Article
Chemistry, Applied
Carlos E. A. de Melo, Moises Dominguez, Marcos C. Rezende, Vanderlei G. Machado
Summary: Solvatochromic dyes, especially Effenberger's dye (ED), have been used to probe the polarity of the medium. Six imine probes inspired by ED were synthesized and characterized, showing positive solvatochromism similar to ED. The study highlights the importance of polarizability in solvation of the dyes.
Article
Agricultural Engineering
Xinquan Liang, Yuan Zhu, Benkun Qi, Shiqian Li, Jianquan Luo, Yinhua Wan
Summary: This study investigated the pretreatment of corn stover using lactic acid-based deep eutectic solvents with varying hydrogen bond acceptor structures. The results showed that DESs with short alkyl chain HBAs were more effective in removing lignin and xylan and promoting enzymatic digestion. Additionally, the hydrogen bond acidity of the DESs was found to have a strong positive relationship with pretreatment efficacy, providing insights into the design and selection of DESs for lignocellulose pretreatment.
BIORESOURCE TECHNOLOGY
(2021)
Article
Chemistry, Physical
Luis Moreira, Ruben Elvas-Leitao, Filomena Martins
Summary: Quantitative structure-property relationships were established and a new model equation mKAT was proposed to improve the interpretation of solvent effects in the heterolysis reaction of 3-bromo-3-ethylpentane.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Zhiyu Hu, Zirui Song, Zhaodong Huang, Shusheng Tao, Bai Song, Ziwei Cao, Xinyu Hu, Jiae Wu, Fengrong Li, Wentao Deng, Hongshuai Hou, Xiaobo Ji, Guoqiang Zou
Summary: This research proposes a novel electrolyte for high-voltage aqueous rechargeable energy storage devices, utilizing polyethylene glycol (PEG) and N, N-dimethylformamide (DMF) as co-solvents to reconstruct the hydrogen bond network. The electrolyte achieves a wide electrochemical window and enhances the performance of zinc cells and zinc-ion supercapacitors, significantly improving their cycle life.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Michael H. Abraham, Ricardo Sanchez-Moreno
Summary: Experimentally determined water-solvent partition coefficients of fluorescein were used to obtain descriptors for predicting the properties of fluorescein.
JOURNAL OF SOLUTION CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Yilin Ma, Qiu Zhang, Luojia Liu, Yixin Li, Haixia Li, Zhenhua Yan, Jun Chen
Summary: This study presents a simple strategy to improve the performance of aqueous Zn batteries by suppressing side reactions and enhancing the reversibility of the Zn electrode. By introducing DMF to the electrolyte, the water activity is effectively reduced, leading to higher efficiency and longer cycle life.
NATIONAL SCIENCE REVIEW
(2022)
Article
Engineering, Chemical
Ping Lu, Peizhuo Sun, Qiang Ma, Huaneng Su, Puiki Leung, Weiwei Yang, Qian Xu
Summary: This study introduces a ternary deep eutectic solvent (DES) by introducing glycerol into the original binary DES, aiming to improve the electrochemical performance of redox flow batteries. The results show that the mass transfer resistance and electrochemical performance of the redox pairs in the ternary DES solvent are improved.
Article
Chemistry, Physical
Zhiming Zhao, Jun Yin, Jian Yin, Xianrong Guo, Yongjiu Lei, Zhengnan Tian, Yunpei Zhu, Omar F. Mohammed, Husam N. Alshareef
Summary: Sustainable battery development is aiming at using aqueous electrolytes to store renewable energy on a large scale. However, the hydrogen evolution reaction (HER) on the anode of aqueous batteries poses a challenge. In this study, by regulating mass transfer kinetics and blocking proton conduction with N-methyl-2-pyrrolidone (NMP), the HER in aqueous batteries is mitigated and stable full-cell batteries are achieved with high Coulombic efficiency.
ENERGY STORAGE MATERIALS
(2023)
Article
Engineering, Chemical
Yiping Huang, Defang Ouyang, Yuanhui Ji
Summary: This study systematically investigated the solvation mechanisms of aspirin and etomidate in four combinations of ionic liquids through molecular dynamics simulations and DFT calculations. The results showed that the solvation properties were closely related to the hydrogen-bond basicity of anions and the hydrogen-bond acidity of cations. The study also found differences in solvation mechanisms between aspirin and etomidate.
