Article
Clinical Neurology
Aixia Zhang, Dan Qiao, Yuchen Wang, Chunxia Yang, Yanfang Wang, Ning Sun, Xiaodong Hu, Zhifen Liu, Kerang Zhang
Summary: By integrating neuroimaging and clinical data, machine learning methods were used to classify bipolar depression and unipolar depression at the individual level. The study found that functional differences in the reward circuit can help differentiate different types of depression and the classification model achieved high accuracy.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Diana Bogdanova
Summary: Recent studies compare psychomotor reactivity disorders and gait activity in unipolar and bipolar depression, and find significant differences among the three groups. Bipolar patients exhibit more inhibited psychomotor skills than unipolar patients and healthy controls. The simplified variant of the equilibriometric task is the most sensitive and psychomotor reactivity is a more precise marker than psychomotor activity. These findings are important for distinguishing similar psychiatric conditions and developing new diagnostic and therapeutic approaches.
Article
Psychology, Multidisciplinary
Ma Ruihua, Zhao Meng, Chen Nan, Liu Panqi, Guo Hua, Liu Sijia, Shi Jing, Zhao Ke, Tan Yunlong, Tan Shuping, Yang Fude, Tian Li, Wang Zhiren
Summary: This study aimed to investigate differences in facial emotion recognition among patients with UD, BD, and normal controls. It found that UD patients performed poorly in recognizing negative expressions and had longer recognition times, while BD patients had lower accuracy in recognizing positive expressions and longer recognition times. Rapid facial expression recognition may serve as a potential endophenotype for early identification of unipolar and BD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda, David L. Dunner, Claire O'Donovan, Janusz K. Rybakowski, Adam Bayes, Verinder Sharma, Philip Boyce, Vijaya Manicavasagar
Summary: The study developed a new measure for identifying bipolar disorder, comparing the classification accuracy of a weighting rating scale with equivalent weightings for each item. Results showed that both methods had extremely high classificatory accuracy, and identified optimal cut-off scores for diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
HaoFei Wang, Shui Tian, Rui Yan, Hao Tang, Jiabo Shi, RongXin Zhu, Yu Chen, YingLin Han, Zhilu Chen, HongLiang Zhou, Shuai Zhao, ZhiJian Yao, Qing Lu
Summary: This study investigated the neural oscillation patterns and cognitive impairments in patients with unipolar depression (UD) and bipolar depression (BD) using magnetoencephalography (MEG). The results showed that BD patients had more severe cognitive impairments in different dimensions compared to UD patients, and these impairments were associated with disrupted beta power modulations.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Laura Orsolini, Leonardo Ricci, Simone Pompili, Angelica Cicolini, Umberto Volpe
Summary: The aim of this study was to evaluate the baseline hsCRP levels in inpatients with unipolar and bipolar depression and their relationship with psychopathological, temperamental, and chronotype features. Results showed that previous suicide attempt, death, and self-harm/self-injury thoughts were significantly associated with higher hsCRP levels. Linear regression analysis revealed that higher scores on the depressive affective temperament and lower scores on the hyperthymic and irritable affective temperaments, as well as lower MEQ scores, predicted higher hsCRP levels.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Sandeep Grover, Himani Adarsh
Summary: This study aimed to evaluate the prevalence of mixed specifier in patients with unipolar and bipolar depression in India. The results showed that about one-fifth of patients with both types of depression exhibited mixed features during the acute phase of the illness, with no significant difference in the prevalence between the two groups.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Donato Favale, Maria Nacci, Antonello Bellomo, Julio Torales, Joao Mauricio Casltadelli-Maia, Antonio Ventriglio
Summary: This study found that patients with bipolar depression showed higher levels of psychopathological issues, depressive and anxious symptoms, and suicidality compared to patients with unipolar depression. They also had lower levels of hope and resilience, which were positively correlated with each other and inversely correlated with psychopathology, depressive symptoms, and suicidal symptoms. Therefore, specific psycho-educational and psychotherapeutic interventions should be promoted to increase levels of hope and resilience in mood disorders, especially in bipolar depression.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Psychiatry
Shuqi Kong, Zhiang Niu, Dongbin Lyu, Lvchun Cui, Xiaohui Wu, Lu Yang, Hong Qiu, Wenjie Gu, Yiru Fang
Summary: This study investigates the seasonal symptoms and non-enzymatic oxidative stress in first hospitalized patients with bipolar and unipolar depression, aiming to differentiate between the two disorders and reduce misdiagnosis. The study finds that patients with bipolar depression have distinct seasonal characteristics compared to those with unipolar depression. Clinical symptoms and indicators of oxidative stress may serve as factors for distinguishing between seasonal unipolar depression and bipolar depression. Young individuals aged 15-35 are more likely to develop bipolar depression in winter.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Nina Vindegaard Sorensen, Beate Holmelund Frandsen, Sonja Orlovska-Waast, Terkild Brink Buus, Niels Odum, Rune Haubo Christensen, Michael Eriksen Benros
Summary: This study systematically evaluated the circulating immune cells in blood and cerebrospinal fluid (CSF) from patients with unipolar depression compared to healthy controls. The findings suggest that patients with depression have higher overall leukocyte count, higher neutrophil count, higher monocyte count, and significant alterations in lymphocyte subsets. These immune cell alterations may be related to depression severity.
