Article
Oncology
Andrew E. E. Sloan, Charles J. J. Nock, Xiaobu Ye, Robert Buerki, Susan Chang, Glenn Lesser, Andrew Norden, Timothy Cloughesy, Jeffrey Olson, Amber Kerstetter-Fogle, Jeremy Rich, Joy Fisher, Serena Desideri, Naoko Takebe, William Timmer, Stuart Grossman, Michael Prados
Summary: SHH signaling promotes the proliferation and self-renewal of glioma stem cells (GSC). A study on patients with recurrent glioblastoma (GBM) treated with GDC-0449 found that the drug can inhibit the formation and proliferation of GSC, but its clinical efficacy is limited as a single agent. This suggests that the growth and maintenance of GBM may not solely depend on the SHH pathway, and targeting SMO may require combined approaches.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Dermatology
M. Slowinska, M. Dudzisz-Sledz, P. Sobczuk, I Lasinska, A. Pietruszka, B. Cybulska-Stopa, A. Kowalczyk, T. Switaj, I Czarnecka, H. Kosela-Paterczyk, P. Rogala, E. Paluchowska, K. Skladowski, J. Mackiewicz, P. Rutkowski, W. Owczarek
Summary: This retrospective study analyzed the efficacy and safety of vismodegib treatment in 108 patients with locally advanced or metastatic disease. The results showed that vismodegib had a good response rate and improved overall survival in these patients. Female gender was identified as an independent prognostic factor for progression-free survival.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Biochemistry & Molecular Biology
B. S. Manoj, Moni Gupta, M. Iqbal Jeelani, Sachin Gupta
Summary: Climate change has caused long-term changes in temperature and weather patterns, leading to unprecedented drought conditions. This study found that by imposing drought stress and applying chitosan treatment, the antioxidant content of red kidney bean seeds can be improved.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Ngoc Minh Nguyen, Jungsook Cho
Summary: This review discusses the importance of the Hedgehog (Hh) signaling pathway in cancer, the emergence of Hh pathway inhibitors, and the mechanisms of drug resistance. Additionally, strategies to overcome resistance are addressed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hui Wang, Qian Meng, Yiluan Ding, Muya Xiong, Mengying Zhu, Yuanyuan Yang, Haixia Su, Lei Gu, Yechun Xu, Li Shi, Hu Zhou, Naixia Zhang
Summary: The study identified Vismodegib as an inhibitor of USP28 through high-throughput screening, and characterized the interaction between Vismodegib and USP28 using various biophysical and biochemical techniques. It was confirmed that Vismodegib can downregulate levels of substrate proteins by interacting with USP28 and USP25.
Article
Chemistry, Applied
Ilona Sadok, Agnieszka Szmagara, Agnieszka Krzyszczak
Summary: This paper presents a method for determining patulin in berries and stone fruits using ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry and QuEChERS pretreatment. The method was successfully validated for various fruit matrices and showed a high incidence of patulin contamination in moldy fruit samples.
Article
Oncology
Raoul Tibes, Heidi E. Kosiorek, Amylou C. Dueck, Jeanne Palmer, Lisa Sproat, James Bogenberger, Shahrukh Hashmi, Ruben Mesa, William Hogan, Mark R. Litzow, Aref Al-Kali
Summary: In this study, the combination of azacitidine and Sonidegib showed efficacy in newly diagnosed AML/MDS patients, but had limited response in relapsed/refractory cases of myeloid neoplasms.
Article
Food Science & Technology
B. S. Manoj, Moni Gupta, M. Iqbal Jeelani, Sachin Gupta
Summary: This study assessed the application of 0.25% chitosan as seed priming or foliage spray on Phaseolus vulgaris L. grown under restricted irrigations. The results showed that it enhanced the antioxidant potential of dry seed and increased the content of phenolic compounds, particularly ferulic acid.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Natalia Garcia, Ayman Al-Hendy, Edmund C. Baracat, Katia Candido Carvalho, Qiwei Yang
Summary: This study investigated the expression profile of Hedgehog pathway markers in uterine leiomyosarcoma (LMS) cells and the inhibitory effects of targeted drugs on LMS cell behavior. Inhibiting SMO, GLI, and DNMTs showed promising results in reducing LMS proliferation, migration, and invasion, suggesting potential therapeutic targets for this aggressive tumor. Blocking multiple components in the Hedgehog pathway exhibited potentiated effects on inhibiting LMS malignant features, warranting further investigation for clinical applications.
