Article
Oncology
Daniela S. Gutierrez-Torres, Lanqing Wang, Benjamin C. Blount, Baoyun Xia, Connie S. Sosnoff, Meredith S. Shiels, Maki Inoue-Choi, Arash Etemadi, Neal D. Freedman
Summary: The study found that there is good agreement between self-reported non-daily smoking and serum cotinine concentrations, indicating that non-daily smokers are exposed to high levels of carcinogenic nitrosamines regardless of the number of cigarettes they smoke per month.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Substance Abuse
Xiong Lei, Hezhi Wen, Zhixiao Xu
Summary: Urinary NNAL is negatively correlated with lung function indicators including FEV1/FVC%, FEV1%, FEV1/FEV6%, FEV3/FEV6%, PEF%, FEF25-75%, and FENO.
TOBACCO INDUCED DISEASES
(2023)
Article
Multidisciplinary Sciences
Xin Chen, Liang Sheng, Jiguang Ma, Dan Qi, Xuqi Li, Zheng Wang, Zheng Wu, Lucas Wong, Jason H. Huang, Erx Wu, Qingyon Ma, Dong Zhang
Summary: Cigarette smokers have a higher risk of pancreatic cancer, but the mechanisms of cigarette metabolites are not fully understood. This study demonstrates that NNK, a component of cigarette smoke, promotes the growth and migration of pancreatic cancer cells and the progression of chronic pancreatitis to pancreatic cancer. These findings provide potential strategies and targets for early prevention and treatment of pancreatic cancer.
Article
Chemistry, Multidisciplinary
Yani Zheng, Yin Dai, Junqiang Hong, Huizhu Fan, Qing Zhang, Wei Jiang, Wei Xu, Jianwen Fei, Junli Hong
Summary: In this study, a magnetic molecularly imprinted polymer (MMIP) functionalized with dendritic nanoclusters was synthesized to selectively recognize the major carcinogen NNK. The resulting MMIPs exhibited high adsorption capacity, fast binding kinetics, and good selectivity for trace amounts of NNK. A rapid, low-cost, and efficient method for detecting NNK in tobacco products was established.
Article
Medicine, Research & Experimental
Hyun-Ji Jang, Hye-Jin Boo, Hye-Young Min, Yun Pyo Kang, Sung Won Kwon, Ho-Young Lee
Summary: The prevalence of metabolic syndrome (MetS) has increased globally, and it raises the risk of lung cancer. Tobacco smoking (TS) potentially increases the risk of MetS. A study evaluated the impact of exposure to tobacco smoke condensate (TSC) and two tobacco carcinogens on MetS development in mice. The results showed that exposure to TSC or the carcinogens led to major changes associated with MetS in mice.
Article
Multidisciplinary Sciences
Sampada S. Nikam, Murari Gurjar, Hitesh Singhavi, Anand Patil, Arjun Singh, Peter Villalta, Pankaj Chaturvedi, Samir S. Khariwala, Vikram Gota, Irina Stepanov
Summary: Biomarkers of exposure to harmful tobacco constituents are essential for identifying at-risk individuals, developing interventions, and implementing tobacco control measures. Despite the high prevalence of tobacco use in many parts of the world, tobacco biomarker studies are limited. A robust method for simultaneous analysis of urinary tobacco biomarkers has been successfully established in Mumbai, India, providing a new research capacity for tobacco carcinogenesis in Indian smokeless tobacco users.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Hao Zhou, Rong Liu, Qianqian Chen, Xiantong Zheng, Jingli Qiu, Tongyan Ding, Limin He
Summary: The method based on SMISPE combined with LC-MS/MS is developed for determining residues of VCM and NVCM in milk samples, showing good linear correlation and high recoveries. It efficiently eliminates interference from matrix compounds and reduces baseline noise, making it useful for residue monitoring.
Article
Substance Abuse
Song Ge, Weixia Ma, Zhe Qu, Xingmei Zhu, Zijing Chen, Xuechun Lin, Zhenmei Fu
Summary: A negative association was found between urinary tobacco-specific nitrosamines and cognitive functioning in older adults. The study analyzed a total of 1673 older adults and found that participants with higher levels of urinary tobacco-specific nitrosamines performed worse in processing speed, sustained attention, and working memory.
