Review
Nutrition & Dietetics
Tobias Ziegler, Melina Tsiountsioura, Lisa Meixner-Goetz, Gerhard Cvirn, Manfred Lamprecht
Summary: With the increasing elderly population, neurodegenerative diseases are on the rise, making it important to detect brain aging early and slow down its progression. Neurotrophins such as BDNF and NGF, as well as amyloid-beta and tau proteins, play significant roles in cognitive function and aging. Polyphenols, a class of plant-metabolites, have gained attention for their health benefits and anti-oxidative properties in relation to these biomarkers.
Article
Biochemistry & Molecular Biology
Yiyuan Xia, Zhi-Hao Wang, Pai Liu, Laura Edgington-Mitchell, Xia Liu, Xiao-Chuan Wang, Keqiang Ye
Summary: Neurotrophins such as BDNF promote neuronal survival and synaptic plasticity by activating tropomyosin receptor kinases. Reduced levels of BDNF and its receptor TrkB in Alzheimer's disease contribute to cognitive decline. The research shows that the TrkB receptor phosphorylates APP, reducing amyloid-beta production, but this process is disrupted by delta-secretase cleavage in AD.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Hermann Russ, Michele Mazzanti, Chris Parsons, Katrin Riemann, Alexander Gebauer, Gerhard Rammes
Summary: Soluble amyloid beta oligomers are highly toxic to neurons and a major cause of Alzheimer's disease. A new class of drugs, A beta aggregation inhibitors or modulators, aim to stop the formation of toxic A beta oligomers at the source. GAL-201, a novel A beta aggregation modulator, has shown potential as an orally available AD treatment with a superior clinical profile.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Zidan Zhao, Rebecca J. Hood, Lin Kooi Ong, Giovanni Pietrogrande, Sonia Sanchez Bezanilla, Kirby E. Warren, Marina Ilicic, Murielle G. Kluge, Clifford TeBay, Ole P. Ottersen, Sarah J. Johnson, Michael Nilsson, Frederick R. Walker
Summary: This study showed that low oxygen post-conditioning (LOPC) may improve cognition in mice after experimental stroke. LOPC not only enhanced learning and memory, but also reduced neuronal loss, restored vascular deficits, and decreased the severity of amyloid-beta (Aß) burden in the brain. These findings provide further insight into the cognitive benefits of LOPC post-stroke.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Sara Soleimani Asl, Alireza Gharebaghi, Siamak Shahidi, Simin Afshar, Fereshte Kalhori, Kimia Amiri, Fatemeh Mirzaei
Summary: Preconditioning stem cells with deferoxamine before transplantation can enhance the neuroprotective effects of stem cells, increase antioxidant capacity, and improve cell homing efficiency.
Article
Medicine, General & Internal
Teodora Yaneva-Sirakova, Latchezar Traykov, Kiril Karamfiloff, Ivo Petrov, Julieta Hristova, Dobrin Vassilev
Summary: Carotid stenting can affect the levels of neurotrophins, which are important for the survival, development, and function of neurons.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Cong Duc Nguyen, Jaehee Yoo, Sun-Young Hwang, Sung-Young Cho, Myeonghun Kim, Hyemin Jang, Kyoung Ok No, Jeong Cheol Shin, Jae-Hong Kim, Gihyun Lee
Summary: Honeybee venom has antioxidant and neuroprotective effects, alleviating neural oxidative stress caused by amyloid-beta and enhancing cognitive ability and neural cell genesis. Therefore, honeybee venom is of significant importance in the treatment of neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Meiyu Wan, Shengqi Sun, Xiaoke Di, Minghui Zhao, Fengjuan Lu, Zhifei Zhang, Yang Li
Summary: The study confirms that ICA can repair neuronal damage, enhance synaptic plasticity, and ultimately improve learning and memory impairment through the regulation of the BDNF-Tr kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Devaraj Basavarajappa, Caridad Galindo-Romero, Vivek Gupta, Marta Agudo-Barriuso, Veer B. Gupta, Stuart L. Graham, Nitin Chitranshi
Summary: In this review, the recent research progress on the degenerative mechanisms of retinal ganglion cells (RGCs) in glaucoma is discussed. High intraocular pressure is not the sole factor contributing to glaucoma pathogenesis. The balance of pro-survival and pro-death signaling pathways in the retina strongly influences RGC function and survival. Various molecules and regulated cell death pathways are involved in the development of glaucoma.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sareer Ahmad, Myeung Hoon Jo, Muhammad Ikram, Amjad Khan, Myeong Ok Kim
Summary: The study revealed that Luteolin has protective effects against amyloid-beta-induced neuroinflammation, amyloidogenesis, and synaptic dysfunction in mice, potentially through inhibition of JNK signaling and modulation of inflammatory and cell death markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Metin Yesiltepe, Tao Yin, Marc D. Tambini, Lionel Breuillaud, Simone P. Zehntner, Luciano D'Adamio
Summary: This study reveals that specific APP mutations lead to behavioral deficits and alterations in glutamate release, rather than amyloid pathology associated with AD. Furthermore, female rats performed significantly worse than male rats in task performance.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yanran Li, Kai Yin, Yu Diao, Mei Fang, Junliang Yang, Jian Zhang, Hongtao Cao, Xiaoliang Liu, Jie Jiang
Summary: In this study, a simple ionotronic junctionless oxide transistor array with pain-perception abilities is successfully realized. The researchers simulated important pain-perception characteristics of nociceptors and established a graded pain-perception network system. This work may open new avenues for bionic medical machines and humanoid robots.