MOLECULAR PSYCHIATRY
(2023)
Review
Clinical Neurology
Sara Jimenez-Fernandez, Manuel Gurpegui, Daniel Garrote-Rojas, Luis Gutierrez-Rojas, Maria D. Carretero, Christoph U. Correll
Summary: This study aimed to investigate the differences in oxidative stress markers and antioxidants between patients with bipolar depression and unipolar depression. The results showed that both bipolar depression and unipolar depression may be associated with an impaired oxidative stress balance, with significantly higher uric acid levels observed in unipolar depression compared to bipolar depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Ibrahim H. Aslan, David S. Baldwin
Summary: The study found that patients with unipolar depression showed higher levels of rumination and performed better in some neuropsychological tests compared to those with bipolar depression. There was no significant difference in rumination between the two depression groups when duration of illness was controlled. A negative relationship was observed between rumination and emotion regulation as well as psychological resilience in both patient groups, but not in healthy controls.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Rodrigo Simonini Delfino, Jose Alberto Del-Porto, Juliana Surjan, Eduardo Magalhaes, Lorena Catarina Del Sant, Ana Cecilica Lucchese, Marco Aurelio Tuena, Carolina Nakahira, Victor Augusto Rodoalho Fava, Matheus Souza Steglich, Matheus Ghossain Barbosa, Luciana Maria Sarin, Acioly Luiz Tavares Lacerda
Summary: This study aimed to evaluate the anti-anhedonic effect of esketamine in patients with unipolar and bipolar depression. Results showed a significant reduction in anhedonia severity after multiple subcutaneous esketamine infusions, indicating effectiveness in both types of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biology
Antonio Tundo, Sophia Betro', Rocco de Filippis, Fulvia Marchetti, Daniele Nacca, Roberta Necci, Marica Iommi
Summary: This study reviewed the effectiveness and safety of pramipexole augmentation in the treatment of treatment-resistant depression. The results showed that pramipexole augmentation had a treatment response rate of 62.5% for both unipolar and bipolar depression, with good safety. However, further confirmation is needed.
Article
Neurosciences
Xinping Kuai, Dandan Shao, Shengyu Wang, Pu-Yeh Wu, Yan Wu, Xuexue Wang
Summary: This study suggests that neuromelanin-sensitive magnetic resonance imaging techniques can be used to differentiate BD-II from UD, by measuring signal intensities and volumes in the substantia nigra region.
Article
Neurosciences
Kristin Murtha, Bart Larsen, Adam Pines, Linden Parkes, Tyler M. Moore, Azeez Adebimpe, Aaron Alexander-Bloch, Monica E. Calkins, Diego G. Davila, Martin A. Lindquist, Allyson P. Mackey, David R. Roalf, J. Cobb Scott, Daniel H. Wolf, Ruben C. Gur, Raquel E. Gur, Ran Barzilay, Theodore D. Satterthwaite
Summary: Socioeconomic status (SES) has an impact on cognitive performance, particularly working memory (WM). This study found that both neighborhood SES and parental education were associated with greater activation of the executive system related to WM. Additionally, distinct patterns of brain activity within the executive system were identified, which mediated the relationship between SES and task performance.
Review
Anesthesiology
Alina T. Henn, Bart Larsen, Lennart Frahm, Anna Xu, Azeez Adebimpe, J. Cobb Scott, Sophia Linguiti, Vaishnavi Sharma, Allan Basbaum, Gregory Corder, Robert H. Dworkin, Robert R. Edwards, Clifford J. Woolf, Ute Habel, Simon B. Eickhoff, Claudia R. Eickhoff, Lisa Wagels, Theodore D. Satterthwaite
Summary: Neuroimaging is a powerful tool for studying the relationship between chronic pain and brain structure. A meta-analysis of structural magnetic imaging studies found subtle but widespread alterations in brain structure associated with chronic pain. These alterations primarily occurred in brain regions involved in pain processing.