Article
Surgery
Ronan J. Kelly, Amir M. Ansari, Tomoharu Miyashita, Marianna Zahurak, Frank Lay, A. Karim Ahmed, Louis J. Born, Maryam K. Pezhouh, Kevan J. Salimian, Christopher Ng, Aerielle E. Matsangos, Anne-Heloise Stricker-Krongrad, Ken-ichi Mukaisho, Guy P. Marti, Christine H. Chung, Marcia I. Canto, Michelle A. Rudek, Stephen J. Meltzer, John W. Harmon
Summary: Itraconazole significantly reduces the development of esophageal adenocarcinoma and SHH expression in a preclinical animal model of Barrett's Metaplasia. In humans, BE tissue expresses higher levels of SHH, Indian Hedgehog, and bone morphogenic protein compared to normal squamous esophageal epithelium.
Article
Food Science & Technology
Haopeng Dai, Min He, Guilin Hu, Zhongrong Li, Abdulbaset Al-Romaima, Zhouwei Wu, Xiaocui Liu, Minghua Qiu
Summary: The study aimed to investigate the ACE inhibitory effect of bioactive peptides from green coffee beans. Through in vitro and in silico methods, it was found that two peptides have the potential to be used as antihypertensive agents.
Article
Biochemistry & Molecular Biology
Weicheng Wu, Jingqiu Chen, Dandan Yu, Shiguo Chen, Xingqian Ye, Zhiguo Zhang
Summary: Different cooking methods have significant effects on the glucosinolate content in red cabbage, with microwaving and steaming being able to better retain glucosinolates. Boiling, microwaving, steaming, frying, and stir-frying resulted in reductions in glucosinolate levels.
Article
Biochemistry & Molecular Biology
Lu-Ning Sun, Yang Zhao, Zhou-Yi Qian, Xiang-Long Chen, Hong Ma, Yu-Jiao Guo, Hao Shen, Yong-Qing Wang
Summary: In this study, an LC-MS/MS method was developed and validated for the determination of orelabrutinib, zanubrutinib, ibrutinib, and its active metabolite dihydrodiol ibrutinib in human plasma. The method demonstrated good selectivity, precision, accuracy, and other validation parameters. It was successfully applied to quantify the plasma levels of these drugs in clinical patients.
Article
Chemistry, Applied
Yu Hu, Jianxin Li, Alan K. Chang, Yanan Li, Xia Tao, Wenbao Liu, Zhina Wang, Weiping Su, Zehao Li, Xiao Liang
Summary: In this study, six xanthones from mangosteen were found to inhibit the activity of PTP1B, with garcinone E being the most effective inhibitor. These compounds were distributed in eleven tissues, and mangosteen could be a promising source of natural compounds with high PTP1B inhibitory activity.
Article
Chemistry, Multidisciplinary
Yufeng Ma, Fengsen Zhang, Yijing Zhong, Yongchun Huang, Qiangqiang Yixizhuoma, Qiangqiang Jia, Shoude Zhang
Summary: Phosphodiesterase type 5 (PDE5) regulates the duration of cGMP signal by hydrolyzing cGMP to GMP. Inhibiting PDE5A has been effective in treating pulmonary arterial hypertension and erectile dysfunction. A new LC/MS-based enzymatic activity assay without labeling was developed, which quantifies cGMP and GMP to detect PDE5A activity. This method was verified with a fluorescently labeled substrate and a new PDE5A inhibitor with an IC50 value of 870 nM was identified. Overall, this strategy provides a new method for screening PDE5A inhibitors.
FRONTIERS IN CHEMISTRY
(2023)
Article
Meteorology & Atmospheric Sciences
Yao Feng, Hong Wang, Wenbin Liu, Fubao Sun
Summary: Soil moisture has a significant impact on plant transpiration and photosynthesis, as well as on the land energy and water balance. This study examines global soil moisture-climate interactions during the peak growing season from 1982 to 2015. The results show positive interactions between soil moisture and precipitation, evapotranspiration, and negative interactions with temperature. The compounded effect of climate factors strengthens the soil moisture-climate interactions. Precipitation, evapotranspiration, and temperature are the main drivers of soil moisture variations in different regions. The study emphasizes the importance of considering climate factors and their interactions in understanding soil moisture dynamics and its response to climate extremes.
