Article
Neurosciences
Bar Richmond-Hacham, Haim Izchak, Tomer Elbaum, Doaa Qubty, Miaad Bader, Vardit Rubovitch, Chaim C. G. Pick
Summary: This study aimed to evaluate the effect of mTBI on cognition in different injury locations and found sex differences in these effects. The results showed that different mTBI impact sites result in dissociable patterns of cognitive deficits, with variations across sexes, time points, and memory domains.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Clinical Neurology
Paul G. Harch
Summary: This systematic review examines the evidence for hyperbaric oxygen therapy in Persistent Postconcussion Syndrome using a dose-analysis based on the scientific definition of hyperbaric oxygen therapy. The results suggest that hyperbaric oxygen therapy at 1.5 ATA can significantly improve symptoms and cognitive function in patients with mild traumatic brain injury Persistent Postconcussion Syndrome, with positive and negative results found at different doses of oxygen and pressure.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Rael T. Lange, Sara M. Lippa, Tracey A. Brickell, Ping-Hong Yeh, John Ollinger, Megan Wright, Angela Driscoll, Jamie Sullivan, Samantha Braatz, Rachel Gartner, Elizabeth Barnhart, Louis M. French
Summary: This study found a significant impact of PTSD on neuropsychological outcomes after MTBI, but no relationship between PTSD and white matter integrity. Concurrent PTSD and MTBI should be considered a risk factor for poor neuropsychological outcomes that requires early intervention.
JOURNAL OF NEUROTRAUMA
(2021)
Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Cell Biology
Sung Ho Jang, You Sung Seo
Summary: Diffusion tensor tractography is a valuable method to evaluate axonal injury in concussion (mTBI) patients. It reveals characteristic features such as tearing, narrowing, and discontinuations of neural tracts, which provide insights into the extent and patterns of axonal injury. Axonal injury in concussion (mTBI) patients is characterized by their occurrence in long neural tracts and multiple injuries. However, the corticospinal tract discontinuation is commonly observed in diffuse axonal injury, while partial tearing and narrowing in subcortical white matter are frequently observed in concussion (mTBI) patients. These differences suggest that the forces causing axonal injury in concussion (mTBI) patients are weaker than those in diffuse axonal injuries. Additionally, the presence of collateral branches in concussion (mTBI) patients indicates a relatively weaker impact on the brain compared to diffuse axonal injury. The characteristics of axonal injury in concussion (mTBI) patients reviewed in this study provide valuable supplementary information for the diagnosis of axonal injury in concussion (mTBI) patients.
NEURAL REGENERATION RESEARCH
(2022)
Review
Psychiatry
Kathryn A. Ritchie, Beth S. Slomine
Summary: Mild traumatic brain injury (mTBI) is a significant public health concern for children. While most children recover within 1 month after mTBI, 10-30% experience lingering neuropsychiatric or neuropsychological symptoms. Factors associated with prolonged recovery include preinjury mental health concerns, female sex, and family characteristics. Early management includes reassurance and brief rest, while specialized evaluation and multimodal therapies are recommended for symptoms lasting more than 4 weeks.
CURRENT OPINION IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Kaisa Maki, Taina Nybo, Marja Hietanen, Antti Huovinen, Ivan Marinkovic, Harri Isokuortti, Susanna Melkas
Summary: Perceived injustice is associated with self-reported symptoms in patients with mild traumatic brain injury (mTBI). Our results suggest that perceived injustice could be a relevant construct to consider in clinical management of patients with mTBI, and it could be a potential target for psychological interventions promoting recovery after mTBI.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2022)
Article
Multidisciplinary Sciences
Mohammed M. Alnawmasi, Sieu K. Khuu
Summary: This study investigated the impact of TBI on the allocation and maintenance of visual attention to multiple moving targets using a multiple object tracking task. The results showed that patients with mild TBI had greater deficits in maintaining visual attention and detecting targets, particularly when the tracking load and distraction increased.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Lisa Cipolotti, James K. Ruffle, Joe Mole, Tianbo Xu, Harpreet Hyare, Tim Shallice, Edgar Chan, Parashkev Nachev
Summary: Cipolotti and colleagues examined fluid intelligence in patients with focal brain lesions and found that performance on Raven's Advanced Progressive Matrices was impaired in patients with frontal lesions, particularly those in the right hemisphere. These findings suggest that a predominantly right frontal network is critical for high-level functions involved in fluid intelligence. The study also highlights the usefulness of Raven's Advanced Progressive Matrices as a clinical index of fluid intelligence and a marker of right frontal lobe dysfunction.