Article
Energy & Fuels
Jyoti Gahtori, Vivek Kumar Shrivastaw, Tuhin S. Khan, M. Ali Haider, Subham Paul, Ankur Bordoloi
Summary: The paper investigates the influence of different modifiers on mesoporous TiO2 catalysts loaded with Co, Mn, and Pt for aqueous phase Fischer-Tropsch synthesis. The catalysts were synthesized using a two-step method and characterized using various techniques. The results show that a balanced surface acidity to basicity ratio plays a crucial role in the activation and hydrogenation of CO.
Article
Chemistry, Physical
Meiling Tang, Xiaoqi Yi, Haiming Huang, Yingli Feng, Gang Chen, Xiaojing Mu
Summary: Aqueous biphasic systems (ABSs) have gained increasing attention for the extraction of active components due to their high extraction efficiency and product purity. This study investigated the solvent factors influencing extraction by designing four new ABSs with different organic solvents for paeonol extraction. The results showed that replacing acetone/thf with ethyl acetate (EA) in ABSs improved the paeonol yield. Furthermore, the solvatochromic parameters of the top phase in ABSs were detected, and it was found that the dipolarity/dipolarizability, hydrogen bond acidity, and hydrogen bond basicity of the top phase medium were strongly correlated with paeonol yield and partition coefficient. These findings highlight the importance of hydrogen bonding and hydrophobic interactions in efficient extraction, and the solvatochromic parameters can provide guidance for solvent selection in ABS extraction.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Chemistry, Multidisciplinary
Maria Chiara Storer, Christopher A. A. Hunter
Summary: This review presents the Surface Site Interaction Point (SSIP) approach for describing non-covalent interactions between molecules. It focuses on the empirical non-covalent interaction parameters alpha and beta, and provides rules of thumb for estimating free energy changes. The review also introduces a computational approach using the Molecular Electrostatic Potential (MEP) surface to obtain SSIPs and predicts thermodynamic properties. This method is simple, accurate, and applicable in complex molecular systems without computationally expensive simulations.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Physical
Guijie Zhao, Wei Shi, Xin Xin, Fengcai Ma, Yongqing Li
Summary: This study investigates the excited state intramolecular proton transfer process (ESIPT) of Compound 1 under different solvent conditions using density functional and time-dependent density functional methods. The results show that the photophysical properties of Compound 1 are influenced by the solvent environment.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Wenliang Wu, Hongshuai Gao, Bin Hai, Binqi Wang, Min Yu, Yi Nie
Summary: The study found that [PSmim][HSO4] is the most effective catalyst among the four SFILs tested, significantly reducing reaction time and decreasing the ratio of n-octanol to glucose. Additionally, [PSmim][HSO4] can be easily regenerated and reused multiple times.
Article
Biochemistry & Molecular Biology
Qinghui Chen, Yehong Chen, Chaojun Wu
Summary: In this study, the changes in the properties and microstructure of cellulose nanofibrils (CNFs) treated with Deep Eutectic Solvent (DESs) based on oxalic acid as hydrogen bond donors (HBD) and choline chloride, betaine, and N-methylmorpholine-N-oxide (NMMO) as hydrogen bond acceptors (HBA) were investigated. The results showed that the crystal structures of CNFs were unchanged, but the hydrogen bond network evolved, increasing the crystallinity and crystallite size. Further analysis revealed that all three hydrogen bonds were disrupted to different degrees and evolved in a certain order.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Rami S. Arafah, Antonio E. Riberio, Alirio E. Rodrigues, Luis S. Pais
Summary: This study successfully separated multiple stereoisomers of nadolol using high pH reversed-phase fixed-bed and simulated moving bed preparative chromatographic techniques, and transformed them into two high-purity stereoisomers. The feasibility of this method was validated through experimental results.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Lucas F. A. S. Zafanelli, Ezzeldin Aly, Alirio E. Rodrigues, Jose A. C. Silva
Summary: In this study, a fixed-bed adsorption apparatus was developed to investigate the adsorption breakthrough curve of green hydrogen blended in natural gas grids at cryogenic temperatures and high pressures. The results showed that the novel apparatus is a reliable tool for screening adsorbents and studying the dynamic separation of green hydrogen from natural gas.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Engineering, Chemical
Rafael O. M. Dias, Idelfonso B. R. Nogueira, Alexandre F. P. Ferreira, Alirio E. Rodrigues, Ana M. M. Ribeiro
Summary: In a simulated moving bed (SMB), regeneration is achieved by using a desorbent and recovering it in downstream separations. The proper selection of an appropriate adsorbent/desorbent pair is crucial for the effectiveness of the SMB process. By developing a parameter called SMB performance indicator (SPI) using readily available literature data, the selection process can be fast and easily accomplished. This metric considers adsorption selectivity, adsorption capacity, and enthalpy ratio, and can determine the most suitable adsorbent/desorbent pair for a specific gas separation in SMB through simple calculations.
