Article
Chemistry, Analytical
Andy Hsien Wei Koh, Russ Chess-Williams, Anna Elizabeth Lohning
Summary: This study evaluated the quantities of biogenic amines in pre-workout supplements containing bitter orange and compared them to standardized reference materials. The results showed that most supplements did not meet the ratios found in the reference materials, suggesting potential authenticity issues with the plant-derived active components in these supplements.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Electrochemistry
Ayhan Altun, Roxana-Mihaela Apetrei, Pinar Camurlu
Summary: Biosensing devices for urea detection have been extensively studied due to the importance of analyzing urea levels in biological fluids. The use of specific electrochemical methods and bio-materials have shown promising results for accurate urea detection, potentially playing a crucial role in clinical diagnostics.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Chemistry, Applied
Jun Li, Jie Xu, Xiaomin Wang, Xiaochuan Wei, Jinge Lv, Limin Wang
Summary: Novel 4-methoxylaryl and 4-trifluoromethoxyaryl DPP-based levelers were synthesized and evaluated for their inhibitory ability on copper electrodeposition. Among them, 4-trifluoromethoxy-DPP showed optimal inhibition and strong adsorption capacity, making it a promising leveler for microvia filling. The systematic study demonstrated that 4-trifluoromethoxy-DPP achieved a high filling rate of 96.9% under the synergistic effect of the microvia filling performance.
Article
Chemistry, Physical
Qian Guo, Wen-Fang Deng, Jun-Li Xiao, Pan-Chang Shi, Jin-Lan Li, Zhi-Xu Zhou, Chun Ji
Summary: Indole derivatives, widely present in natural products and biologically active molecules, play a significant role in heterocyclic chemistry. In this study, a title compound, 3,4-di(1H-indol-3-yl)-1H-pyrrole-2,5-dione, was designed and synthesized by a three-step reaction. The compound was characterized by various spectra and confirmed by X-ray diffraction analysis. Its molecular structure was further optimized by DFT calculation. Additionally, the geometric parameters, MEP, FMO, Hirshfeld analysis, and infrared characteristic vibrational absorption bands were analyzed, along with the antitumor activity evaluated on A549 cells.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Syeda Shaista Gillani, Munawar Ali Munawar, Hafiz Adnan Ahmad, Rabia Babar, Khalid Mohammed Khan, Jamil Anwar Chaudhary
Summary: In this study, 2,5-diphenyl-3,4-di(phenylethenyl)cyclopentadienone, pyrrole, and thiophene were successfully synthesized using a two-step strategy. The efficient installation of various groups on the cyclopentadienone, pyrrole, and thiophene rings was achieved, resulting in an extended conjugated framework.
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
(2022)
Article
Crystallography
Yun-Yee Low, Siew-Huah Lim
Summary: The compound is a monoclinic crystal with the chemical formula C34H30O7. The crystal structure belongs to space group C2/c (no. 15), with lattice parameters a= 29.4446(6) Å, b= 12.4393(3) Å, c = 14.9807(3) Å, and β= 90.390(1) degrees. The unit cell volume is 5486.9(2) Å^3, and there are 8 molecules in the unit cell. The refinement results show R-gt(F) = 0.0408 and wR(ref)(F-2) = 0.1023, with a measurement temperature of 100 K.
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
(2023)
Article
Chemistry, Physical
Mohd Mehkoom, S. M. Afzal, Shabbir Ahmad, Salman A. Khan
Summary: This study investigates the linear and nonlinear optical properties of a pyrazoline derivative and evaluates its potential applications in optical switching, optical communication, and optical data storage devices. The compound exhibits good nonlinear optical behavior and shows promise in these applications.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Ozgur Yilmaz, Sadin Ozdemir, Serpil Gonca, Nermin Simsek Kus, Hatice Derya Kaynarpinar
Summary: In this article, the synthesis of ribose and furan derivatives with potential biological activities was successfully carried out and their biological activities were discussed. Among them, dimethyl 3,4-dihydroxytetrahydrofuran-2,5-dicarboxylate showed excellent antioxidant, antimicrobial, and DNA-degrading properties.
MONATSHEFTE FUR CHEMIE
(2022)
Article
Chemistry, Multidisciplinary
Mohamed A. A. Radwan, Fahad M. Alminderej, Hala E. M. Tolan, Hanem M. Awad
Summary: A series of chalcone imide derivatives, including p-tolyl-1H-pyrrole-2,5-dione and 4-bromophenyl-1H-pyrrole-2,5-dione derivatives, were synthesized and evaluated for their antiproliferative effects on human cancer cells. Compounds with specific structures showed high activity against liver cancer cells, while all compounds were more effective against breast cancer cells than the positive control doxorubicin. These results suggest the potential of selected chalcone-imide moieties as promising antiproliferative agents for further research.
EGYPTIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Aleksandra Redzicka, Benita Wiatrak, Izabela Jeskowiak-Kossakowska, Andrzej Kochel, Remigiusz Placzek, Zaneta Czyznikowska
Summary: In this study, the biological activity of a series of 15 newly designed and synthesized compounds, 2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl] derivatives of pyrrolo[3,4-c]pyrrole 3a-3o, was characterized. The compounds were obtained with good yields and their chemical structures were characterized using various techniques. A colorimetric inhibitor screening assay was used to investigate the inhibitory effects of the compounds on COX-1, COX-2, and LOX activity. Molecular docking simulations were also performed to analyze the interactions between the ligands and cyclooxygenase/lipooxygenase. The results indicate that all tested compounds influence the activity of COX-1, COX-2, and LOX.
Article
Multidisciplinary Sciences
Roza Al-Aqar
Summary: This article investigates the photophysical properties of a compound, showing that the absorption and emission peaks shift in different solvents due to solvent polarity. The compound is found to have fluorescent properties in various solvents, with sensitivity to solvent polarity.
BAGHDAD SCIENCE JOURNAL
(2022)
Review
Chemistry, Medicinal
Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi
EXPERT OPINION ON THERAPEUTIC PATENTS
(2016)
Review
Oncology
Rita Morigi, Alessandra Locatelli, Alberto Leoni, Mirella Rambaldi
RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
(2015)
Review
Biochemistry & Molecular Biology
Rita Morigi, Mirella Rambaldi, Alessandra Locatelli, Alberto Leoni
CURRENT MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Medicinal
Jussara Amato, Rita Morigi, Bruno Pagano, Alessia Pagano, Stephan Ohnmach, Alessio De Magis, Yee-Peng Tiang, Giovanni Capranico, Alessandra Locatelli, Alessandra Graziadio, Alberto Leoni, Mirella Rambaldi, Ettore Novellino, Stephen Neidle, Antonio Randazzo
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Article
Chemistry, Analytical
Rita Gatti, Rita Morigi
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2017)
Article
Chemistry, Medicinal
Rita Morigi, Beatrice Vitali, Cecilia Prata, Rogers A. N. Palomino, Alessandra Graziadio, Alessandra Locatelli, Mirella Rambaldi, Alberto Leoni
MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Sujeet Kumar, Vidya Gopalakrishnan, Mahesh Hegde, Vivek Rana, Sharad S. Dhepe, Sureshbabu A. Ramareddy, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Mrinal Srivastava, Sathees C. Raghavan, Subhas S. Karki
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2014)
Article
Chemistry, Medicinal
Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Concettina Cappadone, Giovanna Farruggia, Stefano Iotti, Lucia Merolle, Maddalena Zini, Claudio Stefanelli
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2014)
Article
Multidisciplinary Sciences
Alessio De Magis, Stefano G. Manzo, Marco Russo, Jessica Marinello, Rita Morigi, Olivier Sordet, Giovanni Capranico
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Chemistry, Medicinal
Rita Morigi, Alessandra Locatelli, Alberto Leoni, Mirella Rambaldi, Roberta Bortolozzi, Elena Mattiuzzo, Roberto Ronca, Federica Maccarinelli, Ernest Hamel, Ruoli Bai, Andrea Brancale, Giampietro Viola
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Ilaria Conti, Rita Morigi, Alessandra Locatelli, Mirella Rambaldi, Gloria Bua, Giorgio Gallinella, Alberto Leoni
Article
Chemistry, Medicinal
Jussara Amato, Giulia Miglietta, Rita Morigi, Nunzia Iaccarino, Alessandra Locatelli, Alberto Leoni, Ettore Novellino, Bruno Pagano, Giovanni Capranico, Antonio Randazzo
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Laura Verardi, Jessica Fiori, Vincenza Andrisano, Alessandra Locatelli, Rita Morigi, Marina Naldi, Carlo Bertucci, Elena Strocchi, Carla Boga, Gabriele Micheletti, Natalia Calonghi
Article
Biochemistry & Molecular Biology
Rita Morigi, Elena Catanzaro, Alessandra Locatelli, Cinzia Calcabrini, Valentina Pellicioni, Alberto Leoni, Carmela Fimognari
Summary: A series of new Knoevenagel adducts with two indolinone systems were synthesized and evaluated on 60 human cancer cell lines, showing some potent antiproliferative effects, with compound 5b being the most active and further studied in Jurkat cells to determine its effects on cell cycle phases and cell death induction, as well as oxidative stress and DNA damage analysis.
Article
Biochemistry & Molecular Biology
Francesca Bonvicini, Alessandra Locatelli, Rita Morigi, Alberto Leoni, Giovanna Angela Gentilomi
Summary: Isatin and its derivatives are important heterocycles with various biological activities and are essential building blocks in organic synthesis. In this study, a small library of 18 isatin hybrids were synthesized and evaluated for antimicrobial potential, with two lead compounds showing inhibitory activity against S. aureus at very low concentrations.
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)