Article
Chemistry, Multidisciplinary
Yahui Zhang, Yi Chen, Mei Guo, Ge Sun, Rongbin Que, Ranran Cui, Yu Gao, Haijun Chen
Summary: The direct C-H functionalization of TH gamma Cs at the alpha-position has been developed. This mild and simple strategy enables the coupling of TH gamma Cs with various anilines and indoles, leading to satisfactory to excellent yields. The method has potential applications in synthesizing complex compounds and functionalizing similar biologically active structures.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Ahmad Saifuddin Mohamad Arshad, Ramu Meesala, Nur Aziah Hanapi, Mohd Nizam Mordi
Summary: A convenient synthesis for constructing aromatic beta-carbolines through iron-catalyzed decarboxylative/dehydrogenative aromatization has been developed with good functional group tolerance and high yields. The method was also applied in the gram-scale synthesis of important natural beta-carboline synthons, demonstrating practical access to specific compounds.
Article
Chemistry, Multidisciplinary
Zhihui Shao, Xiaoyu Zhang, Xinyan Li, Weilin Wang, Jiaqiao Ding, Bing Cui, Mingqin Zhao
Summary: An efficient and green method for the synthesis of tetrahydro-beta-carbolines using a dehydrogenative coupling reaction between alcohols and tryptamines is reported. The reaction proceeds under mild conditions with the presence of a catalytic amount of (PNP)-P-iPr Mn catalyst and a weak base (Na2CO3). This strategy shows good tolerance towards various benzylic and aliphatic alcohol substrates with different functional groups, leading to diverse products in good to excellent yields.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Haijun Chen, Panpan Qiao, Yining Luo, Jing Hu, Yu Gao
Summary: This study presents a copper-catalyzed method for the efficient synthesis of complex structures with excellent chemoselectivity under mild reaction conditions at room temperature for the first time.
Article
Biochemistry & Molecular Biology
Anna Jaromin, Beata Gryzlo, Marek Jamrozik, Silvia Parapini, Nicoletta Basilico, Marek Cegla, Donatella Taramelli, Agnieszka Zagorska
Summary: Malaria remains a major threat with drug resistance on the rise. New tetrahydro-beta-carbolines were synthesized and tested for antiplasmodial activity, with N-(3,3-dimethylbutyl)-1-octyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b] indole-3-carboxamide (7) showing the most promising results. Further research is being conducted on its potential mechanisms of action and delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Koonchira Buaban, Weerachai Phutdhawong, Thongchai Taechowisan, Waya S. Phutdhawong
Summary: A series of tetrahydro-ss-carbolines with alkyl or acyl side chains were synthesized and showed good antifungal activity, with 2-octyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole (3g) demonstrating a minimum inhibitory concentration of 0.1 µg/mL.
Article
Chemistry, Analytical
Luis Fabricio Santana Santos, Miliana Gouveia da Silva, Alain Gaujac, Sandro Navickiene
Summary: Alkaloids in tobacco play a crucial role in enhancing smokers' susceptibility to chemical dependence. This study developed and validated a microextraction analytical method for determining and quantifying beta-carboline alkaloids in tobacco, providing a fast, practical, economical, and environmentally friendly technique.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Chemistry, Organic
Zhang Xiaoyu, Li Xinyan, Cui Bing, Shao Zhihui, Zhao Mingqin
Summary: In this study, a new Pictet-Spengler oxidation reaction was developed using a pincer manganese catalyst, leading to the synthesis of 12 THBC products. The compounds exhibited good antioxidant activity, indicating their potential application in various fields.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Aarzoo Kamboj, Binita Sihag, Deshkanwar Singh Brar, Arshpreet Kaur, Deepak B. Salunke
Summary: Malaria is a preventable and treatable disease, but can be fatal if ignored. Current means to overcome malaria include ACT and RTS, S/AS01 vaccine, but they have limitations. Researchers are exploring the use of natural products containing beta-carboline scaffold to design new drugs to combat this deadly disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Luisina Rodriguez, Andres Lopez, Guillermo Moyna, Gustavo A. Seoane, Danilo Davyt, Aprimelvaro Vazquez, Gonzalo Hernandez, Ignacio Carrera
Summary: This study analyzed the composition of ayahuasca samples using NMR and LC-MS/MS techniques, revealing the presence of fructose in addition to major alkaloids. Harmine and other alkaloids were found in the suspended solids for the first time, shedding new light on the components of the psychedelic beverage.