TOBACCO INDUCED DISEASES
(2023)
Article
Biochemical Research Methods
Huanli Wang, Lulu Guo, Fuqiang Liu, Wu Fan, Guobi Chai, Qingzhao Shi, Qidong Zhang, Jian Mao, Jianping Xie
Summary: This study established a UHPLC-HRMS/MS method to investigate the metabolites of NNK and their distribution in the rat brain. NNK and its metabolites were found in various brain regions, and the content of NNAL was at least threefold higher than that of NNK, indicating rapid carbonyl reduction of NNK in the brain. Compared to alpha-methyl hydroxylation, NNK and NNAL were more inclined to the alpha-methylene hydroxylation pathway. Synchronous pharmacokinetic results indicated poor metabolic activity of NNK in the central nervous system compared to the blood.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Fanny Varenne, Porkodi Kadhirvel, Pauline Bosman, Loic Renault, Audrey Combes, Valerie Pichon
Summary: This study focused on the development and characterization of molecularly imprinted polymers (MIPs) for the selective solid-phase extraction of oxazepam from environmental water and human urine samples. By optimizing the extraction procedure, high enrichment factors were achieved, leading to good extraction recoveries.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Green & Sustainable Science & Technology
Tamara Tadic, Bojana Markovic, Jelena Radulovic, Jelena Lukic, Ljiljana Surucic, Aleksandra Nastasovic, Antonije Onjia
Summary: In this study, a core-shell amino-functionalized glycidyl methacrylate magnetic molecularly imprinted polymer (MIP) was synthesized and used as a sorbent for the analysis of trace amounts of aniline in textile wastewater samples. The MIP showed good selectivity and efficiency in separating and detecting aniline, with a method detection limit of 1 ng mL(-1). The results demonstrate that the studied MIP can be a reliable sorbent for the analysis of trace aniline in real wastewater samples.
Article
Oncology
Eun Young Park, Min Kyung Lim, Eunjung Park, Jin-Kyoung Oh, Do-Hoon Lee
Summary: The study in the Republic of Korea found a significant association between urinary NNAL levels and lung cancer risk in the general population, with higher NNAL levels indicating a greater risk of lung cancer. This association is independent of cigarette smoking and nicotine uptake quantification.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Gege Feng, Jianchun Sun, Miao Wang, Mengqiang Wang, Zhuang Li, Shanshan Wang, Lufei Zheng, Jing Wang, Yongxin She, A. M. Abd El-Aty
Summary: Molecularly imprinted polymers with high selectivity towards 29 sulfonylurea herbicides were successfully synthesized and applied in liquid chromatography-tandem mass spectrometry. The method demonstrated good performance in detecting sulfonylurea herbicides in agricultural products, with high recovery rates and low relative standard deviations.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Analytical
Lorenzo Martello, Nina Maria Ainali, Dimitrios N. Bikiaris, Dimitra A. Lambropoulou
Summary: In this study, novel molecularly imprinted polymers (MIPs) were synthesized using penconazole as the template and various combinations of functional monomers and cross-linkers. The MIPs showed higher affinity for triazole pesticides in apple juice compared to non-imprinted polymers. The developed MIP-d-SPE-LC-MS method exhibited excellent selectivity and good performance for the enrichment and determination of triazole compounds in apple juice and river water samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Agriculture, Multidisciplinary
Jia Lin Wang, Chen Yi Zhang, Xuan Li, Xiao Dong Wang, Min Cao, Tadao Asami, Xiao Hui Xiong, Jian Song Chen, Yi Chen Lu
Summary: This study developed organophosphorus magnetic molecularly imprinted polymers (OMMIPs) with high adsorption capacities and good applicability for efficient extraction and pre-concentration of multiple organophosphorus pesticides (OPPs) from foodstuffs. The OMMIP-based methods demonstrated rapid screening for 90 kinds of pesticides in various agro-products and achieved compliant recoveries, low detection limits, and simultaneous quantification of multi-pesticides. Additionally, the yolk-shell-structured OMMIPs showed excellent ultraviolet light-driven catalytic degradation activity toward OPPs, making them eco-friendly for self-cleaning regeneration and reducing laboratory pesticide discharge.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
