Article
Neurosciences
Wen-Jing Ren, Ya-Fei Zhao, Jie Li, Patrizia Rubini, Zeng-Qiang Yuan, Yong Tang, Peter Illes
Summary: This study found that in a mouse model of major depressive disorder, depression-like behavior can be aggravated by microinjecting the P2X7R agonist ATP or its analog dibenzoyl-ATP into the medial prefrontal cortex, and this effect can be reversed by the P2X7R antagonist JNJ-47965567.
Article
Pharmacology & Pharmacy
Jing Cao, Xin Liu, Jia-Xin Liu, Shuang Zhao, Yue-Xian Guo, Gui-Ying Wang, Xiu-Li Wang
Summary: The study demonstrates the important role of CaMKII-positive neurons in layer II/III of the medial prefrontal cortex in paclitaxel-induced neuropathic pain and anxiety.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
David M. Bortz, Catalina M. Feistritzer, Anthony A. Grace
Summary: This study suggests that the medial prefrontal cortex (mPFC) to medial septum (MS) pathway may be involved in regulating cognitive flexibility and dopamine neuron activity. Activation of the mPFC-MS pathway improves strategy switching, while inhibition produces different effects. The pathway bidirectionally regulates dopamine neuron activity. This study reveals a potential top-down circuit from the prefrontal cortex to the midbrain that can manipulate dopamine activity to promote cognitive flexibility.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Axel Fogaca Rosado, Laura Menegatti Bevilacqua, Eduardo Luiz Gasnhar Moreira, Manuella Pinto Kaster
Summary: This study aimed to evaluate if variability in baseline flexibility can enable differences in coping strategies, changes in neuroplasticity, and behavioral outcomes in responses to chronic social defeat stress (CSDS). The results showed that animals with high behavioral flexibility exhibited changes in their coping strategies during the CSDS protocol, and they also displayed higher dendritic complexity in certain cortical areas. Moreover, high flexibility was associated with better emotional responses and motivation. However, exposure to CSDS reversed the beneficial effects of high flexibility in male mice.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Neurosciences
Johan Alsio, Olivia Lehmann, Colin McKenzie, David E. Theobald, Lydia Searle, Jing Xia, Jeffrey W. Dalley, Trevor W. Robbins
Summary: Across-species studies have found an evolutionarily conserved role for serotonin in flexible behavior, including reversal learning. This study aimed to investigate the contribution of serotonin in the orbitofrontal cortex (OFC) and medial prefrontal cortex (mPFC) to visual discrimination and reversal learning. The findings revealed differential effects of serotonin within the two prefrontal cortex subregions on cognitive flexibility during visual discrimination and reversal learning.
Article
Psychiatry
Sidney Yap, Jessica Luki, Christopher C. Hanstock, Peter Seres, Tami Shandro, Sarah E. C. Hanstock, Alynna Lirette, Huaying (Helen) Zhao, Katherine J. Aitchison, Jean-Michel Le Melledo
Summary: The study found that perimenopause is associated with decreases in MPFC Glu levels, which may contribute to the increased risk of experiencing depression during this period. Further research should focus on assessing MPFC Glu levels in perimenopausal women suffering from MD.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Biology
Geoffrey W. Diehl, A. David Redish
Summary: Decision-making requires different aspects of information and involves multiple cognitive processes. The rodent medial prefrontal cortex (mPFC) is believed to play a central role in these abilities. Previous studies on mPFC function have yielded controversial results, but this study with rats performing an economic decision task revealed four distinct functional domains within mPFC, closely related to anatomical subregions. Dorsal mPFC regions were more involved in processing active decisions, while ventral regions were more engaged in motivational factors.
Article
Biochemistry & Molecular Biology
Xuanyue Ma, Liuren Li, Ziming Li, Zhengyi Huang, Yaorong Yang, Peng Liu, Daji Guo, Yueyao Li, Tianying Wu, Ruixiang Luo, Junyu Xu, Wen-Cai Ye, Bin Jiang, Lei Shi
Summary: The regulation of mRNA translation plays a crucial role in brain development and function. In this study, researchers found that the translation elongation factor eEF2 is involved in controlling protein synthesis and cognitive functions in the hippocampus. They also discovered a novel role for eEF2 in prefrontal cortex excitatory neurons, where its reduction leads to impaired synaptic transmission, decreased spine density, and altered social behavior and anxiety levels. These findings highlight the importance of eEF2 in promoting AMPAR-mediated synaptic transmission and social novelty behavior in the prefrontal cortex.
