Article
Chemistry, Multidisciplinary
Xucong Huang, Zhenghua Wu, Yanchao Liu, Mengqi Jia, Wenjuan Zhao, Shuowen Wang, Xinhui Jiang, Yuefen Lou, Guorong Fan
Summary: A simple, sensitive, and rapid LC-MS/MS method was developed for the simultaneous determination of BIC, M7, and M8 active metabolites in SD rat plasma. The method showed excellent linearity and accuracy for quantitation in plasma samples. Pharmacokinetic analysis revealed improved parameters in the BIC-NPs group compared to the BIC group, with a significant increase in AUC(0-t) for BIC and a double peak phenomenon observed for M7.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yixin Hu, Jianyuan Wu, Xin Jiang, Guiying Chen, Yang Zhang, Luqin Si, Hongliang Jiang, Jiangeng Huang, Jianying Huang
Summary: A rapid, simple and sensitive LC-MS/MS method was developed and validated to quantify abiraterone and its metabolites in human plasma. The method showed good accuracy, precision and stability, making it suitable for pharmacokinetic studies.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Elena Genova, Marianna Lucafo, Marco Pelin, Veronica Di Paolo, Luigi Quintieri, Giuliana Decorti, Gabriele Stocco
Summary: Thiopurines are commonly used in the treatment of chronic autoimmune conditions and leukemia, but may cause gastrointestinal toxicity. This study investigated the metabolite concentrations of thiopurines in intestinal cells, finding associations between metabolite concentrations and cytotoxicity. The findings suggest that short growth times before treatment should be used to study the association between thiopurine metabolite concentrations and cytotoxicity activity in vitro.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Analytical
Emma Eckernas, Adam Bendrioua, Chiara Cancellerini, Christopher Timmermann, Robin Carhart-Harris, Kurt-Jurgen Hoffmann, Michael Ashton
Summary: A highly sensitive LC-MS/MS method has been developed and validated for the quantification of DMT and its metabolites in human plasma. The method showed good accuracy, precision, sensitivity, and selectivity. It can be applied to future studies aiming to characterize DMT disposition and its relationship to immediate psychedelic or long-term antidepressive effects.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Food Science & Technology
Xuan Zeng, Yuying Zheng, Yan He, Wei Peng, Weiwei Su
Summary: Naringin is a dietary flavonoid glycoside with multiple bioactivities. This study developed a rapid and sensitive method for simultaneous determination of ten flavonoid metabolites of naringin in rat urine. The results revealed the visible individual difference and low urinary recovery of flavonoid metabolites in the excretion of naringin, which may be helpful for further study to understand the in vivo behavior and action mechanism of naringin.
Article
Food Science & Technology
Fulya Tasci, Hale Secilmis Canbay, Mahmut Doganturk
Summary: The study found antibiotic residues in non-compliant milk samples, suggesting that not all milk producers adhere to good veterinary practices.
