期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 49, 期 -, 页码 182-192出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2014.12.011
关键词
Oxytocin; Intranasal administration; Social cognition; Social behavior
资金
- Australian Research Council Linkage Grant [LP110100513]
- National Health and Medical Research Council Project Grant [10436644]
- National Health and Medical Research Council Career Development Fellowship [1061922]
- National Health and Medical Research Council of Australia [1061922] Funding Source: NHMRC
Accumulating evidence demonstrates the important role of oxytocin (OT) in the modulation of social cognition and behavior. This has led many to suggest that the intranasal administration of OT may benefit psychiatric disorders characterized by social dysfunction, such as autism spectrum disorders and schizophrenia. Here, we review nasal anatomy and OT pathways to central and peripheral destinations, along with the impact of OT delivery to these destinations on social behavior and cognition. The primary goal of this review is to describe how these identified pathways may contribute to mechanisms of OT action on social cognition and behavior (that is, modulation of social information processing, anxiolytic effects, increases in approach-behaviors). We propose a two-level model involving three pathways to account for responses observed in both social cognition and behavior after intranasal OT administration and suggest avenues for future research to advance this research field. (C) 2014 Elsevier Ltd. All rights reserved.
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