Article
Clinical Neurology
John R. Sheets, Robert G. Briggs, Isabella M. Young, Michael Y. Bai, Yueh-Hsin Lin, Anujan Poologaindran, Andrew K. Conner, Christen M. O'Neal, Cordell M. Baker, Chad A. Glenn, Michael E. Sughrue
Summary: This study utilized fMRI studies to establish a neuroanatomical model, describing the structural connectivity of the SMA outside of the motor network, and identified four left hemisphere regions of the SMA. Consistent interconnections between these areas were found, as well as connections to other brain regions.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Behavioral Sciences
Annelies van Royen, Eva van Malderen, Maurane Desmeta, Lien Goossens, Sandra Verbeken, Eva Kemps
Summary: This study assessed changes in inhibitory control (IC) during a single session of IC training in adolescents. Results showed that adolescents who received the training had the highest commission error (CE) rates during the training, which significantly decreased after the training. However, there were no differences in CE before compared to after the training. Additionally, there were no differences in reaction time (RT) before, during, or after the training. The experimental group did not show significant differences compared to the control group in CE or RT before, during, or after the training.
Article
Neurosciences
Sophia Bakola, Kathleen J. Burman, Sylwia Bednarek, Jonathan M. Chan, Natalia Jermakow, Katrina H. Worthy, Piotr Majka, Marcello G. P. Rosa
Summary: The study investigated cortical projections to the caudomedial frontal cortex in marmosets, revealing differences in labeled neurons distribution within different areas of 6M, suggesting homologues of SMA and pre-SMA. This indicates that marmosets can be valuable models for studying movement planning and control due to conservation of cortical motor control circuit in simian primates.
Article
Behavioral Sciences
Noham Wolpe, Frank H. Hezemans, Charlotte L. Rae, Jiaxiang Zhang, James B. Rowe
Summary: The pre-supplementary motor area (pre-SMA) plays a central role in the initiation and inhibition of voluntary action. It has been found that the pre-SMA optimizes action selection and inhibition by dynamically adjusting thresholds, but its specific contribution to action inhibition remains unclear.
Article
Clinical Neurology
Ya-Wen Xu, Peng Lin, Pei-Sen Yao, Shu-Fa Zheng, De-Zhi Kang
Summary: This study evaluated the structure and function of corticospinal projection originating from SMA using DTI and TMS, finding that contralesional ACST fibers were more abundant than ipsilesional ACST fibers in patients with SMA tumors. Most patients with SMA tumor experienced temporary akinesia postoperatively, and in a patient with M1 glioma, 741 fibers of ipsilateral ACST and no fibers of ipsilateral CST were detected.
Article
Psychology, Biological
Louisa Kulke, Lena Brummer, Arezoo Pooresmaeili, Annekathrin Schacht
Summary: In this study, it was found that emotional faces, especially happy and angry ones, significantly affect shifts of attention in both overt and covert conditions. The modulation of ERPs by facial expressions was similar regardless of whether eye movements were executed or withheld, suggesting that emotional content enhances both types of attention shifts.
Article
Neurosciences
Salim Al-Wasity, Stefan Vogt, Aleksandra Vuckovic, Frank E. Pollick
Summary: The study used fMRI NF to train healthy participants to self-regulate brain signals, showing a gradual increase in SMA-related activity only in the NF group and shorter reaction times in a Go/No-go task after the NF training. These results suggest that NF can help participants develop greater control over a specifically targeted motor region, with implications for motor skill learning and rehabilitation.
