Article
Microbiology
Brittney D. Gimza, Jessica K. Jackson, Andrew M. Frey, Bridget G. Budny, Dale Chaput, Devon N. Rizzo, Lindsey N. Shaw
Summary: Staphylococcus aureus controls infection by producing extracellular proteases, with aureolysin and staphopain A being essential for hypervirulence.
Article
Chemistry, Analytical
Hong Zhao, Yuying Wang, Liangjuan Zhao, Zhizheng Dong, Jiebo Mi, Huabing Zhao, Jing Wang, Jing Zeng, Hongbin Wang, Libing Wang
Summary: A novel strategy for pathogenic bacteria detection based on targeted analysis of characteristic peptides has been successfully applied to the detection of Staphylococcus aureus. The key to the success lies in the identification of reliable characteristic peptides that provide high specificity.
Article
Immunology
Dhanwini Rudraprasad, Mudigunda V. Sushma, Aravind Kumar Rengan, Milind N. Naik, Joveeta Joseph
Summary: In this study, the protein cargo of extracellular vesicles (EVs) in Staphylococcus aureus endophthalmitis was characterized using a mouse model. The researchers identified significant differences in the amounts of certain proteins between the infected and control groups. Annexin A5, cathepsin D, and C5a play important roles in the pathogenesis of endophthalmitis and may serve as prognostic markers.
MICROBES AND INFECTION
(2022)
Review
Immunology
Hamid Reza Jahantigh, Sobhan Faezi, Mehri Habibi, Mehdi Mahdavi, Angela Stufano, Piero Lovreglio, Khadijeh Ahmadi
Summary: Staphylococcus aureus is an opportunistic pathogen that poses a serious threat to human health due to its antibiotic resistance. The development of a prophylactic vaccine against this pathogen is crucial but has faced challenges in clinical trials. Efforts are being made to explore multiple antigens and virulence mechanisms to identify suitable candidates for vaccine development.
Review
Multidisciplinary Sciences
Juan Chen, Huyue Zhou, Jingbin Huang, Rong Zhang, Xiancai Rao
Summary: This review explores the impact of sub-MICs of antibiotics on the virulence of Staphylococcus aureus, focusing on various aspects such as changes in cell morphology, virulence factor expression, bacterial adherence and invasion, biofilm formation, and small-colony variant production. Antibiotics at sub-MIC levels can alter bacterial virulence in S. aureus, leading to deformed cells, abnormal immune responses, and changes in disease development. The study also addresses the mechanisms underlying these antibiotic-induced alterations in virulence.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Immunology
Peng Gao, Yuanxin Wei, Suying Hou, Pok-Man Lai, Han Liu, Sherlock Shing Chiu Tai, Victor Yat Man Tang, Pradeep Halebeedu Prakash, Kong-Hung Sze, Jonathan Hon Kwan Chen, Hongzhe Sun, Xuechen Li, Richard Yi-Tsun Kao
Summary: This study identified the first inhibitor of SaeR, a protein involved in regulating virulence factors in Staphylococcus aureus. The inhibitor, named HR3744, showed in vitro and in vivo effectiveness against S. aureus infections. The findings suggest that SaeR could be a potential target for the development of antivirulence drugs.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Chemistry, Applied
Ines Rodriguez-Canas, Jesus M. Gonzalez-Jartin, Rebeca Alvarino, Amparo Alfonso, Mercedes R. Vieytes, Luis M. Botana
Summary: This study presents a reliable method to quantify 32 mycotoxins in cheese. The method involves a QuEChERS extraction process and UHPLC-MS/MS detection. The method was validated for accuracy and precision, and applied to the analysis of 38 commercial cheese samples. High occurrences of beauvericin and enniatins were found, with ochratoxin A concentrations posing a potential risk to human health in three samples.