Review
Chemistry, Analytical
Andrina Lerchi, Tristan Krap, Patrick Eppenberger, Antonella Pedergnana
Summary: This article reviews and discusses the possibilities and limitations of the analytical protocols used in residue analysis in archaeology, with a focus on the decomposition processes of adipocere, potential misidentifications, and proposing new research avenues.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Siyang Xing, Tingxuan Gao, Changkun Jin, Hongguo Dong, Xueying Shao, Kui Wang, Bolin Zhu
Summary: A Cp*RhCl2-catalyzed formal [3+3]-cycloaddition involving sequential ring opening of aziridines initiated by C-H activation and Michael addition has been developed for the construction of cis-1,4-disubstituted tetrahydro-gamma-carbolines. The advantages of this strategy include broad substrate scope, excellent cis-diastereoselectivities, highly functionalized products, and mild conditions.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Haibo Mei, Aiyao Liu, Jingrui He, Yingjie Yu, Jianlin Han
Summary: A series of indole-derived alkenes have been designed and used in a photocatalytic cascade reaction with bromodifluoroacetate esters to efficiently synthesize tetracyclic tetrahydro-gamma-carboline compounds.
Article
Medicine, Legal
Sharni Collins, Barbara Stuart, Maiken Ueland
Summary: Determining the post-mortem interval (PMI) is crucial in complex death investigations involving human remains. It can greatly assist in reconstructing forensically relevant events surrounding the death. However, due to the complexities of decomposition, PMI determination can still be challenging in some cases. Therefore, identifying biomarkers of human decomposition is an emerging and essential area of research.
FORENSIC SCIENCE INTERNATIONAL
(2023)
Article
Microbiology
Jessica Aparecida Silva Moretto, Paloma Nathane Nunes de Freitas, Eryka Costa de Almeida, Lucas Miguel Altarugio, Simone Vieira da Silva, Marli de Fatima Fiore, Ernani Pinto
Summary: This study evaluated the production of volatile organic compounds (VOCs) by two strains of Microcystis aeruginosa. The results showed that light intensity and external application of certain compounds can affect the production of VOCs.
Article
Biochemical Research Methods
Simon D. Brandt, Pierce Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M. Schwelm, Kyla Whitelock, Alexander Stratford, Volker Auwaerter, Adam L. Halberstadt
Summary: This study characterized a novel lysergamide N,N-diethyl-1-propanoyl-6-(prop-2-en-1-yl)-9,10-didehydroergoline-8 beta-carboxamide (1P-AL-LAD) using various analytical methods. In vitro metabolism studies confirmed that 1P-AL-LAD acted as a prodrug and converted to AL-LAD as the most abundant metabolite. 1P-AL-LAD induced dose-dependent head twitch response (HTR) in mice, similar to other hallucinogenic substances.
DRUG TESTING AND ANALYSIS
(2022)
Article
Chemistry, Medicinal
Mai A. Elhemely, Asma A. Belgath, Sherihan El-Sayed, Kepa K. Burusco, Manikandan Kadirvel, Annalisa Tirella, Katherine Finegan, Richard A. Bryce, Ian J. Stratford, Sally Freeman
Summary: A set of meta-substituted 3-arylisoquinolinones with substantial cytotoxicity in various cancer cell lines has been discovered. These compounds have the potential to mimic colchicine and interact with microtubules, leading to antiproliferative effects and inhibition of endothelial cell formation.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Tomas Herraiz, Adriana Pena, Haroll Mateo, Marta Herraiz, Antonio Salgado
Summary: This study discovers that new beta-carbolines can be formed when L-tryptophan reacts with alpha-dicarbonyl compounds. The formation of these beta-carbolines increases under acidic conditions and with increasing temperature. These alpha-dicarbonyl-derived beta-carbolines are present in foods, formed during heating processes, and can be considered as advanced glycation end products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemical Research Methods
Pierce Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M. Schwelm, Alexander Stratford, Volker Auwaerter, Stephen J. Chapman, Adam L. Halberstadt, Simon D. Brandt
Summary: This study describes the analysis of a novel lysergamides compound, 1cP-AL-LAD, using various chromatographic, mass spectrometric, and spectroscopic methods. The compound was found in both purchased samples and blotters sold online for recreational use. The findings provide valuable information for those interested in the chemistry of lysergamides.
