Review
Chemistry, Multidisciplinary
Swee Ching Tan, Subrat Kumar Bhattamisra, Dinesh Kumar Chellappan, Mayuren Candasamy
Summary: Centella asiatica, a popular herb known for its therapeutic effects, especially in treating skin conditions, contains various active compounds including asiaticoside and madecassoside. This review primarily focuses on the therapeutic potential, pharmacokinetics, and toxicity of madecassoside, despite its relatively limited scientific reports compared to other constituents of Centella asiatica.
APPLIED SCIENCES-BASEL
(2021)
Review
Agronomy
Rambir Singh, Balasiewdor Kharsyntiew, Poonam Sharma, Uttam Kumar Sahoo, Prakash Kumar Sarangi, Piotr Prus, Florin Imbrea
Summary: The Indian subcontinent is suitable for cultivating C. asiatica, with the Western Ghats, North East, Eastern Himalaya, and Western Himalaya regions in India having genotypes with the highest centelloside content. Open cultivation is preferred in the Western mountainous areas, while shade cultivation is suitable in the Central plains of India. Hydroponic and tissue culture methods have been successfully used to increase centelloside production using supplements and elicitors, such as sucrose, auxins, cytokinins, kinetin, and methyl jasmonate. Freeze drying is identified as the most efficient post-harvest method.
Article
Agricultural Engineering
Satyendra Pratap Singh, Ankita Misra, Bhanu Kumar, Dibyendu Adhikari, Sharad Srivastava, Saroj Kanta Barik
Summary: In this study, we identified the distribution of different chemotypes of Centella asiatica and the suitable climatic conditions for its growth through laboratory analysis and ecological niche modeling. This helps in large-scale commercial cultivation of C. asiatica and obtaining germplasms with high bioactive compounds. The study also establishes a protocol for sustainable supply of other medicinal plants.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Biotechnology & Applied Microbiology
Sujata Mandal, Tuyelee Das, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Abilash Valsala Gopalakrishnan, Manoj Kumar, Arabinda Radha, Arabinda Ghosh, Nobendu S. Mukerjee, Mahipal Shekhawat, Devendra Kumar Pandey, Abhijit Dey
Summary: In vitro culture of plant cells, tissues, and organs is an eco-friendly biotechnological strategy for producing plant chemicals. This review focuses on increasing the production of triterpenoid saponins in Centella asiatica by using genetic engineering tools and proper strategies. It discusses the roles of different carbon sources, biotic and abiotic elicitors, and plant growth regulators at different growth stages. The study also highlights various techniques such as organogenesis and somatic embryogenesis. The review provides valuable insights into biotechnological interventions for enhancing triterpenoid saponin yield in C. asiatica.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Eun Kim, Jun Soo Park, Min Seop Kim, Min Young Jeong, Hyun Jin Park, Jun Hyuk Choi, Jae Hee Seo, Yong Seok Choi, Myung Joo Kang
Summary: This study successfully designed a high-payload topical preparation of Centella asiatica using nanocrystallization technique, which showed higher accumulation in the skin layer and better skin absorption profile, with no signs of irritation in normal rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Organic
Xiaoyang Han, Jingyi Zhao, Xuancheng Chang, Qiuyun Li, Zixin Deng, Yi Yu
Summary: Advances in sequencing technologies have led to the discovery of the glycosylation pathway and the involvement of two UGTs in the biosynthesis of asiaticoside and madecassoside.
Article
Biochemistry & Molecular Biology
Gouri Priya Ranjith, S. Jisha, Achutan Sudarsanan Hemanthakumar, Chinthu Saji, Rajesh A. Shenoi, Kallevettankuzhy Krishnannair Sabu
Summary: The triterpenoid saponins asiaticoside and madecassoside from Centella asiatica could be significantly increased with the addition of silver nitrate, which also upregulated the gene expression related to triterpenoid biosynthesis, suggesting its potential as a metabolite stimulant in enhancing the formation of bioactive molecules.