Article
Microbiology
James T. Sorrentino, Gregory J. Golden, Claire Morris, Chelsea D. Painter, Victor Nizet, Alexandre Rosa Campos, Jeffrey W. Smith, Christofer Karlsson, Johan Malmstrom, Nathan E. Lewis, Jeffrey D. Esko, Alejandro Gomez Toledo
Summary: Studies have found that sepsis can cause specific alterations in the cellular proteome of organs, and these changes are closely related to disease progression and organ failure. Dysregulated vascular responses may play a potential role in organ failure during sepsis.
Article
Biochemical Research Methods
Yingshan Dong, Xinyu Miao, Yun-Dan Zheng, Jiajia Liu, Qing-Yu He, Ruiguang Ge, Xuesong Sun
Summary: Misuse of antibiotics has caused a serious threat to human health due to the emergence of drug-resistant bacteria. Resistant bacteria exhibit stronger amino acid synthesis and energy storage, while enhancing virulence under iron-restricted stress. This study provides insights into the adaptive mechanisms of bacterial resistance and potential novel drug development for treating drug-resistant bacterial infections.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Microbiology
Jakub M. Kwiecinski, Diamond A. Jelani, Ernesto J. Fuentes, Alexander R. Horswill
Summary: This study describes two novel inhibitors of the two-component regulatory system ArlRS in Staphylococcus aureus and demonstrates their high efficacy and specificity. These inhibitors disrupt the signaling pathway of S. aureus and result in the loss of virulence traits, showing significant therapeutic potential.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Sanghun Kim, Jin-Hyung Lee, Yong-Guy Kim, Yulong Tan, Jintae Lee
Summary: The study found that hydroquinones, especially TBHQ, have inhibitory effects on biofilm formation and virulence factor production by Staphylococcus aureus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Nathanial J. Torres, Devon N. Rizzo, Maria A. Reinberg, Mary-Elizabeth Jobson, Brendan C. Totzke, Jessica K. Jackson, Wenqi Yu, Lindsey N. Shaw
Summary: We have identified two M20B aminopeptidases that play an integral role in the pathogenesis of S. aureus. The deletion of leucine aminopeptidase has been previously shown to attenuate the virulence of S. aureus. In this study, we investigated the role of 10 other aminopeptidases and found that mutations in PepT1 and PepT2 from the M20B family significantly decreased survival and impaired the ability to resist phagocytosis and survive within human macrophages.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Na Zhao, Danhong Cheng, Ziyu Yang, Yao Liu, Yanan Wang, Ying Jian, Hua Wang, Min Li, Taeok Bae, Qian Liu
Summary: By analyzing S. aureus strains, it was found that the low activity of the SaeRS two-component system is an important factor for S. aureus colonization in the nasal cavity of seniors. Seniors have a nasal environment that favors colonization of S. aureus with higher adhesion and lower virulence.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Biochemistry & Molecular Biology
Pietro Speziale, Giampiero Pietrocola
Summary: NETs are essential components of the innate immune system during bacterial infections. Staphylococcus aureus can evade NET-mediated killing through various mechanisms, such as degrading NETs and inhibiting their formation. Understanding the virulence factors involved in NET formation/neutralization could lead to potential therapeutic interventions against this pathogen.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Infectious Diseases
Bingjie Wang, Jingjing Duan, Ye Jin, Qing Zhan, Yanlei Xu, Huilin Zhao, Xinyi Wang, Lulin Rao, Yinjuan Guo, Fangyou Yu
