期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1218, 期 27, 页码 4138-4143出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2010.11.081
关键词
Microfluidics; Inertial separation; Contraction-expansion array microchannel; Dean flow; Fluorescent solution
资金
- National Research Laboratory (NRL) [R0A-2008-000-20109-0]
- Ministry of Education, Science and Technology (MEST) [2009-0093663]
- National Research Foundation of Korea [2008-0060165, R0A-2008-000-20109-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We report a contraction-expansion array (CEA) microchannel that allows inertial size separation by a force balance between inertial lift and Dean drag forces in fluid regimes in which inertial fluid effects become significant. An abrupt change of the cross-sectional area of the channel curves fluid streams and produces a similar effect compared to Dean flows in a curved microchannel of constant cross-section, thereby inducing Dean drag forces acting on particles. In addition, the particles are influenced by inertial lift forces throughout the contraction regions. These two forces act in opposite directions each other throughout the CEA microchannel, and their force balancing determines whether the particles cross the channel, following Dean flows. Here we describe the physics and design of the CEA microfluidic device, and demonstrate complete separation of microparticles (polystyrene beads of 4 and 10 mu m in diameter) and efficient exchange of the carrier medium while retaining 10 mu m beads. (C) 2010 Elsevier B.V. All rights reserved.
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