How apoptotic β-cells direct immune response to tolerance or to autoimmune diabetes: a review

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

Macrophages and  -cells are responsible for CXCR2-mediated neutrophil infiltration of the pancreas during autoimmune diabetes

(2014) J. Diana et al.   EMBO Molecular Medicine

Apoptotic Cells Induce Immunosuppression through Dendritic Cells: Critical Roles of IFN-  and Nitric Oxide

(2014) G. Ren et al.   JOURNAL OF IMMUNOLOGY

Immune modulation in humans: implications for type 1 diabetes mellitus

(2014) Bart O. Roep et al.   Nature Reviews Endocrinology

CTSH regulates  -cell function and disease progression in newly diagnosed type 1 diabetes patients

(2014) T. Floyel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells

(2013) Cong Wu et al.   Cellular & Molecular Immunology

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Candidate genes for type 1 diabetes modulate pancreatic islet inflammation andβ-cell apoptosis

(2013) I. Santin et al.   DIABETES OBESITY & METABOLISM

Efferocytosis Promotes Suppressive Effects on Dendritic Cells through Prostaglandin E2 Production in the Context of Autoimmunity

(2013) Irma Pujol-Autonell et al.   PLoS One

Clearing the Dead: Apoptotic Cell Sensing, Recognition, Engulfment, and Digestion

(2013) A. Hochreiter-Hufford et al.   Cold Spring Harbor Perspectives in Biology

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

The immunobiology of apotransferrin in type 1 diabetes

(2012) K. Mangano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic  -Cell Apoptosis in Type 1 Diabetes

(2012) D. L. Eizirik et al.   DIABETES

Apoptotic cell instillation after bleomycin attenuates lung injury through hepatocyte growth factor induction

(2012) Ye-Ji Lee et al.   EUROPEAN RESPIRATORY JOURNAL

Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

(2012) Julien Diana et al.   NATURE MEDICINE

Murine Myeloid Dendritic Cells That Phagocytose Apoptotic T Cells Inhibit the Immune Response via NO

(2012) Kaili Zhong et al.   PLoS One

Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells

(2011) E E Torr et al.   CELL DEATH AND DIFFERENTIATION

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic  -Cell Apoptosis via Regulation of the BH3-Only Protein Bim

(2011) I. Santin et al.   DIABETES

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

(2011) Mei He et al.   EMBO REPORTS

Allogeneic apoptotic thymocyte-stimulated dendritic cells expand functional regulatory T cells

(2011) Thaís Boccia da Costa et al.   IMMUNOLOGY

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation

(2011) Emmet E. McGrath et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cytosolic DNA sensors regulating type I interferon induction

(2011) Sinead E. Keating et al.   TRENDS IN IMMUNOLOGY

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes

(2010) S. Marin-Gallen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic  -Cells

(2010) E. Roggli et al.   DIABETES

Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+Treg

(2010) Rahul Kushwah et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Global gene expression changes in type 1 diabetes: Insights into autoimmune response in the target organ and in the periphery

(2010) Raquel Planas et al.   IMMUNOLOGY LETTERS

Clearance of apoptotic cells: implications in health and disease

(2010) Michael R. Elliott et al.   JOURNAL OF CELL BIOLOGY

Diabetes mellitus and apoptosis: inflammatory cells

(2009) Aidan Ryan et al.   APOPTOSIS

Beta cell apoptosis in diabetes

(2009) Helen E. Thomas et al.   APOPTOSIS

Gene expression profiles for the human pancreas and purified islets in Type 1 diabetes: new findings at clinical onset and in long-standing diabetes

(2009) R. Planas et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

Apoptotic Dendritic Cells Induce Tolerance in Mice through Suppression of Dendritic Cell Maturation and Induction of Antigen-Specific Regulatory T Cells

(2009) R. Kushwah et al.   JOURNAL OF IMMUNOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

In Situ-Targeting of Dendritic Cells with Donor-Derived Apoptotic Cells Restrains Indirect Allorecognition and Ameliorates Allograft Vasculopathy

(2009) Zhiliang Wang et al.   PLoS One

Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?

(2009) Sylvain Perruche et al.   ARTHRITIS RESEARCH & THERAPY

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

(2008) J. Han et al.   DIABETES

Apoptotic cells induce dendritic cell-mediated suppression via interferon-γ-induced IDO

(2008) Charlotte A. Williams et al.   IMMUNOLOGY

Interferon-  initiates type 1 diabetes in nonobese diabetic mice

(2008) Q. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA