Review
Cell Biology
Elissa Tjahjono, Daniel R. Kirienko, Natalia Kirienko
Summary: Mitochondrial dysfunction is a major cause of various diseases, and surveillance mechanisms play a crucial role in anticipating and repairing damaged mitochondria.
Review
Physiology
Hannah C. Alberico, Dori C. Woods
Summary: Mitochondria play a crucial role in granulosa cell function and can impact the reproductive ability of female mammals through aging.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leonardo Aguilar-Hernandez, Ricardo Alejandre, Julio Cesar Morales-Medina, Tommaso Iannitti, Gonzalo Flores
Summary: Aging is a natural process characterized by the accumulation of cellular damage and debris. It is associated with oxidative stress, cellular senescence, sustained inflammation, and DNA damage, leading to morphological and functional decline. The atrophy is mainly observed in high metabolic tissues such as the brain, particularly in regions related to cognitive behavior. This article reviews the cellular processes triggering aging, distinguishes between normal and pathological aging, and discusses the use of supplements with antioxidant and anti-inflammatory properties in reducing cognitive decline.
JOURNAL OF CHEMICAL NEUROANATOMY
(2023)
Article
Nutrition & Dietetics
Carsten Esselun, Fabian Dieter, Nadine Sus, Jan Frank, Gunter P. Eckert
Summary: The study demonstrates that walnut extract may enhance mitochondrial function, reduce Aβ(1-40) formation, stimulate neurite growth, potentially serving as a promising agent for preventing Alzheimer's disease.
Article
Endocrinology & Metabolism
Natalia Bobba-Alves, Gabriel Sturm, Jue Lin, Sarah A. Ware, Kalpita R. Karan, Anna S. Monzel, Celine Bris, Vincent Procaccio, Guy Lenaers, Albert Higgins-Chen, Morgan Levine, Steve Horvath, Balaji S. Santhanam, Brett A. Kaufman, Michio Hirano, Elissa Epel, Martin Picard
Summary: Stress triggers physiological responses that promote survival, but chronic activation of energy-dependent responses leads to a dysregulated state called allostatic load, which predicts functional decline, accelerates aging, and increases mortality in humans. A study on primary human fibroblast lines found that chronic exposure to glucocorticoids increases cellular energy expenditure and shifts metabolism from glycolysis to mitochondrial oxidative phosphorylation. This stress-induced hypermetabolism is associated with mtDNA instability, affects age-related cytokine secretion, and accelerates cellular aging, suggesting that increased energy expenditure is a potential driver of aging dynamics.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Emilio Sosa-Diaz, Estefani Yaquelin Hernandez-Cruz, Jose Pedraza-Chaverri
Summary: Vitamin D is considered essential for human health and plays a crucial role in delaying cellular senescence and attenuating oxidative stress, making it a promising candidate for preventing age-related diseases. However, further research is needed to fully understand the mechanisms behind its effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Jose Yanez, Andrea Leiva
Summary: The placenta plays a crucial role in cholesterol biosynthesis, metabolism, and exchange between the maternal and fetal compartments. The mechanisms of cholesterol uptake and intracellular traffic in placental cells are not fully understood. Proteins such as LDLR, SR-BI, ABCA1, and ABCG1 are involved in the transport of cholesterol. The role of proteins related to intracellular cholesterol traffic in placental cells during normal and pathological pregnancies is still largely unknown. Oxidative stress induced by ROS has been implicated in lysosomal and mitochondrial dysfunction in hypercholesterolemic pregnancies.
Review
Pharmacology & Pharmacy
Fabio Vivarelli, Silvia Granata, Laura Rullo, Matilde Mussoni, Sanzio Candeletti, Patrizia Romualdi, Carmela Fimognari, Ivan Cruz-Chamorro, Antonio Carrillo-Vico, Moreno Paolini, Donatella Canistro
Summary: Research has shown that e-cigarette consumption may pose various health risks, including carcinogenic effects, respiratory and cardiovascular diseases, as well as risks to fertility and pregnancy.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Robert John Aitken, Joel R. Drevet, Aron Moazamian, Parviz Gharagozloo
Summary: Reactive oxygen species (ROS) play a critical role in defining the functional competence of human spermatozoa. Adequate levels of ROS promote sperm capacitation, while excessive ROS generation leads to oxidative stress, disrupting fertilizing capacity and DNA integrity. Understanding the mechanisms of oxidative stress is essential for developing effective antioxidant strategies.
