A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans

Genome-Wide Association Study of Nicotine Dependence in American Populations: Identification of Novel Risk Loci in Both African-Americans and European-Americans

(2015) Joel Gelernter et al.   BIOLOGICAL PSYCHIATRY

CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control

(2014) D. E. Evans et al.   GENES BRAIN AND BEHAVIOR

Large-Scale Brain Network Coupling Predicts Acute Nicotine Abstinence Effects on Craving and Cognitive Function

(2014) Caryn Lerman et al.   JAMA Psychiatry

The Nicotinic Acetylcholine Receptor  5 Subunit Plays a Key Role in Attention Circuitry and Accuracy

(2013) C. D. C. Bailey et al.   JOURNAL OF NEUROSCIENCE

Nicotine consumption is regulated by a human polymorphism in dopamine neurons

(2013) C Morel et al.   MOLECULAR PSYCHIATRY

Subjective, Physiological and Cognitive Responses to Intravenous Nicotine: Effects of Sex and Menstrual Cycle Phase

(2013) Elise E DeVito et al.   NEUROPSYCHOPHARMACOLOGY

21st-Century Hazards of Smoking and Benefits of Cessation in the United States

(2013) Prabhat Jha et al.   NEW ENGLAND JOURNAL OF MEDICINE

COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers

(2013) A I Herman et al.   PHARMACOGENOMICS JOURNAL

Role of α5* nicotinic acetylcholine receptors in the effects of acute and chronic nicotine treatment on brain reward function in mice

(2013) Christie D. Fowler et al.   PSYCHOPHARMACOLOGY

Smoking and Genetic Risk Variation Across Populations of European, Asian, and African American Ancestry-A Meta-Analysis of Chromosome 15q25

(2012) Li-Shiun Chen et al.   GENETIC EPIDEMIOLOGY

Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by α3β4α5 nicotinic acetylcholine receptors

(2012) Anne Tammimäki et al.   NEUROPHARMACOLOGY

Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine

(2012) Mehmet Sofuoglu et al.   NEUROPSYCHOPHARMACOLOGY

Nicotinic acetylcholine receptor variation and response to smoking cessation therapies

(2012) Andrew W. Bergen et al.   Pharmacogenetics and Genomics

The drug effects questionnaire: psychometric support across three drug types

(2012) Meghan E. Morean et al.   PSYCHOPHARMACOLOGY

Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy

(2011) Jane E. Sarginson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

(2011) Christie D. Fowler et al.   NATURE

Aversion to Nicotine Is Regulated by the Balanced Activity of β4 and α5 Nicotinic Receptor Subunits in the Medial Habenula

(2011) Silke Frahm et al.   NEURON

Smoking Cessation Pharmacogenetics: Analysis of Varenicline and Bupropion in Placebo-Controlled Clinical Trials

(2011) David P King et al.   NEUROPSYCHOPHARMACOLOGY

CHRNA3 rs1051730 Genotype and Short-Term Smoking Cessation

(2011) M. R. Munafo et al.   NICOTINE & TOBACCO RESEARCH

Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans

(2010) Helen M. Hansen et al.   HUMAN MOLECULAR GENETICS

Acetylcholine Receptor (AChR)  5 Subunit Variant Associated with Risk for Nicotine Dependence and Lung Cancer Reduces ( 4 2)2 5 AChR Function

(2010) A. Kuryatov et al.   MOLECULAR PHARMACOLOGY

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

(2010) Jason Z Liu et al.   NATURE GENETICS

Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes

(2010) Richard Sherva et al.   NEUROPSYCHOPHARMACOLOGY

Associations of Variants in CHRNA5/A3/B4 Gene Cluster with Smoking Behaviors in a Korean Population

(2010) Ming D. Li et al.   PLoS One

A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction

(2010) L. E. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

(2010) Nancy L. Saccone et al.   PLoS Genetics

Variants in nicotinic acetylcholine receptors α5 and α3 increase risks to nicotine dependence

(2009) Xiangning Chen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy

(2009) Rachel M. Freathy et al.   HUMAN MOLECULAR GENETICS

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

(2009) Jen C. Wang et al.   HUMAN MOLECULAR GENETICS

Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals

(2009) Esther H Lips et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes

(2009) Timothy B. Baker et al.   NICOTINE & TOBACCO RESEARCH

Variants in Nicotinic Receptors and Risk for Nicotine Dependence

(2008) Laura Jean Bierut et al.   AMERICAN JOURNAL OF PSYCHIATRY

The CHRNA5-A3 Region on Chromosome 15q24-25.1 Is a Risk Factor Both for Nicotine Dependence and for Lung Cancer

(2008) Margaret R. Spitz et al.   JNCI-Journal of the National Cancer Institute

α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking

(2008) W Berrettini et al.   MOLECULAR PSYCHIATRY

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS