Article
Nutrition & Dietetics
Anita Helland, Marianne Bratlie, Ingrid Hagen, Oivind Midttun, Arve Ulvik, Gunnar Mellgren, Per M. Ueland, Oddrun A. Gudbrandsen
Summary: This study aimed to investigate the effects of a light breakfast on serum concentrations of metabolites and B-vitamins related to the one-carbon metabolism. The results showed that the intake of a low nutrient breakfast significantly affected the serum concentrations of several metabolites and B-vitamins.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Nutrition & Dietetics
Jessica M. Williamson, Anya L. Arthurs, Melanie D. Smith, Claire T. Roberts, Tanja Jankovic-Karasoulos
Summary: Folate is an essential dietary micronutrient involved in one-carbon metabolism. The World Health Organisation recommends folic acid (FA) supplementation before conception and during early pregnancy to reduce the risk of fetal neural tube defects. Many countries have implemented mandatory FA fortification policies and recommendations for periconceptional FA supplementation, which have been successful in reducing the incidence of neural tube defects. However, excessive intake of FA has been associated with an increased risk of gestational diabetes mellitus. This article summarizes the current knowledge on the relationship between high FA intake, disrupted one-carbon metabolism, and the pathogenesis of gestational diabetes mellitus, highlighting the need for further research in this area.
Article
Pharmacology & Pharmacy
Takayuki Koga, Kie Inoue, Fuka Hirayama, Makoto Hiromura, Kiyonaga Fujii, Yuji Ishii, Masayo Hirao-Suzuki, Shuso Takeda, Akihisa Toda, Fumio Soeda
Summary: Allergic contact dermatitis (ACD) is a common skin disorder caused by contact with allergens. The optimal treatment for ACD is to avoid contact with allergens. However, in some cases, avoiding exposure is not possible when the allergens are unknown. Therefore, establishing treatment methods other than allergen avoidance is important.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Agriculture, Dairy & Animal Science
Esra Tugce Gul, Osman Olgun, Gozde Kilinc, Alponder Yilidz, Ainhoa Sarmiento-Garcia
Summary: The purpose of this study was to evaluate the performance, quality of eggs internally and externally, and antioxidant capacity of yolks in laying quails with the administration of choline and betaine to diets containing reduced methionine levels. The results showed that methionine can be reduced to a level of 0.30% without negative effects on egg production, while the combination of methionine (0.30%) and betaine (0.20%) can improve the antioxidant stability of eggs.
Article
Clinical Neurology
Mengyuan Miao, Jigang Du, Bizhong Che, Yufei Guo, Jintao Zhang, Zhong Ju, Tan Xu, Xiaoyan Zhong, Yonghong Zhang, Chongke Zhong
Summary: This study found that poststroke depression patients had lower levels of choline and betaine compared to those without depression. Adjusted odds ratios for the highest tertile of choline and betaine were significantly lower, and each 1 SD increase in choline or betaine was associated with a decreased risk of PSD. The addition of choline or betaine to the risk factors model improved risk reclassification for PSD.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhang, Brian Head, Scott W. Leonard, Jaewoo Choi, Robyn L. Tanguay, Maret G. Traber
Summary: The study investigates the molecular mechanism of Vitamin E in embryogenesis, revealing that Vitamin E deficiency leads to complex biochemical pathway changes, with betaine playing a key role in maintaining glutathione homeostasis. Additionally, changes in amino acids and thiols during embryonic development are associated with Vitamin E deficiency.
Article
Nutrition & Dietetics
Heleen Van Puyvelde, Nikos Papadimitriou, Joanna Clasen, David Muller, Carine Biessy, Pietro Ferrari, Jytte Halkjaer, Kim Overvad, Anne Tjonneland, Renee T. Fortner, Verena Katzke, Matthias B. Schulze, Paolo Chiodini, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Marije F. Bakker, Antonio Agudo, Eva Ardanaz, Maria Dolores Chirlaque Lopez, Maria-Jose Sanchez, Ulrika Ericson, Bjorn Gylling, Therese Karlsson, Jonas Manjer, Julie A. Schmidt, Genevieve Nicolas, Corinne Casagrande, Elisabete Weiderpass, Alicia K. Heath, Lode Godderis, Koen Van Herck, Dirk De Bacquer, Marc J. Gunter, Inge Huybrechts
Summary: The study did not find strong evidence for an association between methyl-group donors involved in one-carbon metabolism and breast cancer risk. However, there was a potential U-shaped trend suggested for dietary folate intake and breast cancer risk. Further research is needed to clarify this association.
Article
Nutrition & Dietetics
Peicong Ge, Yaobo Zhao, Yuanren Zhai, Qian Zhang, Xun Ye, Jia Wang, Rong Wang, Yan Zhang, Dong Zhang, Jizong Zhao
Summary: Circulating choline and betaine are negatively associated with the risk of MMD and its subtypes.
FRONTIERS IN NUTRITION
(2022)
Article
Entomology
Jingjing Li, Fangfang Li, Na Yu, Zewen Liu
Summary: Homocysteine metabolism plays a crucial role in spider species, and the BRP pathway is essential in P. pseudoannulata.