Article
Health Care Sciences & Services
Atsumi Nitta, Naotaka Izuo, Kohei Hamatani, Ryo Inagaki, Yuka Kusui, Kequan Fu, Takashi Asano, Youta Torii, Chikako Habuchi, Hirotaka Sekiguchi, Shuji Iritani, Shin-ichi Muramatsu, Norio Ozaki, Yoshiaki Miyamoto
Summary: Suppressing Piccolo in the medial prefrontal cortex of mice leads to a reduction in synaptic proteins, electrophysiological impairments, and abnormal behaviors resembling those seen in schizophrenia.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Xiaojun Hou, Fan Yang, Angcheng Li, Debao Zhao, Nengjun Ma, Linying Chen, Suijin Lin, Yuanxiang Lin, Long Wang, Xingxue Yan, Min Zheng, Tae Ho Lee, Xiao Zhen Zhou, Kun Ping Lu, Hekun Liu
Summary: The isomerase Pint is involved in regulating epileptic susceptibility, with its deficiency leading to increased seizure susceptibility in mice. The role of Pint in epilepsy may be related to its impact on the phosphorylation levels of AMPA receptors and CaMKII.
Article
Neurosciences
Christina M. Mecca, Dongman Chao, Guoliang Yu, Yin Feng, Ian Segel, Zhiyong Zhang, Dianise M. Rodriguez-Garcia, Christopher P. Pawela, Cecilia J. Hillard, Quinn H. Hogan, Bin Pan
Summary: The study showed that alterations in endocannabinoid (eCB) signaling in the medial prefrontal cortex (mPFC) are related to the development of depression after pain in rats with traumatic neuropathy (SNI). This suggests a potential mechanism for pain-induced depression involving excessive release of 2-arachidonoylglycerol (2-AG) and loss of CB1R function leading to excessive GABA release in the mPFC.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Yan-xin Che, Xiao-yan Jin, Rong-hua Xiao, Ming Zhang, Xiao-hui Ma, Fei Guo, Yang Li
Summary: In this study, the antidepressant effects of a candidate antidepressant M2 were investigated through experiments involving brain slice recordings and protein expression analysis. The results showed that M2 produced rapid antidepressant effects in the medial prefrontal cortex (mPFC) by enhancing neurotransmission through dopamine D2 receptor-mediated mechanisms.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Neurosciences
Cong-Cong Fu, Xin-Yi Zhang, Liu Xu, Hui-Xian Huang, Shuang Xu, Qiao-Qi Wu, Zhen Wang, Xi Gu, Li-Fang Lin, Song Lin, Ying-Ying Fang, Xiong Cao, Xuemin Wang
Summary: This study suggests that dysregulation of neuronal PPAR gamma in the medial prefrontal cortex may contribute to an increased risk for depression in obese populations.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
David M. Bortz, Catalina M. Feistritzer, Cassidy C. Power, Anthony A. Grace
Summary: This study investigates how the activation of the medial septum (MS) influences dopamine (DA) neuron activity and performance in strategy switching after discrimination training. The results show that MS activation improves the switching of the previously learned strategy and may do so through the regulation of DA neuron responsivity.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Cell Biology
Ji Hyeong Baek, Hyeonwi Son, Jae Soon Kang, Dae Young Yoo, Hye Jin Chung, Dong Kun Lee, Hyun Joon Kim
Summary: This study found that long-term hyperglycemia may lead to disturbances in glutamatergic signaling and neural damages, causing depressive behaviors. Insulin treatment can improve blood glucose levels, but has limited effects on depressive-like behaviors. The changes induced by hyperglycemia in the medial prefrontal cortex (mPFC) are difficult to reverse with insulin treatment alone.
Article
Engineering, Multidisciplinary
Wenzhao Liu, Tomasz Tarasiuk, Mariusz Gorniak, Mehdi Savaghebi, Juan C. Vasquez, Chun-Lien Su, Josep M. Guerrero
IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS
(2019)
Article
Oncology
Lei Zhong, Shu Zhou, Rongsheng Tong, Jianyou Shi, Lan Bai, Yuxuan Zhu, Xingmei Duan, Wenzhao Liu, Jinku Bao, Lingyu Su, Qian Peng
INVESTIGATIONAL NEW DRUGS
(2019)
Article
Agriculture, Multidisciplinary
Junzhu Pang, Xiaoke Wang, Changhui Peng, Yujing Mu, Zhiyun Ouyang, Fei Lu, Hongxing Zhang, Shuoxin Zhang, Wenzhao Liu
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2019)
Article
Environmental Sciences
Yaping Wang, Wenzhao Liu, Gang Li, Weiming Yan, Guangyao Gao
Article
Soil Science
Xin Fu, Jun Wang, Upendra M. Sainju, Fazhu Zhao, Wenzhao Liu
APPLIED SOIL ECOLOGY
(2019)
Article
Soil Science
Xin Fu, Jun Wang, Upendra M. Sainju, Wenzhao Liu
SOIL & TILLAGE RESEARCH
(2019)
Article
Engineering, Biomedical
Dize Li, Yihan Li, Annie Shrestha, Si Wang, Qingqing Wu, Lingjie Li, Chao Guan, Chao Wang, Tiwei Fu, Wenzhao Liu, Yuanding Huang, Ping Ji, Tao Chen
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Physics, Multidisciplinary
Dong-Ni Yang, Zhen-Sheng Zhong, Wen-Zhao Liu, Thitima Rujiralai, Jie Ma
Article
Multidisciplinary Sciences
Wenzhao Liu, Lingyu Su, Xudong Xie, Xuerong Xiang, Jiao Huang, Ping Ji
SCIENTIFIC REPORTS
(2019)
Article
Automation & Control Systems
Wenzhao Liu, Tomasz Tarasiuk, Chun-Lien Su, Mariusz Gorniak, Mehdi Savaghebi, Juan Carlos Vasquez, Josep M. Guerrero
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2019)
Article
Engineering, Electrical & Electronic
Wenzhao Liu, Frede Blaabjerg, Dao Zhou, Shih-Feng Chou
Summary: This article proposes an improved control strategy to enhance the inverter current quality and mitigate active/reactive instantaneous power oscillations. A simplified peak current-limited control strategy is also developed to improve the reliability of the grid-connected system and reduce computation burden. Experimental tests are carried out to verify the effectiveness of the proposed strategy using dSPACE-DS1007 and MATLAB/Simulink.