Article
Biochemistry & Molecular Biology
Ana F. Costa, Emanuel Senra, Isabel Faria-Ramos, Andreia Teixeira, Joao Morais, Mariana Pacheco, Celso A. Reis, Catarina Gomes
Summary: Expression of SLeX is associated with malignant transformation of cancer cells and their invasive properties. In this study, the role of ST3GalIV in the biosynthesis of SLeX and malignant properties of GI cancer cells was investigated. The findings suggest that ST3GalIV is the main enzyme driving the biosynthesis of SLeX and affects cancer cell motility.
GLYCOCONJUGATE JOURNAL
(2023)
Article
Multidisciplinary Sciences
Juliana Pocas, Catarina Marques, Catarina Gomes, Andreia Hanada Otake, Filipe Pinto, Mariana Ferreira, Tiago Silva, Isabel Faria-Ramos, Rita Matos, Ana Raquel Ribeiro, Emanuel Senra, Bruno Cavadas, Silvia Batista, Joana Maia, Joana A. Macedo, Luis Lima, Luis Pedro Afonso, Jose Alexandre Ferreira, Lucio Lara Santos, Antonio Polonia, Hugo Osorio, Mattias Belting, Celso A. Reis, Bruno Costa-Silva, Ana Magalhaes
Summary: Gastric cancer is influenced by the expression of syndecan-4 (SDC4) which is associated with poor patient survival. SDC4 plays a crucial role in regulating the motility and invasion of gastric cancer cells. Additionally, SDC4 decorated with heparan sulfate is involved in the distribution, uptake, and functional effects of extracellular vesicles (EVs) derived from gastric cancer cells. SDC4 knockout disrupts the tropism of EVs for common gastric cancer metastatic sites. These findings provide insight into the molecular implications of SDC4 expression in gastric cancer cells and present potential therapeutic strategies targeting the glycan-EV axis to limit tumor progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Physical
William Q. Rios, Bruno Antunes, Alirio E. Rodrigues, Ines Portugal, Carlos M. Silva
Summary: Analytical equations for effectiveness factors of reversible reactions are developed and numerically validated in this study. These equations are expressed in terms of irreversible nth order Thiele modulus, thermodynamic equilibrium constant, ratios of effective diffusivities, and ratios of surface concentrations. The application of these equations is demonstrated for two liquid phase reactions catalyzed by Amberlyst-15.
Article
Chemistry, Multidisciplinary
Alvaro M. Martins, Tania M. Lopes, Francisca Diniz, Jose Pires, Hugo Osorio, Filipe Pinto, Daniela Freitas, Celso A. Reis
Summary: Alterations in glycosylation machinery in cancer cells lead to the synthesis of abnormal glycan structures in tumor cells. Extracellular vesicles (EVs) are involved in cancer communication and progression, and certain tumor-associated glycans have been identified in cancer EVs. This study investigates the impact of 3D tumor architecture on the selective packaging of cellular glycans into EVs. The results show differential packaging of specific proteins and glycans in EVs produced by 2D and 3D cultured cells, suggesting distinct biological functions and correlation with clinical data.
Article
Food Science & Technology
Luana P. Queiroz, Carine M. Rebello, Erbet A. Costa, Vinicius V. Santana, Bruno C. L. Rodrigues, Alirio E. Rodrigues, Ana M. Ribeiro, Idelfonso B. R. Nogueira
Summary: This work proposes a novel framework based on scientific machine learning to tackle an emerging problem in flavor engineering and industry. By combining generative and reinforcement learning models, new flavor molecules are designed. The potential of the framework is validated by evaluating the synthesis accessibility, number of atoms, and likeness to natural or pseudo-natural products of the designed molecules.