Article
Nutrition & Dietetics
Xiong-Fei Pan, Jae Jeong Yang, Xiao-Ou Shu, Steven C. Moore, Nicholette D. Palmer, Marta Guasch-Ferre, David M. Herrington, Sei Harada, Heather Eliassen, Thomas J. Wang, Robert E. Gerszten, Demetrius Albanes, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Huilian Zhu, Lynne E. Wagenknecht, Wei Zheng, Hui Cai, Qiuyin Cai, Charles E. Matthews, Cristina Menni, Katie A. Meyer, Loren P. Lipworth, Jennifer Ose, Myriam Fornage, Cornelia M. Ulrich, Danxia Yu
Summary: The study showed that circulating choline, carnitine, and DMG were associated with unfavorable cardiometabolic risk profiles, while circulating betaine was associated with a favorable cardiometabolic risk profile.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Ecology
Rachel Stirrup, Michaela A. Mausz, Eleonora Silvano, Andrew Murphy, Richard Guillonneau, Mussa Quareshy, Branko Rihtman, Maria Aguilo Ferretjans, Ruo He, Jonathan D. Todd, Feng Chen, David J. Scanlan, Yin Chen
Summary: Lipids play a crucial role in maintaining cell integrity and homeostasis. The cosmopolitan marine roseobacter clade (MRC) and SAR11 clade bacteria produce a variety of amino acid-containing lipids. The study reveals that these lipids are present in both the inner and outer membranes of MRC bacteria. The inability to produce these lipids impacts membrane proteome, nutrient transport, competitiveness, and phage attachment.
Article
Agriculture, Dairy & Animal Science
Aisha Zaki, Shouqun Jiang, Saad Zaghloul, Talaat K. El-Rayes, Ahmed A. Saleh, Mahmoud Mostafa Azzam, Marco Ragni, Mahmoud Alagawany
Summary: This research evaluated the effects of using betaine as a substitute for choline on the productive performance, egg quality parameters, fatty acids profile, and antioxidant status in laying hens. The results showed that replacing choline with betaine did not significantly affect body weight, egg production, and feed intake. However, egg weight and egg mass increased, and yolk color improved in the group supplemented with betaine. The levels of various blood parameters, liver malondialdehyde content, yolk vitamin E, and fatty acid levels were not significantly affected by betaine supplementation. Additionally, hens fed betaine displayed an increased antibody titer for Newcastle disease virus.
Article
Multidisciplinary Sciences
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y. H. Yang, Ellis Patrick
Summary: Cardiovascular disease remains a leading cause of mortality, affecting an estimated half a billion people in 2019. However, the detection of signals between specific pathophysiology and coronary plaque phenotypes using complex multi-omic discovery datasets is challenging due to individual diversity and risk factors. This study illustrates different methods for identifying subcohorts of individuals with subclinical coronary artery disease (CAD) and distinct metabolomic signatures, showing that utilizing these subcohorts can improve prediction and facilitate the discovery of novel biomarkers.
Article
Multidisciplinary Sciences
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y. . H. Yang, Ellis Patrick
Summary: Cardiovascular disease remains a leading cause of mortality, affecting an estimated half a billion people in 2019. However, detecting signals between specific pathophysiology and coronary plaque phenotypes using complex multiomic discovery datasets is challenging due to individual diversity and risk factors. Various methods, including knowledge-guided and data-driven approaches, can help identify subcohorts with distinctive metabolomic signatures and subclinical CAD, improving prediction and facilitating the discovery of new biomarkers. Analyzing cohort heterogeneity through these subcohorts can advance our understanding of CVD and provide more effective preventative treatments.