Article
Chemistry, Analytical
Imoh Etim, Benson Abasifreke, Rongjin Sun, Daniel Kuddabujja, Dong Liang, Ting Du, Song Gao
Summary: This study developed a sensitive LC-MS/MS method for simultaneous quantification of MMF, MPA, MPAG, and AcMPAG. The method showed good linearity and reproducibility, and was successfully applied in a rat PK study.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
Ruirui Chang, Si-Tao Xu, Hao-Wen Jin, Yong-Jie Zhao, Tian-Yu Hu, Guangji Wang, Jiankun Wang, Le Zhen
Summary: A LC-MS/MS method was developed for simultaneous determination of ZL-01 and its metabolites in rat plasma, considering stability issues. The method showed good linearity, precision, and accuracy, and was successfully applied in pharmacokinetic studies. Results suggested rapid metabolism of ZL-01 and identified M8 as a main metabolite after oral absorption.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Alessandro Di Giorgi, Giorgia Sprega, Lourdes Poyatos, Esther Papaseit, Clara Perez-Mana, Annagiulia Di Trana, Maria Rosaria Vari, Francesco Paolo Busardo, Simona Pichini, Simona Zaami, Alfredo Fabrizio Lo Faro, Magi Farre
Summary: The aim of this study was to determine the excretion of methylone and its metabolites in sweat after controlled doses of 50, 100, 150, and 200 mg of methylone were ingested by twelve healthy volunteers in a clinical trial. Methylone and its metabolites, 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone (MDC), were detected in sweat patches using liquid chromatography-tandem mass spectrometry. Methylone and MDC were found in sweat after 2 hours and reached their highest concentration at 24 hours following the administration of doses. However, HMMC was not detectable at any time interval. Sweat has proven to be a suitable matrix for determining the concentration of methylone and its metabolites in clinical and toxicological studies, indicating recent drug consumption.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Zhendong Chen, Liang Li, Yan Zhan, Yifan Zhang, Haiyan Liu, Jianjun Zou, Dafang Zhong
Summary: Henagliflozin is a specific inhibitor of SGLT2 proposed for T2DM treatment. This study identified 8 metabolites of henagliflozin in human plasma and urine, focusing on the glucuronidation and O-deethylation pathways. A LC-MS/MS method was developed for quantification of M5-1, M5-2, and M5-3 in human plasma.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Tengteng Ping, Min Zheng, Pingping Zhang, Tianhao Yan, Xufeng Miao, Ke Wang, Kaoqi Lian
Summary: An analytical method using a 96-well protein precipitation plate combined with HPLC-MS/MS was developed and validated for the simultaneous determination of 12 anti-obesity drugs in human plasma. This method offers advantages of efficient and rapid analysis, simple operation, high accuracy and sensitivity. It can be used for clinically monitoring adverse reactions and guiding the appropriate use of weight-loss drugs for obese individuals.
Article
Chemistry, Analytical
Xinbo Wang, Xuli Lang, Fenghe Wang, Huixin Tan, Gang Li, Peng Li, Jinping Hu, Baolian Wang, Yan Li
Summary: In this study, three major metabolites of NTB-3119 were identified in vitro and in vivo. A sensitive and specific LC-MS/MS method was established for the quantitative analysis of NTB-3119 and its major metabolites in mouse plasma.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Engineering, Environmental
Bibai Du, Quan Li, Zibin Pan, Yun Zhang, Ruiman Xie, Dan Luo, Lixi Zeng
Summary: An improved LC-MS/MS method was developed for simultaneous determination of synthetic phenol antioxidants and relevant metabolites, enhancing sensitivity with APCI and eliminating background contamination by installing a trap column. The method allows for accurate detection of target substances in environmental samples.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Shasha Jin, Zhihong Li, Qing Yang, Boyu Fang, Xiaoqiang Xiang, Chao Peng, Weimin Cai
Summary: A sensitive and specific chiral liquid chromatography-tandem mass spectrometry method was developed to simultaneously identify the enantiomers of warfarin and hydroxywarfarins. This method has advantages in baseline resolution and analysis processes.
Article
Biochemistry & Molecular Biology
Lourdes Poyatos, Alfredo Fabrizio Lo Faro, Diletta Berardinelli, Giorgia Sprega, Sara Malaca, Simona Pichini, Marilyn A. Huestis, Esther Papaseit, Clara Perez-Mana, Francesco Paolo Busardo, Magi Farre
Summary: This study defined the pharmacokinetics of methylone and HMMC in human plasma for the first time and validated a new LC-MS/MS method. Methylone exhibited dose-proportional pharmacokinetics, while HMMC showed faster kinetics compared to methylone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Xuan Wu, Wei Zhang, Naiqi Wu, Su-Seng Pang, Yi Ding, Guang He
Summary: This study investigates the structural evolution and stability of nanoporous materials in lithium-ion batteries using Li-Ag composites as a case study. The results show that the rationally designed nanoporous AgLi framework can achieve dendrite-free anodes with stable electrochemical performance.