Article
Agricultural Engineering
Renju Kunjumon, Anil John Johnson, Rajani Kurup Sukumaryamma Remadevi, Sabulal Baby
Summary: This study screened the ASI and MAD contents of Centella asiatica accessions from a wide geographical area in south India, and identified elite lines with high saponin contents. The study also revealed the preferences of Centella asiatica for soil and ecological factors. These findings have important implications for the collection, cultivation, and conservation of Centella asiatica resources.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Review
Plant Sciences
Ziliang He, Yeye Hu, Zhiqiang Niu, Kang Zhong, Tingwu Liu, Meng Yang, Lilian Ji, Weicheng Hu
Summary: This review comprehensively summarized the pharmacokinetic and pharmacological properties of asiaticoside (AS). AS has a variety of pharmacological effects including anti-neural inflammation, anti-cancer, and protective effects for the skin, cardiovascular system, and pulmonary system. Future research should focus on improving bioavailability of AS and conducting clinical assessment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Agricultural Engineering
Faiznur Mohd Fuad, Masrina Mohd Nadzir
Summary: This study developed a ultrasound-assisted extraction method for extracting asiaticoside from Centella asiatica using betaine-based natural deep eutectic solvents (NADES) for the first time. The optimal conditions were determined through single-factor experiments and response surface methodology (RSM). The optimized UAE-NADES technique provided a higher yield compared to the conventional extraction method.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Review
Biochemistry & Molecular Biology
Lucio Ricardo Leite Diniz, Leonardo Luiz Calado, Allana Brunna Sucupira Duarte, Damiao Pergentino de Sousa
Summary: Studies have shown that Centella asiatica extracts (CAE) display activity in tissue regeneration, cell migration, and wound repair process. Its active component, asiatic acid, is directly associated with its healing activity. This study discusses the effects of Centella asiatica and asiatic acid in different stages of the healing process of cutaneous wounds, including phytochemical and antimicrobial aspects.
Article
Plant Sciences
Chien-Feng Huang, Tung-Wei Hung, Shun-Fa Yang, Yi-Lun Tsai, Jen-Te Yang, Chia-Liang Lin, Yi-Hsien Hsieh
Summary: The study found that asiatic acid (AA) can inhibit the metastatic properties of renal cell carcinoma (RCC) cells by suppressing the p-ERK/p-p38MAPK axis and down-regulating MMP-15 expression. These findings are important for exploring AA as a potential anti-metastatic agent for RCC.
Review
Integrative & Complementary Medicine
Kyoung Sik Park
Summary: This study provides a comprehensive overview of the beneficial effects of C. asiatica on skin diseases by summarizing the potent dermatological effects and underlying molecular mechanisms confirmed in pharmacological studies. It highlights the therapeutic effects of compounds like asiaticoside and madecassoside in treating dermatological diseases through various signaling pathways, but emphasizes the need for further controlled clinical trials to fully validate the therapeutic potential of C. asiatica.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Agricultural Engineering
Poonam Kumari, Prabhjot Kaur, Vijay Kumar, Babita Pandey, Romaan Nazir, Kajal Katoch, Padmanabh Dwivedi, Abhijit Dey, Devendra Kumar Pandey
Summary: This study optimized extraction conditions to increase the yield of asiaticoside in Centella asiatica. The use of RSM and ANN models helped establish effective prediction models for ultrasonic extraction parameters. Results showed that the RBF model performed better than MLP and RSM, indicating the potential for using RSM and ANN systems for the optimization and production of valuable bioactive compounds.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Zetty Shafiqa Othman, Mohamad Yusof Maskat, Nadhratun Naiim Mobarak, Rozida Mohd Khalid, Shikh Mohd Shahrul Nizan Shikh Zahari, Nur Hasyareeda Hassan