Article
Agriculture, Multidisciplinary
Shan Huang, Si Ying Lim, Sock Hwee Tan, Mark Y. Chan, Wuzhong Ni, Sam Fong Yau Li
Summary: The relationship between TMAO, betaine, and choline with acute myocardial infarction (AMI) is unclear. This study found that high betaine + low TMAO levels are associated with a significant protective effect against AMI. Furthermore, age is positively correlated with TMAO concentration, indicating a potential interplay between age and the risk of AMI associated with metabolite combination.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Susanne H. Kirsch, Wolfgang Herrmann, Vera Kruse, Rudolf Eckert, Stefan Graeber, Juergen Geisel, Rima Obeid
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2015)
Article
Nutrition & Dietetics
Rima Obeid, Susanne H. Kirsch, Sarah Dilmann, Cosima Klein, Rudolf Eckert, Juergen Geisel, Wolfgang Herrmann
EUROPEAN JOURNAL OF NUTRITION
(2016)
Article
Nutrition & Dietetics
Irene Pusceddu, Markus Herrmann, Susanne H. Kirsch, Christian Werner, Ulrich Huebner, Marion Bodis, Ulrich Laufs, Stefan Wagenpfeil, Juergen Geisel, Wolfgang Herrmann
EUROPEAN JOURNAL OF NUTRITION
(2016)
Article
Nutrition & Dietetics
Irene Pusceddu, Markus Herrmann, Susanne H. Kirsch, Christian Werner, Ulrich Huebner, Marion Bodis, Ulrich Laufs, Thomas Widmann, Stefan Wagenpfeil, Juergen Geisel, Wolfgang Herrmann
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Food Science & Technology
Rima Obeid, Hussain M. Awwad, Susanne H. Kirsch, Christiane Waldura, Wolfgang Herrmann, Stefan Graeber, Juergen Geisel
MOLECULAR NUTRITION & FOOD RESEARCH
(2017)
Article
Medical Laboratory Technology
Wolfgang Herrmann, Susanne H. Kirsch, Vera Kruse, Rudolf Eckert, Tefan Graeber, Juergen Geisel, Rima Obeid
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2013)
Review
Medical Laboratory Technology
Susanne H. Kirsch, Wolfgang Herrmann, Rima Obeid
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2013)
Article
Biochemical Research Methods
Hussain Mohamad Awwad, Susanne H. Kirsch, Juergen Geisel, Rima Obeid
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2014)
Article
Oncology
Charlotte Dahlem, Wei Xiong Siow, Maria Lopatniuk, William K. F. Tse, Sonja M. Kessler, Susanne H. Kirsch, Jessica Hoppstaedter, Angelika M. Vollmar, Rolf Mueller, Andriy Luzhetskyy, Karin Bartel, Alexandra K. Kiemer
Article
Biochemistry & Molecular Biology
Charlotte Dahlem, Ali Abuhaliema, Sonja M. Kessler, Tarek Kroehler, Ben G. E. Zoller, Shilpee Chanda, Yingwen Wu, Simon Both, Fabian Mueller, Konstantin Lepikhov, Susanne H. Kirsch, Stephan Laggai, Rolf Muller, Martin Empting, Alexandra K. Kiemer
Summary: This study validated IMP2 as a potential target for colorectal cancer and established a screening assay for small-molecule inhibitors of IMP2. In vitro and in vivo studies demonstrated that IMP2 knockout reduces tumor cell proliferation and growth. Ten compounds from different libraries showed target specificity and were validated in vitro. The three most active compounds also exhibited reduced tumor xenograft growth in vivo. These findings support IMP2 as a druggable target to reduce tumor cell proliferation.
ACS CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kristine A. Keon, Samir Benlekbir, Susanne H. Kirsch, Rolf Mueller, John L. Rubinstein
Summary: V-ATPases play an important role in acidification of intracellular compartments and V-ATPase inhibitors have potential applications in cell biology research and therapy. This study determined the binding structures of V-o complex from yeast with two inhibitors, revealing different binding sites on the surface of the proton-carrying c ring.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lena Keller, Emilia Oueis, Amninder Kaur, Nasim Safaei, Susanne H. Kirsch, Antonia P. Gunesch, Sibylle Haid, Ulfert Rand, Luka Cicin-Sain, Chengzhang Fu, Joachim Wink, Thomas Pietschmann, Rolf Mueller
Summary: A new strain of actinobacteria, Kibdelosporangium persicum sp. nov., collected from a hot desert in Iran, yielded a novel family of sesquarterpenoids (persicamidines A-E) with remarkable antiviral activity. Extensive NMR analysis revealed a hexacyclic terpenoid molecule with a modified sugar moiety on one side and a unique isourea moiety fused to the terpenoid structure. Persicamidines A-E exhibited potent activity against hCoV-229E and SARS-CoV-2 viruses in the nanomolar range, along with excellent selectivity indices, showing promise as potential drug candidates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Joscha Meiers, Jan Dastbaz, Sebastian Adam, Sari Rasheed, Susanne H. Kirsch, Peter Meiser, Peter Gross, Rolf Mueller, Alexander Titz
Summary: The highly glycosylated spike protein of SARS-CoV-2 is crucial for infection and is a target for antiviral agents and vaccines. A pineapple-derived lectin AcmJRL has been found to bind mannosides and is present in the medication bromelain. This study showed that AcmJRL binds to the spike protein of SARS-CoV-2 with a low-micromolar K-D in a carbohydrate-dependent manner.
Article
Biochemistry & Molecular Biology
Carla I. I. Seegers, Danielle J. Lee, Patricia Zarnovican, Susanne H. Kirsch, Rolf Mueller, Thomas Haselhorst, Francoise H. Routier
Summary: The opportunistic fungus Aspergillus fumigatus causes various diseases and forms a biofilm that protects it from the host's immune defenses and antifungal drugs. This study discovered drugs that inhibit biofilm synthesis and disrupt existing biofilms, including Actinomycin X2, Actinomycin D, Rifaximin, and Imatinib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Susanne H. Kirsch, F. P. Jake Haeckl, Rolf Mueller
Summary: The central enzyme in bacterial gene expression, RNA polymerase (RNAP), is an ideal target for antibiotics. However, known RNAP inhibitors are facing resistance issues, prompting the urgent need for novel inhibitors with different target sites.
NATURAL PRODUCT REPORTS
(2022)