Article
Neurosciences
Konstantina Kilteni, Christian Houborg, Henrik Ehrsson
Summary: The brain compensates for intrinsic delays in sensory feedback by predicting the sensory consequences of movement through a forward model. However, even minimal temporal errors disrupt this predictive attenuation, leading to perceptual and neural changes.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Allan Lohse, Annemette Lokkegaard, Hartwig R. Siebner, David Meder
Summary: Impulsivity refers to acting prematurely or without forethought, and it is a major issue in many neuropsychiatric disorders. The pre-supplementary motor area (pre-SMA) may play a role in inhibitory control and impulsivity. In this study, low-frequency rTMS of the pre-SMA was found to modulate task-related engagement and influence risky choice behavior during sequential gambling, providing evidence for a causal link between pre-SMA activity and impulsive risk-taking behavior.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychology, Developmental
Athina Manoli, Simon P. Liversedge, Edmund J. S. Sonuga-Barke, Julie A. Hadwin
Summary: The study found that elevated ADHD symptoms were associated with more errors and slower saccade latencies for angry faces, while angry faces were linked to faster saccade onsets when anxiety symptoms were high, and this effect prevailed when both anxiety and ADHD symptoms were high.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Clinical Neurology
Jacob S. Young, Andrew J. Gogos, Alexander A. Aabedi, Ramin A. Morshed, Matheus P. Pereira, Samuel Lashof-Regas, Ziba Mansoori, Tracy Luks, Shawn L. Hervey-Jumper, Javier E. Villanueva-Meyer, Mitchel S. Berger
Summary: This study aimed to identify which patients with SMA gliomas would develop a postoperative SMA syndrome. The results showed that more extensive resections involving the posterior SMA region and posterior cingulate gyrus increased the likelihood of postoperative SMA syndrome.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Melina Engelhardt, Giulia Kern, Jari Karhu, Thomas Picht
Summary: The aim of this study was to develop a repetitive nTMS protocol for non-invasive functional mapping of SMA and assure the effects are caused by SMA activation. The study found that stimulation of SMA led to a significant reduction in finger taps and less accurate performance in other tasks compared to M1 stimulation. These error maps can aid preoperative diagnostics in patients with SMA related lesions.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Clinical Neurology
Maria Chiara Piani, Eleonora Maggioni, Giuseppe Delvecchio, Paolo Brambilla
Summary: This review summarizes the current evidence from functional magnetic resonance imaging (fMRI) studies investigating sustained attention in patients with major depressive disorder (MDD). The results indicate quantitative alterations in key brain regions involved in attention, executive control, and default mode networks during attention tasks in MDD patients. However, the generalizability of the results is limited due to heterogeneity in study designs and fMRI acquisition techniques and processing methods.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Arni Kristjansson, Tomas Kristjansson
Summary: Go/No-Go responses in visual search provide different estimates of visual attention compared to standard tasks, leading to a significant impact on prominent visual attention theories. These tasks also shed new light on attentional priming.
Article
Multidisciplinary Sciences
Dominic M. D. Tran, William G. Nicholson, Justin A. Harris, Irina M. Harris, Evan J. Livesey
Summary: This study found that inhibiting motor system activity to former go cues relies on goal-directed cognitive control processes. Under low working memory load, corticospinal excitability to trained stop and go cues was suppressed. Conversely, under high working memory load, cortical suppression to go cues was reduced, indicating the need for executive control mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Developmental
Lisa A. Jacobson, Alison E. Pritchard, Taylor A. Koriakin, Kelly E. Jones, E. Mark Mahone
JOURNAL OF ATTENTION DISORDERS
(2020)
Article
Psychology, Clinical
Lisa A. Jacobson, Luther G. Kalb, E. Mark Mahone
CLINICAL NEUROPSYCHOLOGIST
(2020)
Article
Clinical Neurology
Jewel E. Crasta, Beth S. Slomine, E. Mark Mahone, Stacy J. Suskauer
DEVELOPMENTAL NEUROREHABILITATION
(2020)
Article
Clinical Neurology
Harvey S. Singer, Shelley McDermott, Lisa Ferenc, Mathew Specht, E. Mark Mahone
PEDIATRIC NEUROLOGY
(2020)
Article
Psychology, Clinical
T. Andrew Zabel, Roshni Rao, Lisa A. Jacobson, Alison E. Pritchard, E. Mark Mahone, Luther Kalb
Summary: This study examined the use of subtests from the WISC-5 to identify youth at risk for Intellectual Disability (ID). The findings suggest that the first several subtests of the WISC-5 can be used to predict Full Scale IQ (FSIQ) and determine the need for further assessment.
CLINICAL NEUROPSYCHOLOGIST
(2022)
Article
Clinical Neurology
Y. Shishido, E. M. Mahone, L. A. Jacobson
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2020)
Article
Clinical Neurology
Nicolaas A. Puts, Matthew Ryan, Georg Oeltzschner, Alena Horska, Richard A. E. Edden, E. Mark Mahone
PSYCHIATRY RESEARCH-NEUROIMAGING
(2020)
Article
Clinical Neurology
T. A. Zabel, L. A. Jacobson, A. E. Pritchard, E. M. Mahone, L. Kalb
Summary: Recent events such as the global pandemic have pushed neuropsychologists to expand their capacity for remote assessments. A study evaluated an online methodology for categorizing pediatric patients based on caregiver-reported impairments, identifying four patient subtypes. Pre-appointment classification of patient complexity may enhance efficient triage and personalized assessment strategies in the future.
