期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1218, 期 22, 页码 3496-3501出版社
ELSEVIER
DOI: 10.1016/j.chroma.2011.03.071
关键词
Chiral stationary phase; Cyclodextrin; Spacer; Enantioseparation
资金
- National University of Singapore (NUS)
- Natural Science Foundation of Jiangsu Province [BK2010486]
Cyclodextrin and its derivatives are widely used as selectors of chiral stationary phases (CSPs) for high performance liquid chromatography (HPLC) due to their unique molecular structure and resolution capability. Three mono(6(A)-N-(omega-alkenylamino)-6(A)-deoxy)perphenylcarbamoylated beta-cyclodextrin (PICD) based CSPs with different length spacers have been prepared, with their enantioseparation abilities evaluated with 10 model racemates including aromatic alcohols, flavanone compounds, amine and non-protolytic compounds under normal-phase conditions. The effect of spacer length and surface loading on the enantioseparation performance of CSPs is investigated herewith. The results indicate that higher surface loading 6C-PICD displays the best enantioselectivities towards selected racemates under normal-phase conditions. (C) 2011 Elsevier B.V. All rights reserved.
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