Article
Biochemistry & Molecular Biology
Laura M. Vecchio, Patricia Sullivan, Amy R. Dunn, Marie Kristel Bermejo, Rong Fu, Shababa T. Masoud, Emil Gregersen, Nikhil M. Urs, Reza Nazari, Poul Henning Jensen, Amy Ramsey, David S. Goldstein, Gary W. Miller, Ali Salahpour
Summary: TH plays a crucial role in Parkinson's disease, increasing TH activity leads to oxidative stress and accumulation of toxic dopamine metabolites in vivo, augmenting toxicity.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Zuemruet Duygu Sen, Tara Chand, Lena Vera Danyeli, Vinod Jangir Kumar, Lejla Colic, Meng Li, Merve Yemisken, Nooshin Javaheripour, Alexander Refisch, Nils Opel, Tamar Macharadze, Moritz Kretzschmar, Esra Ozkan, Matthias Deliano, Martin Walter
Summary: This study examines the effect of ketamine on behavioral affective reactivity using the affect-modulated startle reflex paradigm (AMSR) and resting-state functional connectivity (rsFC). The results suggest that ketamine may attenuate the motivational significance of pleasant stimuli in healthy participants one day after infusion, and also decrease rsFC within the modulatory startle reflex pathway.
SCIENTIFIC REPORTS
(2023)
Article
Behavioral Sciences
Li -Min Zhang, Na-Na Liu, Lu Cao, Yue Xin, Dong-Xue Zhang, Yang Bai, Wei -Chao Zheng, Xin-Ying Bi, Bao-Heng Xing, Wei Zhang
Summary: The study investigated the neurotoxic effects of S-ketamine on offspring mice, showing that it may lead to ADHD- and depression-like behaviors. Changes in neuronal amount, glial activation, synaptic function, and inhibitory presynaptic proteins were observed in the hippocampus, amygdala, and habenula nucleus.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
Robert J. McDonald, Nancy S. Hong, Carlie Germaine, Bryan Kolb
Summary: The amygdala plays a role in emotions and modulates consolidation in other brain systems linked to learning and memory. This series of experiments further explores the role of the amygdala in memory modulation and consolidation. The experiments evaluated the effects of amygdala damage on drug-induced dendritic changes in the nucleus accumbens and prefrontal cortex, and the results suggest that not all memory modulators require the amygdala to impact memory.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Endocrinology & Metabolism
Jiyoung S. Kim, Kevin C. Williams, Rebecca A. Kirkland, Ruth Schade, Kimberly G. Freeman, Carolina R. Cawthon, Allison W. Rautmann, Jessica M. Smith, Gaylen L. Edwards, Travis C. Glenn, Philip V. Holmes, Guillaume de Lartigue, Claire B. de La Serre
Summary: Microbiota composition modulates reward signaling and the vagus nerve plays a role in mediating microbiota to brain communication. High-fat diet microbiota alters feeding behavior and reduces reward system activity. Selective gut to brain communication restoration can restore feeding behavior and reward system functionality.
MOLECULAR METABOLISM
(2023)
Article
Neurosciences
Michael Kalyn, Marc Ekker
Summary: In this study, cerebroventricular microinjections of MPTP in adult transgenic zebrafish resulted in reduced dopaminergic neurons, mitochondrial fragmentation, and activation of the pink1/parkin pathway. This led to transient locomotor and olfactory impairments in the animals, contributing to a better understanding of the impact of mitochondria on dopaminergic survivability.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Toxicology
Xixin Wang, Fangyan Wu, Hongyuan Zou, Yanan Yang, Gaoyang Chen, Kechun Liu, Yun Zhang, Li Liu
Summary: This study investigated the neurotoxicity of pyrazinamide (PZA) to larval zebrafish and found that PZA caused severe nerve damage in zebrafish larvae at certain concentrations. However, this nerve injury was found to be reversible after PZA withdrawal.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Neurosciences
Seongsik Yun, Ben Yang, Justin D. Anair, Madison M. Martin, Stefan W. Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, Ann Kennedy, Jones G. Parker
Summary: Psychosis is associated with elevated dopamine transmission, and antipsychotic drugs are thought to rebalance the output by blocking D2 receptors. However, this study found that the efficacy of antipsychotic drugs is associated with the reversal of abnormal D1-SPN dynamics, not D2-SPN dynamics. The findings suggest that D1-SPN modulation plays an important role in the mechanism of antipsychotic drugs.