IEEE JOURNAL OF EMERGING AND SELECTED TOPICS IN POWER ELECTRONICS
(2021)
Review
Computer Science, Information Systems
Tomasz Tarasiuk, Shantha Gamini Jayasinghe, Mariusz Gorniak, Andrzej Pilat, Viknash Shagar, Wenzhao Liu, Josep M. Guerrero
Summary: This paper discusses contemporary problems concerning ship microgrids, focusing on power electronics and power quality issues. It provides an overview of international classification society requirements and other industry standards, emphasizing power quality control recommendations for ship microgrids.
Proceedings Paper
Engineering, Electrical & Electronic
Wenzhao Liu, Dao Zhou, Frede Blaabjerg
2020 IEEE 9TH INTERNATIONAL POWER ELECTRONICS AND MOTION CONTROL CONFERENCE (IPEMC2020-ECCE ASIA)
(2020)
Proceedings Paper
Energy & Fuels
Wenzhao Liu, Dao Zhou, Michael Hartmann, Francesco Iannuzzo, Frede Blaabj Erg
2020 IEEE ENERGY CONVERSION CONGRESS AND EXPOSITION (ECCE)
(2020)
Article
Materials Science, Multidisciplinary
Wenzhao Liu, Li Li, Suni Liu, Bing Liu, Zhaoyang Wu, Jianru Deng
JOURNAL OF MATERIALS CHEMISTRY C
(2019)
Article
Neurosciences
Yang He, Jun Tang, Meng Zhang, Junjie Ying, Dezhi Mu
Summary: This study investigated the protective effects and mechanisms of human placenta derived mesenchymal stem cells (hPMSCs) transplantation in a rat model of hypoxic-ischemic encephalopathy (HIE). The results showed that hPMSCs transplantation reduced apoptosis and improved long-term neurological prognosis. Furthermore, the downregulation of Sema 3A/NRP-1 expression and activation of the PI3K/Akt/mTOR signaling pathway played a key role in the protective effects of hPMSCs.
Article
Neurosciences
Emily L. Isenstein, Edward G. Freedman, Jiayi Xu, Ian A. DeAndrea-Lazarus, John J. Foxe
Summary: This study evaluated electrophysiological discrimination of parametric somatosensory stimuli in healthy young adults to understand how the brain processes the duration of tactile information. The results showed that participants did not electrophysiologically discriminate between 100 and 115 ms, but they exhibited distinct electrophysiological responses when the deviant stimuli were 130, 145, and 160 ms. These findings contribute to a better understanding of tactile sensitivity in different clinical conditions.
Article
Neurosciences
Juliana R. Souza, Ludmila Lima-Silveira, Daniela Accorsi-Mendonca, Benedito H. Machado
Summary: This study demonstrates that A2A receptors play a crucial role in modulating synaptic transmission in the NTS neurons and are required for the enhancement of glutamatergic transmission observed under short-term sustained hypoxia conditions.
Article
Neurosciences
Miki Hashizume, Rina Ito, Rie Suge, Yasushi Hojo, Gen Murakami, Takayuki Murakoshi
Summary: The basolateral amygdaloid complex (BLA) is closely involved in the formation of emotional memories, including both aversive memory and contextual fear memory. Acute sleep deprivation (SD) disrupts the acquisition of tone-associated fear memory in juvenile rats, but has no significant effect on contextual fear memory. Slow network oscillation in the amygdala contributes to the formation of amygdala-dependent fear memory in relation to sleep.
Article
Neurosciences
Qunxian Wang, Shipeng Guo, Dongjie Hu, Xiangjun Dong, Zijun Meng, Yanshuang Jiang, Zijuan Feng, Weihui Zhou, Weihong Song
Summary: GSDME plays a crucial role in the pathogenesis of Alzheimer's disease by regulating the switch from apoptosis to pyroptosis and participating in neuroinflammatory response. Knockdown of GSDME has been shown to improve cognitive impairments, indicating that GSDME could be a therapeutic target for Alzheimer's disease.