, Manfred van Dulmen, Ronald Cohen, Lawrence H. Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad
AGING NEUROPSYCHOLOGY AND COGNITION
(2014)