Article
Environmental Sciences
Ming Fu, Chenming Wang, Shiru Hong, Xin Guan, Hua Meng, Yue Feng, Yang Xiao, Yuhan Zhou, Chenliang Liu, Guorong Zhong, Yingqian You, Tianhao Wu, Handong Yang, Xiaomin Zhang, Meian He, Huan Guo
Summary: This study investigated the individual and mixture effect of plasma metals on blood mitochondrial DNA copy number. The results showed that plasma copper, rubidium and titanium were associated with increased blood mitochondrial DNA, and there was a significant mixture effect of all metals on mitochondrial DNA copy number among elderly population.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Kuo Chen, Pengwei Lu, Narasimha M. Beeraka, Olga A. Sukocheva, SubbaRao Madhunapantula, Junqi Liu, Mikhail Y. Sinelnikov, Vladimir N. Nikolenko, Kirill Bulygin, Liudmila M. Mikhaleva, Igor Reshetov, Yuanting Gu, Jin Zhang, Yu Cao, Siva G. Somasundaram, Cecil E. Kirkland, Ruitai Fan, Gjumrakch Aliev
Summary: This article discusses the role of epigenetic regulation of mitochondrial DNA (mtDNA) in cancer cells and the potential use of mtDNA modifications as novel targets for breast cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Mingming Chen, Yiyi Wang, Shoulong Deng, Zhengxing Lian, Kun Yu
Summary: This article discusses the relationship between aging and skeletal muscle atrophy, focusing on the key role of oxidative stress and oxidative damage in muscle atrophy during aging. It also explores the excessive production of reactive oxygen species in aging skeletal muscle and its potential molecular mechanism of ROS-mediated mitochondrial dysfunction. Furthermore, potential antioxidant and anti-inflammatory strategies for the treatment of sarcopenia during aging are summarized.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mashun Onishi, Koji Okamoto
Summary: Mitophagy is a crucial selective autophagy pathway that degrades dysfunctional mitochondria to maintain cellular health. Proper regulation of mitochondrial quantity and quality through mitophagy is essential for cellular energy balance, differentiation, and developmental processes. Defects in mitophagy can lead to various pathologies such as inflammation, tissue injury, neurodegeneration, and aging.
Article
Cell Biology
Tenghui Yu, Jesse Slone, Wensheng Liu, Ryan Barnes, Patricia L. Opresko, Landon Wark, Sabine Mai, Steve Horvath, Taosheng Huang
Summary: Mitochondrial dysfunction plays a crucial role in the aging process, and the accumulation of mutations in the mitochondrial genome is believed to contribute to this dysfunction. By studying a mouse model with error-prone mitochondrial DNA polymerase, researchers found that high levels of mitochondrial DNA mutations can lead to oxidative damage, compromised DNA integrity, and accelerated aging. These findings suggest that mitochondria play a central role in aging and may guide future research on potential therapeutics to mitigate the aging process.
Review
Biochemistry & Molecular Biology
Ioannis Smyrnias
Summary: Mitochondrial function is crucial for cellular processes, and the mitochondrial unfolded protein response is a key mechanism for maintaining mitochondrial stability, aiding in cellular recovery by regulating other processes.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
K. K. Ridout, M. Levandowski, S. J. Ridout, L. Gantz, K. Goonan, D. Palermo, L. H. Price, A. R. Tyrka
MOLECULAR PSYCHIATRY
(2018)
Article
Biochemistry & Molecular Biology
Kathryn K. Ridout, Mariam Khan, Samuel J. Ridout
Article
Public, Environmental & Occupational Health
Kelly C. Young-Wolff, Amy Alabaster, Brigid Mccaw, Nicole Stoller, Carey Watson, Stacy Sterling, Kathryn K. Ridout, Tracy Flanagan
JOURNAL OF WOMENS HEALTH
(2019)
Editorial Material
Neurosciences
Kathryn K. Ridout
BIOLOGICAL PSYCHIATRY
(2018)
Article
Behavioral Sciences
Nicole R. Nugent, Leslie Brick, Michael F. Armey, Audrey R. Tyrka, Kathryn K. Ridout, Lisa A. Uebelacker
Summary: The study examined the effects of hatha yoga as an adjunctive intervention for major depression on inflammatory markers, focusing on IL-6. Results showed a significant reduction in IL-6 concentrations in the yoga treatment group compared to the health education control group. Further research is needed to explore the long-term effects of hatha yoga on immune function.