ADVANCED ENERGY MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Huixia Zhang, Yan Li, Zheng Li, Christopher Wai-Kei Lam, Peng Zhu, Caiyun Wang, Hua Zhou, Wei Zhang
Summary: A novel and sensitive pre-column derivatization method using HPLC-MS/MS was developed to determine ribonucleotides and deoxyribonucleotides in human cells. The method was proven to be simple, rapid, sensitive, and reliable, making it suitable for specific expanded studies in intracellular pharmacology in vitro.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2022)
Review
Chemistry, Medicinal
Peng Zhu, Jianqiang Qian, Zhongyuan Xu, Chi Meng, Weizhong Zhu, Fansheng Ran, Wei Zhang, Yanan Zhang, Yong Ling
Summary: The study summarizes the diverse biological activities of piperlongumine (PL) and its derivatives, with a focus on their antitumor effects. Researchers discussed the therapeutic potential of PL and its derivatives in treating various diseases, especially cancer, as well as the challenges and future directions for research in this area.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Fei-Long Chen, Dong-Li Liu, Jing Fu, Ji Yang, Li-Ping Bai, Wei Zhang, Zhi-Hong Jiang, Guo-Yuan Zhu
Summary: Atrachinenins A-C (1-3), isolated from the rhizomes of Atractylodes chinensis, are meroterpenoids with novel C-27 skeletons. Atrachinenin A (1) features a unique cage-like skeleton, while atrachinenin B (2) has an additional peroxyl bridge ring, forming a complex cyclic ring system. Structural elucidation was done through various spectroscopic techniques and a plausible biosynthetic pathway was proposed. Atrachinenin A exhibited potential TGF-beta inhibitory activity at 25 μmol/L.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Cai-Ren Wang, Hong-Wei Chen, Yan Li, Ming-Yue Zhou, Vincent Kam-Wai Wong, Zhi-Hong Jiang, Wei Zhang
Summary: This study elucidated the multi-target mechanism of polyphenols in blueberry leaves (PBL) on non-alcoholic fatty liver disease (NAFLD) through network pharmacology and biological experiments, highlighting the potential liver-protective effect of PBL through modulation of the apoptosis pathway.
Article
Chemistry, Multidisciplinary
Tianpeng Yin, Jingguang Lu, Qinghua Liu, Guoyuan Zhu, Wei Zhang, Zhihong Jiang
Summary: A method for simultaneous quantitation of four characteristic components in Uncariae Ramulus Cum Uncis through H-1 NMR spectrometry was developed, showing rapid, accurate, and precise results. The method demonstrated linearity, sensitivity, accuracy, and precision, making it a powerful tool for quantifying alkaloids in traditional Chinese medicines.
Article
Electrochemistry
Yue Wang, Xuan Wu, Jianfeng Sun, Caiyun Wang, Guoyuan Zhu, Li-Ping Bai, Zhi-Hong Jiang, Wei Zhang
Summary: In this study, a novel bismuth oxide surface-decorated nanoporous bismuth (Bi2O3@NPBi) was prepared, which showed high cycling stability and capacity for sensitive detection of heavy metal ions with little interference from co-existing ions.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Mingyue Zhou, Xuan Wu, Yan Li, Huixia Zhang, Qinghua Liu, Linlin Song, Caiyun Wang, Betty Yuen Kwan Law, Zhihong Jiang, Wei Zhang
Summary: Alzheimer's disease is a neurodegenerative disease associated with aging, characterized by the deposition of abnormally phosphorylated tau filaments and amyloid beta-peptides fibrils. In this study, atomic zinc sites were used to screen potential inhibitors of A beta aggregation in turmeric. The developed method shows promise for efficient drug discovery from natural product resources.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Qian-Bao Liu, Jing-Guang Lu, Zhi-Hong Jiang, Wei Zhang, Wen-Jia Li, Zheng-Ming Qian, Li-Ping Bai
Summary: Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is a sensitive surface analytical technology that allows for simultaneous acquisition of diverse chemical components and their precise locations on the surfaces of samples. In this study, a new sample preparation strategy was developed to perform in situ chemical analysis of Cordyceps sinensis using TOF-SIMS. The technique was successfully applied to compare natural and cultured Cordyceps sinensis, revealing important differences in their chemical distributions. Overall, TOF-SIMS is considered an advanced and promising analytical technology for the research of traditional Chinese medicines.