Summary: The study identified the conserved role of mraZ in Staphylococcus aureus, highlighting its essential contribution to virulence and immune evasion. MraZ was found to regulate various virulence genes and may serve as a potential target for anti-virulence therapy.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Plant Sciences
Robert O. Bussey, Amninder Kaur, Daniel A. Todd, Joseph M. Egan, Tamam El-Elimat, Tyler N. Graf, Huzefa A. Raja, Nicholas H. Oberlies, Nadja B. Cech
PHYTOCHEMISTRY LETTERS
(2015)
Article
Biochemical Research Methods
Daniel A. Todd, David B. Zich, Keivan A. Ettefagh, Jeffrey S. Kavanaugh, Alexander R. Horswill, Nadja B. Cech
JOURNAL OF MICROBIOLOGICAL METHODS
(2016)
Article
Plant Sciences
Joshua J. Kellogg, Daniel A. Todd, Joseph M. Egan, Huzefa A. Raja, Nicholas H. Oberlies, Olav M. Kvalheim, Nadja B. Cech
JOURNAL OF NATURAL PRODUCTS
(2016)
Article
Plant Sciences
Martha Leyte-Lugo, Emily R. Britton, Daniel H. Foil, Adam R. Brown, Daniel A. Todd, Jose Rivera-Chavez, Nicholas H. Oberlies, Nadja B. Cech
PHYTOCHEMISTRY LETTERS
(2017)
Article
Chemistry, Multidisciplinary
Iriny Ekladious, Rong Liu, Heng Zhang, Daniel H. Foil, Daniel A. Todd, Tyler N. Graf, Robert F. Padera, Nicholas H. Oberlies, Yolonda L. Colson, Mark W. Grinstaff
Article
Plant Sciences
Travis V. Gulledge, Nicholas M. Collette, Emily Mackey, Stephanie E. Johnstone, Yasamin Moazami, Daniel A. Todd, Adam J. Moeser, Joshua G. Pierce, Nadja B. Cech, Scott M. Laster
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
Article
Microbiology
Agnes Roux, Daniel A. Todd, Jose V. Velazquez, Nadja B. Cech, Abraham L. Sonenshein
JOURNAL OF BACTERIOLOGY
(2014)
Article
Chemistry, Multidisciplinary
Iriny Ekladious, Rong Liu, Nitinun Varongchayakul, Luis A. Mejia Cruz, Daniel A. Todd, Heng Zhang, Nicholas H. Oberlies, Robert F. Padera, Yolonda L. Colson, Mark W. Grinstaff
Article
Multidisciplinary Sciences
Adam R. Brown, Keivan A. Ettefagh, Daniel Todd, Patrick S. Cole, Joseph M. Egan, Daniel H. Foil, Tyler N. Graf, Bryan D. Schindler, Glenn W. Kaatz, Nadja B. Cech
Article
Multidisciplinary Sciences
Daniel A. Todd, Travis V. Gulledge, Emily R. Britton, Martina Oberhofer, Martha Leyte-Lugo, Ashley N. Moody, Tatsiana Shymanovich, Laura F. Grubbs, Monika Juzumaite, Tyler N. Graf, Nicholas H. Oberlies, Stanley H. Faeth, Scott M. Laster, Nadja B. Cech
Article
Cell Biology
Michael R. Williams, Stephen K. Costa, Livia S. Zaramela, Shadi Khalil, Daniel A. Todd, Heather L. Winter, James A. Sanford, Alan M. O'Neill, Marc C. Liggins, Teruaki Nakatsuji, Nadja B. Cech, Ambrose L. Cheung, Karsten Zengler, Alexander R. Horswill, Richard L. Gallo
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Maria Ngu-Schwemlein, John Merle, T'ea Cameron, Charlexia Witcher, Daniel Todd
Summary: The study investigated the role of tryptophan in mercury(II) complexes by designing dicysteinyl peptides with two tryptophan residues. Results showed that the tryptophan residues can participate in mercury(II) coordination interactions, offering insights into designing more effective metal chelating agents.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Letter
Dermatology
Morgan M. Severn, Young-Saeng K. Cho, Haider S. Manzer, Zoie L. Bunch, Ali Shahbandi, Daniel A. Todd, Nadja B. Cech, Alexander R. Horswill
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Microbiology
Alexandra E. Paharik, Corey P. Parlet, Nadjali Chung, Daniel A. Todd, Emilio I. Rodriguez, Michael J. Van Dyke, Nadja B. Cech, Alexander R. Horswill
CELL HOST & MICROBE
(2017)
Article
Microbiology
Daniel A. Todd, Corey P. Parlet, Heidi A. Crosby, Cheryl L. Malone, Kristopher P. Heilmann, Alexander R. Horswill, Nadja B. Cech
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)