DRUG TESTING AND ANALYSIS
(2023)
Article
Chemistry, Analytical
Matthias J. Richter, Lea Wagmann, Simon D. Brandt, Markus R. Meyer
Summary: The study identified in vitro metabolites of synthetic cannabinoid receptor agonists 2F-QMPSB and SGT-233, and found suitable targets for toxicological screenings. Different enzymes and human carboxylesterases were involved in their metabolism. Various CYP isoforms played important roles in the metabolism of these compounds.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2023)
Article
Neurosciences
Adam L. Halberstadt, Dino Luethi, Marius C. Hoener, Daniel Trachsel, Simon D. Brandt, Matthias E. Liechti
Summary: This study investigated the structure-activity relationships of 4-thio-substituted phenylalkylamines and found that these compounds have psychedelic effects, supporting their classification as psychedelics.
PSYCHOPHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Simon D. Brandt, Pierce V. Kavanagh, Folker Westphal, Benedikt Pulver, Hannes M. Schwelm, Alexander Stratford, Volker Auwaerter, Adam L. Halberstadt
Summary: Preclinical investigations have shown that EIPLA exhibits LSD-like properties and can mimic the effects of known psychedelic drugs, making it important for forensic and clinical research.
DRUG TESTING AND ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Tomas Herraiz
Summary: This study reveals that soy sauce contains bioactive beta-carbolines which can inhibit monoamine oxidase-A and -B. These findings suggest that soy sauce can be a dietary source of MAO inhibitors, with potential antidepressant and neuroprotective effects.
Article
Biochemistry & Molecular Biology
Kathleen Elverson, Jim Warwicker, Sally Freeman, Forbes Manson
Summary: Mutations in the BEST1 gene lead to the instability and loss of function of the Best1 protein, causing untreatable inherited retinal dystrophies. 4PBA and 2-NOAA have been shown to rescue the function of mutant Best1, but their therapeutic concentration is too high. A virtual docking model and screening of FDA-approved compounds identified tadalafil as a compound that can fully restore the ion channel function of a specific mutant Best1.
Article
Agriculture, Multidisciplinary
Tomais Herraiz, Adriana Pena, Antonio Salgado
Summary: This research identifies and characterizes perlolyrine, a beta-carboline compound with a furan moiety, and reveals its formation mechanism and occurrence in various foods. Perlolyrine is formed from the reaction of L-tryptophan with 3-deoxyglucosone, an intermediate of carbohydrate degradation, under acidic conditions and temperatures in the range of 70-110 degrees C. It is widely present in processed foods and is ingested daily through the diet.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Medicinal
J. Jonathan Nue-Martinez, David Cisneros, Maria del Valle Moreno-Blazquez, Cristina Fonseca-Berzal, Jose Ignacio Manzano, Damien Kraeutler, Marzuq A. Ungogo, Maha A. Aloraini, Hamza A. A. Elati, Alexandra Ibanez-Escribano, Laura Lagartera, Tomas Herraiz, Francisco Gamarro, Harry P. de Koning, Alicia Gomez-Barrio, Christophe Dardonville
Summary: In this study, we synthesized a series of analogues and conducted antiprotozoal screening and SAR studies of kDNA binders for trypanosomatid parasites. We found that compound 3a exhibited good activity and selectivity against all three parasites, making it a promising candidate for in vivo studies.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rachael N. Magwaza, Muna Abubaker, Buthaina Hussain, Michael Haley, Kevin Couper, Sally Freeman, Niroshini J. Nirmalan
Summary: The emergence of drug-resistant malaria requires the development of new therapies. A study identified a novel quinoline compound with high antimalarial activity, particularly against the ring stages of the parasite lifecycle. The compound showed synergistic activity when combined with artemether and maintained activity against different strains of the parasite, suggesting no cross-resistance.
Article
Biochemistry & Molecular Biology
Kathleen Elverson, Sally Freeman, Forbes Manson, Jim Warwicker
Summary: Many transmembrane proteins are modulated by intracellular or extracellular pH. Mutagenesis guided by amino-acid conservation and structure can be used to investigate pH dependence, but prediction of pKas can streamline this process. The hypothesis of modulation of calcium/proton coupling and pH-dependent activity through the extent of structural relaxation applies to various proteins, including bestrophin 1, TMEM16A, calmodulin, and calbindin D9k. Predicting altered pH dependence for mutations in ion channel disorders can support experimental studies and clinical intervention.
Article
Biochemical Research Methods
Verena Angerer, Yasmin Schmid, Florian Franz, Heike Gnann, Jan Manuel Speer, Anke Gnann, Stephan Helmecke, Armin Buchwald, Simon D. Brandt, Torsten Passie, Matthias E. Liechti, Volker Auwaerter
Summary: Administration of the new psychoactive substance 5,6-methylenedioxy-2-aminoindane (MDAI) to six volunteers revealed that acute subjective effects were qualitatively comparable with 3,4-methylenedioxymethamphetamine (MDMA) based on psychometric measures. Physiological and endocrine measures were also included. In serum and urine, MDAI could be detected for at least 4 and 6 days.
DRUG TESTING AND ANALYSIS
(2023)
Article
Agriculture, Multidisciplinary
Tomais Herraiz, Adriana Pena, Antonio Salgado
Summary: Perlolyrine is a naturally occurring compound found in many foods. It is formed from the reaction of L-tryptophan with carbohydrates and is generated during the heating process. The highest concentrations of perlolyrine are present in tomato concentrate and soy sauce, and it is ingested daily through diet.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Correction
Biochemical Research Methods
Yong Wang, Suhua Yu, Rui Li, Jing Wan, Yuheng Wang, Zongli Huo, Chunyong Wu, Li Mi, Songqin Liu
JOURNAL OF CHROMATOGRAPHY A
(2024)
Review
Biochemical Research Methods
Israel D. Souza, Maria Eugenia C. Queiroz
Summary: Organic-silica hybrid monolithic materials have gained significant attention in separation science and sample preparation due to their unique properties. This review summarizes the characteristics, current status, and recent developments of these materials, as well as discusses synthesis methods, characterization techniques, and strategies for improving extraction efficiency in various applications.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Bhagwat Upreti, Bhanu Prasad Vempatapu, Jagdish Kumar, Pankaj K. Kanaujia
Summary: Lubricating oils are essential for the effective performance of internal combustion engines. This study presents a new HPLC method for determining additives in finished lubricating oils and polar substances in used engine oils.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zongqing Huang, Haoju Hua, Xiuzhen Du, Zipeng Zhen, Wei Zhao, Jun Feng, Ji-an Li
Summary: This study successfully isolated VHHs against the SUMO protein for the first time using biopanning of an immune camelid nanobody library. The VHHs were coupled to agarose resins to form affinity chromatography resins, allowing for one-step purification of various SUMO fusions.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Xueting Qiu, Xuben Hou, Yue Yang, Hao Fang, Fei Cui, Xinying Yang
Summary: In this study, a new method based on electrophoretically mediated microanalysis was developed for the investigation of PTPRO enzymatic activity. The method was successfully used to determine the kinetics of PTPRO and the inhibitory concentration of PTPRO inhibitors. The method exhibited improved accuracy and reduced consumption compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Feifei Luo, Mengmeng Hao, Lei Zhang, Yangguo Xie, Wei Hou, Hongya Wang, Zhongli Zhang
Summary: In this study, a comprehensive screening and structure elucidation of 23 nonvolatile organic compounds (NVOCs) in two antibody drugs was conducted. Seven previously unreported compounds were identified. A quantitative method with high sensitivity, accuracy, and precision was developed for evaluating the safety of NVOCs in drug products.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zuzana Vosahlova, Kveta Kalfkova, Martin Gilar, Jakub Szymarek, Maria Mazurkiewicz-Beldzinska, Sylwia Studzi
Summary: A hydrophilic interaction liquid chromatography method was developed for the separation and identification of oligonucleotide impurities and metabolites, and successfully applied to the analysis of serum samples from Spinraza-treated patients.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Aswanidevi Kongasseri, Thirumalai Madhesan, Sangeetha Krishna Kumar, Sushmitha Pedugu Sivaraman, Suchashrita Mitra, Pitchaiah Kancharlapalli Chinaraga, C. V. S. Brahmmananda Rao, Sivaraman Nagarajan, Prabhakaran Deivasigamani, Akhila Maheswari Mohan
Summary: This study focuses on the sequential separation of trivalent lanthanides using modified C-18 silica-packed supports and reversed-phase HPLC technique. By tuning the column modifiers and separation parameters, the researchers achieved systematic separation of Ln(3+). The results showed that the choice of column modifiers and fine-tuning of the modification procedure were crucial for achieving excellent separation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Raquel Perez-Robles, Szabolcs Fekete, Robert Kormany, Natalia Navas, Davy Guillarme
Summary: There is a mismatch between the sample diluent and the mobile phase in HILIC analysis, leading to analyte breakthrough and peak distortion. Adding a weak solvent for pre-injection can effectively prevent these issues and improve sensitivity.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oleg Pokrovskiy, Irina Rostovschikova, Konstantin Ustinovich, Ilya Voronov, Dmitry Kosyakov
Summary: A chromatography-like propagation of water through the material bed was observed during supercritical fluid extraction of aroma plants with high moisture content, which could be significant for modeling the kinetics of supercritical fluid extraction of non-volatile compounds.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Yasar Kemal Recepoglu, Ozguer Arar, Asli Yuksel
Summary: Biosorption using phosphorylated hazelnut shell waste (FHS) is a promising method for lithium removal and recovery. This study investigated the performance of a continuous-flow packed-bed column system using FHS for ultra-low level lithium removal. The results showed that the lihium biosorption capacity of the FHS column was unaffected by the bed height, but decreased with increasing flow rate.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Jian Sun, Zheheng Zheng, Zixiao Jia, Jiabin Wang, Xucong Lin
Summary: In this study, an ionic covalent organic framework (iCOF) surface grafting monolithic sorbent was prepared for in-tube solid-phase microextraction (SPME) of aristolochic acids (AAs) in various samples. The density of quaternary ammonium ions in the iCOF was modulated for enhanced adsorption of AAs. The iCOF surface grafting monolithic sorbent was confirmed by different means. Several operating conditions were optimized to develop the online in-tube SPME-HPLC method, which showed good linearity, low limits of detection, and high recoveries for AAs in serum samples. This study presents a feasible approach for the application of COF-based monolithic sorbents in sample preparation.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Zeng Wen, Ruihan Peng, Die Gao, Jing Lin, Jia Zeng, Zhou Li, Famin Ke, Zhining Xia, Dandan Wang
Summary: A chitosan-alginate sponge with multiple cross-linking networks was developed for adsorption and enrichment of anionic dyes from food samples. The sponge showed better three-dimensional network structure, mechanical behavior, and stability compared to pure chitosan and alginate sponges. The adsorption performance and selectivity of the sponge were systematically studied, and it maintained high adsorption capacity and selectivity for anionic dyes. The sponge also showed satisfactory reusability and was successfully combined with high-performance liquid chromatography for the enrichment and detection of anionic dyes in candy and cocktail samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Hairong Zhang, Xiaojuan Jiang, Dandan Zhang, Yuexin Yang, Qiang Xie, Caisheng Wu
Summary: Analysis of in vivo exposure to traditional Chinese medicine using mass spectrometry is helpful for identifying effective ingredients and developing new drugs. This study focused on Forsythia suspensa (Lian Qiao) and used metabolomics technology to explore its in vivo exposure. By comparing the differences before and after administration, a complete set of nontargeted analysis strategies for TCM exposure was established. The study identified 393 Lian Qiao-related chemical components in mice after administration, including prototypes and metabolites. This study provides a reference for research on the active ingredients of Lian Qiao in vivo.
JOURNAL OF CHROMATOGRAPHY A
(2024)
Article
Biochemical Research Methods
Oscar Castejon-Musulen, Ricardo Lopez, Ignacio Ontan, Vicente Ferreira
Summary: A quantitative analytical method was developed and validated in this study to determine the concentrations of 81 aroma-relevant wine volatiles. The method utilizes stir bar sorptive extraction and multidimensional gas chromatography with flame ionization detector or mass spectrometer. The method demonstrated good linearity, reproducibility, and recovery, and was successfully applied to analyze 20 wine samples.
JOURNAL OF CHROMATOGRAPHY A
(2024)