NATURE NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Se Jong Oh, Kyung Rok Nam, Namhun Lee, Kyung Jun Kang, Kyo Chul Lee, Yong Jin Lee, Jae Yong Choi
Summary: Developmental complex trauma is strongly associated with psychiatric disorders in adulthood, particularly affecting the amygdala-mPFC circuit and neuroendocrine changes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jacopo Lamanna, Francesco Isotti, Mattia Ferro, Sara Spadini, Gabriella Racchetti, Laura Musazzi, Antonio Malgaroli
Summary: Unpredictable chronic mild stress (CMS) is a commonly used experimental method to induce depressive-like behaviors in rats. This study found that CMS vulnerable rats showed occluded DA-dependent synaptic plasticity in the medial prefrontal cortex (mPFC), possibly due to differential expression of AMPA receptors. Interestingly, this difference was not observed when rats were acutely treated with sub-anesthetic ketamine. The study provides insights into the neurophysiological mechanisms of stress vulnerability and the antidepressant action of ketamine.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Xin Fu, Eric Teboul, Grant L. Weiss, Pantelis Antonoudiou, Chandrashekhar D. Borkar, Jonathan P. Fadok, Jamie Maguire, Jeffrey G. Tasker
Summary: The authors study how the modulation of Gq activity in basolateral amygdala parvalbumin interneurons mediates the transitions between brain and behavioral states, particularly fear-related ones.
NATURE COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Yajie Guo, Zhongxin Jiang, Tingting Jin, Jinfang Huang, Xiangrong Sun
Summary: This study found that microinjection of CaSR agonist R568 into the basolateral amygdala (BLA) can inhibit food intake and induce anxiety-depression-like behaviors in mice. Dynorphin and gamma-aminobutyric acid neurons, activated by glutamatergic signals, reduce dopamine levels in the arcuate nucleus of the hypothalamus (ARC) and ventral tegmental area (VTA).
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Muhammad O. Chohan, Halli Fein, Sarah Mirro, Kally C. O'Reilly, Jeremy Veenstra-VanderWeele
Summary: Repeated activation of designer receptors exclusively activated by designer drugs (DREADDs) on dopaminergic (DA) neurons leads to homeostatic changes in basal behavior and response to amphetamine. These findings emphasize the importance of considering neuroadaptive changes in chronic or repeated DREADD activation.
PSYCHOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
William B. Foster, Katherine F. Beach, Paige F. Carson, Kagan C. Harris, Brandon L. Alonso, Leo T. Costa, Roy C. Simamora, Jaclyn E. Corbin, Keegan F. Hoag, Sophia I. Mercado, Anya G. Bernhard, Cary H. Leung, Eric J. Nestler, Laura E. Been
Summary: In placental mammals, elevated levels of estradiol during pregnancy decrease rapidly after birth, potentially leading to an estrogen withdrawal state that affects affective states in the postpartum period. The neural mechanisms underlying these affective changes are not well studied.
HORMONES AND BEHAVIOR
(2023)
Article
Neurosciences
Daniela L. Uliana, Felipe Gomes, Anthony A. Grace
Summary: The nucleus reuniens (RE) plays a role in regulating emotional and motivational behavior, as well as the neurophysiological changes induced by stress. Stress exposure leads to increased immobility and decreased dopamine neuron activity, while inactivation of the RE reverses these changes and restores dopaminergic activity.
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Biology
Pauline Belujon, Anthony A. Grace
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2015)
Editorial Material
Clinical Neurology
Pauline Belujon
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2017)
Review
Clinical Neurology
Pauline Belujon, Anthony A. Grace
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Neurosciences
Celine Nicolas, Clovis Tauber, Francois-Xavier Lepelletier, Sylvie Chalon, Pauline Belujon, Laurent Galineau, Marcello Solinas
NEUROPSYCHOPHARMACOLOGY
(2017)
Article
Substance Abuse
Pauline Belujon, Anthony A. Grace
Article
Neurosciences
Pauline Belujon, Anthony A. Grace
BIOLOGICAL PSYCHIATRY
(2014)
Article
Neurosciences
Pauline Belujon, Mary H. Patton, Anthony A. Grace
Article
Clinical Neurology
Pauline Belujon, Mary H. Patton, Anthony A. Grace
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Neurosciences
P. Belujon, J. Baufreton, L. Grandoso, E. Boue-Grabot, T. F. C. Batten, L. Ugedo, M. Garret, A. I. Taupignon
JOURNAL OF NEUROPHYSIOLOGY
(2009)
Article
Clinical Neurology
Pauline Belujon, Daniel J. Lodge, Anthony A. Grace
MOVEMENT DISORDERS
(2010)
Editorial Material
Clinical Neurology
Pauline Belujon, Anthony A. Grace
MOVEMENT DISORDERS
(2013)
Editorial Material
Neurosciences
Pauline Belujon, Anthony A. Grace
Review
Clinical Neurology
Marcello Solinas, Pauline Belujon, Pierre Olivier Fernagut, Mohamed Jaber, Nathalie Thiriet
JOURNAL OF NEURAL TRANSMISSION
(2019)
Article
Pharmacology & Pharmacy
Adelie Salin, Emilie Dugast, Virginie Lardeux, Marcello Solinas, Pauline Belujon
Summary: During abstinence from chronic cocaine, there are changes in the activity of brain structures involved in drug-seeking behavior, specifically the BLA-VP pathway, which contributes to the decrease in VTA dopamine activity.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)