Article
Neurosciences
Anna M. Fiorito, Andre Aleman, Giuseppe Blasi, Josiane Bourque, Hengyi Cao, Raymond C. K. Chan, Asadur Chowdury, Patricia Conrod, Vaibhav A. Diwadkar, Vina M. Goghari, Salvador Guinjoan, Raquel E. Gur, Ruben C. Gur, Jun Soo Kwon, Johannes Lieslehto, Paulina B. Lukow, Andreas Meyer-Lindenberg, Gemma Modinos, Tiziana Quarto, Michael J. Spilka, Venkataram Shivakumar, Ganesan Venkatasubramanian, Mirta Villarreal, Yi Wang, Daniel H. Wolf, Je-Yeon Yun, Eric Fakra, Guillaume Sescousse
Summary: This study conducted an image-based meta-analysis of functional magnetic resonance imaging studies and found no significant differences in brain activation patterns between individuals at risk of schizophrenia and healthy control subjects in response to negative emotional stimuli.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Biology
Danni Tu, Manu S. Goyal, Jordan D. Dworkin, Samuel Kampondeni, Lorenna Vidal, Eric Biondo-Savin, Sandeep Juvvadi, Prashant Raghavan, Jennifer Nicholas, Karen Chetcuti, Kelly Clark, Timothy Robert-Fitzgerald, Theodore D. Satterthwaite, Paul Yushkevich, Christos Davatzikos, Guray Erus, Nicholas J. Tustison, Douglas G. Postels, Terrie E. Taylor, Dylan S. Small, Russell T. Shinohara
Summary: A central challenge in medical imaging studies is to extract biomarkers that can characterize disease pathology or outcomes. This paper presents a fully automated framework for translating radiological diagnostic criteria into image-based biomarkers, with excellent classification performance.
Article
Psychology, Developmental
Bridget W. Mahony, Danni Tu, Srishti Rau, Siyuan Liu, Francois M. Lalonde, Aaron F. Alexander-Bloch, Theodore D. Satterthwaite, Russell T. Shinohara, Dani S. Bassett, Michael P. Milham, Armin Raznahan
Summary: This study aims to analyze the correlations between cognitive ability and psychopathology. The research fills the gap by focusing on a diverse care-seeking population and quantifying the relationships between full-scale IQ and multiple dimensions of psychopathology. The findings reveal the differential coupling between psychopathology dimensions as a function of IQ.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Valerie J. Sydnor, Theodore D. Satterthwaite
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Marina S. Borges, Mauricio S. Hoffmann, Andre Simioni, Luiza K. Axelrud, Danielle S. Teixeira, Andre Zugman, Andrea Jackowski, Pedro M. Pan, Rodrigo A. Bressan, Nadine Parker, Jurgen Germann, Patricia P. Bado, Theodore D. Satterthwaite, Michael P. Milham, M. Mallar Chakravarty, Luis Augusto Paim Rohde, Euripedes Constantino Miguel, Tomas Paus, Giovanni A. Salum
Summary: This study investigates the relationship between deviations in cerebellar volume and psychopathology, executive functions, and academic achievement in children and adolescents. The findings suggest that deviations in typical cerebellar development are associated with long-lasting consequences in youth. This study highlights the potential of typical developing models and emphasizes the important role of the cerebellum in mental health, cognition, and education.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemical Research Methods
Tyler M. Moore, Akira Di Sandro, J. Cobb Scott, Katherine C. Lopez, Kosha Ruparel, Lucky J. Njokweni, Satrajit Santra, David S. Conway, Allison M. Port, Lisa D'Errico, Sage Rush, Daniel H. Wolf, Monica E. Calkins, Raquel E. Gur, Ruben C. Gur
Summary: This study describes the application of CAT and related methods to the Penn Computerized Neurocognitive Battery (CNB) and a well-validated clinical assessment, aiming to increase efficiency and domain coverage. The final CAT-CCNB battery consists of 21 cognitive tests and five adaptive clinical scales. CAT-CCNB shows promise as a maximally efficient tool for neuropsychiatric assessment.