FRONTIERS IN CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Mingyue Zhou, Yan Li, Chuanjin Huang, Cairen Wang, Qinghua Liu, Qibo Deng, Huixia Zhang, Tianpeng Yin, Guoyuan Zhu, Caiyun Wang, Yunfeng Zhao, Wei Zhang
Summary: Carbon nanomaterials, particularly graphene oxide (GO), have great potential in materials science and biomedicine. However, GO lamelayers tend to aggregate and are difficult to disperse in solution, resulting in low loading efficiency. To address this issue, oriented layered graphene oxide pad (OGO) was synthesized as a carrier to improve loading capacity and stability. The OGO structure showed good reproducibility and recyclability, with open channels and low pore curvature for better flow and higher fishing sites density. The CMP@OGO achieved 1.5 to 2 times higher loading capacity compared to GO. Moreover, the established CMP@OGO exhibited stability and high reuse rate, making it a promising platform for active compound screening.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Microbiology
Xiaodan Chen, Wei Li, Jianying Chen, Xiaoyong Zhang, Wei Zhang, Xuewu Duan, Bingfu Lei, Riming Huang
Summary: Research findings suggest that MNQ-based carbon dots (2-CDs) exhibit better inhibitory effects on Penicillium italicum and have improved water dispersibility. Transcriptomics and metabolomics analysis shed light on the mechanism of action of 2-CDs, providing new insights into their molecular effects.
Article
Chemistry, Applied
Yulin Wu, Jun Liu, Huili Hao, Lianmei Hu, Xiaoyong Zhang, Lianxiang Luo, Jincheng Zeng, Wei Zhang, Io Nam Wong, Riming Huang
Summary: Investigation on Caulerpa chemnitzia polysaccharides led to the discovery of a new polysaccharide (CCP) with immunomodulatory effects, potentially acting through the activation of NF-kappa B signaling pathway and arachidonic acid metabolism pathway.
Article
Chemistry, Analytical
Hui-Xia Zhang, Jian-Feng Qin, Jian-Feng Sun, Yu Pan, Tong-Meng Yan, Cai-Yun Wang, Li-Ping Bai, Guo-Yuan Zhu, Zhi-Hong Jiang, Wei Zhang
Summary: Despite the challenges posed by macromolecular nucleic acids, a recent labeling method using N-(tert-butyldimethylsilyl)-N-methyl-trifluoroacetamide (MTBSTFA) has shown promise in the profiling and characterization of DNA and RNA. This method offers advantages such as strong retention, predictable MS2 data, and avoidance of harmful reagents. It has been successfully applied to the analysis of tRNA, including the detection of modified bases and the discovery of new modifications. The ease of access and simplicity of this method make it a valuable tool for researchers.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Qing-Hua Liu, Yu-Dong Zhang, Zhang-Wen Ma, Zheng-Ming Qian, Zhi-Hong Jiang, Wei Zhang, Liang Wang
Summary: Ophiocordyceps sinensis is a valuable medicinal fungus used in traditional Chinese medicine, with polysaccharides as key constituents. This study confirmed that the polysaccharides extracted from the cultivated fungus were mostly glycogen.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Lingkai Kong, Jieru Meng, Wenyue Tian, Jiazheng Liu, Xueping Hu, Zhi-Hong Jiang, Wei Zhang, Yanzhong Li, Li-Ping Bai
Summary: An efficient approach for the synthesis of 1,2-diaryl diketones was developed from readily available alpha-methylene ketones by catalysis of I-2. In the same oxidation system, a novel one-pot procedure was established for the construction of antiviral and anticancer quinoxalines, showing good functional group tolerance with moderate to excellent yields. The synthesized compounds exhibited inhibitory effects on viral entry and cytotoxicity against cancer cells.
