期刊
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
卷 34, 期 5, 页码 543-560出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/13803395.2012.666227
关键词
Chemotherapy; Breast cancer; Pretreatment cognitive impairment; Functional magnetic resonance imaging; Response inhibition
资金
- Canadian Breast Cancer Foundation
Prechemotherapy neuroimaging data are lacking in posttreatment cognitive impairment studies. Breast cancer patients and noncancer controls were scanned prior to chemotherapy during a response inhibition task. Task reaction times and error rates, as well as neuropsychological tests, hospital records, and salivary biomarkers, were investigated, yielding no significant group differences. Significant group differences observed for the functional magnetic resonance imaging (fMRI) data depended on the type of analysis performed, most consistently implicating widespread attenuated activations in patients. The patient group also revealed considerable variability in task-related brain activity. These pretreatment differences highlight the need to understand the effects of confounding variables before considering posttreatment effects.
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