JOURNAL OF NEUROSCIENCE METHODS
(2023)
Article
Clinical Neurology
J. Cobb Scott, Tyler M. Moore, David R. Roalf, Theodore D. Satterthwaite, Daniel H. Wolf, Allison M. Port, Ellyn R. Butler, Kosha Ruparel, Caroline M. Nievergelt, Victoria B. Risbrough, Dewleen G. Baker, Raquel E. Gur, Ruben C. Gur
Summary: This study describes the development of novel performance validity measures using psychometric concepts and data embedded within the Penn Computerized Neurocognitive Battery. The results show proof-of-concept evidence for these measures detecting patterns of invalid responding and predicting validity rules in both developmental and adult datasets.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Ting Yat Wong, Tyler M. Moore, Jakob Seidlitz, Kenneth S. L. Yuen, Kosha Ruparel, Ran Barzilay, Monica E. Calkins, Aaron F. Alexander-Bloch, Theodore D. Satterthwaite, Raquel E. Gur, Ruben C. Gur
Summary: Understanding how traumatic stress affects brain development during adolescence is crucial. This study aimed to investigate deviations from normal brain gray matter in youths with traumatic exposures. Results showed that high traumatic stress load was associated with poorer cognitive functioning and more psychopathology, mediated by accelerated gray matter maturation. Additionally, individuals with higher stressor reactivity scores showed greater acceleration of gray matter maturation under traumatic stress.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Nynke A. Groenewold, Janna Marie Bas-Hoogendam, Alyssa R. Amod, Max A. Laansma, Laura S. Van Velzen, Moji Aghajani, Kevin Hilbert, Hyuntaek Oh, Ramiro Salas, Andrea P. Jackowski, Pedro M. Pan, Giovanni A. Salum, James R. Blair, Karina S. Blair, Joy Hirsch, Spiro P. Pantazatos, Franklin R. Schneier, Ardesheer Talati, Karin Roelofs, Inge Volman, Laura Blanco-Hinojo, Narcis Cardoner, Jesus Pujol, Katja Beesdo-Baum, Christopher R. K. Ching, Sophia Thomopoulos, Andreas Jansen, Tilo Kircher, Axel Krug, Igor Nenadic, Frederike Stein, Udo Dannlowski, Dominik Grotegerd, Hannah Lemke, Susanne Meinert, Alexandra Winter, Michael Erb, Benjamin Kreifelts, Qiyong Gong, Su Lui, Fei Zhu, Benson Mwangi, Jair C. Soares, Mon-Ju Wu, Ali Bayram, Mesut Canli, Rasit Tukel, P. Michiel Westenberg, Alexandre Heeren, Henk R. Cremers, David Hofmann, Thomas Straube, Alexander G. G. Doruyter, Christine Lochner, Jutta Peterburs, Marie-Jose Van Tol, Raquel E. Gur, Antonia N. Kaczkurkin, Bart Larsen, Theodore D. Satterthwaite, Courtney A. Filippi, Andrea L. Gold, Anita Harrewijn, Andre Zugman, Robin Buelow, Hans J. Grabe, Henry Voelzke, Katharina Wittfeld, Joscha Boehnlein, Katharina Dohm, Harald Kugel, Elisabeth Schrammen, Peter Zwanzger, Elisabeth J. Leehr, Lisa Sindermann, Tali M. Ball, Gregory A. Fonzo, Martin P. Paulus, Alan Simmons, Murray B. Stein, Heide Klumpp, K. Luan Phan, Tomas Furmark, Kristoffer N. T. Mansson, Amirhossein Manzouri, Suzanne N. Avery, Jennifer Urbano Blackford, Jacqueline A. Clauss, Brandee Feola, Jennifer C. Harper, Chad M. Sylvester, Ulrike Lueken, Dick J. Veltman, Anderson M. Winkler, Neda Jahanshad, Daniel S. Pine, Paul M. Thompson, Dan J. Stein, Nic J. A. Van der Wee
Summary: Limited convergence exists in neuroimaging investigations of subcortical brain region volumes in social anxiety disorder (SAD). Variations in methodological approaches and sample selection based on age and clinical characteristics may contribute to inconsistent findings. A global mega-analysis initiated by the ENIGMA-Anxiety Working Group revealed subtle volumetric alterations in subcortical regions in SAD patients. Differences were found in putamen and pallidum volumes, with additional factors such as comorbid anxiety disorders and age of SAD onset influencing these volumetric differences.
MOLECULAR PSYCHIATRY
(2023)
Review
Behavioral Sciences
Arielle S. Keller, Valerie J. Sydnor, Adam Pines, Damien A. Fair, Dani S. Bassett, Theodore D. Satterthwaite
Summary: In this article, we explain the developmental improvements in youth executive function (EF) that are supported by hierarchical changes in functional brain systems. The study focuses on the hierarchical sensorimotor-association axis of cortical organization and demonstrates that functional system developmental profiles vary along this axis. The article proposes that attention and frontoparietal control systems play a central role in the maturation of healthy EF, and reduced functional system differentiation across the sensorimotor-association axis contributes to transdiagnostic EF deficits.
TRENDS IN COGNITIVE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Thomas G. Brooks, Nicholas F. Lahens, Gregory R. Grant, Yvette I. Sheline, Garret A. Fitzgerald, Carsten Skarke
Summary: Many chronic diseases are characterized by disrupted sleep-wake cycles, indicating disrupted biorhythms. In this study, the association between wrist temperature amplitudes and future disease onset was investigated. It was found that decreased wrist temperature amplitudes were significantly associated with various diseases, suggesting peripheral thermoregulation as a potential digital biomarker.
NATURE COMMUNICATIONS
(2023)