Article
Integrative & Complementary Medicine
Huanhuan Yu, Huilan Tang, Guang Hu, Zhu Chen, Mudan Guo, Bo Jiang, En Zhang, Changhua Hu
Summary: The study revealed that the contents of main compounds were generally higher in traditional decoction of Coptidis Rhizoma than in dispensing granules originating from the same raw materials. Different processing methods of Scutellaria-coptis traditional decoction and dispensing granules resulted in differences in chemical composition and hypoglycemic effects, indicating the need for further research on the substitutability of dispensing granules and traditional decoction.
Article
Food Science & Technology
Narendra Kumar Nagendla, Kathirvel Muralidharan, Malothu Raju, Harshavardhan Mohan, Piramanayagam Selvakumar, Murali Mohan Bhandi, Mohana Krishna Reddy Mudiam, Vaikundamoorthy Ramalingam
Summary: Comprehensive metabolic profiling of Mangifera indica leaf extracts revealed their potential therapeutic application in tissue engineering and regenerative medicine. In vitro studies demonstrated that the extracts promote myoblast cell proliferation and induce myotube formation through oxidative stress. Western blot analysis confirmed the upregulation of myogenic marker proteins, indicating myogenic differentiation. In vivo studies showed that the extracts expedite acute wound repair and improve blood perfusion. The leaves of M. indica can be considered as an excellent therapeutic agent for tissue repair and wound healing applications.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Qing Hou, Yuting Huang, Linhong Jiang, Kai Zhong, Yina Huang, Hong Gao, Qian Bu
Summary: Ascidians are marine sources with unique bioactive compounds and high nutritive content, mainly consisting of glycerophospholipids and glycerolipids. They could potentially be used as health-promoting food for humans due to their high levels of glycerophospholipids.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Shuang Wu, Hui-Min Li, YI-Fan Bing, Yan Zheng, Wen-Lan Li, Xiang Zou, Zhong-Yuan Qu
Summary: The paper investigates the antidepressant quality markers (Q-markers) of Bupleurum scorzonerifolium (BS) using UPLC-ESI-Q-TOF-MS. SSa, SSc, and SSd were confirmed as Q-markers of BS, and the contents of these markers in 10 batches of BS from different origins were determined. This study provides a reliable method for the quality evaluation of BS for depression treatment.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Plant Sciences
Mengmeng Song, Xianjie Sheng, Jianrong Zhang, Xinru Li, Qianyun Dai, Yan Chen, An Kang
Summary: The study aimed to investigate the regulatory effect of SB-CC and its main constituents on the AHR-CYP1A axis in vitro and in vivo. The results suggested that SB-CC exerted dual regulatory effect on the AHR-CYP1A axis by increasing CYP1A expression but simultaneously inhibiting CYP1A activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Renhao Chen, Qi Wang, Zhifeng Li, Dongxu Wang, Shilin Yang, Yulin Feng
Summary: The traditional Chinese medicine complex prescription Tongfengxiaofang (TFXF) has a therapeutic effect on hyperuricemia (HUM) by regulating biochemical indices and gene expression levels in mice. Metabolomics analysis revealed the impact of TFXF on various metabolic pathways.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Plant Sciences
Fan He, Yu-Feng Huang, Wei Dai, Xian-You Qu, Jing-Guang Lu, Chi-Chou Lao, Wen-Hui Luo, Dong-Mei Sun, Mei Wei, Sheng-Yuan Xiao, Ying Xie, Liang Liu, Hua Zhou
Summary: In this study, the TOF-SIMS image analysis technology was used for the first time to detect Chinese herbal medicine. Taking Coptis rhizome as an example, the distribution of nine active compounds in the cross-section of Coptis rhizome was studied. The results showed that these compounds had different distribution patterns in the cross-section and their contents increased with the growth years.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Analytical
Jing Shang, Liang Cao, Yudan Mei, Xi Zhang, Zhipeng Ke, Wenjun Liu, Zhenzhong Wang, Wei Xiao
Summary: The study investigated the influence of vinegar processed Schisandrae Chinensis Fruit on the dissolution of constituents in Ziziphi spinosae Semen when co-decocted, showing a decrease in jujuboside A content. Pre-extracted solvents of vSCF improved the content of JuA in coupled decoction, with 60% ethanol showing the best effect. The transformed compounds of JuA induced by organic acid in vSCF were identified, suggesting a potential for stronger binding affinity toward calmodulin in further pharmacological and pharmacokinetic studies.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Applied