CHILD NEUROPSYCHOLOGY
(2021)
Article
Neurosciences
Dejan B. Budimirovic, Annette Schlageter, Stela Filipovic-Sadic, Dragana D. Protic, Eran Bram, E. Mark Mahone, Kimberly Nicholson, Kristen Culp, Kamyab Javanmardi, Jon Kemppainen, Andrew Hadd, Kevin Sharp, Tatyana Adayev, Giuseppe LaFauci, Carl Dobkin, Lili Zhou, William Ted Brown, Elizabeth Berry-Kravis, Walter E. Kaufmann, Gary J. Latham
Article
Clinical Neurology
Marie Moore Channell, Laura J. Mattie, Debra R. Hamilton, George T. Capone, E. Mark Mahone, Stephanie L. Sherman, Tracie C. Rosser, Roger H. Reeves, Luther G. Kalb
Summary: This study used the Down Syndrome Cognition Project database to identify three classes of cognitive and behavioral profiles among individuals with Down syndrome. The largest normative class displayed consistent cognition and adaptive behavior, while the cognitive class showed lower scores and more autism symptomatology. The smallest behavioral class exhibited higher rates of maladaptive behavior and autism symptomatology, but similar cognition levels to the normative class. Gender and household income were the only demographic variables to differ among classes.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2021)
Article
Clinical Neurology
C. Chen, K. S. Rosch, K. E. Seymour, D. Crocetti, E. M. Mahone, S. H. Mostofsky
Summary: The study found that boys and girls with ADHD exhibit increased mirror overflow compared to same-sex TD children, with boys with ADHD showing more variable tap times but no diagnostic effect observed in girls.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Article
Neurosciences
Shannon L. Dean, Laura Tochen, Farhan Augustine, Syed F. Ali, Deana Crocetti, Shreenath Rajendran, Mary E. Blue, E. Mark Mahone, Stewart H. Mostofsky, Harvey S. Singer
Summary: Recent studies suggest that the cerebellum plays a significant role in repetitive behaviors, as evidenced by findings in typically developing children and deer mice. Reduced white matter volume in the posterior cerebellar lobule VI-VII was associated with poorer motor control in children with stereotypies, while an increase in anterior vermis gray matter correlated with higher Stereotypy Severity Scores (SSS). In deer mice, a higher volume of the anterior vermal granular cell layer was linked to increased activity levels, while higher cell counts in the dentate nucleus were observed in high activity animals. These findings emphasize the importance of further investigating the role of the cerebellum in repetitive behaviors.
Article
Behavioral Sciences
Farhan Augustine, Mary B. Nebel, Stewart H. Mostofsky, E. Mark Mahone, Harvey S. Singer
Summary: Motor stereotypies are repetitive, purposeless movements that can occur not only in children with neurodevelopmental disorders, but also in typically developing children. This study found reduced functional connectivity between prefrontal cortical and striatal regions in children with primary complex motor stereotypies, which may provide a potential mechanism for the presence and persistence of these behaviors in developmentally normal children.
Article
Clinical Neurology
Erin F. Jones, Alison Pritchard, Lisa A. Jacobson, E. Mark Mahone, T. Andrew Zabel
Summary: Parent-reported satisfaction is important in pediatric neuropsychology, but self-report of patient experience post-assessment has been under-explored. Findings suggest that most referred pediatric patients can independently complete self-report questionnaires and provide varying responses to clinical experiences.
APPLIED NEUROPSYCHOLOGY-CHILD
(2022)
Article
Psychology, Developmental
Ghazala T. Saleem, Jeanne Langan, Jacob McPherson, Beth S. Slomine, E. Mark Mahone, Martha Bridge Denckla, Stacy J. Suskauer
Summary: By conducting an exploratory factor analysis, this study found that the Gaits and Stations variables in the Revised Physical and Neurological Examination of Subtle Signs have construct validity, which can assist in evaluating the constructs of standing postural control in youth with mild neuromotor impairments.
JOURNAL OF MOTOR LEARNING AND DEVELOPMENT
(2021)