JOURNAL OF CLIMATE
(2023)
Article
Chemistry, Organic
A'lvaro Gutierrez-Bonet, Wenbin Liu
Summary: Using alpha-fluoroalkyl or fluorobenzyl radicals generated from easily accessible alpha-fluorocarboxylic acids, we achieved the rapid synthesis of fluorine-containing building blocks through Giese-type addition reactions. This method allows for the preparation of mono- and difluorinated Michael addition adducts as well as unnatural fluorinated amino acids under mild reaction conditions.
Article
Biotechnology & Applied Microbiology
Chen Jin, Yayu Wu, Haipeng Zhang, Bai Xu, Wenbin Liu, Chunnan Ji, Panpan Li, Zhenni Chen, Bing Chen, Jiayin Li, Xianming Wu, Peipei Jiang, Yali Hu, Zhifeng Xiao, Yannan Zhao, Jianwu Dai
Summary: This study created a linearly ordered spinal cord-like structure by placing human spinal cord neural progenitor cells and spinal cord astrocytes on a linearly ordered collagen scaffold. The structure promoted neural and vascular regeneration, inhibited inflammation and glial scar formation, and facilitated neural circuit reconstruction and motor functional recovery. Therefore, this research is of great importance in the treatment of spinal cord injury.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Microbiology
Yan Ma, Ping Guo, Xueqin Chen, Minhua Xu, Wenbin Liu, Xiaobao Jin
Summary: This study reported for the first time that Achromobacter isolated from the intestinal tract of Periplaneta americana exhibited activity against Klebsiella pneumoniae and could produce antibacterial compounds, laying the foundation for the development of secondary metabolites from insect intestinal microorganisms.
Article
Energy & Fuels
Wen-Bin Liu, Phuong Nguyen Thanh, Ming-Yuan Cho, Thao Nguyen Da
Summary: The hybrid convolution neural network and gated recurrent unit model (CNN-GRU) were developed to categorize the leakage current pulse of the 15 kV HDPE insulator in Taiwan's transmission towers. The CNN-GRU outperformed other deep learning algorithms in terms of several benchmarks, demonstrating significant improvements. This methodology provides comprehensive information about the contamination levels of insulator surfaces based on the characteristics of leakage currents.
Article
Plant Sciences
Wen-Bin Liu, Jing Tang, Jia-Lin Li, Chen Chen, Li Wu, Jun-Sen Li, Yu-Hua Long
Summary: One new chromone (1) and four known alkaloids were isolated from the mangrove endophytic fungus Aspergillus sp. ZJ-68. Their structures were determined by using HRESIMS and NMR spectroscopic analyses. Compound 1 exhibited significant anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 4.094 +/- 0.8 mu M, which was superior to the positive drug indomethacin (IC50=35.8 +/- 0.5 mu M).
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Physical
Wenbin Liu, Yiwei Huang, Guolin Huang, Lijiao Fan, Yuming Xie, Qin Zhang, Jeffery Shi
Summary: The synthesis of magnetic amidoxime-functionalized mesoporous silica (MMS-AO) was achieved through a combination of soft template method and co-condensation method in weak alkali oil/water phase, resulting in a core-shell structure with Fe3O4 as the core for easy recovery. Characterization techniques demonstrated the efficacy of MMS-AO for U(VI) removal, including high sorption capacity, selectivity, and reusability. The sorption process followed Langmuir isotherm and pseudo-second-order kinetic models, with a maximum sorption amount of 236.70 mg.g(-1) achieved at 298 K and pH 5.50 within 90 minutes. Thermodynamic analysis confirmed the spontaneity and endothermic nature of the sorption process, while XPS analysis provided insights into the chelation mechanism between U(VI) and amidoxime groups. (c) 2023 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Organic
Ziyi Chen, Qinyan Cai, Yannick T. Boni, Wenbin Liu, Jiantao Fu, Huw M. L. Davies
Summary: The rhodium-catalyzed enantioselective C-H functionalization of unactivated C-H bonds by donor/acceptor carbene-induced C-H insertion can be extended to substrates containing nitrogen functionality. The rhodium-stabilized donor/acceptor carbenes are generated by rhodium-catalyzed decomposition of aryldiazoacetates. The phthalimido group is the optimal nitrogen protecting group. C-H functionalization at the most sterically accessible site can be achieved using Rh-2(S-2-Cl-5-BrTPCP)(4) as catalyst, while Rh-2(S-TPPTTL)(4) is the most effective catalyst for functionalization at tertiary C-H bonds and for the desymmetrization of N-phthalimidocyclohexane.
