☆ 4.5 Article

ASCENDING PARABRACHIO-THALAMO-STRIATAL PATHWAYS: POTENTIAL CIRCUITS FOR INTEGRATION OF GUSTATORY AND ORAL MOTOR FUNCTIONS

NEUROSCIENCE (2015)

期刊

NEUROSCIENCE

卷 294, 期 -, 页码 1-13

出版社

PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.neuroscience.2015.02.045

关键词

parabrachial nucleus; thalamus; corpus striatum; taste; rat

类别

Neurosciences

资金

Asahi Glass Foundation
Takeda Science Foundation
Grant for Promoted Research from Kanazawa Medical University [S2014-9]
[24700833]
[26750043]
[25830034]
[26350592]
Grants-in-Aid for Scientific Research [26350592, 26750043] Funding Source: KAKEN

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

摘要

The medial parabrachial nucleus (MPB) and external part of the medial parabrachial nucleus (MPBE) relay gustatory, oral mechanosensory and other visceral information in the rat brain and reportedly project not only to the parvicellular part of the posteromedial ventral thalamic nucleus (VPMpc) but also to the ventrocaudal part of the intralaminar thalamic nuclei. Generally, the intralaminar thalamic nuclei project topographically to the caudate putamen (CPu); however, it is unclear where the ventrocaudal part of the intralaminar thalamic nuclei projects within the CPu. Thus, we visualized neural pathways from the MPB and MPBE to the CPu via the ventrocaudal part of the intralaminar thalamic nuclei using an anterograde tracer, biotinylated dextran amine, and a retrograde tracer, cholera toxin B subunit. We found that the MPB and MPBE sent a relatively stronger input to the ventrocaudal part of the intralaminar thalamic nuclei such as the oval paracentral thalamic nucleus (OPC), central medial thalamic nucleus (CM) and parafascicular thalamic nucleus (PF) and retroreuniens area (RRe) as compared to the VPMpc. In turn, these thalamic nuclei projected to the ventral part of the CPu with the topographical arrangement as follows: the OPC to the ventrocentral part of the CPu; ventrolateral part of the PF to the ventrolateral part of the CPu; and the caudal part of the CM, ventromedial part of the PF and RRe to the ventromedial part of the CPu. Further, we found that the VPMpc rather projected to the interstitial nucleus of the posterior limb of the anterior commissure than the CPu. The ventral part of the CPu is reported to be involved in jaw movement as well as food and water intake functions. Therefore, these parabrachio-thalamo-striatal pathways that we demonstrated here suggest that gustatory and oral mechanosensory information affects feeding behavior within the ventral part of the CPu. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

主要评分

4.5

评分不足

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning

Li Shen, Guang-Wei Zhang, Can Tao, Michelle B. Seo, Nicole K. Zhang, Junxiang J. Huang, Li I. Zhang, Huizhong W. Tao

Summary: Valence detection and processing in animals are crucial for survival in complex environments. The study shows that somatostatin neurons in the medial septum play a critical role in encoding reward signals and positive valence, contributing significantly to appetitive behaviors and associative learning. This neural pathway provides insights into how rewarding taste signals are transformed and how reward-cue associative learning is mediated in the brain.

NATURE COMMUNICATIONS (2022)