Ridha Ben Said, Mohamed Ali Ben Aissa, Seyfeddine Rahali, Bahoueddine Tangour, Mariusz Kowalczyk, Wieslaw Oleszek, Anna Stochmal, Arafa Hamed
Summary: The present study tentatively elucidated the structure of two acylated polyoxypregnane glycosides from Caralluma quadrangula and revealed their characteristic fragmentation behaviors using mass spectrometry-based methods. The results showed that mass spectrometry provides efficient, sensitive, and selective information for the analysis of pregnane glycosides.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiuyun Li, Chenglun Zhang, Enhui Wu, Liang Han, Xiangliang Deng, Zhongfeng Shi
Summary: This study aimed to investigate the effects and mechanisms of action of Osthole (OST) in breast cancer 4T1 cells. The results showed that OST inhibited cell proliferation, blocked cells from remaining in S-phase, and induced apoptosis. OST mainly affected phospholipid biosynthesis, methyl histidine metabolism, pyrimidine metabolism, and beta-oxidation of very long-chain fatty acid pathways in 4T1 cells, possibly via inhibition of mTOR/SREBP1/FASN signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Applied
Chen He, Jun Cao, Yuyan Bao, Zexin Sun, Zhongyuan Liu, Chuan Li
Summary: A comprehensive lipidomic evaluation was conducted on tilapia muscle, head, and viscera, revealing higher lipid content in head and viscera compared to muscle. The study showed that polyunsaturated fatty acids had higher percentages in phospholipids than in triacylglycerols, with C52:2 and C52:3 identified as the most abundant triacylglycerols. Ultra-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry identified 622, 530, and 513 lipids in the muscle, head, and viscera respectively, with five fatty acids and 33 lipid species considered as potential biomarkers.
Article
Chemistry, Analytical
ShaoJing Liu, Sen Guo, YuFei Hou, ShanShan Zhang, Lu Bai, ChiTang Ho, LiLi Yu, Lin Yao, BingNan Zhao, NaiSheng Bai
Summary: This study investigated the chemical composition differences of 35 oil peony leaves from four provinces in China using methods such as high-performance liquid chromatography (HPLC). Seventeen common characteristic peaks were identified, and the similarity of the samples ranged from 0.864 to 0.999. Multivariate analysis divided the samples into four groups. Ten marker components closely related to quality evaluation were determined. This study provides a reasonable method for the discrimination and quality evaluation of oil peony leaves from different producing areas.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemical Research Methods
Su Guan, Kun Liu, Zimeng Liu, Liping Zhou, Bingjie Jia, Zichen Wang, Yao Nie, Xuyu Zhang
Summary: This study identified potential metabolic biomarkers to improve the diagnostic accuracy of sepsis, through metabolomic profiling and regression analysis. A model incorporating ten metabolic biomarkers and traditional physiological indicators showed better differentiation for sepsis diagnosis. The study suggests metabolomic profiling could be an effective tool for sepsis diagnosis.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Food Science & Technology
Shruti Sharma, Robin Joshi, Dinesh Kumar
Summary: The study investigated and compared the nutritional potential and chemical diversity of different parts of Polygonatum verticillatum, revealing that leaves contain the highest polyphenols and amino acids, while fruits exhibit the highest antioxidant activity. The findings suggest that all parts have similar nutritional potential and utilizing aerial parts instead of rhizomes could prevent overexploitation of the plant.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Ming Cheng, Jiali He, Huaijie Wang, Chuan Li, Gang Wu, Kexue Zhu, Xiaoai Chen, Yanjun Zhang, Lehe Tan
Summary: This study investigated the impact of different solvents and methods on the phenolic profile and antioxidant activity of jackfruit pulp. The results showed significant differences in total phenolic content (TPC) among different extraction methods, with microwave-assisted extraction using 60% ethanol showing the highest TPC and antioxidant activity. Correlation analysis revealed a significant positive correlation between TPC and antioxidant activity. UPLC-ESI-Q-TOF-MS/MS analysis identified 78 phenolic compounds, with 60% ethanol-MAE being the most effective.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)