Article
Engineering, Biomedical
Bibin Anand, Qi Wu, Maryam Nakhaei-Nejad, Govindarajan Karthivashan, Lyudmyla Dorosh, Sara Amidian, Abhishek Dahal, Xiuju Li, Maria Stepanova, Holger Wille, Fabrizio Giuliani, Satyabrata Kar
Summary: Native PLGA nanoparticles show therapeutic potential in the treatment of Alzheimer's disease by suppressing aggregation of beta-amyloid peptides, triggering their disassembly, reducing phosphorylation of tau protein, enhancing neuronal viability, and attenuating memory deficits and A beta levels in animal models of AD.
BIOACTIVE MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Mariana Kulka, Satyabrata Kar
Summary: The study found that native PLGA can inhibit the aggregation of A beta peptides and disassemble existing aggregates, protecting neurons from toxicity associated with Alzheimer's disease pathology at temperatures outside the physiological range. These findings support the unique therapeutic potential of PLGA nanoparticles in the treatment of AD.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Muhammad Ikram, Myeung Hoon Jo, Kyonghwan Choe, Amjad Khan, Sareer Ahmad, Kamran Saeed, Min Woo Kim, Myeong Ok Kim
Summary: Cycloastragenol demonstrated positive effects against oxidative stress, neurogenic dysfunction, MAP kinase activation, mitochondrial apoptosis, and memory impairment in an A beta-induced mouse model of Alzheimer's disease.
Article
Cell Biology
Olga Ya Ivanova, Yulia V. Dobryakova, Sergey V. Salozhin, Viktor A. Aniol, Mikhail V. Onufriev, Natalia V. Gulyaeva, Vladimir A. Markevich
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2017)
Article
Neurosciences
M. I. Zaichenko, V. A. Markevich, G. A. Grigoryan
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2016)
Article
Neurosciences
I. G. Sil'kis, V. A. Markevich
NEUROCHEMICAL JOURNAL
(2017)
Article
Chemistry, Multidisciplinary
A. N. Rodionov, L. V. Snegur, A. A. Simenel, Yu. V. Dobryakova, V. A. Markevich
RUSSIAN CHEMICAL BULLETIN
(2017)
Article
Neurosciences
M. V. Onufriev, Sh. S. Uzakov, S. V. Freiman, M. Yu. Stepanichev, Yu. V. Moiseeva, N. A. Lazareva, V. A. Markevich, N. V. Gulyaeva
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2017)
Article
Neurosciences
M. Zaichenko, G. A. Grigoryan, V. A. Markevich
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2018)
Article
Neurosciences
Yulia V. Dobryakova, Artem Kasianov, Maria I. Zaichenko, Mikhail Y. Stepanichev, Ekaterina A. Chesnokova, Petr M. Kolosov, Vladimir A. Markevich, Alexey P. Bolshakov
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Yulia V. Dobryakova, Olga Y. Ivanova, Vladimir A. Markevich
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2018)
Article
Chemistry, Applied
Alexey N. Rodionov, Lubov V. Snegur, Yulia V. Dobryakova, Mikhail M. Ilyin, Vladimir A. Markevich, Alexander A. Simenel
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Neurosciences
Y. Dobryakova, M. Yu Stepanichev, V. A. Markevich, A. P. Bolshakov
Summary: The role of cholinergic neurotransmission in the hippocampus is still debated, but recent studies indicate that septal cholinergic input could modulate the plasticity of CA3 to CA1 synapses. This study aimed to investigate the role of septal input in the development of long-term potentiation (LTP) in this synapse. The results showed that tetanization of the ventral hippocampal commissure (VHC) induced a larger increase in fEPSP amplitude compared to tetanization of the medial septal area (MSA). Elimination of septal cholinergic neurons abolished LTP development in both experimental series.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Review
Food Science & Technology
Alexey P. Bolshakov, Mikhail Yu. Stepanichev, Yulia V. Dobryakova, Yulia S. Spivak, Vladimir A. Markevich
Article
Neurosciences
M. Zaichenko, Ph Kh Zakirov, V. A. Markevich, G. A. Grigoryan
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2020)
Article
Neurosciences
O. Ya. Ivanova, Y. V. Dobryakova, V. A. Markevich
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2019)
Article
Neurosciences
A. M. Ravodina, I. G. Silkis, V. A. Markevich
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA
(2018)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.