BEHAVIORAL MEDICINE
(2021)
Article
Neurosciences
Kathryn K. Ridout, Samuel J. Ridout, Constance Guille, Douglas A. Mata, Huda Akil, Srijan Sen
BIOLOGICAL PSYCHIATRY
(2019)
Article
Endocrinology & Metabolism
Kathryn K. Ridout, Stephanie H. Parade, Hung-Teh Kao, Stevie Magnan, Ronald Seifer, Barbara Porton, Lawrence H. Price, Audrey R. Tyrka
PSYCHONEUROENDOCRINOLOGY
(2019)
Correction
Endocrinology & Metabolism
Kathryn K. Ridout, Stephanie H. Parade, Hung-Teh Kao, Stevie Magnan, Ronald Seifer, Barbara Porton, Lawrence H. Price, Audrey R. Tyrka
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Kathryn K. Ridout, Jesse L. Coe, Stephanie H. Parade, Carmen J. Marsit, Hung-Teh Kao, Barbara Porton, Linda L. Carpenter, Lawrence H. Price, Audrey R. Tyrka
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Cell Biology
Teresa E. Daniels, Alexander Sadovnikoff, Kathryn K. Ridout, Corina Lesseur, Carmen J. Marsit, Audrey R. Tyrka
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2020)
Article
Psychiatry
Samuel J. Ridout, Kathryn K. Ridout, Jonathan Kole, Kelly L. Fitzgerald, Abigail A. Donaldson, Brian Alverson
Summary: Depression comorbid with eating disorders is common and can worsen the severity of both disorders. Little is published regarding depression and eating disorders in male adolescents. This retrospective observational study found that male adolescents had significantly greater pre-hospitalization weight loss and longer eating disorder duration, and were 1.6 times more likely to have comorbid depression compared to female patients, suggesting increased detection and treatment in adolescent males is warranted.
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
Kathryn K. Ridout, Shariful A. Syed, Hung-Teh Kao, Barbara Porton, Anna Rozenboym, Jean Tang, Sasha Fulton, Tarique Perera, Andrea P. Jackowski, John G. Kral, Audrey R. Tyrka, Jeremy Coplan
Summary: This study investigated the relationship between early-life stress and adult telomere length as well as neuroendocrine markers. The results showed that individuals reared with variable foraging demand (VFD) had longer telomeres compared to non-VFD individuals, and telomere length was associated with plasma glucagon-like peptide 1 (pGLP-1) and insulin resistance.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2022)
Article
Health Care Sciences & Services
Kathryn K. Ridout, Mubarika Alavi, Samuel J. Ridout, Maria T. Koshy, Sameer Awsare, Brooke Harris, David R. Vinson, Constance M. Weisner, Stacy Sterling, Esti Iturralde
Summary: Suicide-related emergency department encounters declined in 2020 during the COVID-19 pandemic, but reached 2019 levels in June-August; compared to 2019, patients in 2020 were more likely to have co-occurring substance use disorders or lack mental health or suicide diagnoses associated with outpatient visits.
LANCET REGIONAL HEALTH-AMERICAS
(2021)
Article
Education & Educational Research
Samuel J. Ridout, Kathryn K. Ridout, Brian Theyel, Lisa M. Shea, Lauren Weinstock, Lisa A. Uebelacker, Gary Epstein-Lubow
ACADEMIC PSYCHIATRY
(2020)
Letter
Medicine, General & Internal
Kelly C. Young-Wolff, Varada Sarovar, Lue-Yen Tucker, Nancy C. Goler, Stacey E. Alexeeff, Kathryn K. Ridout, Lyndsay A. Avalos
