期刊
JOURNAL OF CHROMATOGRAPHY A
卷 1217, 期 25, 页码 4204-4211出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2010.03.014
关键词
Melamine; Cyanuric acid; Milk powder; Direct analysis in real time (DART); Time-of-flight mass spectrometry; Orbitrap mass spectrometry
资金
- Ministry of Education, Youth and Sports of the Czech Republic [MSM 6046137305]
The use of fast semi-automated method employing direct analysis in real time (DART) ion source coupled to time-of-flight mass spectrometry (TOFMS) for analysis of melamine (MEL) and cyanuric acid (CYA) in milk powder and milk based products has been demonstrated in this study. Simple sample extraction procedure employing methanol-5% aqueous formic acid mixture, which enabled disruption of melamine-cyanurate complex, was followed by direct, high-throughput (30s per run) examination of sample extracts spread on a glass rod by mass spectrometry under ambient conditions, without any prior chromatographic separation. After optimization of instrument parameter settings, limits of detection (LODs) 170 and 450 mu g kg(-1) were achieved for MEL and CYA, respectively. In the final phase of study, the possibility of minimizing spectral interference, thus improving method performance characteristics through the use of ultrahigh resolving power offered by Orbitrap based mass analyzer is demonstrated. (C) 2010 Elsevier B.V. All rights reserved.
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