Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Silvia Pasquini, Chiara Contri, Stefania Merighi, Stefania Gessi, Pier Andrea Borea, Katia Varani, Fabrizio Vincenzi
Summary: Adenosine plays an important role in regulating CNS activity, and its receptors are promising therapeutic targets for neuropsychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Amir Parsa Abhari, Masoud Etemadifar, Niloufar Yazdanpanah, Nima Rezaei
Summary: N-methyl-D-aspartate receptors (NMDARs) play a crucial role in regulating physiological processes in the brain and nervous system. Dysfunction of NMDARs can contribute to various pathologies, including cell death and brain dysfunction. Research has shown the significant involvement of NMDARs in demyelinating disorders and anti-NMDAR encephalitis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Article
Physiology
Yi-Shiou Tseng, Chun-Hou Liao, Wen-Bin Wu, Ming-Chieh Ma
Summary: The study demonstrates that NMDAR blockade alleviates D-serine-induced renal injury, possibly through the involvement of NOX4-mediated oxidative stress. These findings have important implications for preventing acute renal injury caused by D-serine.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Eva del Valle, Nuria Rubio-Sardon, Carlota Menendez-Perez, Eva Martinez-Pinilla, Ana Navarro
Summary: Neuropsychiatric disorders are a diverse group of pathologies that affect the mental and physical health of individuals. Finding new biomarkers, such as apolipoprotein D, is crucial for diagnosis and treatment of these disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria S. Hadjiagapiou, George Krashias, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
Summary: Synaptic dysfunction and disrupted communication between neuronal and glial cells are essential in the mechanisms of multiple sclerosis. Antibodies to the NR2 subunit of NMDAR were detected in MS patients and were correlated with clinical outcome. Furthermore, there may be a link between NR2 reactivity and anti-coagulant antibody levels in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Katelyn Cuttler, Maryam Hassan, Jonathan Carr, Ruben Cloete, Soraya Bardien
Summary: Synaptopathies are brain disorders characterized by dysfunctional synapses, which are essential for transmitting information between neurons. Neurexins, a type of synaptic cell adhesion molecule, have gained interest due to their association with neuropsychiatric disorders and neurodegenerative disorders. Both changes in neurexin expression and mutations have been implicated in diseases such as autism spectrum disorder and Parkinson's disease.
Review
Cell Biology
Fabrizio Gardoni, Jennifer Stanic, Diego Scheggia, Alberto Benussi, Barbara Borroni, Monica Di Luca
Summary: Autoimmunity plays an expanding role in CNS disorders, with different types of autoantibodies targeting ionotropic glutamate receptors identified in patients with brain disorders. Research has improved our understanding of the effects induced by NMDAR and AMPAR autoantibodies at excitatory glutamatergic synapses. Animal studies have shown that autoantibodies can modulate the localization of target subunits at synapses, leading to functional impairments and behavioral alterations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Rischka, Chrysoula Vraka, Verena Pichler, Sazan Rasul, Lukas Nics, Gregor Gryglewski, Patricia Handschuh, Matej Murgas, Godber M. Godbersen, Leo R. Silberbauer, Jakob Unterholzner, Christoph Wotawa, Ahmed Haider, Hazem Ahmed, Roger Schibli, Thomas Mindt, Markus Mitterhauser, Wolfgang Wadsak, Andreas Hahn, Rupert Lanzenberger, Marcus Hacker, Simon M. Ametamey
Summary: This study reports on the performance characteristics of (R)-C-11-Me-NB1, a radioligand used to map GluN2B-enriched NMDARs in the human brain. The radioligand demonstrated high and heterogeneous uptake and a high test-retest reliability. It shows promise in deepening our understanding of the role of GluN2B-containing NMDARs in neurodegenerative and neuropsychiatric diseases such Alzheimer's disease and major depression.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Regina F. Nasyrova, Aiperi K. Khasanova, Kuanysh S. Altynbekov, Azat R. Asadullin, Ekaterina A. Markina, Arseny J. Gayduk, German A. Shipulin, Marina M. Petrova, Natalia A. Shnayder
Summary: Schizophrenia is a severe mental disorder where current antipsychotic treatments are ineffective for about a third of patients and do not address negative symptoms and cognitive deficits. D-Serine and D-Aspartate are promising biological compounds that may play a role in modulating neurotransmission dysfunction and offer potential for a disease-modifying therapy for treatment-resistant Schizophrenia.
Article
Biochemistry & Molecular Biology
Asami Umino, Hisayuki Iwama, Masakazu Umino, Dai Shimazu, Yuji Kiuchi, Toru Nishikawa
Summary: d-Serine has been shown to play an important role in brain functions through its interaction with NMDAR. The selective destruction of neuronal cell bodies in the medial prefrontal cortex results in a significant decrease in tissue and extracellular d-serine concentrations, suggesting that the prefrontal cortical region contains substantial amounts of d-serine. The reduction in GABA levels in the prefrontal cortex supports the perikarya-selective nature of the lesion.
NEUROCHEMICAL RESEARCH
(2022)
Review
Multidisciplinary Sciences
Jeffrey A. Stogsdill, Corey C. Harwell, Steven A. Goldman
Summary: Astrocytes are crucial for the development, plasticity, and maintenance of neural circuits in the central nervous system. They have diverse functions and play integral roles in regulating neural activity. Dysfunction of astrocytes has been implicated in various neurodegenerative and neuropsychiatric disorders. This review focuses on the contributions of astrocytes to synaptic development and maturation, as well as their role in supporting myelin integrity and potential therapeutic strategies targeting these cells.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Review
Psychiatry
Hiroki Ishiguro, Berhanu Geresu Kibret, Yasue Horiuchi, Emmanuel S. Onaivi
Summary: The endocannabinoid system (ECS) is an important biological system composed of cannabinoid receptors and endocannabinoids, which have diverse physiological effects and potential for treating neuropsychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Herman Wolosker, Inna Radzishevsky
Summary: This study reveals a biochemical pathway for the synthesis of D-glutamate in mammalian cells mediated by promiscuous catalysis of the pyridoxal 5'-phosphate enzyme SDHL, advancing our knowledge on this less-studied D-amino acid in mammals. D-Amino acids may have unique roles in biochemistry, intercellular signaling, and potentially serve as disease biomarkers.
BIOCHEMICAL JOURNAL
(2021)