Summary: Asiaticoside, a pentacyclic triterpene found in Centella asiatica, has broad pharmacological actions. This study focused on optimizing extraction parameters using protic ionic liquids as additives to increase asiaticoside yield and antioxidant capacity. The optimal conditions were determined to be 66 degrees C, 12 hours extraction time, and 20% triethylammonium hydrogen sulfate, resulting in high asiaticoside yield and antioxidant capacity. The findings highlight the potential of protic ionic liquids for bioactive extractions and suggest further research on solute-solvent interactions for efficient plant extraction processes.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Romina J. Ronchi, Claire Beaufay, Joanne Bero, Juan B. Robirosa, Marcia Mazzuca, Jorge A. Palermo, Joelle Quetin-Leclercq, Marianela Sanchez
CHEMICAL BIOLOGY & DRUG DESIGN
(2019)
Article
Biochemical Research Methods
Claire Beaufay, Guillaume Henry, Camille Streel, Emilie Bony, Marie-France Herent, Joanne Hero, Joelle Quetin-Leclercq
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2019)
Article
Endocrinology & Metabolism
Rafael Teixeira Freire, Joanne Bero, Claire Beaufay, Denise Medeiros Selegato, Aline Coqueiro, Young Hae Choi, Joelle Quetin-Leclercq
Article
Food Science & Technology
Nguyen Le Anh Dao, Tran Minh Phu, Caroline Douny, Joelle Quetin-Leclercq, Bui Thi Buu Hue, Le Thi Bach, Truong Quynh Nhu, Bui Thi Bich Hang, Do Thi Thanh Huong, Nguyen Thanh Phuong, Patrick Kestemont, Marie-Louise Scippo
Summary: The study demonstrated that dip treatments in solutions of Phyllanthus amarus and Euphorbia hirta extracts significantly reduced total viable counts and lipid oxidation in striped catfish fillets, extending their shelf life.
JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Schioppa, Fanta Fall, Sergio Ortiz, Jacques H. Poupaert, Joelle Quetin-Leclercq
Summary: Pentacyclic triterpenes (PTs) are commonly found in medicinal plants with antiparasitic effects. This study aimed to determine the stability of triterpenic esters in different biological-like media and their main microsomal degradation products. The results showed that these esters exhibited good stability in aqueous and plasma solutions, but degradation was observed in acidic media. Moreover, hepatic microsomal metabolism varied depending on the concentration and position of the ester link, suggesting different metabolic pathways for these compounds.
Article
Biochemistry & Molecular Biology
Hafiz Abdul Khaliq, Sergio Ortiz, Mireille Alhouayek, Giulio G. Muccioli, Joelle Quetin-Leclercq
Summary: The anti-inflammatory potential of Convolvulus arvensis was evaluated and the results showed that the extracts and major constituents of the plant can significantly inhibit the expression of pro-inflammatory mediators, supporting its use in the treatment of inflammatory diseases.
Article
Infectious Diseases
Sandrine Verstraeten, Lucy Catteau, Laila Boukricha, Joelle Quetin-Leclercq, Marie-Paule Mingeot-Leclercq
Summary: The study showed the synergy between pentacyclic triterpenes and ampicillin towards Methicillin-Resistant S. aureus by binding to LTA, inducing membrane permeabilization and depolarization. This effect was not accompanied by significant changes in cellular concentration, suggesting a mediated effect through lipid membranes.
Review
Pharmacology & Pharmacy
Espoir K. Kambale, Joelle Quetin-Leclercq, Patrick B. Memvanga, Ana Beloqui
Summary: Diabetes is a chronic condition with high blood glucose levels that cannot be cured. Managing diabetes involves a healthy lifestyle, exercise, and medication. Nanoparticulate delivery systems have shown promise in enhancing the effectiveness of herbal treatments for diabetes, but further clinical trials are needed.
Article
Agriculture, Dairy & Animal Science
Esaie Tchetan, Pascal Abiodoun Olounlade, Erick Virgile Bertrand Azando, Hafiz Abdul Khaliq, Sergio Ortiz, Alban Houngbeme, Georcelin Goue Alowanou, Bossima Ivan Koura, Guenole Coovi Akouedegni, Marcel Romuald Benjamin Houinato, Sylvie Mawule Hounzangbe-Adote, Fernand Ahokanou Gbaguidi, Joelle Quetin-Leclercq
Summary: In this study, the anthelmintic activity, cytotoxicity, and chemical composition of plants used in Benin to treat digestive parasitosis in small ruminants were explored. The results are important for the rational use of these plants and for the identification of new anthelmintic molecules.