Review
Medicine, General & Internal
Sung-Ho Jang, Min-Jye Cho
Summary: This review paper discusses the application of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) in the diagnosis of traumatic axonal injury (TAI) in individuals with concussion or mild traumatic brain injury (mTBI). While several hundred DTI-based studies have reported TAI in concussion or mTBI, there are fewer case studies focusing on individual patients. The summary of these studies suggests that DTI can be used as a non-invasive tool for determining the presence and severity of TAI in individual patients with concussion or mTBI. However, certain conditions need to be met for an accurate diagnosis, and further studies are required to improve the precision of TAI diagnosis in individual patients.
Article
Psychology, Clinical
Josh W. Faulkner, Deborah L. Snell, Alice Theadom, Susan Mahon, Suzanne Barker-Collo
Summary: The study found that psychological flexibility significantly affects postconcussion symptoms and functional status in individuals with mTBI, serving as an important treatment target in mTBI interventions. Researchers suggest that psychological flexibility is a psychological mechanism that contributes to recovery outcomes in individuals with mTBI.
REHABILITATION PSYCHOLOGY
(2021)
Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Ken Tang, Ayushi Shukla, Adrian Onicas, Sunny Guo, Naomi Goodrich-Hunsaker, Nishard Abdeen, Miriam H. Beauchamp, Christian Beaulieu, Bruce Bjornson, William Craig, Mathieu Dehaes, Quynh Doan, Sylvain Deschenes, Stephen B. Freedman, Bradley G. Goodyear, Jocelyn Gravel, Andree-Anne Ledoux, Roger Zemek, Catherine Lebel
Summary: In this study, the largest sample to date was used to investigate the white matter microstructural changes and their relation to persistent symptoms after pediatric mTBI. The results showed that white matter microstructural changes suggesting neuroinflammation and axonal swelling occurred chronically and continued 6 months post injury in children with mTBI, especially in younger children with persistent symptoms. The white matter microstructure appears more organized in children without persistent symptoms, indicating better clinical outcomes.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
Paola Fuentes-Claramonte, Nuria Ramiro, Llanos Torres, Isabel Argila-Plaza, Pilar Salgado-Pineda, Joan Soler-Vidal, Maria Angeles Garcia-Leon, Auria Albacete, Clara Bosque, Francesco Panicalli, Ester Boix, Josep Munuera, Josep Tristany, Salvador Sarro, Miquel Bernardo, Raymond Salvador, Peter J. McKenna, Edith Pomarol-Clotet
Summary: This fMRI study provides evidence that reduced prefrontal activation, especially in the left anterior frontal cortex, is a brain functional correlate of negative symptoms in schizophrenia. The unexpected finding of reduced inferior parietal cortex activation may reflect its involvement in cognitive control.
NEUROIMAGE-CLINICAL
(2022)
Article
Medicine, General & Internal
Sung Ho Jang, Seong Ho Kim, Hyeok Gyu Kwon
Summary: This study found a high diagnostic sensitivity of traumatic axonal injury (TAI) of the spinothalamic tract (STT) in patients with mild traumatic brain injury (TBI) suffering from central pain symptoms using diffusion tensor tractography (DTT). However, the generalizability of the study results may be limited by the small number of subjects who visited the university hospital and the constraints of DTT technology.
Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mikko J. Pyysalo, Liisa M. Pyysalo, Tanja Pessi, Pekka J. Karhunen, Terho Lehtimaki, Niku Oksala, Juha E. Ohman
ACTA ODONTOLOGICA SCANDINAVICA
(2016)
Article
Critical Care Medicine
Harri Isokuortti, Grant L. Iverson, Anneli Kataja, Antti Brander, Juha Ohman, Teemu M. Luoto
JOURNAL OF NEUROTRAUMA
(2016)
Article
Critical Care Medicine
Heidi Losoi, Noah D. Silverberg, Minna Waljas, Senni Turunen, Eija Rosti-Otajarvi, Mika Helminen, Teemu M. Luoto, Juhani Julkunen, Juha Ohman, Grant L. Iverson
JOURNAL OF NEUROTRAUMA
(2016)
Article
Sport Sciences
Timo Hanninen, Markku Tuominen, Jari Parkkari, Matti Vartiainen, Juha Ohman, Grant L. Iverson, Teemu M. Luoto
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2016)
Article
Clinical Neurology
Heikki Kiiski, Jyrki Tenhunen, Marika Ala-Peijari, Heini Huhtala, Mari Hamalainen, Jaakko Langsjo, Eeva Moilanen, Susanna Narkilahti, Juha Ohman, Jukka Peltola
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2016)
Article
Neurosciences
Lihua Sun, Jari Perakyla, Kaisa M. Hartikainen
FRONTIERS IN HUMAN NEUROSCIENCE
(2017)
Article
Psychology, Clinical
Lihua Sun, Jari Perakyla, Katri Holm, Joonas Haapasalo, Kai Lehtimaki, Keith H. Ogawa, Jukka Peltola, Kaisa M. Hartikainen
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2017)
Article
Neurosciences
Jari Perakyla, Lihua Sun, Kai Lehtimaki, Jukka Peltola, Juha Ohman, Timo Mottonen, Keith H. Ogawa, Kaisa M. Hartikainen
JOURNAL OF COGNITIVE NEUROSCIENCE
(2017)
Article
Critical Care Medicine
Veronica Maki-Marttunen, Venla Kuusinen, Jari Perakyla, Keith H. Ogawa, Maarja Brause, Antti Brander, Kaisa M. Hartikainen
JOURNAL OF NEUROTRAUMA
(2017)
Article
Neurosciences
Venla Kuusinen, Elena Cesnaite, Jari Perakyla, Keith H. Ogawa, Kaisa M. Hartikainen
FRONTIERS IN HUMAN NEUROSCIENCE
(2018)
Article
Neurosciences
Mia Pihlaja, Laura Failla, Jari Perakyla, Kaisa M. Hartikainen
FRONTIERS IN HUMAN NEUROSCIENCE
(2020)
Article
Neurosciences
Venla Kuusinen, Jari Perakyla, Lihua Sun, Keith H. Ogawa, Kaisa M. Hartikainen
Summary: The study revealed a vulnerability to depression-related brain activity pattern in patients with previous MTBI, with the new index eFAA showing potential as a biomarker of altered affective brain functions in MTBI.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Psychiatry
Jari Perakyla, Kaija Jarventausta, Piia Haapaniemi, Joan A. Camprodon, Kaisa M. Hartikainen
Summary: This study assessed executive functions in patients with major depressive disorder before and after electroconvulsive therapy (ECT), finding significant improvement in depression and executive functions post-ECT. Novel indices derived from threat modulation of executive function and working memory show promise as objective biomarkers of depression severity pre-ECT and cognitive outcome post-ECT.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Neurosciences
Kaisa M. Hartikainen
Summary: Research indicates a dominant role of the right hemisphere in emotion, attention, and arousal functions, especially prioritizing emotionally arousing stimuli with survival value. Task performance may be impacted when attention is captured by unpleasant emotional stimuli due to right hemisphere damage or interference.
Article
Psychology, Multidisciplinary
Mikko Erkkila, Jari Perakyla, Kaisa M. Hartikainen
FRONTIERS IN PSYCHOLOGY
(2018)