Article
Chemistry, Medicinal
Jose Raul Montero Bastidas, Scott L'Heureux, Wenbin Liu, Ken Lee, Abdellatif El Marrouni
Summary: The development of practical synthetic protocols integrating novel technologies allows for rapid and extensive exploration of chemical space in medicinal chemistry. Cross-electrophile coupling (XEC) enables the diversification of an aromatic core with alkyl halides, increasing the sp3 character. In this study, we demonstrate the complementary use of two alternative approaches - either photo- or electro-catalyzed XEC - to access novel tedizolid analogs. The utilization of parallel photochemical and electrochemical reactors with high light intensity and constant voltage results in good conversions and expedited production of a wide range of derivatives.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Xue Jiang, Fangsheng Wu, Xiaoyu Huang, Shan He, Qiaoying Han, Zihua Zhang, Wenbin Liu
Summary: In order to address the shortcomings of detection methods for new psychoactive substances, researchers developed a graphene oxide modified by molecularly imprinted polymers (GO-MIPs). The GO-MIPs showed satisfactory selectivity and stability due to the specific imprinted cavities for 4-MEC. An electrochemical sensor was fabricated using the GO-MIPs, which exhibited high selectivity in detecting 4-MEC over a linear concentration range with a low detection limit. This provides an accurate, efficient, convenient, and sensitive method for public security departments to detect illicit drugs and new psychoactive substances.
Article
Multidisciplinary Sciences
Weiyuan Liu, Bai Xu, Shuaijing Zhao, Shuyu Han, Rui Quan, Wenbin Liu, Chunnan Ji, Bing Chen, Zhifeng Xiao, Man Yin, Yanyun Yin, Jianwu Dai, Yannan Zhao
Summary: This study demonstrates that the covalent interactions between cells and biomaterials can significantly enhance cell adhesion, spreading, and differentiation, and improve the microenvironment for spinal cord injury. Furthermore, the covalent conjugation strategies applied in a rat SCI model showed great potential for neural regeneration.
Article
Computer Science, Interdisciplinary Applications
Wen-Bin Liu, Dong-Jun Ma, Jian-Zhen Qian, Ming-Yu Zhang, An-Min He, Nan-Sheng Liu, Pei Wang
Summary: In this study, a new geometrical method is developed to enhance the accuracy of free-surface particle detection in complex flows. An efficient semi-geometrical method is proposed based on the geometrical method to reduce the computational cost. The accuracy and robustness of the proposed method are demonstrated by performing tests on several model problems.
COMPUTER PHYSICS COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Qin Zhang, Lijiao Fan, Wenbin Liu, Yuming Xie, Jiangang Li, Guolin Huang
Summary: The UiO-66-NH2@Ni-MOF core-shell structure was prepared by in-diffusion growth of 2D Ni-MOF on UiO-66-NH2 using PVP as a structural guide. It was found to have endothermic and spontaneous adsorption properties for U(VI) in aqueous solution. The adsorption capacity was 581.40 mg/g at pH 5.00 and 308 K according to Langmuir model, and the adsorption process followed the pseudo-second-order kinetic model. After five sorption-desorption cycles, the adsorption capacity remained at 83.83% of its original value, indicating its promising potential for repetitive usage.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Medicine, Legal
Hanyue Cui, Ye Xin, Fangqi Cao, Ziye Gan, Yuxiang Tian, Wenbin Liu, Ping Shi
Summary: This study analyzed eight CpG sites in the hTERT promoter region using real-time methylation-specific PCR and found that CpG2, CpG5, and CpG8 were closely related to tumors. The remaining five CpG sites had a large error in predicting age alone, but combining them to establish a model yielded better results with an average age error of 4.35 years. This study provides a reliable and accurate detection method for the DNA methylation status of multiple CpG sites on the hTERT gene promoter, which can be used for the prediction of forensic age and assistant diagnosis of clinical diseases.
Article
Multidisciplinary Sciences
Wenbin Liu, Ertong Li, Lingyan Liu, Fangyuan Tian, Xiongming Luo, Yanqu Cai, Jie Wang, Xiaobao Jin
Summary: In this study, rare actinomycetes were isolated from the gut of Periplaneta americana and screened for anti-fungal activity. Gordonia strain WA8-44 exhibited significant anti-fungal activity and yielded three anti-fungal compounds, including Collismycin A, which showed activity against filamentous fungi for the first time. Molecular docking revealed the potential binding affinities of Collismycin A against Candida albicans target proteins.