Article
Biochemistry & Molecular Biology
Caroline Waingeh Nain, Eric Mignolet, Marie-France Herent, Joelle Quetin-Leclercq, Cathy Debier, Melissa M. Page, Yvan Larondelle
Summary: This study compared the antioxidant activity of green tea extracts (GTEs) with different catechins profiles, and found that the EGC-rich GTE exhibited stronger antioxidant activity than the EGCG-rich GTE in DHA-rich oil.
Review
Food Science & Technology
Hafiz Abdul Khaliq, Mireille Alhouayek, Joelle Quetin-Leclercq, Giulio G. G. Muccioli
Summary: Inflammation is a defensive response of the organism to various injuries. Chronic inflammatory diseases are challenging to treat, and phytochemicals may provide an interesting alternative approach. AMP-activated protein kinase plays an important role in regulating inflammatory responses. This review summarizes studies on phytochemicals that activate AMPK to improve chronic inflammatory disease models, and highlights factors to consider when investigating AMPK in the context of phytochemicals.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Anais Pannequin, Joelle Quetin-Leclercq, Jean Costa, Aura Tintaru, Alain Muselli
Summary: Chromatographic and spectroscopic methods were used to investigate the volatile metabolites of the liverwort Plagiochila porelloides harvested in Corsica. Three new compounds were isolated and their structures were determined. The essential oil and extract of P. porelloides showed moderate antiprotozoal and anticancer activities.
Article
Biochemistry & Molecular Biology
Allison Ledoux, Carla Hamann, Olivier Bonnet, Kateline Jullien, Joelle Quetin-Leclercq, Alembert Tchinda, Jacqueline Smadja, Anne Gauvin-Bialecki, Erik Maquoi, Michel Frederich
Summary: Casearia coriacea Vent., a plant endemic to the Mascarene Islands, exhibited potent antiplasmodial activity through the presence of three identified compounds, caseamembrin T (1), corybulosin I (2), and isocaseamembrin E (3), with IC50 values ranging from 0.25 to 0.51 μg/mL. While these compounds also showed antileishmanial and antitrypanosomal properties, they exhibited selectivity towards the malaria parasite with selectivity indices ranging from 6 to 12 and 25 to 100, respectively. Additionally, compounds 1-3 demonstrated promising activity against pancreatic carcinoma cells (IC50 < 1 μg/mL). However, the main compound, caseamembrin T (1), displayed significant toxicity when evaluated on zebrafish embryos.
Article
Biochemistry & Molecular Biology
Esaie Tchetan, Sergio Ortiz, Pascal Abiodoun Olounlade, Kristelle Hughes, Patrick Laurent, Erick Virgile Bertrand Azando, Sylvie Mawule Hounzangbe-Adote, Fernand Ahokanou Gbaguidi, Joelle Quetin-Leclercq
Summary: By performing LC-MS/MS analysis and molecular networking, the main compounds in Terminalia leiocarpa were identified as ellagic acid and derivatives, gallic acid, astragalin, rutin, quinic acid, and fructose. Among them, ellagic acid and gallic acid showed good anthelmintic activity against C. elegans. Other unidentified compounds may also contribute to the observed activity.
Article
Biochemistry & Molecular Biology
Kristelle Hughes, Thanh Binh Le, Patrick Van Der Smissen, Donatienne Tyteca, Marie-Paule Mingeot-Leclercq, Joelle Quetin-Leclercq
Summary: Leishmaniasis, a neglected tropical disease, still infects thousands of people per year worldwide. Resistance to major treatments has become a healthcare burden, especially in low-income countries. Eugenol, a phenylpropanoid, has shown antileishmanial activity against Leishmania mexicana mexicana (Lmm), but its mechanism of action is still unclear.