Article
Chemistry, Multidisciplinary
Vinicius V. Santana, Marcio A. F. Martins, Jose M. Loureiro, Ana M. Ribeiro, Luana P. Queiroz, Carine M. Rebello, Alirio E. Rodrigues, Idelfonso B. R. Nogueira
Summary: Model-based optimization of SMBRs requires efficient solvers and significant computational power. Despite the applications of artificial neural networks (ANNs) in modeling SMB units, their usage in reactive SMBRs is limited. The evaluation of the representation capability of ANNs is an open issue, and the optimal assessment using surrogate models remains unresolved. The main contributions of this study are the optimization of SMBRs based on deep recurrent neural networks (DRNNs) and the characterization of feasible operation regions using metaheuristic techniques. The results show that DRNN-based optimization can effectively address complex optimization problems while achieving optimality.
Article
Chemistry, Multidisciplinary
Beatriz C. Silva, Carine Menezes Rebello, Aliirio E. Rodrigues, Ana M. Ribeiro, Alexandre F. P. Ferreira, Idelfonso B. R. Nogueira
Summary: This study proposes a novel strategy for the design of adsorption heat pumps, which involves simultaneous optimization and material screening using the particle swarm optimization (PSO) approach. The proposed framework effectively evaluates different adsorbents and temperature intervals to find the optimal solution in terms of maximum performance and minimum heat supply cost. This approach provides a fast and intuitive evaluation of multiple design and operation variables.
Article
Chemistry, Multidisciplinary
Luana P. Queiroz, Carine M. Rebello, Erbet A. Costa, Vinicius V. Santana, Bruno C. L. Rodrigues, Alirio E. Rodrigues, Ana M. Ribeiro, Idelfonso B. R. Nogueira
Summary: This study proposes a scientific machine learning (SciML) approach to design new flavor molecules. By analyzing and studying the molecules generated by the model, it was found that this method has the potential for application in the flavor industry.
Article
Engineering, Chemical
Carina A. E. Costa, Filipa M. Casimiro, Carlos Vega-Aguilar, Alirio E. Rodrigues
Summary: In this study, solvent fractionation was used to obtain lignin fractions with a narrowed molecular weight and specific structural characteristics, improving its homogeneity and purity. The water-soluble fraction had more phenolic OH, less aliphatic OH groups, and less aryl-ether linkages, indicating higher condensation degree. On the other hand, the insoluble fraction from the 60% acetone mixture had the lowest molecular weight and highest inorganic material content. The fraction with the highest potential (IF 30:70) showed an increase of about 13% for vanillin and 19% for syringaldehyde after alkaline oxidation, suggesting its potential as a source of high added-value monomeric phenolic compounds.
Article
Engineering, Environmental
A. Catarina Faria, C. V. Miguel, Alexandre F. P. Ferreira, A. E. Rodrigues, Luis M. Madeira
Summary: In this study, nickel-substituted hydrotalcites promoted with cesium were synthesized and their dual-function ability as a high-temperature CO2 adsorbent and methanation catalyst was evaluated. It was found that materials impregnated using the direct impregnation method had a higher number of basic sites, which facilitated greater CO2 sorption. However, these materials exhibited lower selectivity towards methane, resulting in a higher CO formation. Therefore, materials prepared using the powder impregnation method were chosen for further investigation in a parametric study.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Julia C. Kessler, Vanessa Vieira, Isabel M. Martins, Yaidelin A. Manrique, Patricia Ferreira, Ricardo C. Calhelha, Andreia Afonso, Lillian Barros, Alirio E. Rodrigues, Madalena M. Dias
Summary: This study explores the potential of almond, hazelnut, and walnut extracts as food flavouring agents, suggesting a new added-value application for lower quality or excess production fruits. The extracts were characterized and evaluated, and almond extract was identified as the most promising ingredient to increase the sensory value of food products.
Article
Biochemistry & Molecular Biology
Ines F. Mota, Filipa Antunes, Joana F. Fangueiro, Carina A. E. Costa, Alirio E. Rodrigues, Manuela E. Pintado, Patricia S. Costa
Summary: Lignin has been investigated as a potential ingredient for cosmetics due to its UV protection, antioxidant, and antimicrobial properties. This study presents a simple method to obtain light-colored lignin from sugarcane bagasse and demonstrates its excellent antioxidant and emulsifying capabilities. The safety and stability of lignin in an oil-in-water emulsion are also confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
